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1. 发明公开

EP3858365A1 GOLD OPTIMIZED CAR T-CELLS 有权转让
公开(公告)号：EP3858365A1
公开(公告)日：2021-08-04
申请号：EP21157792.9
申请日：2017-08-31
申请人： Chimera Bioengineering Inc. , Wang, Benjamin , Zeiner, Gusti
发明人： WANG, Benjamin , ZEINER, Gusti
IPC分类号： A61K35/17 , A61K35/28 , A61K39/00 , A61K39/395 , C12N5/00
摘要： The present invention relates to a method of controlling a transgene, comprising the steps of obtaining a primary T-cell comprising a chimeric antigen receptor, and a heterologous nucleic acid comprising a polynucleotide encoding the transgene that is operably linked to a polynucleotide encoding a RNA degradation element (RDE), wherein the RDE is an AU rich element, wherein the heterologous nucleic acid is transcribed to make a transcript encoding the transgene operably linked to the RDE; exposing the primary T-cell to a ligand for the chimeric antigen receptor wherein binding of the ligand by the chimeric antigen receptor activates the primary T-cell and thereby changes a metabolic state of the primary T-cell; and expressing the transgene wherein the amount of polypeptide made from the transgene is increased after the change in metabolic state of the primary T-cell.

2. 发明公开

EP3506916A1 GOLD OPTIMIZED CAR T-CELLS 有权转让
公开(公告)号：EP3506916A1
公开(公告)日：2019-07-10
申请号：EP17847552.1
申请日：2017-08-31
申请人： Chimera Bioengineering Inc. , Wang, Benjamin , Zeiner, Gusti
发明人： WANG, Benjamin , ZEINER, Gusti
IPC分类号： A61K35/17 , A61K35/28 , A61K39/00 , A61K39/395 , C12N5/00

3. 发明申请

WO2013052927A3 BROADBAND SOLAR CONTROL FILM 审中-公开
标题翻译：宽带太阳能控制电影
公开(公告)号：WO2013052927A3
公开(公告)日：2013-07-18
申请号：PCT/US2012059142
申请日：2012-10-05
申请人： SVAYA NANOTECHNOLOGIES INC , KROGMAN KEVIN , PARCE J WALLACE , SCHMID SIGLINDE , FARDY MELISSA , HOOD THOMAS G , WHITE STEVEN D , WANG BENJAMIN
发明人： KROGMAN KEVIN , PARCE J WALLACE , SCHMID SIGLINDE , FARDY MELISSA , HOOD THOMAS G , WHITE STEVEN D , WANG BENJAMIN
IPC分类号： G02B5/20 , B32B15/08 , B32B27/06 , G02B5/26
CPC分类号： G02B5/208 , B29D11/00634 , B32B15/08 , B32B27/06 , G02B5/282 , G02B5/285
摘要： Traditional solar control applications rely on thin metal films to reflect EM radiation with wavelengths longer than that of the visible spectrum. Unfortunately such films also block radiation in cellular, GPS, and radio frequency bands. In one aspect, the disclosure provides a selectively-blocking filter that uses one or more optical filters tuned to a specific range(s) of wavelengths (e.g. for blocking IR radiation), while readily transmitting other wavelengths (e.g. both visible light and cellular/GPS signals). The filters can be manufactured on both flexible and rigid substrates.
摘要翻译：传统的太阳能控制应用依靠薄金属膜来反射波长比可见光谱更长的电磁辐射。不幸的是，这些电影也阻挡了蜂窝，GPS和无线电频段的辐射。在一个方面，本公开提供了一种选择性阻挡滤光器，其使用被调谐到特定波长范围（例如用于阻挡IR辐射）的一个或多个滤光器，同时容易地传输其他波长（例如，可见光和蜂窝/ GPS信号）。滤波器可以在柔性和刚性基板上制造。

4. 发明申请

WO2012082611A2 POROUS FILMS BY BACKFILLING WITH REACTIVE COMPOUNDS 审中-公开
标题翻译：通过用活性化合物回填的多孔膜
公开(公告)号：WO2012082611A2
公开(公告)日：2012-06-21
申请号：PCT/US2011/064397
申请日：2011-12-12
申请人： SVAYA NANOTECHNOLOGIES, INC. , KROGMAN, Kevin , OLMEIJER, David , SHAH, Rajul , WANG, Benjamin
发明人： KROGMAN, Kevin , OLMEIJER, David , SHAH, Rajul , WANG, Benjamin
IPC分类号： C08J5/18
CPC分类号： B32B3/26 , C08J5/18 , C08J9/40 , C08J2201/038 , Y10T428/249953 , Y10T428/249956 , Y10T428/249991
摘要： The invention provides methods for modifying one or more properties of porous thin films. In such methods, a formulation comprising a reactive species is applied to the porous thin film and allowed to crosslink. In some embodiments, the crosslinked network thus formed imparts increased mechanical strength and wear resistance to the porous thin films.
摘要翻译：本发明提供了用于改变多孔薄膜的一种或多种性质的方法。在这样的方法中，将包含反应性物种的制剂施加到多孔薄膜并使其交联。在一些实施方案中，如此形成的交联网络赋予了多孔薄膜增加的机械强度和耐磨性。

5. 发明申请

WO2012003177A2 METHODS AND APPARATUS FOR THERMAL BASED SUBSTRATE PROCESSING WITH VARIABLE TEMPERATURE CAPABILITY 审中-公开
标题翻译：具有可变温度能力的基于热的基板加工的方法和装置
公开(公告)号：WO2012003177A2
公开(公告)日：2012-01-05
申请号：PCT/US2011/042125
申请日：2011-06-28
申请人： APPLIED MATERIALS, INC. , TZU, Gwo-Chuan , YUAN, Xiaoxiong , KHANDELWAL, Amit , WANG, Benjamin Cheng , GELATOS, Avgerinos V. , WU, Kai , KARAZIM, Michael P. , LIN, Jing , CUVALCI, Olkan
发明人： TZU, Gwo-Chuan , YUAN, Xiaoxiong , KHANDELWAL, Amit , WANG, Benjamin Cheng , GELATOS, Avgerinos V. , WU, Kai , KARAZIM, Michael P. , LIN, Jing , CUVALCI, Olkan
IPC分类号： H01L21/205
CPC分类号： C23C16/4412 , C23C16/45565 , C23C16/45587 , C23C16/4585 , C23C16/46 , C23C16/52
摘要： A substrate support may include a body; an inner ring disposed about the body; an outer ring disposed about the inner ring forming a first opening therebetween; a first seal ring disposed above the first opening; a shadow ring disposed above the inner ring, extending inward from the outer ring and forming a second opening between the shadow and outer rings; a second seal ring disposed above the second opening; a space at least partially defined by the body and the inner, outer, first, second, and shadow rings; a first gap defined between a processing surface of a substrate when present and the shadow ring; and a plurality of second gaps fluidly coupled to the space; wherein the first gap and the plurality of second gaps are configured such that, when a substrate is present, a gas provided to the space flows out of the space through the first gap.
摘要翻译：衬底支撑件可以包括主体; 围绕身体设置的内圈; 围绕所述内圈设置的外圈，在其间形成第一开口; 设置在所述第一开口上方的第一密封环; 设置在所述内圈上方的从所述外圈向内延伸并在所述阴影和外圈之间形成第二开口的阴影环; 设置在所述第二开口上方的第二密封环; 至少部分地由身体和内，外，第一，第二和第二和阴影环限定的空间; 限定在衬底的处理表面和阴影环之间的第一间隙; 以及流体耦合到所述空间的多个第二间隙; 其中所述第一间隙和所述多个第二间隙被配置为使得当存在基板时，设置到所述空间的气体通过所述第一间隙流出所述空间。

6. 发明申请

WO2009158024A3 MICROFLUIDIC DROPLETS FOR METABOLIC ENGINEERING AND OTHER APPLICATIONS 审中-公开
标题翻译：用于代谢工程和其他应用的微流控溅射
公开(公告)号：WO2009158024A3
公开(公告)日：2010-03-18
申请号：PCT/US2009003822
申请日：2009-06-26
申请人： MASSACHUSETTS INST TECHNOLOGY , HARVARD COLLEGE , WANG BENJAMIN L , HUMPHRY KATHERINE J , WEITZ DAVID A , STEPHANOPOULOS GREGORY
发明人： WANG BENJAMIN L , HUMPHRY KATHERINE J , WEITZ DAVID A , STEPHANOPOULOS GREGORY
IPC分类号： C12Q1/04 , G01N21/00
CPC分类号： B01L3/502715 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2400/0421
摘要： The present invention relates generally to the use of droplets to culture and/or assay cells or other species. In some cases, the cells or other species may be sorted based upon the results of the culture and/or assay. In some embodiments, cells other species can be encapsulated in droplets and exposed to one or more agents (e.g., a sugar, an indicator dye, etc.). For instance, in some cases, exposure of cells to the agents may result in the production of metabolites or other compounds (e.g., amino acids, proteins, organic acids, etc.) which may be, for example, assayed or otherwise determined. In some embodiments, the reaction of an agent with cells and/or other species within a droplet may reveal a property of the cells or other species (e.g., sugar consumption, growth rate, ability to withstand exposure to the agent, etc.). As an example, cells that produce desired metabolites or exhibit certain properties may be separated from the other cells via sorting techniques. Other aspects of the invention relate to devices or kits for implementing such sorts, methods of promoting such techniques, or the like.
摘要翻译：本发明一般涉及使用液滴来培养和/或测定细胞或其它物种。在一些情况下，可以基于培养和/或测定的结果对细胞或其它物种进行分类。在一些实施方案中，细胞其他物质可以被包封在液滴中并暴露于一种或多种试剂（例如，糖，指示剂染料等）。例如，在某些情况下，细胞暴露于试剂可导致生成代谢物或其它化合物（例如，氨基酸，蛋白质，有机酸等），其可以例如被测定或以其它方式测定。在一些实施方案中，药剂与细胞和/或液滴内的其它物质的反应可以揭示细胞或其他物种的性质（例如，糖消耗，生长速率，耐受试剂暴露的能力等）。作为实例，产生所需代谢物或显示某些特性的细胞可以通过分选技术与其他细胞分离。本发明的其他方面涉及用于实现这种类型的装置或套件，促进这种技术的方法等。

7. 发明申请

WO2006138353A2 DENTAL RESTORATIVE SYSTEM AND COMPONENTS 审中-公开
标题翻译：牙科恢复系统和组件
公开(公告)号：WO2006138353A2
公开(公告)日：2006-12-28
申请号：PCT/US2006/023130
申请日：2006-06-14
申请人： ZIMMER DENTAL INC. , BASSETT, Jeffrey, A. , GERVAIS, Christopher, M. , WOOLF, Kent , WANG, Benjamin, W. , DONAHOE, Ryan, M. , SALAMA, Maurice , SALAMA, Henry , GARBER, David
发明人： BASSETT, Jeffrey, A. , GERVAIS, Christopher, M. , WOOLF, Kent , WANG, Benjamin, W. , DONAHOE, Ryan, M. , SALAMA, Maurice , SALAMA, Henry , GARBER, David
IPC分类号： A61C13/225 , A61C8/00
CPC分类号： A61C8/0006 , A61C8/0001 , A61C8/0012 , A61C8/0013 , A61C8/0025 , A61C8/005 , A61C8/0054 , A61C8/0059 , A61C8/006 , A61C8/0066 , A61C8/0068 , A61C8/0069 , A61C8/0075 , A61C8/0077 , A61C8/0078 , A61C8/0093 , A61C2008/0046
摘要： Disclosed within is a dental restorative system including a dental fixture component (1300) having a longitudinal axis (1319), a body portion (1395), and an emergence profile portion (1340) adjacent to the body portion (1395). The dental fixture component (1300) also has a tapered coronal portion (1335) adjacent to the emergence profile portion (1340), with the tapered coronal portion (1335) having one end adjacent to the emergence profile portion (1340) and a terminal end (1337) with a non-frustoconical surface and a non-circular cross section. The emergence profile portion (1340) may include one or more concave surfaces (1332, 1333). The dental fixture component (1300) may further include an interproximally sloping margin shoulder (1350). Certain embodiments of the dental fixture component (1300) include threaded body portions (1396). Alternative embodiments of the dental fixture component are also disclosed.
摘要翻译：公开了一种牙科修复系统，其包括具有纵向轴线（1319），主体部分（1395）和邻近主体部分（1395）的出血轮廓部分（1340）的牙科固定部件（1300）。牙科固定部件（1300）还具有与出苗轮廓部分（1340）相邻的锥形冠部部分（1335），其中锥形冠部部分（1335）具有与出芽轮廓部分（1340）相邻的一端，并且终端（1337）具有非截头圆锥形表面和非圆形横截面。出苗轮廓部分（1340）可以包括一个或多个凹面（1332,1333）。牙科固定部件（1300）还可以包括邻近侧倾的边缘肩部（1350）。牙科固定部件（1300）的某些实施例包括螺纹主体部分（1396）。还公开了牙科固定部件的替代实施例。

8. 发明申请

WO2019160815A1 COORDINATING GENE EXPRESSION USING RNA DESTABILIZING ELEMENTS 审中-公开
公开(公告)号：WO2019160815A1
公开(公告)日：2019-08-22
申请号：PCT/US2019/017503
申请日：2019-02-11
申请人： CHIMERA BIOENGINEERING, INC. , WANG, Benjamin , ZEINER, Gusti , MCNALLY, Krista
发明人： WANG, Benjamin , ZEINER, Gusti , MCNALLY, Krista
IPC分类号： A61K35/17 , C12N15/85
摘要： Control Devices are disclosed including RNA destabilizing elements (RDE), and RNA control devices, combined with transgenes, including Chimeric Antigen Receptors (CARs) in eukaryotic cells. RDEs can be combined with RNA control devices to make RDEs that include ligand mediated control. These smart RDEs and other RDEs can be used to optimize expression of transgenes, e.g., CARs, in the eukaryotic cells so that, for example, effector function is optimized. CARs and transgene payloads can also be engineered into eukaryotic cells so that the transgene payload is expressed and delivered at desired times from the eukaryotic cell.

9. 发明申请

WO2018045177A1 GOLD OPTIMIZED CAR T-CELLS 审中-公开
标题翻译：金优化汽车T细胞
公开(公告)号：WO2018045177A1
公开(公告)日：2018-03-08
申请号：PCT/US2017/049628
申请日：2017-08-31
申请人： CHIMERA BIOENGINEERING, INC. , WANG, Benjamin , ZEINER, Gusti
发明人： WANG, Benjamin , ZEINER, Gusti
IPC分类号： A61K35/17 , A61K35/28 , A61K39/00 , A61K39/395 , C12N5/00
摘要： Control Devices are disclosed including RNA destabilizing elements (RDE), RNA control devices, and destabilizing elements (DE) combined with Chimeric Antigen Receptors (CARs) or other transgenes in eukaryotic cells. Multicistronic vectors are also disclosed for use in engineering host eukaryotic cells with the CARs and transgenes under the control of the control devices. These control devices can be used to optimize expression of CARs in the eukaryotic cells so that, for example, effector function is optimized. CARs and transgene payloads can also be engineered into eukaryotic cells so that the transgene payload is expressed and delivered after stimulation of the CAR on the eukaryotic cell.
摘要翻译：在真核细胞中公开了控制装置，包括RNA失稳元件（RDE），RNA控制装置和与嵌合抗原受体（CAR）或其他转基因组合的去稳定元件（DE）。还公开了多顺反子载体用于在控制装置的控制下用CAR和转基因工程宿主真核细胞。这些控制装置可用于优化真核细胞中CAR的表达，以便例如效应功能得到优化。 CARs和转基因有效载荷也可以被工程化为真核细胞，从而转基因有效载荷在CAR在真核细胞上被刺激后被表达和递送。

10. 发明申请

WO2013070473A1 BRIDGING FILMS FOR POROUS THIN FILMS 审中-公开
标题翻译：用于多孔薄膜的布线
公开(公告)号：WO2013070473A1
公开(公告)日：2013-05-16
申请号：PCT/US2012/062892
申请日：2012-11-01
申请人： SVAYA NANOTECHNOLOGIES, INC. , SCHMID, Siglinde , FARDY, Melissa , PARCE, J., Wallace , RIEKEN, Keith , WANG, Benjamin , KROGMAN, Kevin
发明人： SCHMID, Siglinde , FARDY, Melissa , PARCE, J., Wallace , RIEKEN, Keith , WANG, Benjamin , KROGMAN, Kevin
IPC分类号： B32B5/18 , B32B27/16 , B32B37/02 , C08J5/18
CPC分类号： C08J5/18 , B32B17/10036 , B32B17/10165 , B32B17/10449 , B32B17/10587 , B32B17/10761 , B32B27/065 , B32B2307/204 , B32B2457/00 , C08J7/042 , C08J2329/14 , C08J2337/00 , C08J2367/02 , Y10T428/23 , Y10T428/24355 , Y10T428/24364 , Y10T428/249953 , Y10T428/249981 , B32B17/10 , B32B2367/00
摘要： The disclosure provides methods and materials for preparing bridging films. In one aspect, the bridging films are non-porous and are suitable for protecting adjacent porous films. For example, the bridging films contact a porous film and protect the porous film from transfer of gases and/or liquids into the pores of the porous film. In another example, bridging films protect the porous film from abrasion.
摘要翻译：本公开提供了制备桥接膜的方法和材料。一方面，桥接膜是无孔的并且适用于保护邻近的多孔膜。例如，桥接膜接触多孔膜并保护多孔膜不会将气体和/或液体转移到多孔膜的孔中。在另一个实例中，桥接膜保护多孔膜免受磨损。

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