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1. 发明申请

WO2010008726A1 NOVEL SYNERGISTIC EFFECTS 审中-公开
标题翻译：新的协同效应
公开(公告)号：WO2010008726A1
公开(公告)日：2010-01-21
申请号：PCT/US2009/047449
申请日：2009-06-16
申请人： IMMUNOGEN INC. , LUTZ, Robert J. , WHITEMAN, Kathleen R.
发明人： LUTZ, Robert J. , WHITEMAN, Kathleen R.
IPC分类号： A61K39/38
CPC分类号： C07K16/2803 , A61K31/198 , A61K31/436 , A61K31/454 , A61K31/57 , A61K31/675 , A61K31/69 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/24 , A61K2300/00
摘要： The present invention encompasses a combination of at least one conjugate and one or more chemotherapeutic agent(s) which when administered exerts an unexpectedly enhanced therapeutic effect. The therapeutic effectiveness of the combination is greater than that of the conjugate alone or the administration of one or more of the drug(s) without the conjugate. The present invention is also directed to compositions comprising at least one conjugate and at one or more of chemotherapeutic agent and to methods of treating cancer using at least one conjugate and at least one or more of chemotherapeutic agent (s). The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of one or more chemotherapeutic agent(s) and at least one conjugate. In each case, such combination has therapeutic synergy or improves the therapeutic index in the treatment of cancer over the anticancer agent(s) alone.
摘要翻译：本发明包括至少一种缀合物和一种或多种化学治疗剂的组合，其当施用时施加意想不到的增强的治疗效果。组合的治疗效果大于单独的缀合物或施用一种或多种没有缀合物的药物。本发明还涉及包含至少一种缀合物和一种或多种化学治疗剂的组合物和使用至少一种缀合物和至少一种或多种化学治疗剂治疗癌症的方法。本发明还提供了通过施用治疗有效量的一种或多种化学治疗剂和至少一种缀合物来调节所选细胞群体例如癌细胞的生长的方法。在每种情况下，这种组合具有治疗性协同作用或改善治疗癌症的治疗指数超过单独的抗癌剂。

2. 发明申请

WO2011091286A1 COMPOSITIONS AND METHODS FOR TREATMENT OF OVARIAN CANCER 审中-公开
标题翻译：用于治疗OVARIAN癌症的组合物和方法
公开(公告)号：WO2011091286A1
公开(公告)日：2011-07-28
申请号：PCT/US2011/022103
申请日：2011-01-21
申请人： IMMUNOGEN, INC. , WHITEMAN, Kathleen, R. , O'LEARY, James, J. , LUTZ, Robert, John
发明人： WHITEMAN, Kathleen, R. , O'LEARY, James, J. , LUTZ, Robert, John
IPC分类号： C07K16/00 , C07K17/00 , C07K17/14
CPC分类号： C07K16/2803 , A61K2039/505
摘要： The present invention relates to surprisingly effective anti-cancer drug combinations, pharmaceutical compositions comprising the same, and uses thereof in the treatment of ovarian cancer. In particular, the present invention is based on the discovery that the administration of a CD56 antibody linked to a cytotoxic compound ( e.g. , an immunoconjugate) in combination with at least two chemotherapeutic agents (in particular a taxane compound and a platinum compound), improves the therapeutic index in the treatment of ovarian cancer over and above the additive effects of the anticancer agents used alone. In one embodiment of the invention, combinations of the CD56 antibody, or fragment thereof, linked to a cytotoxic compound plus additional chemotherapeutic agents have a synergistic effect in the ovarian cancer therapeutic index. The present invention also provides methods of modulating the growth of selected cell populations, such as ovarian cancer cells, by administering a therapeutically effective amount of such combinations.
摘要翻译：本发明涉及惊人的有效的抗癌药物组合，包含其的药物组合物及其在治疗卵巢癌中的用途。特别地，本发明是基于以下发现：与至少两种化学治疗剂（特别是紫杉烷化合物和铂化合物）组合施用与细胞毒性化合物（例如，免疫偶联物）连接的CD56抗体改善治疗卵巢癌的治疗指标超过单独使用的抗癌剂的加和效应。在本发明的一个实施方案中，与细胞毒性化合物加上其他化学治疗剂连接的CD56抗体或其片段的组合在卵巢癌治疗指数中具有协同作用。本发明还提供了通过施用治疗有效量的这种组合来调节所选细胞群体如卵巢癌细胞的生长的方法。

3. 发明申请

WO2012135675A3 METHODS FOR INCREASING EFFICACY OF FOLR1 CANCER THERAPY 审中-公开
标题翻译：增加FOLR1癌症治疗效果的方法
公开(公告)号：WO2012135675A3
公开(公告)日：2012-12-06
申请号：PCT/US2012031544
申请日：2012-03-30
申请人： IMMUNOGEN INC , CARRIGAN CHRISTINA N , WHITEMAN KATHLEEN R , PAYNE GILLIAN , LADD SHARRON
发明人： CARRIGAN CHRISTINA N , WHITEMAN KATHLEEN R , PAYNE GILLIAN , LADD SHARRON
IPC分类号： A61K39/395
CPC分类号： A61K47/48638 , A61K47/6809 , A61K47/6849 , A61K47/6869 , C07K16/28 , G01N33/57492
摘要： Methods to improve the success of cancer therapies that target the human folate receptor 1 are provided. Kits comprising reagent useful in the methods are further provided.
摘要翻译：提供了改善靶向人叶酸受体1的癌症治疗成功的方法。还提供了包含在该方法中有用的试剂的试剂盒。

4. 发明申请

WO2012138537A1 COMPOSITIONS AND METHODS FOR TREATMENT OF OVARIAN, PERITONEAL, AND FALLOPIAN TUBE CANCER 审中-公开
标题翻译： OVARIAN，PERITONEAL和FALLOPIAN TUBE CANCER的组合物和方法
公开(公告)号：WO2012138537A1
公开(公告)日：2012-10-11
申请号：PCT/US2012/031181
申请日：2012-03-29
申请人： IMMUNOGEN, INC. , WHITEMAN, Kathleen R. , O'LEARY, James J. , LUTZ, Robert John
发明人： WHITEMAN, Kathleen R. , O'LEARY, James J. , LUTZ, Robert John
IPC分类号： A61K39/00 , C12P21/08
CPC分类号： C07K16/2803 , A61K39/39558 , C07K2317/24 , A61K2300/00
摘要： The disclosure relates to anti-cancer drug combinations, pharmaceutical compositions for treating ovarian, peritoneal, or fallopian tube cancer. Specifically, the disclosure is based on the discovery that the administration of a CD56 antibody linked to a cytotoxic compound (e.g." an immunoconjugate) in combination with a chemotherapeutic agent (in particular a gemcitabine compound, a topotecan compound, and a doxorubicin compound), improves the therapeutic index in the treatment of ovarian, peritoneal, or fallopian tube cancer over and above the additive effects of the anticancer agents used alone. Combinations of the CD56 antibody, or fragment thereof, linked to a cytotoxic compound plus an additional chemotherapeutic agent have a synergistic effect in the ovarian cancer therapeutic index. Further disclosed are methods of modulating the growth of selected cell populations, such as ovarian, peritoneal, or fallopian tube cancer cells, by administering a therapeutically effective amount of such combinations.
摘要翻译：本公开涉及抗癌药物组合，用于治疗卵巢，腹膜或输卵管癌的药物组合物。具体地，本公开是基于以下发现：与化学治疗剂（特别是吉西他滨化合物，拓扑替康化合物和多柔比星化合物）联合的细胞毒性化合物（例如“免疫偶联物”）的CD56抗体的施用，改善治疗卵巢，腹膜或输卵管癌的治疗指标，超过单独使用的抗癌剂的加和效应。与细胞毒性化合物加上另外的化学治疗剂连接的CD56抗体或其片段的组合具有进一步公开了通过施用治疗有效量的这种组合来调节所选细胞群体如卵巢，腹膜或输卵管癌细胞的生长的方法。

5. 发明申请

WO2012135675A2 METHODS FOR INCREASING EFFICACY OF FOLR1 CANCER THERAPY 审中-公开
标题翻译：提高FOLR1癌症治疗有效性的方法
公开(公告)号：WO2012135675A2
公开(公告)日：2012-10-04
申请号：PCT/US2012/031544
申请日：2012-03-30
申请人： IMMUNOGEN, INC. , CARRIGAN, Christina, N. , WHITEMAN, Kathleen, R. , PAYNE, Gillian , LADD, Sharron
发明人： CARRIGAN, Christina, N. , WHITEMAN, Kathleen, R. , PAYNE, Gillian , LADD, Sharron
IPC分类号： A61K39/395 , A61K39/44 , A61P35/00 , A61K51/10 , G01N33/574
CPC分类号： A61K47/6851 , A61K47/48638 , A61K47/6809 , A61K47/6849 , A61K47/6869 , C07K16/28 , G01N33/57492
摘要： Methods to improve the success of cancer therapies that target the human folate receptor 1 are provided. Kits comprising reagent useful in the methods are further provided.
摘要翻译：提供了改善靶向人叶酸受体1的癌症疗法的成功的方法。还提供了包含在所述方法中有用的试剂的试剂盒。

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