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1. 发明申请

WO2009039437A1 ANALYTE DETECTION WITH MAGNETIC SENSORS 审中-公开
标题翻译：用磁传感器进行分析检测
公开(公告)号：WO2009039437A1
公开(公告)日：2009-03-26
申请号：PCT/US2008/077111
申请日：2008-09-19
申请人： MAGARRAY, INC. , THE BOARD OF TRUSTEES OF THE LELAND STANDFORD JUNIOR UNIVERSITY , WANG, Shan X. , OSTERFELD, Sebastian J. , YU, Heng , POURMAND, Nader , WHITE, Robert L.
发明人： WANG, Shan X. , OSTERFELD, Sebastian J. , YU, Heng , POURMAND, Nader , WHITE, Robert L.
IPC分类号： B01D11/04
CPC分类号： G01N33/54326 , Y10T436/143333
摘要： Methods for analyte detection with magnetic sensors are provided. Aspects of the methods include producing a magnetic sensor device having a magnetically labeled analyte from a sample, such as a serum sample, bound to a surface of a magnetic sensor thereof; and obtaining a signal, e.g., a real-time signal, from the magnetic sensor to determine whether the analyte is present in the sample. Also provided are devices, systems and kits that find use in practicing the methods of the invention. The methods, devices, systems and kits of the invention find use in a variety of different applications, including detection of biomarkers, such as disease markers.
摘要翻译：提供了使用磁传感器进行分析物检测的方法。所述方法的方面包括制备具有磁性标记的分析物的磁性传感器装置，所述磁性传感器装置与来自其磁性传感器的表面的样品（例如血清样品）结合; 以及从磁传感器获得信号，例如实时信号，以确定分析物是否存在于样品中。还提供了用于实施本发明的方法的装置，系统和试剂盒。本发明的方法，装置，系统和试剂盒可用于各种不同的应用，包括检测生物标志物，例如疾病标记物。

2. 发明申请

WO2007150056A3 METHOD AND DELAY CIRCUIT WITH ACCURATELY CONTROLLED DUTY CYCLE 审中-公开
标题翻译：具有精确控制占空比的方法和延迟电路
公开(公告)号：WO2007150056A3
公开(公告)日：2008-05-08
申请号：PCT/US2007071959
申请日：2007-06-25
申请人： TEXAS INSTRUMENTS INC , WHITE ROBERT L
发明人： WHITE ROBERT L
IPC分类号： H03K3/017
CPC分类号： H03K5/1565 , H03K5/133 , H03L7/0812
摘要： A delay locked loop includes a storage element coupled to a data bus and produces a data synchronization signal. A phase detector receives a data clock (8) signal and the data synchronization signal and produces a delay control signal. A first delay circuit (11) produces a signal which is delayed relative to the data clock signal according to the delay control signal. A second delay circuit receiving the delayed signal produces a control signal coupled to a control input of the storage element by delaying the delayed signal an amount which causes the control signal to have a predetermined duty cycle.
摘要翻译：延迟锁定环包括耦合到数据总线的存储元件并产生数据同步信号。相位检测器接收数据时钟（8）信号和数据同步信号并产生延迟控制信号。第一延迟电路（11）根据延迟控制信号产生相对于数据时钟信号延迟的信号。接收延迟信号的第二延迟电路通过将延迟信号延迟使控制信号具有预定占空比的量而产生耦合到存储元件的控制输入的控制信号。

3. 发明申请

WO2005047864A9 MAGNETIC NANOPARTICLES, MAGNETIC DETECTOR ARRAYS, AND METHODS FOR THEIR USE IN DETECTING BIOLOGICAL MOLECULES 审中-公开
标题翻译：磁性纳米颗粒，磁性探测器阵列及其用于检测生物分子的方法
公开(公告)号：WO2005047864A9
公开(公告)日：2005-07-21
申请号：PCT/US2004038485
申请日：2004-11-12
申请人： UNIV LELAND STANFORD JUNIOR , WANG SHAN X , WHITE ROBERT L , WEBB CHRIS D , LI GUANXIONG
发明人： WANG SHAN X , WHITE ROBERT L , WEBB CHRIS D , LI GUANXIONG
IPC分类号： B01L3/00 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/14 , C40B60/14 , C40B70/00 , G01N33/543 , G01N33/553 , H01F1/00 , H01F10/32 , G01N
CPC分类号： H01F10/3272 , B01J2219/00378 , B01J2219/00497 , B01J2219/00563 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00655 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00734 , B01L3/5027 , B82Y5/00 , B82Y15/00 , B82Y25/00 , B82Y30/00 , C12Q1/6834 , C40B40/06 , C40B40/10 , C40B40/14 , C40B60/14 , C40B70/00 , G01N33/54326 , G01N33/5434 , G01N33/553 , G01N2446/10 , H01F1/0054 , H01F10/3254 , Y10T428/2991 , C12Q2563/143
摘要： Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity.
摘要翻译：公开了磁性纳米粒子及其用于检测生物分子的方法。磁性纳米粒子可以附着于核酸分子，然后通过附着于检测器（例如自旋阀检测器或磁性隧道结检测器）的互补序列捕获。结合的磁性纳米颗粒的检测可以以高特异性和高灵敏度实现。

4. 发明申请

WO1991016212A1 AMPHIBIOUS VEHICLE 审中-公开
标题翻译：大型车
公开(公告)号：WO1991016212A1
公开(公告)日：1991-10-31
申请号：PCT/US1991002503
申请日：1991-04-16
申请人： HART, Douglas, S. , BELLER, Larry, D. , WHITE, Robert, L.
IPC分类号： B60F03/00
CPC分类号： B60F3/0023
摘要： A buoyant boat hull (12) of an amphibious vehicle (10) has concave, quarter cylinder recesses (24) along the sides down from the waterline, such recesses receiving the upper inboard quadrants of helical augers (26). The recesses (24) confine water between the screw threads and project it directly to the rear for more efficient forward thrust. The engine (40) and pumps (38) for the hydraulic motors (30) are mounted on a slide (42) to be moved forward and aft as desired to shift the center of gravity and aid in transition between land and water travel.

5. 发明申请

WO2005113822A3 DNA PROFILING AND SNP DETECTION UTILIZING MICROARRAYS 审中-公开
标题翻译：使用微阵列的DNA分析和SNP检测
公开(公告)号：WO2005113822A3
公开(公告)日：2007-12-13
申请号：PCT/US2005016953
申请日：2005-05-11
申请人： UNIV LELAND STANFORD JUNIOR , KEMP JENNIFER T , WANG SHAN X , WEBB CHRIS D , WHITE ROBERT L
发明人： KEMP JENNIFER T , WANG SHAN X , WEBB CHRIS D , WHITE ROBERT L
IPC分类号： C12Q1/68 , C07H21/02 , C12M1/34 , C12P19/36
CPC分类号： C12Q1/683 , C12Q2525/151
摘要： The present invention provides methods for rapidly identifying and distinguishing between different DNA sequences utilizing short tandem repeat (STR) analysis and DNA microarrays. Specifically, these methods facilitate the deduction of a target molecule's identity, length, and number of STRs. In an embodiment, a labeled STR target sequence is hybridized to a DNA microarray carrying complementary probes. These probes vary in length to cover the range of possible STRs. The labeled single-stranded regions of the DNA hybrids are selectively removed from the microarray surface utilizing a posthybridization enzymatic digestion. The number of repeats in the unknown target is deduced based on the pattern of target DNA that remains hybridized to the microarray. The DNA profiling techniques described herein are useful for performing forensic analysis to uniquely identify individual humans or other species.
摘要翻译：本发明提供使用短串联重复（STR）分析和DNA微阵列快速鉴定和区分不同DNA序列的方法。具体来说，这些方法有助于减少目标分子的身份，长度和STR的数量。在一个实施方案中，标记的STR靶序列与携带互补探针的DNA微阵列杂交。这些探头长度不同以覆盖可能的STR的范围。使用后杂交酶消化，从微阵列表面选择性地除去DNA杂交体的标记单链区域。基于与微阵列杂交的目标DNA的模式，推导出未知目标中的重复数。本文描述的DNA分析技术可用于执行法医分析以唯一地识别个体人或其他物种。

6. 发明申请

WO2005113822A2 DNA PROFILING AND SNP DETECTION UTILIZING MICROARRAYS 审中-公开
标题翻译： DNA分析和SNP检测利用微阵列
公开(公告)号：WO2005113822A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/016953
申请日：2005-05-11
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANDFORD JUNIOR UNIVERSITY , KEMP, Jennifer, T. , WANG, Shan, X. , WEBB, Chris, D. , WHITE, Robert, L.
发明人： KEMP, Jennifer, T. , WANG, Shan, X. , WEBB, Chris, D. , WHITE, Robert, L.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/683 , C12Q2525/151
摘要： The present invention provides methods for rapidly identifying and distinguishing between different DNA sequences utilizing short tandem repeat (STR) analysis and DNA microarrays. Specifically, these methods facilitate the deduction of a target molecule's identity, length, and number of STRs. In an embodiment, a labeled STR target sequence is hybridized to a DNA microarray carrying complementary probes. These probes vary in length to cover the range of possible STRs. The labeled single-stranded regions of the DNA hybrids are selectively removed from the microarray surface utilizing a posthybridization enzymatic digestion. The number of repeats in the unknown target is deduced based on the pattern of target DNA that remains hybridized to the microarray. The DNA profiling techniques described herein are useful for performing forensic analysis to uniquely identify individual humans or other species.
摘要翻译：本发明提供使用短串联重复（STR）分析和DNA微阵列快速鉴定和区分不同DNA序列的方法。具体来说，这些方法有助于减少目标分子的身份，长度和STR的数量。在一个实施方案中，标记的STR靶序列与携带互补探针的DNA微阵列杂交。这些探头长度不同以覆盖可能的STR的范围。通过后杂交酶消化，从微阵列表面选择性地除去DNA杂交体的标记的单链区域。基于与微阵列杂交的目标DNA的模式，推导出未知目标中的重复次数。本文描述的DNA分析技术可用于执行法医分析以唯一地识别个体人或其他物种。

7. 发明申请

WO2010002417A1 GAS CHROMATOGRAPH OVEN 审中-公开
标题翻译：气体色谱炉
公开(公告)号：WO2010002417A1
公开(公告)日：2010-01-07
申请号：PCT/US2008/082253
申请日：2008-11-03
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA , WHITE, Robert, L.
发明人： WHITE, Robert, L.
IPC分类号： G01N30/02
CPC分类号： G01N30/30 , G01N2030/025 , G01N2030/3053 , G01N2030/3084
摘要： A gas chromatograph oven including a housing, a capillary tube and a thermal control assembly. The housing defining a capillary tube receiving space and having at least one outlet port to permit the passage of a fluid from the capillary tube receiving space of the housing. The capillary tube is positioned in the capillary tube receiving space of the housing and has a gas inlet end connectable to a gas injector and a gas detector end connectable to a gas detector. The thermal control assembly is in fluid communication with the capillary tube receiving space of the housing and is connectable to a source of a temperature regulating fluid.
摘要翻译：包括壳体，毛细管和热控制组件的气相色谱仪。壳体限定毛细管容纳空间并且具有至少一个出口以允许来自壳体的毛细管容纳空间的流体通过。毛细管位于壳体的毛细管容纳空间中，并且具有可连接到气体注射器的气体入口端和可连接到气体检测器的气体检测器端。热控制组件与壳体的毛细管接收空间流体连通，并且可连接到温度调节流体源。

8. 发明申请

WO2007150056A2 METHOD AND DELAY CIRCUIT WITH ACCURATELY CONTROLLED DUTY CYCLE 审中-公开
标题翻译：具有精确控制占空比的方法和延迟电路
公开(公告)号：WO2007150056A2
公开(公告)日：2007-12-27
申请号：PCT/US2007/071959
申请日：2007-06-25
申请人： TEXAS INSTRUMENTS INCORPORATED , WHITE, Robert, L.
发明人： WHITE, Robert, L.
IPC分类号： H03K3/017
CPC分类号： H03K5/1565 , H03K5/133 , H03L7/0812
摘要： A delay locked loop includes a storage element coupled to a data bus and produces a data synchronization signal. A phase detector receives a data clock (8) signal and the data synchronization signal and produces a delay control signal. A first delay circuit (11) produces a signal which is delayed relative to the data clock signal according to the delay control signal. A second delay circuit receiving the delayed signal produces a control signal coupled to a control input of the storage element by delaying the delayed signal an amount which causes the control signal to have a predetermined duty cycle.
摘要翻译：延迟锁定环包括耦合到数据总线的存储元件并产生数据同步信号。相位检测器接收数据时钟（8）信号和数据同步信号并产生延迟控制信号。第一延迟电路（11）根据延迟控制信号产生相对于数据时钟信号延迟的信号。接收延迟信号的第二延迟电路通过将延迟信号延迟使控制信号具有预定占空比的量而产生耦合到存储元件的控制输入的控制信号。

9. 发明申请

WO2005047864A3 MAGNETIC NANOPARTICLES, MAGNETIC DETECTOR ARRAYS, AND METHODS FOR THEIR USE IN DETECTING BIOLOGICAL MOLECULES 审中-公开
标题翻译：磁性纳米颗粒，磁性检测器阵列及其在检测生物分子中的应用
公开(公告)号：WO2005047864A3
公开(公告)日：2005-09-29
申请号：PCT/US2004038485
申请日：2004-11-12
申请人： UNIV LELAND STANFORD JUNIOR , WANG SHAN X , WHITE ROBERT L , WEBB CHRIS D , LI GUANXIONG
发明人： WANG SHAN X , WHITE ROBERT L , WEBB CHRIS D , LI GUANXIONG
IPC分类号： B01L3/00 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/14 , C40B60/14 , C40B70/00 , G01N33/543 , G01N33/553 , H01F1/00 , H01F10/32 , G01N33/566 , G01N33/53 , G01N33/537
CPC分类号： H01F10/3272 , B01J2219/00378 , B01J2219/00497 , B01J2219/00563 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00655 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00734 , B01L3/5027 , B82Y5/00 , B82Y15/00 , B82Y25/00 , B82Y30/00 , C12Q1/6834 , C40B40/06 , C40B40/10 , C40B40/14 , C40B60/14 , C40B70/00 , G01N33/54326 , G01N33/5434 , G01N33/553 , G01N2446/10 , H01F1/0054 , H01F10/3254 , Y10T428/2991 , C12Q2563/143
摘要： Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity.
摘要翻译：公开了磁性纳米颗粒及其用于检测生物分子的方法。磁性纳米颗粒可以连接到核酸分子，然后通过与检测器（例如自旋阀检测器或磁性隧道结检测器）连接的互补序列捕获。可以以高特异性和灵敏度实现结合的磁性纳米颗粒的检测。

10. 发明申请

WO2005047864A2 MAGNETIC NANOPARTICLES, MAGNETIC DETECTOR ARRAYS, AND METHODS FOR THEIR USE IN DETECTING BIOLOGICAL MOLECULES 审中-公开
标题翻译：磁性纳米颗粒，磁性探测器阵列及其用于检测生物分子的方法
公开(公告)号：WO2005047864A2
公开(公告)日：2005-05-26
申请号：PCT/US2004/038485
申请日：2004-11-12
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , WANG, Shan, X. , WHITE, Robert, L. , WEBB, Chris, D. , LI, Guanxiong
发明人： WANG, Shan, X. , WHITE, Robert, L. , WEBB, Chris, D. , LI, Guanxiong
IPC分类号： G01N
CPC分类号： H01F10/3272 , B01J2219/00378 , B01J2219/00497 , B01J2219/00563 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00655 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00734 , B01L3/5027 , B82Y5/00 , B82Y15/00 , B82Y25/00 , B82Y30/00 , C12Q1/6834 , C40B40/06 , C40B40/10 , C40B40/14 , C40B60/14 , C40B70/00 , G01N33/54326 , G01N33/5434 , G01N33/553 , G01N2446/10 , H01F1/0054 , H01F10/3254 , Y10T428/2991 , C12Q2563/143
摘要： Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity.
摘要翻译：公开了磁性纳米粒子及其用于检测生物分子的方法。磁性纳米粒子可以附着于核酸分子，然后通过附着于检测器（例如自旋阀检测器或磁性隧道结检测器）的互补序列捕获。结合磁性纳米粒子的检测可以以高特异性和高灵敏度实现。

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