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1. 发明专利

AU2018204883A1 STRUCTURE FOR LIGHT-WEIGHT, COLLAPSIBLE, SAFETY BEDDING 未知
公开(公告)号：AU2018204883A1
公开(公告)日：2019-01-24
申请号：AU2018204883
申请日：2018-07-04
申请人： SOMERS RONALD LAWRENCE DR , WEBER JENNIFER MS
发明人： SOMERS RONALD LAWRENCE , WEBER JENNIFER
IPC分类号： A47D7/04
摘要： A light-weight, collapsible, portable, moisture resistant, sleep-safety support structure may include a soft (to touch), cushioned, fluid-permeable, washable, firm enough, breathe-through mattress, and a pad and a cover with similar properties, for users that have turned face down. The safety support structure may also include air vents throughout the periphery of the frame, particularly at the level of the breathe-through mattress, pad, and cover, as well as above this level. The safety support structure may also include a removable, moisture-proof, combination liner-lid, and flyscreens or similar barriers at the air vents.

2. 发明申请

WO2011106222A3 MODIFIED SUBSTRATES FOR PROTECTION OF PEPTIDE-IMMOBILIZED SURFACES FROM GAMMA RADIATION DEGRADATION 审中-公开
标题翻译：用于保护γ-辐射降解的肽 - 固定化表面的修饰的基质
公开(公告)号：WO2011106222A3
公开(公告)日：2011-11-24
申请号：PCT/US2011025138
申请日：2011-02-17
申请人： CORNING INC , BOOKBINDER DANA C , MARTIN ARTHUR W , PAL SANTONA , SHOGBON CHRISTOPHER B , WEBER JENNIFER , ZHOU YUE
发明人： BOOKBINDER DANA C , MARTIN ARTHUR W , PAL SANTONA , SHOGBON CHRISTOPHER B , WEBER JENNIFER , ZHOU YUE
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , C12N2533/20 , C12N2533/50
摘要： In the present specification and claims, three modified cell culture substrates are disclosed for protecting peptide mimetic surfaces used in cell culture technology. The methods are able to retain the functionality of the bioactive species conjugated to the surface. In particular, a vitronectin peptide fragment Ac-Lys-Gly-Gly-Pro-Gln-Val-Thr-Arg-Gly-Asp-Val-Phe-Thr-Met-Pro-NH2 was able to facilitate growth and proliferation of undifferentiated human embryonic stem cells after stabilization using 3 different modified cell culture substrates for of protection against gamma irradiation. The modified substrates disclosed in this invention are (i) covalent attachment of the antioxidant molecules (via blocking step); (ii) The use of coatings consisting of antioxidants and stabilizers comprising glycoprotiens, sugars, carbohydrates, poly(amino acids), peptides and hydrophilic polymers; and (iii) a third method wherein the same methionine contained in the bioactive sequence used to facilitate growth and proliferation of human embryonic stem cells was also used as a sacrificial coating to protect the same conjugated sequence against damage by gamma irradiation.
摘要翻译：在本说明书和权利要求书中，公开了三种修饰的细胞培养基质，用于保护细胞培养技术中使用的肽模拟物表面。该方法能够保持与表面结合的生物活性物质的功能。具体而言，玻连蛋白肽片段Ac-Lys-Gly-Gly-Pro-Gln-Val-Thr-Arg-Gly-Asp-Val-Phe-Thr-Met-Pro-NH 2能够促进未分化人的生长和增殖胚胎干细胞稳定后使用3种不同的修饰细胞培养基质来防止γ辐射。本发明公开的改性底物是（i）抗氧化剂分子的共价连接（通过封闭步骤）; （ii）使用由抗氧化剂和稳定剂组成的包衣，所述稳定剂包含糖蛋白，糖，碳水化合物，聚（氨基酸），肽和亲水性聚合物; 和（iii）第三种方法，其中用于促进人类胚胎干细胞生长和增殖的生物活性序列中所含的相同甲硫氨酸也用作牺牲性涂层以保护相同的缀合序列免受伽玛辐射的损害。

3. 发明申请

WO2011106222A2 MODIFIED SUBSTRATES FOR PROTECTION OF PEPTIDE-IMMOBILIZED SURFACES FROM GAMMA RADIATION DEGRADATION 审中-公开
标题翻译：用于保护肽固定表面的改性基质从伽马辐射降解
公开(公告)号：WO2011106222A2
公开(公告)日：2011-09-01
申请号：PCT/US2011/025138
申请日：2011-02-17
申请人： CORNING INCORPORATED , BOOKBINDER, Dana C. , MARTIN, Arthur W. , PAL, Santona , SHOGBON, Christopher B. , WEBER, Jennifer , ZHOU, Yue
发明人： BOOKBINDER, Dana C. , MARTIN, Arthur W. , PAL, Santona , SHOGBON, Christopher B. , WEBER, Jennifer , ZHOU, Yue
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , C12N2533/20 , C12N2533/50
摘要： In the present specification and claims, three modified cell culture substrates are disclosed for protecting peptide mimetic surfaces used in cell culture technology. The methods are able to retain the functionality of the bioactive species conjugated to the surface. In particular, a vitronectin peptide fragment Ac-Lys-Gly-Gly-Pro-Gln-Val-Thr-Arg-Gly-Asp-Val-Phe-Thr-Met-Pro-NH2 was able to facilitate growth and proliferation of undifferentiated human embryonic stem cells after stabilization using 3 different modified cell culture substrates for of protection against gamma irradiation. The modified substrates disclosed in this invention are (i) covalent attachment of the antioxidant molecules (via blocking step); (ii) The use of coatings consisting of antioxidants and stabilizers comprising glycoprotiens, sugars, carbohydrates, poly(amino acids), peptides and hydrophilic polymers; and (iii) a third method wherein the same methionine contained in the bioactive sequence used to facilitate growth and proliferation of human embryonic stem cells was also used as a sacrificial coating to protect the same conjugated sequence against damage by gamma irradiation.
摘要翻译：在本说明书和权利要求书中，公开了三种修饰的细胞培养基质，用于保护细胞培养技术中使用的肽模拟表面。该方法能够保留与表面缀合的生物活性物质的功能。特别地，玻连蛋白肽片段Ac-Lys-Gly-Gly-Pro-Gln-Val-Thr-Arg-Gly-Asp-Val-Phe-Thr-Met-Pro-NH2能够促进未分化人的生长和增殖使用3种不同的修饰的细胞培养物底物进行稳定后的胚胎干细胞以防止γ照射。本发明公开的改性底物是（i）抗氧化剂分子的共价连接（通过封闭步骤）; （ii）使用由抗氧化剂和稳定剂组成的涂层，其包含糖调节剂，糖，碳水化合物，聚（氨基酸），肽和亲水性聚合物; 和（iii）第三种方法，其中用于促进人类胚胎干细胞生长和增殖的生物活性序列中所含的相同甲硫氨酸也用作牺牲涂层，以保护相同缀合序列免受γ照射的损伤。

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