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1. 发明申请

WO1997023615A1 MULTIMER FORMS OF INTERLEUKIN-16 (IL-16), PROCESS FOR THE PREPARATION AND USE THEREOF 审中-公开
标题翻译：用于生产和使用IL-16，法多聚体形式
公开(公告)号：WO1997023615A1
公开(公告)日：1997-07-03
申请号：PCT/EP1996005661
申请日：1996-12-17
申请人： BOEHRINGER MANNHEIM GMBH , BUNDESREPUBLIK DEUTSCHLAND, vertreten durch den BUNDESMINISTER FÜR GESUNDHEIT , LANG, Kurt , KURTH, Reinhard , BAIER, Michael , BANNERT, Norbert , METZNER, Karin , WERNER, Albrecht
发明人： BOEHRINGER MANNHEIM GMBH , BUNDESREPUBLIK DEUTSCHLAND, vertreten durch den BUNDESMINISTER FÜR GESUNDHEIT
IPC分类号： C12N15/24
CPC分类号： C07K14/5446 , C07K2319/00
摘要： Eine multimere Form von IL-16, die gegebenenfalls Metallionen in definierter Menge enthält, ist aktiver als bekanntes IL-16.
摘要翻译：本发明涉及IL-16的多聚体形式，其任选地包含在所定义的量的金属离子，并且更具活性比IL-16已知

2. 发明申请

WO1996031607A2 USE OF AN "e;IMMUNODEFICIENCY-VIRUS SUPPRESSING LYMPHOKINE (ISL)"e; TO INHIBIT THE REPLICATION OF VIRUSES, IN PARTICULAR OF RETROVIRUSES 审中-公开
标题翻译：使用“免疫抑制因子抑制LYMPHOKINE（ISL）”来阻止病毒的复制，特别是病毒性肝炎
公开(公告)号：WO1996031607A2
公开(公告)日：1996-10-10
申请号：PCT/EP1996001486
申请日：1996-04-04
申请人： BUNDESREPUBLIK DEUTSCHLAND, vertreten durch den BUNDESMINISTER FÜR GESUNDHEIT , KURTH, Reinhard , BAIER, Michael , METZNER, Karin , WERNER, Albrecht
发明人： BUNDESREPUBLIK DEUTSCHLAND, vertreten durch den BUNDESMINISTER FÜR GESUNDHEIT
IPC分类号： C12N15/19
CPC分类号： C07K14/5446 , A61K38/00 , C07K2319/00 , Y10S930/141
摘要： An isolated polypeptide which inhibits the replication of retroviruses in peripheral blood lymphocytes and i) is coded by the DNA sequence shown in SEQ ID NO: 1 or complementary sequences; ii) is coded by DNA sequences which hybridize with SEQ ID NO: 1 or SEQ ID NO: 3 under stringent conditions; iii) is coded by DNA sequences which, if there was no degeneracy of the genetic code would hybridize under stringent conditions with the sequences defined in i) to ii); is useful as a therapeutic agent for the treatment of viral infections and benign and malignant proliferation diseases.
摘要翻译：抑制外周血淋巴细胞中逆转录病毒复制的分离多肽，i）由SEQ ID NO：1所示的DNA序列或互补序列编码; ii）由在严格条件下与SEQ ID NO：1或SEQ ID NO：3杂交的DNA序列编码; iii）由DNA序列编码，如果遗传密码没有简并性，则在严格条件下与i）至ii）中定义的序列杂交; 可用作治疗病毒感染和良性和恶性增殖疾病的治疗剂。

3. 发明申请

WO1997038105A1 GENOMIC NUCLEIC ACIDS, cDNA AND mRNA WHICH CODE FOR POLYPEPTIDES WITH IL-16 ACTIVITY, PROCESSES FOR THE PRODUCTION THEREOF AND THEIR USE 审中-公开
标题翻译：基因组核酸，具有IL-16活性的多肽的cDNA和mRNA，其生产方法及其使用
公开(公告)号：WO1997038105A1
公开(公告)日：1997-10-16
申请号：PCT/EP1997001753
申请日：1997-04-09
申请人： BUNDESREPUBLIK DEUTSCHLAND VERTRETEN DURCH DEN BUNDESMINISTER FÜR GESUNDHEIT , KURTH, Reinhard , BAIER, Michael , BANNERT, Norbert , METZNER, Karin , WERNER, Albrecht
发明人： BUNDESREPUBLIK DEUTSCHLAND VERTRETEN DURCH DEN BUNDESMINISTER FÜR GESUNDHEIT
IPC分类号： C12N15/24
CPC分类号： C07K14/5446 , A61K38/00
摘要： A nucleic acid with which expression of a polypeptide having interleukin-16 activity can be achieved or regulated in a prokaryotic or eukaryotic host cell, wherein in the region coding for the said polypeptide said nucleic acid (a) corresponds to the DNA sequence SEQ ID NO:1 or its complementary strand; (b) hybridizes under stringent conditions with the DNA of sequence SEQ ID NO:1; (c) or is a nucleic acid sequence which, if there was no degeneracy of the genetic code, would hybridize under stringent conditions with the nucleic acid sequences defined by (a) and (b); (d) and, if it codes for a polypeptide having interleukin-16 activity, has a length of at least 1179 coding nucleotides, is suitable as genomic DNA for the recombinant production of IL-16 in eukaryotic host cells.
摘要翻译：可以在原核或真核宿主细胞中实现具有白细胞介素-16活性的多肽的表达的核酸，其中在编码所述多肽的区域中，所述核酸（a）对应于DNA序列SEQ ID NO ：1或其互补链; （b）在严格条件下与序列SEQ ID NO：1的DNA杂交; （c）或是不存在遗传密码简并性的核酸序列，将在严格条件下与（a）和（b）定义的核酸序列杂交; （d），如果编码具有白细胞介素-16活性的多肽具有至少1179个编码核苷酸的长度，则适合作为在真核宿主细胞中重组产生IL-16的基因组DNA。

4. 发明申请

WO1997023616A1 POLYPEPTIDES WITH INTERLEUKIN 16 ACTIVITY, PROCESS FOR THE PREPARATION AND USE THEREOF 审中-公开
标题翻译：多肽，IL-16的活性，方法用于生产和使用
公开(公告)号：WO1997023616A1
公开(公告)日：1997-07-03
申请号：PCT/EP1996005662
申请日：1996-12-17
申请人： BUNDESREPUBLIK DEUTSCHLAND, vertreten durch den BUNDESMINISTER FÜR GESUNDHEIT , BOEHRINGER MANNHEIM GMBH , KURTH, Reinhard , BAIER, Michael , BANNERT, Norbert , METZNER, Karin , WERNER, Albrecht , LANG, Kurt
发明人： BUNDESREPUBLIK DEUTSCHLAND, vertreten durch den BUNDESMINISTER FÜR GESUNDHEIT , BOEHRINGER MANNHEIM GMBH
IPC分类号： C12N15/24
CPC分类号： C07K14/5446 , A61K38/00
摘要： A nucleic acid can be used to achieve the expression of a polypeptide with interleukin 16 activity in a prokaryotic or eukaryotic host cell. Said nucleic acids in the area coding for said polypeptide corresponds (a) to the DNA sequence of nucleotides 54-1175 from SEQ ID NO:1 or to the complementary strand thereof, (b) hydridises under standard hybridisation conditions with the DNA of the sequence of nucleotides 54-785 of SEQ ID NO:1, (c) hybridises under stringent hydridisation conditions with the DNA of the sequence of nucleotides 786-1175 of SEQ ID NO:1 and starts at the 5' end the DNA sequence of nucleotides 756-785 of SEQ ID NO:1 or a part thereof which codes for a part of the sequence of aminoacids 235-244 of SEQ ID NO: 1, or (d) is a nucleic acid sequence which would hydridise under stringent hybridisation conditions, without the degeneration of the genetic code, with the nucleic acid sequences defined by (a) and (b). Said nucleic acid codes for proteins with improved interleukin 16 activity.
摘要翻译：的核酸与在原核或真核宿主细胞白细胞介素16活性的多肽的表达，其可以实现的，其中所述核酸编码所述区域中的）核苷酸SEQ ID的54-1175的DNA序列的多肽 NO：1或其互补链对应，b）在严格条件下与以下杂交的核苷酸SEQ ID NO的54-785的序列的DNA：1，C）在严格条件下与以下杂交的SEQ核苷酸786-1175的DNA序列 ID NO：1和5“的核苷酸的SEQ ID NO 756-785结束：1或其部分开始由SEQ ID NO的用于氨基酸序列235-244的一部分：1编码，或d）一个核酸序列，其将杂交而是用于由限定的遗传密码的简并性）和b）在严格条件下核酸序列，编码蛋白质的具有增强白介素16-Ab的 tivity。

5. 发明申请

WO2009063336A2 AN IMMORTALIZED HUMAN CD4-POSITIVE CELL AND ITS USE FOR DETERMINING THE PHENOTYPE OF A HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 审中-公开
标题翻译：人体免疫缺陷病毒1型阳性细胞及其用于确定人类免疫缺陷病毒1型
公开(公告)号：WO2009063336A2
公开(公告)日：2009-05-22
申请号：PCT/IB2008/003924
申请日：2008-11-14
申请人： PAUL-EHRLICH-INSTITUT BUNDESAMT FÜR SERA UND IMPFSTOFFE , BINNINGER-SCHINZEL, Dorothea , SCHNIERLE, Barbara , WERNER, Albrecht
发明人： BINNINGER-SCHINZEL, Dorothea , SCHNIERLE, Barbara , WERNER, Albrecht
CPC分类号： G01N33/56988
摘要： The invention relates to an immortalized CD4-positive cell. According to the invention, this cell comprises a gene encoding a CXCR4 chemokine receptor that is capable of serving as a corecep- tor for entry of a Human Immunodeficiency Virus Type 1 (HIV-I) into the cell, and a gene en¬ coding a CCR5 receptor that is not capable of serving as a coreceptor for entry of a Human Im¬ munodeficiency Virus Type 1 into the cell. The invention furthermore relates to a method for the phenotypical characterization of a HIV-I, comprising providing such a cell, adding an HIV-I to the cell under conditions that allow for the entrance of the HIV-I into the cell and the replication of the virus in the cell, and measuring the replication of the HIV-I in the cell.
摘要翻译：本发明涉及永生化的CD4阳性细胞。根据本发明，该细胞包含编码CXCR4趋化因子受体的基因，该基因能够作为将人类免疫缺陷病毒1型（HIV-1）进入细胞的核心选择者，并且编码a 不能作为1型人类免疫缺陷病毒进入细胞的共同受体的CCR5受体。本发明还涉及用于HIV-1表型表征的方法，包括提供这样的细胞，在允许HIV-1进入细胞的条件下向细胞中加入HIV-1，并且复制细胞中的病毒，并测量细胞中HIV-1的复制。

6. 发明申请

WO1998023751A1 PROCESSED POLYPEPTIDES WITH IL-16 ACTIVITY, PROCESSES FOR THEIR PRODUCTION AND THEIR USE 审中-公开
标题翻译：具有IL-16活性的加工聚合物，其生产方法及其使用
公开(公告)号：WO1998023751A1
公开(公告)日：1998-06-04
申请号：PCT/EP1997006476
申请日：1997-11-20
申请人： BUNDESREPUBLIK DEUTSCHLAND, vertreten durch den BUNDESMINISTER FÜR GESUNDHEIT , BOEHRINGER MANNHEIM GMBH , KURTH, Reinhard , BAIER, Michael , WERNER, Albrecht , AMBROSIUS, Dorothee , LANZENDÖRFER, Martin
发明人： BUNDESREPUBLIK DEUTSCHLAND, vertreten durch den BUNDESMINISTER FÜR GESUNDHEIT , BOEHRINGER MANNHEIM GMBH
IPC分类号： C12N15/24
CPC分类号： C07K14/5446 , A61K38/00
摘要： A nucleic acid, which can be used to express a polypeptide with interleukin-16 activity in a prokaryotic or eukaryotic host cell, wherein the said nucleic acid codes for a polypeptide with the amino acid sequence SEQ ID NO:2 and/or a SEQ ID NO:2 N-terminally elongated by Ala-Ser or a form thereof which is shortened at its C-terminus by up to 8 amino acids, is suitable for producing an active IL-16 polypeptide.
摘要翻译：一种核酸，其可用于在原核或真核宿主细胞中表达具有白细胞介素-16活性的多肽，其中所述核酸编码具有氨基酸序列SEQ ID NO：2和/或SEQ ID NO： NO：2通过Ala-Ser或其形式在C末端缩短多达8个氨基酸的N末端延伸，适用于产生活性IL-16多肽。

7. 发明申请

WO1997041231A1 PROCESSED POLYPEPTIDES WITH IL-16 ACTIVITY, PROCESS FOR PREPARING THE SAME AND THEIR USE 审中-公开
标题翻译：用于生产和使用具有IL-16的活性，方法进行处理多肽
公开(公告)号：WO1997041231A1
公开(公告)日：1997-11-06
申请号：PCT/EP1997002216
申请日：1997-04-30
申请人： BUNDESREPUBLIK DEUTSCHLAND vertreten durch DEN BUNDESMINISTER FÜR GESUNDHEIT , BOEHRINGER MANNHEIM GMBH , KURTH, Reinhard , BAIER, Michael , BANNERT, Norbert , WERNER, Albrecht , LANG, Kurt
发明人： BUNDESREPUBLIK DEUTSCHLAND vertreten durch DEN BUNDESMINISTER FÜR GESUNDHEIT , BOEHRINGER MANNHEIM GMBH
IPC分类号： C12N15/24
CPC分类号： C07K14/5446 , A61K38/00
摘要： A nucleic acid makes it possible to express a polypeptide with interleukin-16 activity in a procaryotic or eucaryotic host cell. Said nucleic acid codes for a polypeptide with the amino acid sequence SEQ ID NO:2 or for a SEQ ID NO:2 elongated at the N-terminus by an aspartic acid radical or shortened at the C-terminus by up to 8 amino acids. This nucleic acid is useful for producing an active IL-16 polypeptide.
摘要翻译：的核酸与在原核或真核宿主细胞白细胞介素16活性的多肽的其表达可被实现，其中所述核酸编码具有氨基酸序列SEQ ID NO：2的多肽或N-末端由天冬氨酸残基SEQ延伸 ID NO：2或由它们编码的形式，适合于产生活性IL-16多肽至多8个氨基酸的C末端截短的。

8. 发明授权

US4392136A Circuit arrangement for storing signal values 失效
标题翻译：用于存储信号值的电路布置
公开(公告)号：US4392136A
公开(公告)日：1983-07-05
申请号：US288927
申请日：1981-07-31
申请人： Werner Albrecht , Klaus Fischer , Gerhard Grun
发明人： Werner Albrecht , Klaus Fischer , Gerhard Grun
IPC分类号： G06F3/023 , H04Q9/00 , G08C19/28 , H03K21/36
CPC分类号： G06F3/0232
摘要： In a circuit arrangement including a plurality of multi-position data switches and a memory connected for storing, in respective addressable memory locations, representations of the positions of the data switches, each data switch is a multi-digit coding switch having an actuating input and a plurality of code outputs at which appear a set of signals representative of the setting of the switch upon appearance of a signal at its actuating input, and the arrangement further includes a multiplex signal generator having a plurality of clock outputs each connected to the actuating input of a respective coding switch, the generator being arranged to produce a sequence of pulse signals and to deliver each pulse signal of the sequence to a respective clock output, and a bus bar composed of a plurality of conductors equal in number to the number of code outputs of each coding switch, with each conductor being connected between the memory and a respective coding output of each coding switch so that the appearance of a signal at the actuating input of one coding switch causes the set of signals representative of the current setting of that switch to appear on the conductors.
摘要翻译：在包括多个多位置数据开关的电路装置和连接用于在相应的可寻址存储器位置中存储数据开关的位置的表示的存储器中，每个数据开关是具有致动输入的多位编码开关，多个代码输出出现一组信号，其表示在其启动输入处出现信号时开关的设置，并且该装置还包括具有多个时钟输出的多路复用信号发生器，每个时钟输出连接到致动输入相应的编码开关，所述发生器被布置成产生脉冲信号序列并且将所述序列的每个脉冲信号传送到相应的时钟输出，以及由多个导体数量等于代码数量的多个导体组成的汇流条每个编码开关的输出，每个导体连接在存储器和每个编码开关的相应编码输出之间，因此t 在一个编码开关的启动输入处，信号的出现使代表该开关的当前设置的信号集合出现在导体上。

9. 发明授权

US4078247A Inverter circuit control circuit for precluding simultaneous conduction of thyristors 失效
标题翻译：用于阻止晶闸管同时导通的逆变电路控制电路
公开(公告)号：US4078247A
公开(公告)日：1978-03-07
申请号：US547127
申请日：1975-02-05
申请人： George Werner Albrecht
发明人： George Werner Albrecht
IPC分类号： H02M7/523 , H02M7/525 , H02M7/515
CPC分类号： H02M7/525 , H02M7/523
摘要： A circuit suitable for use in an induction range. The circuit includes a resonant inverter having first and second gate controlled thyristor switches, the main conduction paths of which are serially connected between the power supply terminals. Trigger pulses for the switches are derived from the current supplied to the inverter load coil. The pulses are timed to prevent the first switch from being closed before the second switch has opened so that both switches can never be conductive at the same time. It also includes circuitry for stopping inverter operation in the event of an overcurrent condition and circuitry for adjusting the inverter output power.
摘要翻译：适用于感应范围的电路。电路包括具有第一和第二栅极控制晶闸管开关的谐振逆变器，其主导通路径串联连接在电源端子之间。用于开关的触发脉冲是从提供给变频器负载线圈的电流得出的。脉冲定时以防止第一开关在第二开关打开之前被关闭，使得两个开关不会同时导通。它还包括用于在过电流状况下停止变频器运行的电路和用于调节逆变器输出功率的电路。

10. 发明授权

US4106831A Revolving cable-to-housing connection 失效
标题翻译：旋转电缆到外壳连接
公开(公告)号：US4106831A
公开(公告)日：1978-08-15
申请号：US813820
申请日：1977-07-08
申请人： Werner Albrecht
发明人： Werner Albrecht
IPC分类号： H01R4/64 , H01R35/00 , H01R39/00 , H01R3/06
CPC分类号： H01R39/00 , H01R35/00 , H01R4/64
摘要： A revolving feed through connection has a socket member to which are connected mechanically the electrical conductors; a pair of coaxial conductors are mounted on the socket member and electrically to the said cable conductors while being insulated from each other; a sleeve made of strong material is mounted on the socket member and is firmly connected thereto. Means in the housing define a bearing for the sleeve and receiving the sleeve for permitting turning of the socket with the sleeve about an axis, which is coaxial to the conductors of the pair. The sleeve and bearing are constructed for axially retaining the sleeve in the bearing.
摘要翻译：通过连接的旋转进给器具有插座构件，机械地连接电导体; 一对同轴导体安装在插座构件上并与绝缘的电缆电连接; 由强力材料制成的套筒安装在插座构件上并牢固地连接到其上。壳体中的装置限定了用于套筒的轴承并且容纳套筒以允许套筒绕着套筒绕与该对的导体同轴的轴线转动。套筒和轴承构造用于将套筒轴向保持在轴承中。

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