专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006118955A3 PROCESS FOR PREPARING 3,3-DISUBSTITUTED OXINDOLES AND THIO-OXINDOLES 审中-公开
标题翻译：制备3,3-取代的氧化物和硫代氧化物的方法
公开(公告)号：WO2006118955A3
公开(公告)日：2007-01-11
申请号：PCT/US2006016051
申请日：2006-04-27
申请人： WYETH CORP , WILK BOGDAN KAZIMIERZ
发明人： WILK BOGDAN KAZIMIERZ
IPC分类号： C07D209/34 , C07C233/11 , C07C233/58 , C07C255/35 , C07D213/61 , C07D241/44 , C07D333/64 , C07D333/66 , C07D403/04
CPC分类号： C07D209/34 , C07C233/11 , C07C233/58 , C07C253/30 , C07C255/35 , C07C2601/02 , C07C2601/14 , C07C2602/42 , C07D209/96 , C07D213/61 , C07D241/44 , C07D333/64 , C07D333/66 , C07D403/04 , C07D471/04 , C07C255/46 , C07C255/47
摘要： Methods for preparing oxindole and thio-oxindole compounds are provided, which compounds are useful as precursors to useful pharmaceutical compounds. Specifically provided are methods for preparing 5-pyrrole-3,3-oxindole compounds and 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-lH-indol-5-yl)-l-methyl-lH-pyrrole-2-carbonitrile. Also provided are methods for preparing iminobenzo[b]thio?hene and benzo[b]thiophenone compounds.
摘要翻译：提供了制备羟吲哚和硫代羟吲哚化合物的方法，该化合物可用作有用的药物化合物的前体。具体提供的是制备5-吡咯-3,3-羟吲哚化合物和5-（7-氟-3,3-二甲基-2-氧代-2,3-二氢-1H-吲哚-5-基）-1 甲基-1H-吡咯-2-甲腈。还提供了制备亚氨基苯并[b]硫代苯乙烯和苯并[b]噻吩酮化合物的方法。

2. 发明申请

WO2005104711A3 PURIFICATION OF PROGESTERONE RECEPTOR MODULATORS 审中-公开
标题翻译：孕激素受体调节剂的纯化
公开(公告)号：WO2005104711A3
公开(公告)日：2006-12-28
申请号：PCT/US2005013997
申请日：2005-04-25
申请人： WYETH CORP , WILK BOGDAN KAZIMIERZ , RUBEZHOV ARKADIY ZINOVIY , HADFIELD ANTHONY FRANCIS , HELOM JEAN LOUISE
发明人： WILK BOGDAN KAZIMIERZ , RUBEZHOV ARKADIY ZINOVIY , HADFIELD ANTHONY FRANCIS , HELOM JEAN LOUISE
IPC分类号： C07D265/18 , A61K31/4706 , A61K31/4747 , A61K31/538 , A61K31/5415 , C07D209/96 , C07D403/04 , C07D413/04
CPC分类号： C07D403/04 , C07D209/96 , C07D405/04 , C07D413/04
摘要： Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R 1 are defined herein. The methods include mixing the compound of formula I and a. solvent; adding a base to the solvent; and precipitating purified compound of formula, I.
摘要翻译：提供了用于纯化式I化合物的方法，其中A，B，X，Q和R 1在本文中定义。所述方法包括混合式I化合物和a。溶剂; 向溶剂中加入碱; 并沉淀出纯化的式I化合物。

3. 发明申请

WO2006118955A2 PROCESS FOR PREPARING 3,3-DISUBSTITUTED OXINDOLES AND THIO-OXINDOLES 审中-公开
标题翻译：制备3,3-取代的氧化物和硫代氧化物的方法
公开(公告)号：WO2006118955A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/016051
申请日：2006-04-27
申请人： WYETH , WILK, Bogdan, Kazimierz
发明人： WILK, Bogdan, Kazimierz
IPC分类号： C07D209/34 , C07C255/35 , C07C233/11 , C07C233/58
CPC分类号： C07D209/34 , C07C233/11 , C07C233/58 , C07C253/30 , C07C255/35 , C07C2601/02 , C07C2601/14 , C07C2602/42 , C07D209/96 , C07D213/61 , C07D241/44 , C07D333/64 , C07D333/66 , C07D403/04 , C07D471/04 , C07C255/46 , C07C255/47
摘要： Methods for preparing oxindole and thio-oxindole compounds are provided, which compounds are useful as precursors to useful pharmaceutical compounds. Specifically provided are methods for preparing 5-pyrrole-3,3-oxindole compounds and 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-lH-indol-5-yl)-l-methyl-lH-pyrrole-2-carbonitrile. Also provided are methods for preparing iminobenzo[b]thioρhene and benzo[b]thiophenone compounds.
摘要翻译：提供了制备羟吲哚和硫代羟吲哚化合物的方法，该化合物可用作有用的药物化合物的前体。具体提供的是制备5-吡咯-3,3-羟吲哚化合物的方法和5-（7-氟-3,3-二甲基-2-氧代-2,3-二氢-1H-吲哚-5-基）-1 甲基-1H-吡咯-2-甲腈。还提供了制备亚氨基苯并[b]硫代苯乙烯和苯并[b]噻吩酮化合物的方法。

4. 发明申请

WO2005100291A3 METHOD FOR PREPARING 3-CYCLOPENTYLOXY-4-METHOXYBENZALDEHYDE 审中-公开
标题翻译：制备3-环戊氧基-4-甲氧基苯甲醛的方法
公开(公告)号：WO2005100291A3
公开(公告)日：2005-12-15
申请号：PCT/US2005014022
申请日：2005-04-07
申请人： WYETH CORP , WILK BOGDAN KAZIMIERZ , MWISIYA NALUKUI , HELOM JEAN LOUISE
发明人： WILK BOGDAN KAZIMIERZ , MWISIYA NALUKUI , HELOM JEAN LOUISE
IPC分类号： C07C41/01 , C07C41/26 , C07C43/253 , C07C45/64 , C07C45/71 , C07C45/90 , C07C47/575
CPC分类号： C07C47/575 , C07C41/26 , C07C45/71 , C07C2601/08 , C07C43/253
摘要： Processes for coupling phenol and cycloalkyls including combining an optionally substituted phenol, a cycloalkyl substituted with a leaving group, carbonate salt, tetrahydrofuran, and an optional phase transfer agent are provided. Also provided are processes for preparing 3-cyclopentyloxy-4-methoxybenzaldehyde by combining 3-hydroxy-4-methoxybenzaldehyde, a cyclopentyl compound, a carbonate salt, a solvent, and an optional phase transfer agent.
摘要翻译：提供了将苯酚和环烷基偶合的方法，包括将任选取代的苯酚，被离去基团取代的环烷基，碳酸盐，四氢呋喃和任选的相转移剂组合。还提供了通过3-羟基-4-甲氧基苯甲醛，环戊基化合物，碳酸盐，溶剂和任选的相转移剂组合制备3-环戊氧基-4-甲氧基苯甲醛的方法。

5. 发明申请

WO2005097743A1 SYNTHESIS OF PYRROLE-2-CARBONITRILES 审中-公开
标题翻译：吡咯-2-二氧化碳的合成
公开(公告)号：WO2005097743A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/010468
申请日：2005-03-28
申请人： WYETH , HELOM, Jean, Louise , RUBEZHOV, Arkadiy, Zinoviy , PILCHER, Anthony, Scott , WILK, Bogdan, Kazimierz
发明人： HELOM, Jean, Louise , RUBEZHOV, Arkadiy, Zinoviy , PILCHER, Anthony, Scott , WILK, Bogdan, Kazimierz
IPC分类号： C07D207/416
CPC分类号： C07D207/34
摘要： The instant invention concerns processes for the production of pyrrole-2-carbonitriles such as 1-methylpyrrole-2-carbonifirile. Such processes preferably comprise the steps of reacting a pyrrole with chlorosulfonyl isocyanate in the presence of a solvent and contacting the resulting product with a molar excess of an amide such as N,N-dimethylformamide. The product of this contacting step is then contacted with a molar excess of an organic base to produce a precipitate and a solution phase. The precipitate is then separated from the solution phase and the corresponding pyrrole-2-carbonitrile is isolated from the resulting solution phase.
摘要翻译：本发明涉及生产吡咯-2-碳腈如1-甲基吡咯-2-碳呋喃的方法。这样的方法优选包括在溶剂存在下使吡咯与氯磺酰基异氰酸酯反应并使所得产物与摩尔过量的酰胺如N，N-二甲基甲酰胺接触的步骤。然后将该接触步骤的产物与摩尔过量的有机碱接触以产生沉淀物和溶液相。然后将沉淀物与溶液相分离，并从所得溶液相中分离相应的吡咯-2-腈。

6. 发明申请

WO2005104711A8 PURIFICATION OF PROGESTERONE RECEPTOR MODULATORS 审中-公开
标题翻译：孕激素受体调节剂的纯化
公开(公告)号：WO2005104711A8
公开(公告)日：2006-04-06
申请号：PCT/US2005013997
申请日：2005-04-25
申请人： WYETH CORP , WILK BOGDAN KAZIMIERZ , RUBEZHOV ARKADIY ZINOVIY , HADFIELD ANTHONY FRANCIS , HELOM JEAN LOUISE
发明人： WILK BOGDAN KAZIMIERZ , RUBEZHOV ARKADIY ZINOVIY , HADFIELD ANTHONY FRANCIS , HELOM JEAN LOUISE
IPC分类号： A61K31/4706 , A61K31/4747 , A61K31/538 , A61K31/5415
CPC分类号： C07D403/04 , C07D209/96 , C07D405/04 , C07D413/04
摘要： Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R
摘要翻译：提供了提纯式I化合物的方法，其中A，B，X，Q和R

7. 发明申请

WO2005105817A3 COUPLING PROCESS FOR GENERATING REACTIVE BORON CONTAINING DERIVATIVES OF N-SUBSTITUTED PYRROLE-2 CARBONITRILES TO PRODUCE BIARYLS 审中-公开
标题翻译：用于生成含有N取代的吡咯烷酮二氧化碳的反应性硼的生成偶联剂的联合方法
公开(公告)号：WO2005105817A3
公开(公告)日：2006-01-12
申请号：PCT/US2005013992
申请日：2005-04-25
申请人： WYETH CORP , WILK BOGDAN KAZIMIERZ , RUBEZHOV ARKADIY ZINOVIY , HELOM JEAN LOUISE
发明人： WILK BOGDAN KAZIMIERZ , RUBEZHOV ARKADIY ZINOVIY , HELOM JEAN LOUISE
IPC分类号： A61K31/69 , C07D413/04 , C07F5/02
CPC分类号： C07D413/04 , C07F5/025
摘要： A convenient preparation of boron-containing compounds, borate salts, pyrrolecarbonitrile boron-containing compounds, N-substituted-pyrrole-2-carbonitrile boron-containing compounds, and derivatives thereof is provided. The present invention also provides for the use of these boron-containing compounds and derivatives thereof in coupling reactions to provide bi-aryl compounds.
摘要翻译：提供了含硼化合物，硼酸盐，含有吡咯甲腈的硼化合物，N-取代吡咯-2-腈含硼化合物及其衍生物的方便的制备方法。本发明还提供这些含硼化合物及其衍生物在偶联反应中的用途，以提供双芳基化合物。

8. 发明申请

WO2005105739A2 CYANOPYRROLE CONTAINING CYCLIC CARBAMATE AND THIOCARBAMATE BIARYLS AND METHODS FOR PREPARING THE SAME 审中-公开
标题翻译：含有环状碳酸酯和硫代氨基甲酸酯的CYANOPYRROLE及其制备方法
公开(公告)号：WO2005105739A2
公开(公告)日：2005-11-10
申请号：PCT/US2005/014342
申请日：2005-04-25
申请人： WYETH , WILK, Bogdan, Kazimierz
发明人： WILK, Bogdan, Kazimierz
IPC分类号： C07D207/00
CPC分类号： C07D413/04 , C07D207/34
摘要： Methods for preparing cyclic carbamates and thiocarbamates containing cyanopyrrole moieties and of the formula are provided: Formula (I) Z are the same or different and are H, optionally substituted C 1 to C 6 alkyl, or COR A ; R A is H, optionally substituted C 1 to C 6 alkyl, optionally substituted C 1 to C 6 alkoxy, or optionally substituted C 1 to C 6 aminoalkyl; Q are the same or different and are H, OH, NH 2 , CN, halogen, optionally substituted C 1 to C 6 alkyl, optionally substituted C 1 to C 6 alkenyl, optionally substituted C 1 to C 6 alkynyl, optionally substituted C 1 to C 6 alkoxy, optionally substituted C 1 to C 6 aminoalkyl, or COR B ; and R B is H, optionally substituted C 1 to C 6 alkyl, optionally substituted C 1 to C 6 alkoxy, or optionally substituted C 1 to C 6 aminoalkyl. Compounds including 2-amino-5-(5-cyano-l-methyl-1H-pyrrol-2-yl) benzoic acid methyl ester, 5-[4-amino-3-(1-hydroxy-l-methyl-ethyl)-phenyl]-1-methyl-1H-pyrrole-2-carbonitrile, and 2-amino-5-(5-cyano-1-methyl-lH-pyrrol-2-yl)-phenyl-ethanone, or pharmaceutically acceptable salts thereof, and the uses thereof are also provided.
摘要翻译：提供了含有氰基吡咯部分和下式的环状氨基甲酸酯和硫代氨基甲酸酯的方法：式（I）Z相同或不同，为H，任选取代的C 1至C 6烷基或COR A; 任选取代的C 1 -C 6烷基，任选取代的C 1至C 6烷氧基或任选取代的C 1至C 6氨基烷基; Q相同或不同，为H，OH，NH 2，CN，卤素，任选取代的C 1至C 6烷基，任选取代的C 1至C 6烯基，任选取代的C 1至C 6炔基，任选取代的C 1至C 6烷氧基， C6氨基烷基或CORB; 和R B是H，任选取代的C 1 -C 6烷基，任选取代的C 1 -C 6烷氧基或任选取代的C 1至C 6氨基烷基。包括2-氨基-5-（5-氰基-1-甲基-1H-吡咯-2-基）苯甲酸甲酯，5- [4-氨基-3-（1-羟基-1-甲基 - 乙基） - 苯基] -1-甲基-1H-吡咯-2-甲腈和2-氨基-5-（5-氰基-1-甲基-1H-吡咯-2-基） - 苯基 - 乙酮或其药学上可接受的盐，并提供其用途。

9. 发明申请

WO2005051869A3 CARBON-CARBON CROSS COUPLING CATALYZED BY TRANSITION METALS ON SOLID SUPPORTS 审中-公开
公开(公告)号：WO2005051869A3
公开(公告)日：2005-06-09
申请号：PCT/US2004/039015
申请日：2004-11-19
申请人： WYETH , WILK, Bogdan, Kazimierz
发明人： WILK, Bogdan, Kazimierz
IPC分类号： C07D265/18
摘要： The present invention provides methods of coupling carbon-containing compounds using a transition metal or transition metal complex on a solid support. The solid support can include alkaline earth metal salts, including carbonate and sulfate salts. The transition metals can include palladium or nickel metal. The method can include combining two carbon containing compounds and a transition metal or transition metal complex on a solid support in the presence of a solvent, desirably an alcohol.

10. 发明申请

WO2005051869A2 CARBON-CARBON CROSS COUPLING CATALYZED BY TRANSITION METALS ON SOLID SUPPORTS 审中-公开
标题翻译：通过固体载体上的过渡金属催化的碳 - 碳交联
公开(公告)号：WO2005051869A2
公开(公告)日：2005-06-09
申请号：PCT/US2004039015
申请日：2004-11-19
申请人： WYETH CORP , WILK BOGDAN KAZIMIERZ
发明人： WILK BOGDAN KAZIMIERZ
IPC分类号： B01J21/00 , B01J23/00 , B01J23/44 , B01J23/58 , B01J23/62 , B01J23/755 , B01J23/78 , B01J27/053 , B01J27/232 , B01J31/00 , B01J31/02 , B01J31/18 , B01J31/24 , C07B37/04 , C07C1/20 , C07C2/68 , C07D265/18 , C07B
CPC分类号： C07D265/18 , B01J23/44 , B01J23/58 , B01J23/628 , B01J23/755 , B01J23/78 , B01J27/053 , B01J27/232 , B01J31/0202 , B01J31/1805 , B01J31/24 , B01J2231/4211 , B01J2531/824 , B01J2531/847 , B01J2531/90 , C07B37/04
摘要： The present invention provides methods of coupling carbon-containing compounds using a transition metal or transition metal complex on a solid support. The solid support can include alkaline earth metal salts, including carbonate and sulfate salts. The transition metals can include palladium or nickel metal. The method can include combining two carbon containing compounds and a transition metal or transition metal complex on a solid support in the presence of a solvent, desirably an alcohol.
摘要翻译：本发明提供了使用过渡金属或过渡金属络合物在固体载体上偶合含碳化合物的方法。固体载体可以包括碱土金属盐，包括碳酸盐和硫酸盐。过渡金属可以包括钯或镍金属。该方法可以包括在溶剂（优选为醇）的存在下将两种含碳化合物和过渡金属或过渡金属络合物结合在固体载体上。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式