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1. 发明专利

IL158723A Once-a-day oxycodone formulation 未知
公开(公告)号：IL158723A
公开(公告)日：2013-12-31
申请号：IL15872303
申请日：2003-11-02
申请人： EURO CELTIQUE SA , OSHLACK BENJAMIN , WRIGHT CURTIS , PRATER DEREK
发明人： OSHLACK BENJAMIN , WRIGHT CURTIS , PRATER DEREK
IPC分类号： A61K20060101 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/24 , A61K9/26 , A61K9/30 , A61K9/32 , A61K9/36 , A61K9/44 , A61K9/48 , A61K9/50 , A61K9/52 , A61K9/56 , A61K31/485 , A61P25/04
摘要： The invention is directed to sustained release formulations containing oxycodone or a pharmaceutically acceptable salt thereof which provide a mean C 24/C max oxycodone ratio of 0.6 to 1.0 or 0.7 to 1 after oral administration at steady state to patients and methods thereof.

2. 发明专利

IL181356A ORAL DOSAGE FORM COMPRISING INTERDISPERSED (I) AN OPIOID AGONIST AND (II) AN ORALLY BIOAVAILABLE OPIOID ANTAGONIST IN A NON-RELEASABLE FORM 未知
公开(公告)号：IL181356A
公开(公告)日：2011-10-31
申请号：IL18135607
申请日：2007-02-15
申请人： EURO CELTIQUE SA , OSHLACK BENJAMIN , WRIGHT CURTIS
发明人： OSHLACK BENJAMIN , WRIGHT CURTIS
IPC分类号： A61K9/08 , A61K9/00 , A61K9/02 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K9/28 , A61K9/48 , A61K9/50 , A61K9/52 , A61K9/54 , A61K9/58 , A61K9/70 , A61K31/135 , A61K31/137 , A61K31/451 , A61K31/46 , A61K31/485 , A61K38/00 , A61K45/06 , A61K45/08 , A61K47/02 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/38 , A61P25/04 , A61P39/00 , A61P43/00
摘要： The present invention relates to an opioid antagonist composition comprising an opioid antagonist dispersed in a matrix that renders the antagonist substantially non-releasable, wherein the matrix comprises one or more of a phaimaceutically acceptable hydrophobic material and the antagonist is unavailable to be absorbed during its transit through the gastrointestinal system.

3. 发明专利

IL151057A TAMPER-RESISTANT ORAL OPIOID AGONIST FORMULATIONS 未知
公开(公告)号：IL151057A
公开(公告)日：2008-03-20
申请号：IL15105702
申请日：2002-08-01
申请人： EURO CELTIQUE SA , OSHLACK BENJAMIN , WRIGHT CURTIS
发明人： OSHLACK BENJAMIN , WRIGHT CURTIS
IPC分类号： A61K9/08 , A61K9/00 , A61K9/02 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K9/28 , A61K9/48 , A61K9/50 , A61K9/52 , A61K9/54 , A61K9/58 , A61K9/70 , A61K31/135 , A61K31/137 , A61K31/451 , A61K31/46 , A61K31/485 , A61K38/00 , A61K45/06 , A61K45/08 , A61K47/02 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/38 , A61P25/04 , A61P39/00 , A61P43/00
摘要： The present invention relates to an opioid antagonist composition comprising an opioid antagonist dispersed in a matrix that renders the antagonist substantially non-releasable, wherein the matrix comprises one or more of a phaimaceutically acceptable hydrophobic material and the antagonist is unavailable to be absorbed during its transit through the gastrointestinal system.

4. 发明专利

IL204761A ORAL DOSAGE FORM COMPRISING AN OPIOID AGONIST COATED OVER THE SEQUESTERED FORM OF THE OPIOID ANTAGONIST AND A HYDROPHOBIC MATERIAL 未知
公开(公告)号：IL204761A
公开(公告)日：2011-10-31
申请号：IL20476110
申请日：2010-03-25
申请人： EURO CELTIQUE SA , OSHLACK BENJAMIN , WRIGHT CURTIS
发明人： OSHLACK BENJAMIN , WRIGHT CURTIS
IPC分类号： A61K9/08 , A61K9/00 , A61K9/02 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K9/28 , A61K9/48 , A61K9/50 , A61K9/52 , A61K9/54 , A61K9/58 , A61K9/70 , A61K31/135 , A61K31/137 , A61K31/451 , A61K31/46 , A61K31/485 , A61K38/00 , A61K45/06 , A61K45/08 , A61K47/02 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/38 , A61P25/04 , A61P39/00 , A61P43/00
摘要： The present invention relates to an opioid antagonist composition comprising an opioid antagonist dispersed in a matrix that renders the antagonist substantially non-releasable, wherein the matrix comprises one or more of a phaimaceutically acceptable hydrophobic material and the antagonist is unavailable to be absorbed during its transit through the gastrointestinal system.

5. 发明专利

IL159917A PHARMACEUTICAL COMBINATIONS OF OXYCODONE AND NALOXONE 未知
公开(公告)号：IL159917A
公开(公告)日：2011-01-31
申请号：IL15991704
申请日：2004-01-18
申请人： EURO CELTIQUE SA , COLUCCI ROBERT D , OSHLACK BENJAMIN , WRIGHT CURTIS , BREDER CHRISTOPHER D , HOWARD STEPHEN A
发明人： COLUCCI ROBERT D , OSHLACK BENJAMIN , WRIGHT CURTIS , BREDER CHRISTOPHER D , HOWARD STEPHEN A
IPC分类号： A61K9/00 , A61K9/16 , A61K9/20 , A61K9/24 , A61K9/28 , A61K9/50 , A61K31/485 , A61P23/00 , A61P25/04 , A61P25/30 , A61P25/36
摘要： Disclosed in certain embodiments is a pharmaceutical composition comprising from 10 to 40 mg of oxycodone or a pharmaceutically acceptable salt thereof and 0.65 to 0.90 mg naloxone or a pharmaceutically acceptable salt thereof.

6. 发明专利

GB207564A Improvements in or relating to heels for boots and shoes 未知
公开(公告)号：GB207564A
公开(公告)日：1923-11-26
申请号：GB1485822
申请日：1922-05-26
申请人： FRANCIS WARD , ARTHUR WRIGHT CURTIS
IPC分类号： A43B21/00 , A43B21/34
摘要： 207,564. Ward, F., and Curtis, A. W. May 26, 1922. Heels.-A Louis or like heel comprises a thin metal shell a with a filling b of wood, wood pulp, leather boards &c., the upper edges of the shell and filling being flush to bed against the heel seat of the shoe. to which the heel is secured by inside attaching nails. The heel is fitted with a tread e of leather or rubber.

7. 发明申请

WO2005032555A2 PHARMACEUTICAL COMBINATIONS OF HYDROCODONE AND NALTREXONE 审中-公开
标题翻译：氢醌和纳曲酮的药物组合
公开(公告)号：WO2005032555A2
公开(公告)日：2005-04-14
申请号：PCT/US2004029521
申请日：2004-09-09
申请人： EURO CELTIQUE SA , OSHLACK BENJAMIN , WRIGHT CURTIS , BREDER CHRIS
发明人： OSHLACK BENJAMIN , WRIGHT CURTIS , BREDER CHRIS
IPC分类号： A61K9/00 , A61K9/22 , A61K31/485
CPC分类号： A61K31/485 , A61K31/194 , A61K45/06 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition comprising from about 5 to about 20 mg of hydrocodone or a pharmaceutically acceptable salt thereof and from 0.055 to about 0.56 mg naltrexone or pharmaceutically acceptable salt thereof
摘要翻译：公开了一种药物组合物，其包含约5至约20mg的氢可酮或其药学上可接受的盐和0.055至约0.56mg纳曲酮或其药学上可接受的盐

8. 发明申请

WO0241878A3 TITRATABLE DOSAGE TRANSDERMAL DELIVERY SYSTEM 审中-公开
标题翻译：可调剂量传递系统
公开(公告)号：WO0241878A3
公开(公告)日：2003-03-13
申请号：PCT/US0151197
申请日：2001-11-13
申请人： EURO CELTIQUE SA , WRIGHT CURTIS
发明人： WRIGHT CURTIS
IPC分类号： A61K9/70 , A61K31/445 , A61K31/485 , A61K47/10 , A61K47/14 , A61P25/04
CPC分类号： A61K9/7084 , A61F2013/0296 , A61K9/703 , A61K9/7038 , A61K9/7092 , A61K31/4468 , A61K31/485
摘要： The present invention relates to a titratable dosage transdermal delivery system for systemic delivery of a therapeutic agent or drug. The system comprises a plurality of patch units that are connected along one or more borders. The plurality of patch units are divisible into units along the one or more borders having one or more lines of separation. Each patch unit is surrounded by a border. The therapeutic patch has at least a backing layer and a therapeutic agent comprising layer. The dosage of therapeutic agent delivered to a patient is proportional to the number of patch unit applied per treatment. The system enables systemic administration of a titratable dosage of therapeutic agent, adjustable by the patient under the direction of a physician, through the skin or mucosa. Moreover, the invention relates to a method of making the titratable dosage transdermal delivery system. Furthermore, the invention relates to a method of providing a titratable amount of therapeutic agent to a patient using the transdermal delivery system of the invention.
摘要翻译：本发明涉及用于全身递送治疗剂或药物的滴定剂量透皮递送系统。该系统包括沿着一个或多个边界连接的多个贴片单元。多个贴片单元可以沿着具有一个或多个分离线的一个或多个边界被分割成单元。每个贴片单元都被边框包围。治疗性贴片具有至少背衬层和包含治疗剂的层。递送给患者的治疗剂的剂量与每次治疗施用的贴剂单元的数量成比例。该系统使得能够通过皮肤或粘膜全身施用可滴定剂量的治疗剂，其由患者在医生的指导下调节。此外，本发明涉及制备可滴定剂量透皮递送系统的方法。此外，本发明涉及使用本发明的透皮递送系统向患者提供可滴定量的治疗剂的方法。

9. 发明申请

WO2003013525A1 OPIOID AGONIST FORMULATIONS WITH RELEASABLE AND SEQUESTERED ANTAGONIST 审中-公开
标题翻译：具有可释放和序列拮抗剂的OPIOID AGONIST配方
公开(公告)号：WO2003013525A1
公开(公告)日：2003-02-20
申请号：PCT/US2002/024944
申请日：2002-08-06
申请人： EURO-CELTIQUE S.A. , BREDER, Christopher , OSHLACK, Benjamin , WRIGHT, Curtis
发明人： BREDER, Christopher , OSHLACK, Benjamin , WRIGHT, Curtis
IPC分类号： A61K31/44
CPC分类号： A61K9/2077 , A61K9/14 , A61K9/1635 , A61K9/1647 , A61K9/167 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2081 , A61K9/2086 , A61K9/5026 , A61K9/5078 , A61K9/5084 , A61K31/44 , A61K31/445 , A61K31/46 , A61K31/485 , A61K45/06 , A61K47/32 , A61K47/38 , A61K2300/00
摘要： Disclosed are oral dosage forms, comprising (i) a therapeutically effective amount of an opioid agonist; (ii) an opioid antagonist in releasable form; and (iii) a sequestered opioid antagonist which is not released when the dosage form is administered intact, and methods thereof.
摘要翻译：公开了口服剂型，其包含（i）治疗有效量的阿片样物质激动剂; （ii）可释放形式的阿片拮抗剂; 和（iii）当所述剂型完全施用时不释放的螯合阿片样物质拮抗剂及其方法。

10. 发明申请

WO2003007802A3 PHARMACEUTICAL COMBINATIONS OF OXYCODONE AND NALOXONE 审中-公开
公开(公告)号：WO2003007802A3
公开(公告)日：2003-01-30
申请号：PCT/US2002/023126
申请日：2002-07-18
申请人： EURO-CELTIQUE, S.A. , BREDER, Christopher, D. , COLUCCI, Robert, D. , HOWARD, Stephen, A. , OSHLACK, Benjamin , WRIGHT, Curtis
发明人： BREDER, Christopher, D. , COLUCCI, Robert, D. , HOWARD, Stephen, A. , OSHLACK, Benjamin , WRIGHT, Curtis
IPC分类号： A61P25/30
摘要： Disclosed in certain embodiments is a pharmaceutical composition comprising from 10 to 40 mg of oxycodone or a pharmaceutically acceptable salt thereof and 0.65 to 0.90 mg naloxone or a pharmaceutically acceptable salt thereof.

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