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1. 发明申请

WO2007105210A3 THERAPEUTIC USES OF CANNABIDIOL COMPOUNDS 审中-公开
公开(公告)号：WO2007105210A3
公开(公告)日：2007-09-20
申请号：PCT/IL2007/000319
申请日：2007-03-13
申请人： HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WEISS, Lola , MEINER, Vardiella , LEITERSDORF, Eran , SLAVIN, Shimon , MECHOULAM, Raphael , GALLILY, Ruth , LOTAN, Chaim , DURST, Ronen , PUGATSCH, Thea
发明人： WEISS, Lola , MEINER, Vardiella , LEITERSDORF, Eran , SLAVIN, Shimon , MECHOULAM, Raphael , GALLILY, Ruth , LOTAN, Chaim , DURST, Ronen , PUGATSCH, Thea
IPC分类号： A61K31/35
摘要： The present invention provides the use of a Cannabidiol (CBD) compound for the preparation of a pharmaceutical composition for treatment as well as for the prevention of at least one fundamental parameter affecting a vascular system selected from (a) the cardiovascular system; (b) the peripheral vascular system; or (c) a combination of (a) and (b); as well as pharmaceutical compositions and therapeutic methods for treating the above. A fundamental parameter may include blood/plasma lipid profile; atherosclerosis plaque load; size of heart scar; thickness of heart scar; and cardiac function in general. In accordance with a preferred embodiment the invention concerns treatment of heart scars as well as the preventing the formation of heart scars.

2. 发明申请

WO2005077348A1 TREATING OR PREVENTING DIABETES WITH CANNABIDIOL 审中-公开
标题翻译：用甘露糖治疗或预防糖尿病
公开(公告)号：WO2005077348A1
公开(公告)日：2005-08-25
申请号：PCT/IL2005/000196
申请日：2005-02-16
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , WEISS, Lola , ZEIRA, Michael , MECHOULAM, Raphael , SLAVIN, Shimon , GALLILY, Ruth
发明人： WEISS, Lola , ZEIRA, Michael , MECHOULAM, Raphael , SLAVIN, Shimon , GALLILY, Ruth
IPC分类号： A61K31/05
CPC分类号： A61K31/05 , A61K36/185
摘要： Use of a cannabidiol for the manufacture of a medicament identified for the treatment or prevention of diabetes and/or insulitis.
摘要翻译：使用大麻二醇来制造用于治疗或预防糖尿病和/或胰岛炎的药物。

3. 发明申请

WO1993019756A1 THE USE OF QUINOLINE-3-CARBOXAMIDE COMPOUNDS FOR TREATMENT OF DIABETES 审中-公开
标题翻译：使用喹啉-3-羧酰胺化合物治疗糖尿病
公开(公告)号：WO1993019756A1
公开(公告)日：1993-10-14
申请号：PCT/SE1993000272
申请日：1993-03-31
申请人： KABI PHARMACIA AB , SLAVIN, Shimon , WEISS, Lola , GROSS, David
发明人： KABI PHARMACIA AB
IPC分类号： A61K31/47
CPC分类号： C07D215/54 , A61K31/47 , C07D215/56 , Y10S514/866 , Y10S514/884
摘要： The use of an anti-diabetic quinoline-3-carboxamide compound comprising the structure (I), optionally with substituents for the hydrogen atoms shown (H ), and a salt of the compound (I) where (a)------ represents that there are two conjugated double bonds between the atoms comprised by the dashed line, (b) X1 and X2 are separately selected from an oxygen atom or an NH group, said X1 and X2 being bound by a single bond to the ring when attached to H or H and by a double bond when not bound to H or H , (c) H are hydrogens with the provision that H is only present when at least one of X1 and X2 is the NH group, (d) H and H are hydrogens that are attached to different atoms selected among X1, X2 and the nitrogen atom (N) in the quinoline ring, for the manufacture of a composition intended for the treatment of conditions associated with Type I diabetes. Also described are treatment methods for diabetes in which methods these compounds are administered to a patient. Particularly preferred compounds are N-phenyl-N-methyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-quinoline-3-car boxamide or a salt thereof.
摘要翻译：使用包含结构（I）的抗糖尿病喹啉-3-甲酰胺化合物，任选地具有所示氢原子的取代基（H <1-9>）和化合物（I）的盐，其中（a） - 表示在由虚线包含的原子之间存在两个共轭双键，（b）X1和X2分别选自氧原子或NH 9基团，所述X 1和X 2结合当与H 7或H 8连接时通过单键与环结合，并且当未结合H 7或H 8时，双键，（c）H <1-9>是具有仅当X1和X2中的至少一个是NH 9基团时，H 9中仅存在的条件，（d）H 7和H 8是连接到选自X 1， X2和喹啉环中的氮原子（N），用于制备旨在治疗与I型糖尿病相关的病症的组合物。还描述了其中向患者施用这些化合物的糖尿病的治疗方法。特别优选的化合物是N-苯基-N-甲基-1,2-二氢-4-羟基-1-甲基-2-氧代 - 喹啉-3-酮盒酰胺或其盐。

4. 发明申请

WO2007105210A2 THERAPEUTIC USES OF CANNABIDIOL COMPOUNDS 审中-公开
标题翻译： CANNABIDIOL化合物的治疗用途
公开(公告)号：WO2007105210A2
公开(公告)日：2007-09-20
申请号：PCT/IL2007000319
申请日：2007-03-13
申请人： HADASIT MED RES SERVICE , YISSUM RES DEV CO , WEISS LOLA , MEINER VARDIELLA , LEITERSDORF ERAN , SLAVIN SHIMON , MECHOULAM RAPHAEL , GALLILY RUTH , LOTAN CHAIM , DURST RONEN , PUGATSCH THEA
发明人： WEISS LOLA , MEINER VARDIELLA , LEITERSDORF ERAN , SLAVIN SHIMON , MECHOULAM RAPHAEL , GALLILY RUTH , LOTAN CHAIM , DURST RONEN , PUGATSCH THEA
IPC分类号： A61K31/35
CPC分类号： A61K31/352 , A61K31/35
摘要： The present invention provides the use of a Cannabidiol (CBD) compound for the preparation of a pharmaceutical composition for treatment as well as for the prevention of at least one fundamental parameter affecting a vascular system selected from (a) the cardiovascular system; (b) the peripheral vascular system; or (c) a combination of (a) and (b); as well as pharmaceutical compositions and therapeutic methods for treating the above. A fundamental parameter may include blood/plasma lipid profile; atherosclerosis plaque load; size of heart scar; thickness of heart scar; and cardiac function in general. In accordance with a preferred embodiment the invention concerns treatment of heart scars as well as the preventing the formation of heart scars.
摘要翻译：本发明提供大麻二醇（CBD）化合物用于制备用于治疗的药物组合物以及用于预防影响选自（a）心血管系统的血管系统的至少一个基本参数的用途; （b）外周血管系统; 或（c）（a）和（b）的组合; 以及用于治疗上述的药物组合物和治疗方法。基本参数可以包括血液/血浆脂质分布; 动脉粥样硬化斑块负荷; 心脏瘢痕大小; 心脏瘢痕厚度; 和心脏功能一般。根据优选实施方案，本发明涉及心脏瘢痕的治疗以及防止心脏瘢痕的形成。

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