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    • 2. 发明申请
    • CORRELATION CONFOCAL MICROSCOPE
    • 相关共形显微镜
    • WO2011136857A3
    • 2011-12-22
    • PCT/US2011020186
    • 2011-01-05
    • UNIV BOSTONSIMON DAVIDSERGIENKO ALEXANDERGOLDSTEIN LEE EDWINWEBB ROBERT H
    • SIMON DAVIDSERGIENKO ALEXANDERGOLDSTEIN LEE EDWINWEBB ROBERT H
    • G02B21/00G01B9/04
    • G02B21/0004G02B21/0056G02B21/0084
    • A correlation confocal microscope uses correlated photon pairs to improve resolution. It employs a source of a light beam converging to a point location on a sample, and an objective that gathers light from the point location and generates an image beam. A modulator applies a spatial pattern of modulation to the source light beam to define spatially correlated photons whose spatial correlations are preserved in modulated light gathered from the sample. A filter applies a modulation-selective filter function to the image light beam to generate a filtered light beam of like-modulated photons. A coincidence detector detects temporally coincident photon pairs in the filtered light beam, generating a pulse output that indicates the magnitude of a light-detectable property (such as transmissivity or reflectivity) of the sample at the point location. The modulator may apply phase modulation and the filter may be a phase-sensitive component such as an interferometer.
    • 相关共焦显微镜使用相关光子对来提高分辨率。 它采用聚焦到样本上点位置的光束源,以及从点位置聚集光线并生成图像光束的物镜。 调制器将调制的空间模式应用于源光束以定义空间相关的光子,其空间相关性保存在从样品收集的调制光中。 滤波器对图像光束应用调制选择性滤波功能以生成类似调制光子的滤波光束。 重合检测器检测经滤波的光束中时间上重合的光子对,产生指示样点在点位置处的光可检测特性(诸如透射率或反射率)的大小的脉冲输出。 调制器可以应用相位调制,并且滤波器可以是相位敏感的组件,例如干涉仪。