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1. 发明申请

WO0038706A2 METHODS FOR TREATING CANCER AND FOR MEDIATING CHEMOTAXIS OF DENDRITIC CELLS 审中-公开
标题翻译：治疗癌症和介导树突状细胞化学治疗的方法
公开(公告)号：WO0038706A2
公开(公告)日：2000-07-06
申请号：PCT/US9931096
申请日：1999-12-28
申请人： CHIRON CORP , KETING CHU , XIN HONG , CHAN VIVIEN W F , KOTHAKOTA SRINIVAS , WILLIAMS LEWIS T , WINTER JILL A
发明人： KETING CHU , XIN HONG , CHAN VIVIEN W F , KOTHAKOTA SRINIVAS , WILLIAMS LEWIS T , WINTER JILL A
IPC分类号： C12N15/02 , A61K31/711 , A61K38/00 , A61K38/19 , A61K38/20 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07K14/47
CPC分类号： A61K38/195 , A61K38/2013 , A61K2300/00
摘要： The invention is based on the novel observation, reported herein, that SLC inhibits the growth of tumors in vivo and is a potent chemokine for Dendritic Cells (DC). Thus, the invention provides a method of treating cancer or hyperproliferative disorder in a mammalian subject, comprising: administering a therapeutically effective amount of an SLC to said subject. SLCs useful in the methods of the invention include SLC polypeptides, variants and fragments and related nucleic acids. The methods of the invention are useful in the treatment of cancer and hyperproliferative disorders. In addition, the invention provides methods for modulating dendritic cell function in a mammal, said method comprising administering a therapeutically effective amount of an SLC agent to said mammal, said agent selected from the group consisting of: SLC plypeptides, SLC polypeptide variants, SLC polypeptide fragments, polynucleotides encoding SLC polypeptides, variants and fragments, anti-SLC antibodies and ligands for the CCR7 receptor. Such methods can be used to increase or decrease an immune response, particularly a primary immune response, in a mammal. The methods are particularly useful in the prevention of graft rejection and in the treatment of autoimmune disease. Alternatively, the methods may be used to enhance an immune response.
摘要翻译：本发明基于本文报道的新观察结果，即SLC在体内抑制肿瘤生长并且是树突细胞（DC）的有效趋化因子。因此，本发明提供了治疗哺乳动物受试者中的癌症或过度增殖性病症的方法，其包括：向所述受试者施用治疗有效量的SLC。用于本发明方法的SLC包括SLC多肽，变体和片段以及相关核酸。本发明的方法可用于治疗癌症和过度增殖性疾病。此外，本发明提供了用于调节哺乳动物的树突细胞功能的方法，所述方法包括向所述哺乳动物施用治疗有效量的SLC试剂，所述试剂选自：SLC多肽，SLC多肽变体，SLC多肽片段，编码SLC多肽的多核苷酸，变体和片段，抗SLC抗体和CCR7受体的配体。这些方法可用于增加或减少哺乳动物的免疫应答，特别是初次免疫应答。该方法在预防移植排斥和治疗自身免疫性疾病方面特别有用。或者，该方法可用于增强免疫应答。

2. 发明申请

WO0038706A9 METHODS FOR TREATING CANCER AND FOR MEDIATING CHEMOTAXIS OF DENDRITIC CELLS 审中-公开
标题翻译：用于治疗癌症和介导感染细胞化学的方法
公开(公告)号：WO0038706A9
公开(公告)日：2002-08-22
申请号：PCT/US9931096
申请日：1999-12-28
申请人： CHIRON CORP , CHU KETING , XIN HONG , CHAN VIVIEN W F , KOTHAKOTA SRINIVAS , WILLIAMS LEWIS T , WINTER JILL A
发明人： CHU KETING , XIN HONG , CHAN VIVIEN W F , KOTHAKOTA SRINIVAS , WILLIAMS LEWIS T , WINTER JILL A
IPC分类号： C12N15/02 , A61K31/711 , A61K38/00 , A61K38/19 , A61K38/20 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07K14/47
CPC分类号： A61K38/195 , A61K38/2013 , A61K2300/00
摘要： The invention is based on the novel observation, reported herein, that SLC inhibits the growth of tumors in vivo and is a potent chemokine for Dendritic Cells (DC). Thus, the invention provides a method of treating cancer or hyperproliferative disorder in a mammalian subject, comprising: administering a therapeutically effective amount of an SLC to said subject. SLCs useful in the methods of the invention include SLC polypeptides, variants and fragments and related nucleic acids. The methods of the invention are useful in the treatment of cancer and hyperproliferative disorders. In addition, the invention provides methods for modulating dendritic cell function in a mammal, said method comprising administering a therapeutically effective amount of an SLC agent to said mammal, said agent selected from the group consisting of: SLC plypeptides, SLC polypeptide variants, SLC polypeptide fragments, polynucleotides encoding SLC polypeptides, variants and fragments, anti-SLC antibodies and ligands for the CCR7 receptor. Such methods can be used to increase or decrease an immune response, particularly a primary immune response, in a mammal. The methods are particularly useful in the prevention of graft rejection and in the treatment of autoimmune disease. Alternatively, the methods may be used to enhance an immune response.
摘要翻译：本发明基于本文报道的新观察，SLC抑制体内肿瘤的生长，并且是树突状细胞（DC）的有效趋化因子。因此，本发明提供了在哺乳动物受试者中治疗癌症或过度增殖性疾病的方法，其包括：向所述受试者施用治疗有效量的SLC。可用于本发明方法的SLC包括SLC多肽，变体和片段及相关核酸。本发明的方法可用于治疗癌症和过度增殖性疾病。另外，本发明提供调节哺乳动物树突状细胞功能的方法，所述方法包括向所述哺乳动物施用治疗有效量的SLC剂，所述药物选自：SLC多肽，SLC多肽变体，SLC多肽片段，编码SLC多肽的多核苷酸，变体和片段，抗SLC抗体和CCR7受体的配体。这样的方法可用于增加或减少哺乳动物的免疫应答，特别是初级免疫应答。该方法特别可用于预防移植物排斥和治疗自身免疫性疾病。或者，所述方法可用于增强免疫应答。

3. 发明申请

WO2000038706A3 METHODS FOR TREATING CANCER AND FOR MEDIATING CHEMOTAXIS OF DENDRITIC CELLS 审中-公开
公开(公告)号：WO2000038706A3
公开(公告)日：2000-07-06
申请号：PCT/US1999/031096
申请日：1999-12-28
申请人： CHIRON CORPORATION , CHU, Keting , XIN, Hong , CHAN, Vivien, W., F. , KOTHAKOTA, Srinivas , WILLIAMS, Lewis, T. , WINTER, Jill, A.
发明人： CHU, Keting , XIN, Hong , CHAN, Vivien, W., F. , KOTHAKOTA, Srinivas , WILLIAMS, Lewis, T. , WINTER, Jill, A.
IPC分类号： A61K38/19
摘要： The invention is based on the novel observation, reported herein, that SLC inhibits the growth of tumors in vivo and is a potent chemokine for Dendritic Cells (DC). Thus, the invention provides a method of treating cancer or hyperproliferative disorder in a mammalian subject, comprising: administering a therapeutically effective amount of an SLC to said subject. SLCs useful in the methods of the invention include SLC polypeptides, variants and fragments and related nucleic acids. The methods of the invention are useful in the treatment of cancer and hyperproliferative disorders. In addition, the invention provides methods for modulating dendritic cell function in a mammal, said method comprising administering a therapeutically effective amount of an SLC agent to said mammal, said agent selected from the group consisting of: SLC plypeptides, SLC polypeptide variants, SLC polypeptide fragments, polynucleotides encoding SLC polypeptides, variants and fragments, anti-SLC antibodies and ligands for the CCR7 receptor. Such methods can be used to increase or decrease an immune response, particularly a primary immune response, in a mammal. The methods are particularly useful in the prevention of graft rejection and in the treatment of autoimmune disease. Alternatively, the methods may be used to enhance an immune response.

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