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1. 发明申请

WO2015106269A2 RAPID ACTION INSULIN FORMULATIONS AND PHARMACEUTICAL DELIVERY SYSTEMS 审中-公开
标题翻译：快速行动胰岛素制剂和药物输送系统
公开(公告)号：WO2015106269A2
公开(公告)日：2015-07-16
申请号：PCT/US2015011202
申请日：2015-01-13
申请人： THERMALIN DIABETES LLC , JOSEPH JEFFREY I , BERENSON RICHARD WILLIAM , FRANK BRUCE , WEISS MICHAEL A , HATTIER THOMAS , DUBÉ GREGORY , CHEN ZHIQIANG
发明人： JOSEPH JEFFREY I , BERENSON RICHARD WILLIAM , FRANK BRUCE , WEISS MICHAEL A , HATTIER THOMAS , DUBÉ GREGORY , CHEN ZHIQIANG
IPC分类号： A61K38/28
CPC分类号： A61K38/28 , A61K9/0019 , A61K9/0021 , A61K36/05 , A61K36/23 , A61K45/06 , A61K47/12 , A61K47/183 , A61K47/20 , A61K47/36 , A61M5/142 , A61M5/1723 , A61M25/02 , A61M37/0092 , A61M2025/0253 , A61M2037/0007 , A61M2205/055 , A61M2205/35 , A61M2205/50 , A61M2205/502 , A61M2230/201 , A61N1/0448 , A61N1/327 , A61N7/00 , A61K2300/00
摘要： The present invention provides rapid-acting insulin and insulin analogue formulations. The invention further provides delivery devices, particularly infusion sets, which allow for the rapid absorption of insulin and insulin analogues, as well as other active agents. Methods of using the insulin and insulin analogue formulations as well as the insulin delivery devices for treating subjects with diabetes mellitus are also provided.
摘要翻译：本发明提供快速作用的胰岛素和胰岛素类似物制剂。本发明进一步提供了允许快速吸收胰岛素和胰岛素类似物以及其它活性剂的递送装置，特别是输注装置。还提供了使用胰岛素和胰岛素类似物制剂以及用于治疗患有糖尿病的胰岛素递送装置的方法。

2. 发明申请

WO2014145593A3 SITE 2 INSULIN ANALOGUES 审中-公开
标题翻译：网站2胰岛素类似物
公开(公告)号：WO2014145593A3
公开(公告)日：2015-01-08
申请号：PCT/US2014030387
申请日：2014-03-17
申请人： UNIV CASE WESTERN RESERVE , WEISS MICHAEL A
发明人： WEISS MICHAEL A
IPC分类号： A61K38/28 , C07H21/04 , C07K14/62
CPC分类号： C07K14/62 , A61K38/00
摘要： An insulin analogue contains one or more modifications at a distinct protein surface comprising one or more of the residues at position B13, B17, A12, A13, and/or A17. Formulations of the above analogues at successive strengths U-100 to U-1000 in soluble solutions a at least pH value in the range 6.8-8.0 either in the presence of zinc ions at a molar ratio of 2.2-10 zinc ions per six insulin analogue monomers or in the presence of fewer than 1 zinc ions per six insulin analogue monomers. Use of the above formulation in an insulin pump functionally integrated with a continuous glucose monitor and computer-based control algorithm as a closed-loop system. A method of treating a patient with diabetes mellitus comprises administering a physiologically effective amount of the insulin analogue to a patient by means of intravenous, intraperitoneal, or subcutaneous injection.
摘要翻译：胰岛素类似物在包含位置B13，B17，A12，A13和/或A17的一个或多个残基的不同蛋白质表面上含有一个或多个修饰。上述类似物在连续强度U-100至U-1000的可溶解溶液中的制备，至少pH值在6.8-8.0范围内，或者在锌离子存在下，每六个胰岛素类似物的摩尔比为2.2-10锌离子单体或每六个胰岛素类似物单体存在少于1个锌离子。在与连续葡萄糖监测器和基于计算机的控制算法功能性集成的胰岛素泵中使用上述制剂作为闭环系统。治疗患有糖尿病的患者的方法包括通过静脉内，腹膜内或皮下注射给予患者生理有效量的胰岛素类似物。

3. 发明申请

WO2014145593A2 SITE 2 INSULIN ANALOGUES 审中-公开
标题翻译：网站2胰岛素类似物
公开(公告)号：WO2014145593A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/030387
申请日：2014-03-17
申请人： CASE WESTERN RESERVE UNIVERSITY , WEISS, Michael A.
发明人： WEISS, Michael A.
IPC分类号： A61K38/28
CPC分类号： C07K14/62 , A61K38/00
摘要： An insulin analogue contains one or more modifications at a distinct protein surface comprising one or more of the residues at positions B13, B17, A12, A13, and/or A17. Formulations of the above analogues at successive strengths U-100 to U-1000 in soluble solutions at at least pH value in the range 6.8-8.0 either in the presence of zinc ions at a molar ratio of 2.2-10 zinc ions per six insulin analogue monomers or in the presence of fewer than 1 zinc ions per six insulin analogue monomers. Use of the above formulation in an insulin pump or insulin pump functionally integrated with a continuous glucose monitor and computer-based control algorithm as a closed-loop system. A method of treating a patient with diabetes mellitus comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient by means of intravenous, intraperitoneal, or subcutaneous injection.
摘要翻译：胰岛素类似物在包含位置B13，B17，A12，A13和/或A17的一个或多个残基的不同蛋白质表面上含有一个或多个修饰。上述类似物在连续强度U-100至U-1000的溶液中至少pH值在6.8-8.0范围内，或者在锌离子存在下，每六个胰岛素类似物的摩尔比为2.2-10锌离子单体或每六个胰岛素类似物单体存在少于1个锌离子。在胰岛素泵或胰岛素泵中使用上述配方，其与功能性地与连续葡萄糖监测器和基于计算机的控制算法集成，作为闭环系统。治疗患有糖尿病的患者的方法包括通过静脉内，腹膜内或皮下注射向患者施用生理有效量的胰岛素类似物或其生理上可接受的盐。

4. 发明申请

WO2015106269A3 RAPID ACTION INSULIN FORMULATIONS AND PHARMACEUTICAL DELIVERY SYSTEMS 审中-公开
公开(公告)号：WO2015106269A3
公开(公告)日：2015-07-16
申请号：PCT/US2015/011202
申请日：2015-01-13
申请人： THERMALIN DIABETES, LLC , JOSEPH, Jeffrey, I. , BERENSON, Richard, William , FRANK, Bruce , WEISS, Michael, A. , HATTIER, Thomas , DUBÉ, Gregory , CHEN, Zhiqiang
发明人： JOSEPH, Jeffrey, I. , BERENSON, Richard, William , FRANK, Bruce , WEISS, Michael, A. , HATTIER, Thomas , DUBÉ, Gregory , CHEN, Zhiqiang
IPC分类号： A61K38/28 , A61K38/00
摘要： The present invention provides rapid-acting insulin and insulin analogue formulations. The invention further provides delivery devices, particularly infusion sets, which allow for the rapid absorption of insulin and insulin analogues, as well as other active agents. Methods of using the insulin and insulin analogue formulations as well as the insulin delivery devices for treating subjects with diabetes mellitus are also provided.

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