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1. 发明专利

CA2810068A1 HEAT EXCHANGER USING NON-PURE WATER FOR STEAM GENERATION 未知
公开(公告)号：CA2810068A1
公开(公告)日：2012-03-08
申请号：CA2810068
申请日：2011-03-30
申请人： NATERER GREG , WANG ZHAOLIN , SECNIK EDWARD
发明人： NATERER GREG , WANG ZHAOLIN , SECNIK EDWARD
IPC分类号： B01J7/00 , C01B3/06 , C02F1/04 , F22B1/06 , F22B1/18 , F22B7/02 , F22B37/26 , F28D7/10
摘要： A process and a device are described for producing high purity and high temperature steam from non-pure water which may be used in a variety of industrial processes that involve high temperature heat applications. The process and device may be used with technologies that generate steam using a variety of heat sources, such as, for example industrial furnaces, petrochemical plants, and emissions from incinerators. Of particular interest is the application in a thermochemical hydrogen production cycle such as the Cu-Cl Cycle. Non-pure water is used as the feedstock in the thermochemical hydrogen production cycle, with no need to adopt additional and conventional water pre-treatment and purification processes. The non-pure water may be selected from brackish water, saline water, seawater, used water, effluent treated water, tailings water, and other forms of water that is generally believed to be unusable as a direct feedstock of industrial processes. The direct usage of this water can significantly reduce water supply costs.

2. 发明专利

CA2450779C POWDER FORMATION BY ATMOSPHERIC SPRAY-FREEZE DRYING 未知
公开(公告)号：CA2450779C
公开(公告)日：2012-10-16
申请号：CA2450779
申请日：2003-12-22
申请人： FINLAY WARREN H , WANG ZHAOLIN
发明人： FINLAY WARREN H , WANG ZHAOLIN
IPC分类号： B01J2/04 , A61J3/02 , A61K9/14 , A61K9/19 , F26B5/06
摘要： A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.

3. 发明授权

EP1697035B1 POWDER FORMATION BY ATMOSPHERIC SPRAY-FREEZE DRYING 有权转让
标题翻译：通过大气喷雾冷冻干燥形成粉末
公开(公告)号：EP1697035B1
公开(公告)日：2017-11-15
申请号：EP04802335.2
申请日：2004-12-20
申请人： Finlay, Warren H. , Wang, Zhaolin
发明人： Finlay, Warren H. , Wang, Zhaolin
IPC分类号： B01J2/04 , A61K9/14 , A61J3/02 , F26B5/06 , A61K9/19
CPC分类号： B01J2/04 , A61K9/1623 , A61K9/1682 , F26B5/065 , Y10T436/25
摘要： A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.

4. 发明专利

CA2810068C HEAT EXCHANGER USING NON-PURE WATER FOR STEAM GENERATION 未知
公开(公告)号：CA2810068C
公开(公告)日：2020-01-28
申请号：CA2810068
申请日：2011-03-30
申请人： NATERER GREG , WANG ZHAOLIN , SECNIK EDWARD
发明人： NATERER GREG , WANG ZHAOLIN , SECNIK EDWARD
IPC分类号： B01J7/00 , C01B3/06 , C02F1/04 , F22B1/06 , F22B1/18 , F22B7/02 , F22B37/26 , F28D7/10
摘要： A process and a device are described for producing high purity and high temperature steam from non-pure water which may be used in a variety of industrial processes that involve high temperature heat applications. The process and device may be used with technologies that generate steam using a variety of heat sources, such as, for example industrial furnaces, petrochemical plants, and emissions from incinerators. Of particular interest is the application in a thermochemical hydrogen production cycle such as the Cu-Cl Cycle. Non-pure water is used as the feedstock in the thermochemical hydrogen production cycle, with no need to adopt additional and conventional water pre-treatment and purification processes. The non-pure water may be selected from brackish water, saline water, seawater, used water, effluent treated water, tailings water, and other forms of water that is generally believed to be unusable as a direct feedstock of industrial processes. The direct usage of this water can significantly reduce water supply costs.

5. 发明专利

AU2013290616A1 Powder feeding apparatus 未知
公开(公告)号：AU2013290616A1
公开(公告)日：2015-02-05
申请号：AU2013290616
申请日：2013-07-02
申请人： 3M INNOVATIVE PROPERTIES CO , WANG ZHAOLIN , SIMONS JOHN
发明人： SIMONS JOHN K , WANG ZHAOLIN
IPC分类号： B65G65/48
摘要： Powder feeding apparatuses (100; 200) and methods. The powder feeding apparatus (100; 200) can include first and second cylindrical rollers (106, 107; 206, 207) adjacent to each other and spaced apart by a gap (108; 208). The first roller(106; 206) can rotate intermittently and independently of the second roller(107; 207). The second roller can rotate intermittently and independently of the first roller. Powder from a hopper (102; 202) is fed through the gap as one or both rollers rotate. The powder feeding method may include a method of feeding powder by intermittently and alternately advancing a first and second roller to dispense powder from the hopper.

6. 发明专利

CA2450779A1 POWDER FORMATION BY ATMOSPHERIC SPRAY-FREEZE DRYING 未知
公开(公告)号：CA2450779A1
公开(公告)日：2005-06-22
申请号：CA2450779
申请日：2003-12-22
申请人： FINLAY WARREN HUGH , WANG ZHAOLIN
发明人： FINLAY WARREN H , WANG ZHAOLIN
IPC分类号： A61J3/02 , B01J2/04 , F26B5/06 , A61K9/14 , A61K9/19
摘要： A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particle s. The system has applicability for forming other powders.

7. 发明申请

WO03072016A2 PHARMACEUTICAL COMPOSITIONS IN PARTICULATE FORM 审中-公开
标题翻译：颗粒形式的药物组合物
公开(公告)号：WO03072016A2
公开(公告)日：2003-09-04
申请号：PCT/US0236882
申请日：2002-11-19
申请人： BECTON DICKINSON CO , HWANG C ROBIN , SULLIVAN VINCENT J , HUANG JUAN , WANG ZHAOLIN , MIKSZTA JOHN A , MONTGOMERY DAVID B , FORD BRANDI
发明人： HWANG C ROBIN , SULLIVAN VINCENT J , HUANG JUAN , WANG ZHAOLIN , MIKSZTA JOHN A , MONTGOMERY DAVID B , FORD BRANDI
IPC分类号： A61J3/02 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/18 , A61K9/19 , A61K9/22 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K38/28 , A61K39/00 , A61K39/145 , A61K47/26 , A61K47/36 , A61K48/00 , A61P31/12 , A61K
CPC分类号： A61K9/1694 , A61K9/0019 , A61K9/0043 , A61K9/0075 , A61K9/0078 , A61K9/1623 , A61K9/1652 , A61K9/1688 , A61K47/26
摘要： A method of preparing a pharmaceutical composition is described, comprising (1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; (2) freezing said atomized formulation to form solid particles; and (3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising (1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; (2) freezing said atomized formulation to form solid particles; and (3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35 and about 300m, and/or the powder comprises dried particles having an average mean diameter of between about 35m and about 300m. Compositions made by the above methods, and methods of using the compositions, are also described.
摘要翻译：描述了制备药物组合物的方法，其包括（1）使治疗剂的液体制剂雾化以产生雾化制剂; （2）冷冻所述雾化制剂以形成固体颗粒; 和（3）在大气压下干燥所述固体颗粒以产生粉末，其中所述干燥在振动，内部，机械搅拌或其组合的存在下进行。描述了另一种方法，其包括（1）雾化治疗剂的液体制剂以产生雾化制剂; （2）冷冻所述雾化制剂以形成固体颗粒; 和（3）干燥所述固体颗粒以产生粉末; 其中所述雾化制剂包含平均直径为约35至约300μm的液滴，和/或所述粉末包含平均直径为约35μm至约300μm的干燥颗粒。还描述了通过上述方法制备的组合物以及使用组合物的方法。

8. 发明申请

WO2005061088A1 POWDER FORMATION BY ATMOSPHERIC SPRAY-FREEZE DRYING 审中-公开
标题翻译：由大气喷雾干燥形成的粉末
公开(公告)号：WO2005061088A1
公开(公告)日：2005-07-07
申请号：PCT/CA2004/002160
申请日：2004-12-20
申请人： FINLAY, Warren, H. , WANG, Zhaolin
发明人： FINLAY, Warren, H. , WANG, Zhaolin
IPC分类号： B01J2/04
CPC分类号： B01J2/04 , A61K9/1623 , A61K9/1682 , F26B5/065 , Y10T436/25
摘要： A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.
摘要翻译：公开了一种制造热敏药用粉末的方法。将原始药物溶解在悬浮液中，悬浮在悬浮液中，该悬浮液通过雾化喷嘴喷雾并在冷气相或液氮中在冷冻室或气套中同时雾化（用于冷却目的）。颗粒在大气压下在具有出口过滤器的下游流体流中冷冻干燥，从而除去截留在冷冻颗粒上或内部的水分。该系统适用于形成其他粉末。

9. 发明申请

WO2003011882A1 4'-SUBSTITUTED LEUCOMYCINS 审中-公开
标题翻译： 4'-取代的胆固醇
公开(公告)号：WO2003011882A1
公开(公告)日：2003-02-13
申请号：PCT/US2002/023878
申请日：2002-07-26
申请人： ENANTA PHARMACEUTICALS, INC. , OR, Yat, Sun , PHAN, Ly, Tam , WANG, Zhaolin , JIAN, Tianying
发明人： OR, Yat, Sun , PHAN, Ly, Tam , WANG, Zhaolin , JIAN, Tianying
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： There are described novel 4'-substituted 16-membered macrolides and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.
摘要翻译：描述了新颖的4'-取代的16元大环内酯和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合。还描述了通过向哺乳动物施用含有治疗有效量的本发明化合物的药物组合物以及制备这些化合物的方法来治疗细菌感染的方法。

10. 发明申请

WO2014014650A1 POWDER FEEDING APPARATUS 审中-公开
标题翻译：粉末送料装置
公开(公告)号：WO2014014650A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/049001
申请日：2013-07-02
申请人： 3M INNOVATIVE PROPERTIES COMPANY , SIMONS, John K. , WANG, Zhaolin
发明人： SIMONS, John K. , WANG, Zhaolin
IPC分类号： B65G65/48
CPC分类号： B65D88/546 , B05C1/0826 , B65G65/4881
摘要： Powder feeding apparatuses (100; 200) and methods. The powder feeding apparatus (100; 200) can include first and second cylindrical rollers (106, 107; 206, 207) adjacent to each other and spaced apart by a gap (108; 208). The first roller(106; 206) can rotate intermittently and independently of the second roller(107; 207). The second roller can rotate intermittently and independently of the first roller. Powder from a hopper (102; 202) is fed through the gap as one or both rollers rotate. The powder feeding method may include a method of feeding powder by intermittently and alternately advancing a first and second roller to dispense powder from the hopper.
摘要翻译：粉末供给装置（100; 200）和方法。粉末供给装置（100; 200）可以包括彼此相邻并由间隙（108; 208）隔开的第一和第二圆柱形辊（106,107; 206,207）。第一辊（106; 206）可以间歇地旋转并独立于第二辊（107,207）旋转。第二辊可以间歇地旋转并且独立于第一辊。当一个或两个辊旋转时，来自料斗（102; 202）的粉末通过间隙进给。粉末输送方法可以包括通过间歇地并交替地推进第一和第二辊以从料斗分配粉末来供给粉末的方法。

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