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1. 发明专利

CA2065771A1 METHOD FOR STABILIZING RADIOLABELED BIOLOGICAL MOLECULES USING ION EXCHANGE RESINS 未知
公开(公告)号：CA2065771A1
公开(公告)日：1992-11-02
申请号：CA2065771
申请日：1992-04-10
申请人： TU JAN I , YOST FRED , WEN MEI LI , JAGODA ELAINE
发明人： TU JAN-I , YOST FRED , WEN MEI-LI , JAGODA ELAINE
IPC分类号： G01N33/534 , A61K51/10 , A61K51/12 , G01N33/60 , A61K47/38 , A61K39/395 , A61K43/00
摘要： RA54 METHOD FOR STABILIZING RADIOLABELED BIOLOGICAL MOLECULES USING ION EXCHANGE RESINS A method for the stabilization of radiolabeled biological molecules using an ion exchange resin.

2. 发明申请

WO2011014475A3 TREATING NEGATIVE SYMPTOMS OF SCHIZOPHRENIA ASSOCIATED WITH DEFECTIVE NEUREGULIN 1 审中-公开
公开(公告)号：WO2011014475A3
公开(公告)日：2011-02-03
申请号：PCT/US2010/043306
申请日：2010-07-27
申请人： NATIONAL TAIWAN UNIVERSITY , DCB-USA LLC , FU, Wen-Mei , CHIANG, Ya-Hsuan , HWU, Hai-Gwo , LIU, Chih-Min
发明人： FU, Wen-Mei , CHIANG, Ya-Hsuan , HWU, Hai-Gwo , LIU, Chih-Min
IPC分类号： A61K31/352 , A61K31/135 , A61K31/505 , A61P25/18 , A61P25/00
摘要： Use of a compound that is a serotonin transporter inhibitor, a selective norepinephrine reuptake inhibitor, or a 5-HT1A agonist for alleviating negative symptoms in a schizophrenia patient who carries a defective neuregulin 1 gene.

3. 发明申请

WO2011011315A1 POLYPEPTIDES SELECTIVE FOR AV β3 INTEGRIN CONJUGATED WITH A VARIANT OF HUMAN SERUM ALBUMIN (HSA) AND PHARMACEUTICAL USES THEREOF 审中-公开
标题翻译：选择性与AV血清白蛋白（HSA）和其药物用途相结合的AVß3INTEGRIN的多选择
公开(公告)号：WO2011011315A1
公开(公告)日：2011-01-27
申请号：PCT/US2010/042423
申请日：2010-07-19
申请人： NATIONAL CHENG KUNG UNIVERSITY , NATIONAL TAIWAN UNIVERSITY , DCB-USA LLC , CHUANG, Woei-Jer , FU, Wen-Mei
发明人： CHUANG, Woei-Jer , FU, Wen-Mei
IPC分类号： A61K38/00
CPC分类号： C07K14/70546 , A61K38/00
摘要： The invention generally relates to fusion proteins comprising a rhodostomin variant having an RGD motif variant 48 ARLDDL 53 , wherein the rhodostomin variant is conjugated with a variant of Human Serum Albumin (HSA). The invention also relates to the use of these fusion proteins for treatment and prevention of αvβ3 integrin-associated diseases.
摘要翻译：本发明一般涉及包含具有RGD基序变体48ARLDDL53的罗丹明变体的融合蛋白，其中所述罗丹明变体与人血清白蛋白（HSA）的变体缀合。本发明还涉及这些融合蛋白用于治疗和预防avß3整联蛋白相关疾病的用途。

4. 发明申请

WO2010129490A2 IMPROVED LEAN HC CONVERSION OF TWC FOR LEAN BURN GASOLINE ENGINES 审中-公开
标题翻译：改进了LEAN燃烧汽油发动机的TWC转换
公开(公告)号：WO2010129490A2
公开(公告)日：2010-11-11
申请号：PCT/US2010/033457
申请日：2010-05-04
申请人： BASF CORPORATION , HILGERNDORFF, Marcus , XUE, Wen, Mei , TOLENTINO, Cesar
发明人： HILGERNDORFF, Marcus , XUE, Wen, Mei , TOLENTINO, Cesar
IPC分类号： F01N3/28 , F01N3/20 , B01J23/46 , B01J23/40 , B01D53/94
CPC分类号： B01J23/464 , B01D53/945 , B01D53/9454 , B01D2255/1021 , B01D2255/1023 , B01D2255/1025 , B01D2255/2042 , B01D2255/206 , B01D2255/20715 , B01D2255/2092 , B01D2255/407 , B01D2255/9025 , B01D2258/014 , B01J23/002 , B01J23/40 , B01J23/63 , B01J37/0244 , B01J2523/00 , Y02T10/22 , B01J2523/25 , B01J2523/31 , B01J2523/3706 , B01J2523/3712 , B01J2523/48 , B01J2523/822 , B01J2523/824 , B01J2523/828
摘要： The present invention relates to a catalyst composition comprising a carrier substrate, a layer (i) coated on said carrier substrate comprising at least one precious group metal, a layer (ii) comprising Rh, and a layer (iii) comprising Pd and/or Pt and being substantially free of Ce, Ba and Rh, wherein the layer (iii) has a lower weight than the layer (i) or the layer (ii). Furthermore, the present invention relates to a method for treating an exhaust gas stream using said catalyst composition.
摘要翻译：本发明涉及一种催化剂组合物，其包括载体基质，涂覆在所述载体基质上的包含至少一种贵金属组的层（i），包含Rh的层（ii）和包含Pd和/或 Pt并且基本上不含Ce，Ba和Rh，其中层（iii）具有比层（i）或层（ii）更低的重量。此外，本发明涉及使用所述催化剂组合物处理废气流的方法。

5. 发明申请

WO2009104161A2 A COATING COMPOSITION FOR STRENGTHENING GLASS 审中-公开
标题翻译：用于加强玻璃的涂料组合物
公开(公告)号：WO2009104161A2
公开(公告)日：2009-08-27
申请号：PCT/IB2009/050704
申请日：2009-02-20
申请人： SABMILLER INTERNATIONAL BV , VAN DER WALT, Louis, Stephanus , WEN, Mei , HOPKINS, Thomas, R. , BROTZMAN, Jeffery, Richard , SILVERMAN, Gary, Stephen , CARSON, Stephen, William
发明人： WEN, Mei , HOPKINS, Thomas, R. , BROTZMAN, Jeffery, Richard , SILVERMAN, Gary, Stephen , CARSON, Stephen, William
IPC分类号： C09D175/04 , C08G18/76 , C08G18/28 , C08G18/48 , C08G18/32 , C03C17/32
CPC分类号： C03C17/005 , C03C17/30 , C03C17/322 , C08G18/289 , C08G18/4816 , C08G18/7664 , C09D175/04
摘要： The invention relates to a method of making a coating composition for strengthening glass in a one-coating procedure. The method includes the steps of combining a polyol component, an isocyanate component and a silane adhesion promoter. The silane adhesion promoter typically comprises less than about 15% of the composition.
摘要翻译：本发明涉及一种制备用于在一次涂覆程序中加强玻璃的涂料组合物的方法。该方法包括组合多元醇组分，异氰酸酯组分和硅烷粘合促进剂的步骤。硅烷粘合促进剂通常包含小于组合物的约15％。

6. 发明申请

WO2008106523A3 BIFUNCTIONAL CATALYSTS FOR SELECTIVE AMMONIA OXIDATION 审中-公开
公开(公告)号：WO2008106523A3
公开(公告)日：2008-09-04
申请号：PCT/US2008/055148
申请日：2008-02-27
申请人： BASF CATALYSTS LLC , CAUDLE, Matthew Tyler , DIETERLE, Martin , ROTH, Stanley A. , XUE, Wen-Mei
发明人： CAUDLE, Matthew Tyler , DIETERLE, Martin , ROTH, Stanley A. , XUE, Wen-Mei
IPC分类号： B01J23/42 , B01J23/89 , B01J29/72 , B01J29/74 , B01J35/00 , B01J35/04
摘要： Catalysts, methods, and systems for treating diesel engine exhaust streams are described. In one or more embodiments, the catalyst comprises platinum, a second metal from one of the groups VB, VIB, VIIB, VIIIB, IB, or IIB of the periodic table, a refractory metal oxide, and a zeolite, the oxidation catalyst already being effective to remove ammonia at temperatures less than about 300°C and exhibiting no significant decrease in ammonia oxidation efficiency upon hydrothermal aging. A method aspect includes first passing a vehicle's engine exhaust stream through a NO x abatement catalyst; and passing the exhaust stream exiting the NO x abatement catalyst and containing ammonia through the ammonia oxidation catalyst. Systems including such catalysts are also provided.

7. 发明申请

WO2008088548A2 DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF 审中-公开
标题翻译： DISINTEGRIN变体及其药物用途
公开(公告)号：WO2008088548A2
公开(公告)日：2008-07-24
申请号：PCT/US2007026125
申请日：2007-12-21
申请人： UNIV NAT TAIWAN , DCB USA LLC , CHUANG WOEI-JER , FU WEN-MEI , HUANG TUR-FU , HUANG WENYA , TANG CHIH-HSIN , CHEN CHIU-YUEH
发明人： CHUANG WOEI-JER , FU WEN-MEI , HUANG TUR-FU , HUANG WENYA , TANG CHIH-HSIN , CHEN CHIU-YUEH
IPC分类号： A61K38/02 , A61K38/08 , A61K38/16 , A61P35/00 , C07H21/00 , C07K2/00 , C07K7/06 , C07K14/00 , C12P21/00
CPC分类号： C07K14/46 , A61K38/00 , C07K14/745
摘要： Disintegrin variants and pharmaceutical uses thereof are disclosed. The disintegrin variant includes an isolated polypeptide that has integrin avß3 receptor-antagonist activity and substantially reduced integrin aIIbß3 and/or a5ß1 receptor-blocking activity as compared to a wild-type disintegrin. The variant is encoded by a modified disintegrin nucleotide sequence that encodes a modified amino acid sequence, resulting in a polypeptide having substantially reduced affinity to integrin aIIbß3 and/or a5ß1 as compared to a wild-type disintegrin. The variant is useful for treatment and/or prevention of avß3 integrin-associated diseases in a mammal, which include osteoporosis, bone tumor or cancer growth, angiogenesis-related tumor growth and metastasis, tumor metastasis in bone, malignancy-induced hypercalcemia, angiogenesis-related eye diseases, Paget's disease, rheumatic arthritis, and osteoarthritis. The angiogenesis-related eye diseases include age-related macular degeneration, diabetic retinopathy, corneal neovascularizing diseases, ischaemia-induced neovascularizing retinopathy, high myopia, and retinopathy of prematurity.
摘要翻译：公开了解联蛋白变体及其药物用途。与野生型解联蛋白相比，解联蛋白变体包括具有整联蛋白αvβ3受体拮抗剂活性和显着降低的整联蛋白αIIbβ3和/或α5β1受体阻断活性的分离的多肽。该变体由编码修饰的氨基酸序列的修饰的解联蛋白核苷酸序列编码，与野生型解联蛋白相比，导致与整联蛋白αIIbβ3和/或α5β1具有显着降低的亲和力的多肽。该变体可用于治疗和/或预防哺乳动物中的avβ3整联蛋白相关疾病，包括骨质疏松症，骨肿瘤或癌症生长，血管生成相关的肿瘤生长和转移，骨中的肿瘤转移，恶性肿瘤诱发的高钙血症，血管生成 - 相关的眼疾，佩吉特病，风湿性关节炎和骨关节炎。与血管生成相关的眼病包括年龄相关性黄斑变性，糖尿病性视网膜病，角膜新血管形成疾病，局部缺血诱导的新血管生成性视网膜病，高度近视和早产儿视网膜病。

8. 发明申请

WO2003024397A3 ENHANCEMENT OF LEARNING AND MEMORY AND TREATMENT OF AMNESIA 审中-公开
公开(公告)号：WO2003024397A3
公开(公告)日：2003-03-27
申请号：PCT/US2002/029294
申请日：2002-09-16
申请人： CARLSBAD TECHNOLOGY, INC. , FU, Wen-Mei , LIANG, Keng-Chen , CHIEN, Wei-Lin , KUO, Sheng-Chu , LEE, Fang-Yuan , TENG, Che-Ming
发明人： FU, Wen-Mei , LIANG, Keng-Chen , CHIEN, Wei-Lin , KUO, Sheng-Chu , LEE, Fang-Yuan , TENG, Che-Ming
IPC分类号： A61K31/415
摘要： A method for enhancing learning and memory or treating amnesia. The method includes administrating to a subject in need thereof a compound of the formula (I) : each of Ar 1 , Ar 2 , and Ar 3 , independently, is phenyl, thienyl, furyl, or pyrrolyl ; each of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , independently, is H, nitro, halogen, R, OH, OR, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH 2 , C(O)NHR, C(O)NRR', ROH, ,ROR', RSH, RSR', ROC(O)R'OH, NHR, NRR', RNHR', or RNR'R'', or R 1 and R 2 together, R 3 and R 4 together, or R 5 and R 6 together are ORO ; wherein each of R, R', and R'', independently is C 1 ∼C 6 alkyl ; and n is 1, 2, or 3. The compound is in an effective amount for enhancing learning and memory or treating amnesia.

9. 发明申请

WO2003024397A2 ENHANCEMENT OF LEARNING AND MEMORY AND TREATMENT OF AMNESIA 审中-公开
标题翻译：增强学习和记忆与治疗阿姆斯壮
公开(公告)号：WO2003024397A2
公开(公告)日：2003-03-27
申请号：PCT/US2002/029294
申请日：2002-09-16
申请人： CARLSBAD TECHNOLOGY, INC. , FU, Wen-Mei , LIANG, Keng-Chen , CHIEN, Wei-Lin , KUO, Sheng-Chu , LEE, Fang-Yuan , TENG, Che-Ming
发明人： FU, Wen-Mei , LIANG, Keng-Chen , CHIEN, Wei-Lin , KUO, Sheng-Chu , LEE, Fang-Yuan , TENG, Che-Ming
IPC分类号： A61K
CPC分类号： A61K31/4162 , A61K31/416
摘要： A method for enhancing learning and memory or treating amnesia. The method includes administrating to a subject in need thereof a compound of the formula (I) : each of Ar 1 , Ar 2 , and Ar 3 , independently, is phenyl, thienyl, furyl, or pyrrolyl ; each of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , independently, is H, nitro, halogen, R, OH, OR, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH 2 , C(O)NHR, C(O)NRR', ROH, ,ROR', RSH, RSR', ROC(O)R'OH, NHR, NRR', RNHR', or RNR'R'', or R 1 and R 2 together, R 3 and R 4 together, or R 5 and R 6 together are ORO ; wherein each of R, R', and R'', independently is C 1 ∼C 6 alkyl ; and n is 1, 2, or 3. The compound is in an effective amount for enhancing learning and memory or treating amnesia.
摘要翻译：一种增强学习记忆或治疗健忘症的方法。该方法包括向有需要的受试者施用式（I）化合物：Ar 1，Ar 2和Ar 3各自独立地为苯基，噻吩基，呋喃基或吡咯基; R 1，R 2，R 3，R 4，R 5和R 6各自独立地是H，硝基，卤素，R，OH，OR，C（O）OH，C（O）OR，C（O） O，R（OH）NRR'，ROH，ROR'，RSH，RSR'，ROC（O）R'OH，NHR，NRR'，RNHR' 或RNR'R“，或者R 1和R 2一起为R 3和R 4，或者R 5和R 6一起为ORO; 其中R，R'和R“各自独立地是C 1 -C 6烷基; 并且n为1,2或3.该化合物用于增强学习和记忆或治疗健忘症的有效量。

10. 发明申请

WO2011079175A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF ANGIOGENESIS-RELATED EYE DISEASES 审中-公开
标题翻译：用于治疗与血管发生相关的眼病的组合物和方法
公开(公告)号：WO2011079175A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/061738
申请日：2010-12-22
申请人： NATIONAL CHENG KUNG UNIVERSITY , NATIONAL TAIWAN UNIVERSITY , TWI BIOTECHNOLOGY, INC. , DCB-USA LLC , CHUANG, Woei-Jer , FU, Wen-Mei , HUANG, Yen-Lun
发明人： CHUANG, Woei-Jer , FU, Wen-Mei , HUANG, Yen-Lun
IPC分类号： A61K38/16 , C07K14/00
CPC分类号： A61K38/1703 , A61K47/643
摘要： The invention generally relates to compositions and methods of treatment and/or prevention of angiogenesis-related eye diseases using low doses of rhodostomin variants, and in particular, low doses of a fusion protein comprising a rhodostomm variant, wherein the rhodostomin variant is conjugated with a variant of Human Serum Albumin (HSA) where the cysteine residue at position 34 of the HSA amino acid sequence has been replaced with serine.
摘要翻译：本发明一般涉及使用低剂量罗丹明变种治疗和/或预防血管生成相关眼病的组合物和方法，特别是低剂量的包含罗丹斯通变体的融合蛋白，其中所述罗丹明变体与人血清白蛋白（HSA）的变体，其中HSA氨基酸序列的第34位的半胱氨酸残基被丝氨酸替代。

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