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1. 发明申请

WO2011150411A1 FOOD COMPOSITIONS COMPRISING TAILORED OILS 审中-公开
标题翻译：包含定型油的食品组合物
公开(公告)号：WO2011150411A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/038464
申请日：2011-05-27
申请人： SOLAZYME, INC. , FRANKLIN, Scott , SOMANCHI, Aravind , WEE, Janice , RUDENKO, George , MOSELEY, Jeffrey L , RAKITSKY, Walt
发明人： FRANKLIN, Scott , SOMANCHI, Aravind , WEE, Janice , RUDENKO, George , MOSELEY, Jeffrey L , RAKITSKY, Walt
IPC分类号： A23D9/00 , C11B5/00
CPC分类号： C12N15/79 , A23D7/00 , A23D9/00 , A23K20/158 , C11B1/00 , C11C3/00 , C12N9/0071 , C12N9/16 , C12N9/2431 , C12N9/2465 , C12N15/67 , C12N15/8216 , C12P7/64 , C12P7/6445 , C12P7/6463 , C12Y114/19001 , C12Y301/02 , C12Y301/02014 , C12Y302/01022 , C12Y302/01026 , Y02E50/13 , Y02P30/20 , Y02T50/678
摘要： Methods and compositions for the production of food compositions, oils, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing food compositions, and transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants.
摘要翻译：提供了用于在重组微生物中生产食品组合物，油，燃料，油脂化合物和其它化合物的方法和组合物，包括含油微生物和这种微生物的低成本培养方法。包含编码例如脂肪酶，蔗糖转运蛋白，蔗糖转化酶，果糖激酶，多糖降解酶，酮酰基-ACP合成酶，脂肪酰基-ACP硫酯酶，脂肪酰辅酶A的外源基因的微藻细胞 /醛还原酶，脂肪酰辅酶A还原酶，脂肪醛还原酶，脂肪醛脱羰酶和/或酰基载体蛋白质可用于制造食品组合物，以及运输燃料如可再生柴油，生物柴油和可再生喷气燃料，以及诸如功能流体，表面活性剂，肥皂和润滑剂的油脂化学品。

2. 发明申请

WO2010036774A1 METHODS FOR PURIFICATION OF VIRUSES 审中-公开
标题翻译：病毒纯化方法
公开(公告)号：WO2010036774A1
公开(公告)日：2010-04-01
申请号：PCT/US2009/058174
申请日：2009-09-24
申请人： MEDIMMUNE, LLC , THOMPSON, Mark , WEE, Janice , NAGPAL, Akanksha
发明人： THOMPSON, Mark , WEE, Janice , NAGPAL, Akanksha
IPC分类号： A61K39/155 , C12N7/02
CPC分类号： C12N7/00 , A61K2039/5254 , C12N2760/16051 , C12N2760/18551
摘要： The present invention provides methods for the purification of cell-associated viruses from adherent cells (e.g., MDCK or Vero cells). In particular, the present invention provides purification methods for the production of immunogenic compositions comprising a live attenuated cell-associated virus (e.g., an attenuated respiratory syncytial virus (RSV) or cold- adapted, and/or temperature sensitive influenza virus) that result in levels of host cell DNA (HCD), host cell protein (HCP) and non-specific endonuclease (e.g., Benzonase), which are below the specifications required by regulatory agencies. The immunogenic compositions can be used to actively immunize subjects or to generate antibodies for a variety of uses, including passive immunization and diagnostic immunoassays.
摘要翻译：本发明提供了用于从贴壁细胞（例如MDCK或Vero细胞）纯化细胞相关病毒的方法。特别地，本发明提供用于产生免疫原性组合物的纯化方法，其包含活减毒细胞相关病毒（例如，减毒呼吸道合胞病毒（RSV）或冷适应性和/或温度敏感型流感病毒），其导致宿主细胞DNA（HCD），宿主细胞蛋白（HCP）和非特异性内切核酸酶（例如Benzonase）的水平低于管理机构要求的规格。免疫原性组合物可用于主动免疫受试者或产生用于多种用途的抗体，包括被动免疫和诊断性免疫测定。

3. 发明申请

WO2011130573A1 FUEL AND CHEMICAL PRODUCTION FROM OLEAGINOUS YEAST 审中-公开
标题翻译：燃料和化学生产来自伊利诺伊州
公开(公告)号：WO2011130573A1
公开(公告)日：2011-10-20
申请号：PCT/US2011/032582
申请日：2011-04-14
申请人： SOLAZYME, INC. , FRANKLIN, Scott , DECKER, Stephen, M. , WEE, Janice
发明人： FRANKLIN, Scott , DECKER, Stephen, M. , WEE, Janice
IPC分类号： C12N1/00 , A61K31/20 , A23D9/00
CPC分类号： C12P7/6463 , C10G3/40 , C10G3/52 , C10G2300/1014 , C10L1/026 , C10L1/08 , C10L1/19 , C10L10/08 , C10L2200/043 , C10L2200/0469 , C10L2200/0476 , C10L2200/0492 , C10L2290/26 , C10L2290/54 , C10L2290/544 , C11B1/06 , C11B1/10 , C11C1/025 , C11C3/00 , C11C3/003 , C11C3/10 , C11C3/12 , C12P7/649 , Y02E50/13 , Y02P30/20 , Y02T50/678
摘要： Oleaginous yeast can be used to produce oil that can be extracted from oleaginous yeast biomass and converted into a wide variety of useful products, including fuels, hydrocarbon compositions, and/or oleochemicals.
摘要翻译：油性酵母可用于生产可从含油酵母生物质提取的油，并转化成各种有用的产品，包括燃料，烃组合物和/或油脂化学品。

4. 发明申请

WO2012061647A2 MICROBIAL OILS WITH LOWERED POUR POINTS, DIELECTRIC FLUIDS PRODUCED THEREFROM, AND RELATED METHODS 审中-公开
标题翻译：具有较低PO点的微生物油，其生产的电介质流体及相关方法
公开(公告)号：WO2012061647A2
公开(公告)日：2012-05-10
申请号：PCT/US2011/059224
申请日：2011-11-03
申请人： SOLAZYME, INC. , FRANKLIN, Scott , LU, Wenhua , RAKITSKY, Walter , RODRIGUEZ, Felipe Arana , RUDENKO, George , WEE, Janice , ZHAO, Xinhua
发明人： FRANKLIN, Scott , LU, Wenhua , RAKITSKY, Walter , RODRIGUEZ, Felipe Arana , RUDENKO, George , WEE, Janice , ZHAO, Xinhua
IPC分类号： C11B1/02 , C12P7/64 , H01B3/22 , H01F27/12
CPC分类号： C12P7/6463 , A23D9/007 , A23D9/02 , C10M169/041 , C11B1/025 , C11B1/06 , C11B1/10 , C11B3/001 , C11B3/006 , C11B3/008 , C11B3/06 , C11B3/10 , C11B3/14 , C12N9/2442 , C12N15/79 , C12P7/6409 , C12Y301/02014 , H01B3/20 , H01F27/105 , H01F27/321
摘要： Methods and compositions for the production of dielectric fluids from lipids produced by microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a lipid pathway modification enzyme, a fatty acyl-ACP thioesterase, a desaturase, a fatty acyl-CoA/aldehyde reductase, and/or an acyl carrier protein are useful in manufacturing dielectric fluids.
摘要翻译：提供了用于从由微生物产生的脂质生产介电流体的方法和组合物，包括含油微生物和这种微生物的低成本培养的方法。含有编码例如蔗糖转运蛋白，蔗糖转化酶，果糖激酶，多糖降解酶，脂质途径修饰酶，脂肪酰基-ACP硫酯酶，去饱和酶，脂肪酰辅酶A /醛的外源基因的微藻细胞还原酶和/或酰基载体蛋白质可用于制造介电流体。

5. 发明申请

WO2011150410A2 TAILORED OILS PRODUCED FROM RECOMBINANT HETEROTROPHIC MICROORGANISMS 审中-公开
标题翻译：从重组杂交微生物生产的定制油
公开(公告)号：WO2011150410A2
公开(公告)日：2011-12-01
申请号：PCT/US2011/038463
申请日：2011-05-27
申请人： SOLAZYME, INC. , FRANKLIN, Scott , SOMANCHI, Aravind , WEE, Janice , RUDENKO, George , MOSELEY, Jeffrey L , RAKITSKY, Walt
发明人： FRANKLIN, Scott , SOMANCHI, Aravind , WEE, Janice , RUDENKO, George , MOSELEY, Jeffrey L , RAKITSKY, Walt
IPC分类号： A23D9/02 , A23D7/02
CPC分类号： C12N15/79 , A23D7/00 , A23D9/00 , A23K20/158 , C11B1/00 , C11C3/00 , C12N9/0071 , C12N9/16 , C12N9/2431 , C12N9/2465 , C12N15/67 , C12N15/8216 , C12P7/64 , C12P7/6445 , C12P7/6463 , C12Y114/19001 , C12Y301/02 , C12Y301/02014 , C12Y302/01022 , C12Y302/01026 , Y02E50/13 , Y02P30/20 , Y02T50/678
摘要： Methods and compositions for the production of oil, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants.
摘要翻译：提供了用于在重组微生物中生产油，燃料，油化合物和其它化合物的方法和组合物，包括含油微生物和这种微生物的低成本培养的方法。包含编码例如脂肪酶，蔗糖转运蛋白，蔗糖转化酶，果糖激酶，多糖降解酶，酮酰基-ACP合成酶，脂肪酰基-ACP硫酯酶，脂肪酰辅酶A的外源基因的微藻细胞 /醛还原酶，脂肪酰辅酶A还原酶，脂肪醛还原酶，脂肪醛脱羰酶和/或酰基载体蛋白质可用于制造运输燃料如可再生柴油，生物柴油和可再生喷气燃料，以及油脂化学品例如功能流体，表面活性剂，肥皂和润滑剂。

6. 发明申请

WO2011130576A1 OLEAGINOUS YEAST FOOD COMPOSITIONS 审中-公开
标题翻译： OLEAGOOUS YEAST食品组合物
公开(公告)号：WO2011130576A1
公开(公告)日：2011-10-20
申请号：PCT/US2011/032586
申请日：2011-04-14
申请人： SOLAZYME, INC. , FRANKLIN, Scott , PIECHOCKI, John , NORRIS, Leslie, M. , DECKER, Stephen, M. , WEE, Janice , ZDANIS, Dana
发明人： FRANKLIN, Scott , PIECHOCKI, John , NORRIS, Leslie, M. , DECKER, Stephen, M. , WEE, Janice , ZDANIS, Dana
IPC分类号： A23C9/12
CPC分类号： A21D2/267 , A23L7/198 , A23L33/115 , A23L33/14 , A23L33/145 , A23V2002/00 , A23V2200/254 , A23V2250/76
摘要： The invention provides novel oleaginous yeast biomass, yeast oil, food compositions comprising oleaginous yeast biomass, whole oleaginous yeast cells, and/or yeast oil in combination with one or more edible ingredients, and methods of making such compositions by combining oleaginous yeast biomass or yeast oil with other edible ingredients.
摘要翻译：本发明提供新颖的含油酵母生物质，酵母油，包含含油酵母生物质，整个含油酵母细胞和/或酵母油与一种或多种可食用成分组合的食品组合物，以及通过将含油酵母生物质或酵母油与其他可食用成分。

7. 发明申请

WO2008094438A1 MACROLACTAMS BY ENGINEERED BIOSYNTHESIS 审中-公开
标题翻译： MACROLACTAMS由工程生物学
公开(公告)号：WO2008094438A1
公开(公告)日：2008-08-07
申请号：PCT/US2008/000918
申请日：2008-01-23
申请人： KOSAN BIOSCIENCES INCORPORATED , ASHLEY, Gary , MENZELLA, Hugo, G. , WEE, Janice, Lau , CARNEY, John, R.
发明人： ASHLEY, Gary , MENZELLA, Hugo, G. , WEE, Janice, Lau , CARNEY, John, R.
IPC分类号： C12P19/62 , A01N43/04 , A61K31/70
CPC分类号： C12P17/10 , C07D225/06
摘要： Macrolactams are made by feeding aromatic amino acids as replacement starter units to a mutant strain of the geldanamycin-producing microorganism Streptomyces hygroscopicus var. geldanus NRRL 3602, wherein the gene cluster encoding enzymes for the biosynthesis of the natural starter unit 3-amino-5-hydroxybenzoic acid has been deleted.
摘要翻译：通过将芳香族氨基酸作为替代起始单位加入到产生格尔德霉素的微生物链霉菌吸湿链霉菌变异体的突变菌株中来制备麦芽糖内酰胺。格尔氏菌NRRL 3602，其中编码天然起始单元3-氨基-5-羟基苯甲酸生物合成酶的基因簇已被缺失。

8. 发明申请

WO2012106560A9 TAILORED OILS PRODUCED FROM RECOMBINANT OLEAGINOUS MICROORGANISMS 审中-公开
公开(公告)号：WO2012106560A9
公开(公告)日：2012-08-09
申请号：PCT/US2012/023696
申请日：2012-02-02
申请人： SOLAZYME, INC. , FRANKLIN, Scott , SOMANCHI, Aravind , WEE, Janice , RUDENKO, George , MOSELEY, Jeffrey , RAKITSKY, Walt , ZHAO, Xinhua , BHAT, Riyaz
发明人： FRANKLIN, Scott , SOMANCHI, Aravind , WEE, Janice , RUDENKO, George , MOSELEY, Jeffrey , RAKITSKY, Walt , ZHAO, Xinhua , BHAT, Riyaz
IPC分类号： C12P7/64 , C12N1/13
摘要： Methods and compositions for the production of oil, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty acid hydroxylase, a desaturase enzyme, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants.

9. 发明申请

WO2012106560A1 TAILORED OILS PRODUCED FROM RECOMBINANT OLEAGINOUS MICROORGANISMS 审中-公开
标题翻译：由重组脂质微生物生产的定制油
公开(公告)号：WO2012106560A1
公开(公告)日：2012-08-09
申请号：PCT/US2012023696
申请日：2012-02-02
申请人： SOLAZYME INC , FRANKLIN SCOTT , SOMANCHI ARAVIND , WEE JANICE , RUDENKO GEORGE , MOSELEY JEFFREY , RAKITSKY WALT , ZHAO XINHUA , BHAT RIYAZ
发明人： FRANKLIN SCOTT , SOMANCHI ARAVIND , WEE JANICE , RUDENKO GEORGE , MOSELEY JEFFREY , RAKITSKY WALT , ZHAO XINHUA , BHAT RIYAZ
IPC分类号： C12P7/64 , C12N1/13
CPC分类号： C12P7/6463 , C07C69/52 , C10L1/02 , C10L2200/0476 , C10L2290/26 , C10L2290/30 , C12N9/0071 , C12N9/1029 , C12N9/16 , C12N15/52 , Y02E50/13
摘要： Methods and compositions for the production of oil, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty acid hydroxylase, a desaturase enzyme, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants.
摘要翻译：提供了用于在重组微生物中生产油，燃料，油化合物和其它化合物的方法和组合物，包括含油微生物和这种微生物的低成本培养的方法。包含编码例如脂肪酶，蔗糖转运蛋白，蔗糖转化酶，果糖激酶，多糖降解酶，酮酰基-ACP合成酶，脂肪酰基-ACP硫酯酶，脂肪酰辅酶A的外源基因的微藻细胞 /醛还原酶，脂肪酰辅酶A还原酶，脂肪醛还原酶，脂肪酸羟化酶，去饱和酶，脂肪醛脱羰酶和/或酰基载体蛋白，可用于制造运输燃料如可再生柴油，生物柴油，和可再生喷气燃料，以及油化学品如功能流体，表面活性剂，肥皂和润滑剂。

10. 发明申请

WO2012061647A3 MICROBIAL OILS WITH LOWERED POUR POINTS, DIELECTRIC FLUIDS PRODUCED THEREFROM, AND RELATED METHODS 审中-公开
标题翻译：具有降低的POUR点的微生物油，由其产生的介电流体及相关方法
公开(公告)号：WO2012061647A3
公开(公告)日：2012-08-09
申请号：PCT/US2011059224
申请日：2011-11-03
申请人： SOLAZYME INC , FRANKLIN SCOTT , LU WENHUA , RAKITSKY WALTER , RODRIGUEZ FELIPE ARANA , RUDENKO GEORGE , WEE JANICE , ZHAO XINHUA
发明人： FRANKLIN SCOTT , LU WENHUA , RAKITSKY WALTER , RODRIGUEZ FELIPE ARANA , RUDENKO GEORGE , WEE JANICE , ZHAO XINHUA
IPC分类号： C11B1/02 , C12P7/64 , H01B3/22 , H01F27/12
CPC分类号： C12P7/6463 , A23D9/007 , A23D9/02 , C10M169/041 , C11B1/025 , C11B1/06 , C11B1/10 , C11B3/001 , C11B3/006 , C11B3/008 , C11B3/06 , C11B3/10 , C11B3/14 , C12N9/2442 , C12N15/79 , C12P7/6409 , C12Y301/02014 , H01B3/20 , H01F27/105 , H01F27/321
摘要： Methods and compositions for the production of dielectric fluids from lipids produced by microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a lipid pathway modification enzyme, a fatty acyl-ACP thioesterase, a desaturase, a fatty acyl-CoA/aldehyde reductase, and/or an acyl carrier protein are useful in manufacturing dielectric fluids.
摘要翻译：提供了由微生物产生的脂质制备介电流体的方法和组合物，包括含油微生物和低成本培养这些微生物的方法。包含编码例如蔗糖转运蛋白，蔗糖转化酶，果糖激酶，多糖降解酶，脂质途径修饰酶，脂肪酰基-ACP硫酯酶，去饱和酶，脂肪酰基-CoA /醛的外源基因的微藻细胞还原酶和/或酰基载体蛋白质可用于制造介电流体。

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