专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004093797A2 METHODS, DEVICES, AND COMPOSITIONS FOR LYSIS OF OCCLUSIVE BLOOD CLOTS WHILE SPARING WOUND SEALING CLOTS 审中-公开
标题翻译：方法，装置和组合物，用于在发出密封圈的情况下观察血液动力学
公开(公告)号：WO2004093797A2
公开(公告)日：2004-11-04
申请号：PCT/US2004011840
申请日：2004-04-16
申请人： THROMBOLYTIC SCIENCE INC , GUREWICH VICTOR , WILLIAMS JOHN N , LIU JIAN-NING , SARMIENTOS PAOLO , PAGANI MASSIMILIANO
发明人： GUREWICH VICTOR , WILLIAMS JOHN N , LIU JIAN-NING , SARMIENTOS PAOLO , PAGANI MASSIMILIANO
IPC分类号： A61K20060101 , A61K38/17 , A61K38/46 , A61K38/48 , A61K38/49 , A61L29/16 , A61P7/02 , A61P9/00 , C07H21/04 , C12N9/64 , C12N9/72 , C12P21/02 , A61K
CPC分类号： A61L29/16 , A61K38/00 , A61L31/16 , A61L33/0047 , A61L2300/254 , C12N9/6462 , C12Y304/21073
摘要： It has now been discovered that various mutant forms of pro-urokinase ("pro-UK") perform in the manner of pro-UK in lysing "bad" blood clots (those clots that occlude blood vessels), while sparing hemostatic fibrin in the so-called "good" blood clots (those clots that seal wounds, e.g., after surgery or other tissue injury). Thus, these pro-UK mutants are excellent and safe thrombolytic agents. These advantages allow them to be used in a variety of new methods, devices, and compositions useful for thrombolysis and treating various cardiovascular disorders in clinical situations where administration of other known thrombolytic agents has been too risky or even contraindicated. New methods of making the pro-UK mutants are also disclosed.
摘要翻译：现在已经发现，各种突变形式的尿激酶（“pro-UK”）以亲UK的方式在溶解“不良”血块（堵塞血管的那些凝块）中起作用，同时将止血纤维蛋白所谓“良好的”血块（例如手术或其他组织损伤之后的伤口密封的那些凝块）。因此，这些pro-UK突变体是优秀和安全的溶栓剂。这些优点使得它们可用于各种新的方法，装置和组合物，其可用于溶栓和治疗各种心血管疾病的临床情况，其中施用其它已知的溶栓剂已经过于危险或甚至禁忌。还公开了制备亲英国突变体的新方法。

2. 发明申请

WO1998039042A1 ANESTHETIZING PLASTICS, DRUG DELIVERY PLASTICS, AND RELATED MEDICAL PRODUCTS, SYSTEMS AND METHODS 审中-公开
标题翻译：麻醉药物，药物输送塑料和相关医疗产品，系统和方法
公开(公告)号：WO1998039042A1
公开(公告)日：1998-09-11
申请号：PCT/US1997004948
申请日：1997-03-25
申请人： JACKSON, Richard, R. , WILLIAMS, John, N.
IPC分类号： A61M05/32
CPC分类号： A61K9/1635 , A61K9/7007 , A61K9/7023 , A61L15/44 , A61L29/16 , A61L2300/204 , A61L2300/402 , A61M16/10 , A61M16/18 , A61M35/00
摘要： A compound with topical anesthetic properties is incorporated in polymeric material suitable for forming products useful in the medical arts. A hydrophobic anesthetic compound is used which is more soluble in the polymer than in water so that a quantity of anesthetic compound can be stored in solution in the polymer and not be washed out by aqueous bodily fluid. This results in metered diffusion of drug to the local tissue in an amount sufficient to maintain effective anesthesia of the local tissue while avoiding the associated problems of systemic drug delivery. Examples of medical products include anesthetizing cuffs, films or balloons disposed on catheters or tubes; anesthetic (122) coated sutures (120) or the like; adherent anesthetizing bandages, strips or patches, or in the form of an anesthetizing plastisol or foam suitable for topical application. Methods of manufacturing the compound/polymer are also disclosed.
摘要翻译：具有局部麻醉剂性质的化合物掺入适于形成有用于医学领域的产品的聚合物材料中。使用比在水中更易溶于聚合物的疏水麻醉化合物，使得一定量的麻醉化合物可以储存在聚合物中的溶液中，并且不会被水体液洗掉。这导致药物对局部组织的计量扩散，其量足以维持局部组织的有效麻醉，同时避免了全身药物递送的相关问题。医疗产品的实例包括麻醉袖口，设置在导管或管上的膜或气囊; 麻醉剂（122）涂层缝合线（120）等; 粘附麻醉绷带，条或贴片，或以适于局部应用的麻醉增塑溶胶或泡沫的形式。还公开了制备化合物/聚合物的方法。

3. 发明申请

WO2004093797A3 METHODS, DEVICES, AND COMPOSITIONS FOR LYSIS OF OCCLUSIVE BLOOD CLOTS WHILE SPARING WOUND SEALING CLOTS 审中-公开
公开(公告)号：WO2004093797A3
公开(公告)日：2004-11-04
申请号：PCT/US2004/011840
申请日：2004-04-16
申请人： THROMBOLYTIC SCIENCE, INC. , GUREWICH, Victor , WILLIAMS, John, N. , LIU, Jian-Ning , SARMIENTOS, Paolo , PAGANI, Massimiliano
发明人： GUREWICH, Victor , WILLIAMS, John, N. , LIU, Jian-Ning , SARMIENTOS, Paolo , PAGANI, Massimiliano
IPC分类号： A61K38/49
摘要： It has now been discovered that various mutant forms of pro-urokinase ("pro-UK") perform in the manner of pro-UK in lysing "bad" blood clots (those clots that occlude blood vessels), while sparing hemostatic fibrin in the so-called "good" blood clots (those clots that seal wounds, e.g., after surgery or other tissue injury). Thus, these pro-UK mutants are excellent and safe thrombolytic agents. These advantages allow them to be used in a variety of new methods, devices, and compositions useful for thrombolysis and treating various cardiovascular disorders in clinical situations where administration of other known thrombolytic agents has been too risky or even contraindicated. New methods of making the pro-UK mutants are also disclosed.

4. 发明申请

WO9955286A9 DRUG-CONTAINING TRANSDERMAL PATCHES, PLASTISOLS AND ADHESIVES 审中-公开
标题翻译：含药物的透皮贴剂，贴膏剂和粘合剂
公开(公告)号：WO9955286A9
公开(公告)日：1999-12-16
申请号：PCT/US9909547
申请日：1999-04-30
申请人： ZERA SCIENCE , JACKSON RICHARD , WILLIAMS JOHN N
发明人： JACKSON RICHARD , WILLIAMS JOHN N
IPC分类号： A61F2/958 , A61F13/00 , A61K9/16 , A61K9/70 , A61L15/44 , A61L29/14 , A61L29/16 , A61M16/04 , A61M16/10 , A61M16/18 , A61M25/00 , A61M35/00 , A61K
CPC分类号： A61K9/7061 , A61B17/06166 , A61B2017/00526 , A61F2013/00646 , A61F2013/0296 , A61K9/1635 , A61K9/7007 , A61K9/7023 , A61L15/44 , A61L29/141 , A61L29/16 , A61L2300/402 , A61L2300/45 , A61M16/04 , A61M16/0443 , A61M16/10 , A61M16/18 , A61M25/0009 , A61M25/10 , A61M35/00 , A61M2205/0205
摘要： Drug delivery polymer systems include hydrophobic polymer and a drug that has an aromatic ring. The system comprises, on a carrier (10), a layer (12) comprising the pressure sensitive adhesive having solids in which a drug is substantially soluble, a non-adhesive polymeric resin distributed uniformly in non-particulate manner through the adhesive, in which the drug is substantially soluble, and drug. Another delivery system comprises a non-adhesive layer (14) of polymeric resin in which a drug component is substantially soluble and an adjoining adhesive band (18) arranged to hold the non-adhesive layer against the skin. In both, the drug comprises at least 10 % by weight of the drug-containing layer, preferably in excess of 20 %, or 30 % or 40 % by weight. It is discovered that concentrations in excess of 50 % and 60 % can be achieved in effective formulations. The layer can be thin so that, despite high concentration no more than about 30mg drug per inch square is present, preferably less than 20mg or 10 mg per inch square. In embodiments that achieve a high concentration, the drug component comprises at least two drugs, one of which is soluble in the other, a solution of the drugs in the quantities present in the layer having a melting temperature below room temperature, and lower than the melting temperature of either drug alone. A congealed plastisol layer comprising tetracaine, lidocaine and polyvinyl chloride, is particularly effective for topical anesthetic. Methods of manufacture and preparatory compositions have now been disclosed.
摘要翻译：药物递送聚合物体系包括疏水性聚合物和具有芳香环的药物。该系统在载体（10）上包括包含具有药物基本可溶于其中的固体的压敏粘合剂的层（12），非粘合剂聚合物树脂以非颗粒状方式均匀分布通过粘合剂，其中该药物是基本可溶的和药物。另一种输送系统包括其中药物组分基本可溶的聚合物树脂的非粘合层（14）和布置成将非粘附层保持在皮肤上的邻接粘合带（18）。在两种药物中，药物含有至少10重量％的含药层，优选超过20重量％，或者30重量％或40重量％。发现在有效制剂中可以达到超过50％和60％的浓度。该层可以是薄的，使得尽管高浓度，每平方英寸不超过约30mg药物，优选小于20mg或10mg每平方英寸。在达到高浓度的实施方案中，药物组分包含至少两种药物，其中一种可溶于另一种，药物溶液存在于熔点低于室温的层中，并且低于只有任一种药物的解链温度。包含丁卡因，利多卡因和聚氯乙烯的凝胶增塑溶胶层对局部麻醉剂特别有效。现在已经公开了制造方法和制备组合物。

5. 发明申请

WO03093123A9 SUSPENDED CONTAINERS 审中-公开
标题翻译：悬挂集装箱
公开(公告)号：WO03093123A9
公开(公告)日：2004-12-23
申请号：PCT/US0314175
申请日：2003-05-06
申请人： AJAVA PINATA LLC , MANNION JEFFREY T , WILLIAMS JOHN N
发明人： MANNION JEFFREY T , WILLIAMS JOHN N
IPC分类号： B29C45/00 , B29C45/14 , B65D43/02 , B65D51/24 , B65D25/28
CPC分类号： B29C45/14336 , B29C45/0081 , B29C45/14016 , B29C45/14344 , B29C2045/14967 , B29L2031/565 , B65D43/0202 , B65D51/242 , B65D2543/00092 , B65D2543/0024 , B65D2543/00851
摘要： Suspender units of various forms for packaging containers. A unit has a supporting ring (18) constructed to be connected with the rim of the container and a free suspender (16) is deflectable from a formed position to an upstanding position in which it is capable, via the ring (18), of carrying the weight of the container and goods. The finger suspender (16) is integrated to the connector at a location substantially offset from the central axis of the package. The suspender is joined to the support by a flexible root (R) that forms a flexible hinge.
摘要翻译：用于包装容器的各种形式的悬挂单元。单元具有构造成与容器的边缘连接的支撑环（18），并且自由悬挂件（16）可从成形位置偏转到直立位置，在该位置中，自由吊架能够经由环（18）承载集装箱和货物的重量。手指悬挂器（16）在基本上偏离包装的中心轴线的位置处与连接器集成。悬臂通过形成柔性铰链的柔性根（R）连接到支撑件上。

6. 发明申请

WO9955286A3 DRUG-CONTAINING TRANSDERMAL PATCHES, PLASTISOLS AND ADHESIVES 审中-公开
标题翻译：含药透皮贴片，塑料和粘合剂
公开(公告)号：WO9955286A3
公开(公告)日：2000-07-06
申请号：PCT/US9909547
申请日：1999-04-30
申请人： ZERA SCIENCE , JACKSON RICHARD , WILLIAMS JOHN N
发明人： JACKSON RICHARD , WILLIAMS JOHN N
IPC分类号： A61F2/958 , A61F13/00 , A61K9/16 , A61K9/70 , A61L15/44 , A61L29/14 , A61L29/16 , A61M16/04 , A61M16/10 , A61M16/18 , A61M25/00 , A61M35/00 , A61F13/02
CPC分类号： A61K9/7061 , A61B17/06166 , A61B2017/00526 , A61F2013/00646 , A61F2013/0296 , A61K9/1635 , A61K9/7007 , A61K9/7023 , A61L15/44 , A61L29/141 , A61L29/16 , A61L2300/402 , A61L2300/45 , A61M16/04 , A61M16/0443 , A61M16/10 , A61M16/18 , A61M25/0009 , A61M25/10 , A61M35/00 , A61M2205/0205
摘要： Drug delivery polymer systems include hydrophobic polymer and a drug that has an aromatic ring. The system comprises, on a carrier (10), a layer (12) comprising the pressure sensitive adhesive having solids in which a drug is substantially soluble, a non-adhesive polymeric resin distributed uniformly through the adhesive. Another delivery system comprises a non-adhesive layer (14) of polymeric resin in which a drug component is substantially soluble and an adjoining adhesive band (18) arranged to hold the non-adhesive layer against the skin. The drug comprises at least 10 % by weight of the drug-containing layer, preferably in excess of 20 %, 30 % or 40 % by weight in both of the delivery systems.
摘要翻译：药物递送聚合物体系包括疏水性聚合物和具有芳香环的药物。该系统在载体（10）上包括含有药物基本可溶的固体的压敏粘合剂层（12），均匀地分布在粘合剂中的非粘性聚合物树脂。另一递送系统包括其中药物成分基本可溶的聚合物树脂的非粘合剂层（14）和邻近的粘合带（18），其布置成将非粘合层保持在皮肤上。药物包含至少10重量％的药物含量层，优选在两个递送系统中超过20重量％，30重量％或40重量％。

7. 发明申请

WO2003093123A1 SUSPENDED CONTAINERS 审中-公开
标题翻译：悬挂集装箱
公开(公告)号：WO2003093123A1
公开(公告)日：2003-11-13
申请号：PCT/US2003/014175
申请日：2003-05-06
申请人： AJAVA PINATA, LLC , MANNION, Jeffrey, T. , WILLIAMS, John, N.
发明人： WILLIAMS, John, N.
IPC分类号： B65D25/28
CPC分类号： B29C45/14336 , B29C45/0081 , B29C45/14016 , B29C45/14344 , B29C2045/14967 , B29L2031/565 , B65D43/0202 , B65D51/242 , B65D2543/00092 , B65D2543/0024 , B65D2543/00851
摘要： Suspender units of various forms for packaging containers. A unit has a supporting ring (18) constructed to be connected with the rim of the container and a free suspender (16) is deflectable from a formed position to an upstanding position in which it is capable, via the ring (18), of carrying the weight of the container and goods. The finger suspender (16) is integrated to the connector at a location substantially offset from the central axis of the package. The suspender is joined to the support by a flexible root (R) that forms a flexible hinge.
摘要翻译：用于包装容器的各种形式的悬挂单元。单元具有构造成与容器的边缘连接的支撑环（18），并且自由悬挂件（16）可以从成形位置偏转到直立位置，在该位置中，自由吊架能够经由环（18）携带集装箱和货物的重量。手指悬挂器（16）在基本上偏离包装的中心轴线的位置处与连接器集成。吊架通过形成柔性铰链的柔性根（R）连接到支撑件上。

8. 发明专利

GB9015052D0 INDIVIDUAL SETTING GAUGE FOR VEHICLE SPARK PLUGS 未知
公开(公告)号：GB9015052D0
公开(公告)日：1990-08-29
申请号：GB9015052
申请日：1990-07-07
申请人： WILLIAMS JOHN N , WILLIAMS CHRISTIAN A

9. 发明专利

CA23105A STOP AND LOCK FOR PAWL AND RATCHET MECHANISM 未知
公开(公告)号：CA23105A
公开(公告)日：1886-01-07
申请号：CA23105D
申请人： WILLIAMS JOHN N
发明人： WILLIAMS JOHN N

10. 发明专利

AU2590697A Anesthetizing plastics, drug delivery plastics, and related medical products, systems and methods 未知
公开(公告)号：AU2590697A
公开(公告)日：1998-09-22
申请号：AU2590697
申请日：1997-03-25
申请人： JACKSON RICHARD R , WILLIAMS JOHN N
发明人： JACKSON RICHARD R , WILLIAMS JOHN N
IPC分类号： A61K9/16 , A61K9/70 , A61L15/44 , A61L29/16 , A61M16/10 , A61M16/18 , A61M35/00 , A61M5/32 , A61M25/00

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式