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1. 发明专利

DE112014000093T5 Neuer Scheibenwischer 未知
公开(公告)号：DE112014000093T5
公开(公告)日：2015-09-10
申请号：DE112014000093
申请日：2014-03-18
申请人： WANG JIANCHENG
发明人： WANG JIANCHENG
IPC分类号： B60S1/38 , B60S1/48
摘要： Die vorliegende Erfindung offenbart einen neuen Scheibenwischer, aufweisend eine Glaswischleiste, wobei in der Glaswischleiste eine Flüssigkeitsdurchgangskammer und mehrere mit der Flüssigkeitsdurchgangskammer verbundene Flüssigkeitsauslassöffnungen angeordnet sind. Bei der vorliegenden Erfindung wird eine Struktur verwendet, bei der die Flüssigkeitsauslassöffnungen an der Glaswischleiste angeordnet sind, so dass die Glaswischleiste während der Pendelbewegung die Schmierungsflüssigkeit bieten kann. Dadurch wird die Trockenreibung in der anfänglichen Bewegung unter dem Zustand ohne Regen verringert, so dass der Verschleiß der Glaswischleiste und des Glases verringert wird und die Lebensdauer der Scheibenwischerprodukte verlängert wird. Darüber hinaus sind zwei Kontaktkanten bei der Glaswischleiste verwendet, so dass ein fehlendes Wischen wirksam verhindert werden kann. Ferner wird das zur Verringerung der Reibung und zur Reinigung dienende Glasreinigungswasser aus der Glaswischleiste gespritzt, so dass die Glaswischleiste immer im Schmierungszustand ist, um die Reibkraft zu reduzieren. Dadurch wird das Geräusch des Scheibenwischers weiter wirksam verringert, so dass der Einfluss auf den Fahrer reduziert wird. Das ist förderlich für die Verbesserung der Verwendungsumgebung des Autos.

2. 发明申请

WO2006124897A2 METHODS AND COMPOSITIONS FOR IMPROVING COGNITION 审中-公开
标题翻译：改善认知的方法和组合
公开(公告)号：WO2006124897A2
公开(公告)日：2006-11-23
申请号：PCT/US2006018917
申请日：2006-05-12
申请人： LEXICON GENETICS INC , BARBOSA JOSEPH , DONG LI , FINK CYNTHIA ANN , LANTHORN THOMAS HERBERT , SCHMIDT JAMES M , WANG JIANCHENG , ZIPP G GREGORY
发明人： BARBOSA JOSEPH , DONG LI , FINK CYNTHIA ANN , LANTHORN THOMAS HERBERT , SCHMIDT JAMES M , WANG JIANCHENG , ZIPP G GREGORY
CPC分类号： A61K31/437 , A61K31/4745 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/551
摘要： This invention encompasses methods of improving cognitive performance and of treating, preventing and managing various diseases and disorders, such as Alzheimer's disease, autism, cognitive disorders, dementia, learning disorders, and short- and long-term memory loss.
摘要翻译：本发明包括改善认知表现以及治疗，预防和控制诸如阿尔茨海默病，自闭症，认知障碍，痴呆，学习障碍以及短期和长期记忆丧失的各种疾病和病症的方法。

3. 发明申请

WO2011044195A1 MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 审中-公开
公开(公告)号：WO2011044195A1
公开(公告)日：2011-04-14
申请号：PCT/US2010/051572
申请日：2010-10-06
申请人： BRISTOL-MYERS SQUIBB COMPANY , LEXICON PHARMACEUTICALS, INC. , BI, Yingzhi , DZIERBA, Carolyn, Diane , BRONSON, Joanne, J. , CARSON, Kenneth , CIANCHETTA, Giovanni , DONG, Li , FINK, Cynthia , GREEN, Michael , KIMBALL, David , MACOR, John, E. , KWON, Soojin , WANG, Jiancheng , ZHANG, Yulian , ZIPP, Greg
发明人： BI, Yingzhi , DZIERBA, Carolyn, Diane , BRONSON, Joanne, J. , CARSON, Kenneth , CIANCHETTA, Giovanni , DONG, Li , FINK, Cynthia , GREEN, Michael , KIMBALL, David , MACOR, John, E. , KWON, Soojin , WANG, Jiancheng , ZHANG, Yulian , ZIPP, Greg
IPC分类号： C07D333/24 , A61K31/381 , C07C233/06 , A61P3/00 , A61P25/00
CPC分类号： C07D333/24 , C07C233/60 , C07C2601/02
摘要： The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.

4. 发明申请

WO2009120789A8 BICYCLIC NITROIMIDAZOLES COVALENTLY LINKED TO SUBSTITUTED PHENYL OXAZOLIDINONES 审中-公开
公开(公告)号：WO2009120789A8
公开(公告)日：2009-10-01
申请号：PCT/US2009/038266
申请日：2009-03-25
申请人： GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT , DING, Charles, Z. , LU, Genliang , COMBRINK, Keith , CHEN, Dianjun, D. , SONG, Minsoo , WANG, Jiancheng , MA, Zhenkun , PALMER, Brian, Desmond , BLASER, Adrian , THOMPSON, Andrew, M. , KMENTOVA, Iveta , SUTHERLAND, Hamish, Scott , DENNY, William, Alexander
发明人： DING, Charles, Z. , LU, Genliang , COMBRINK, Keith , CHEN, Dianjun, D. , SONG, Minsoo , WANG, Jiancheng , MA, Zhenkun , PALMER, Brian, Desmond , BLASER, Adrian , THOMPSON, Andrew, M. , KMENTOVA, Iveta , SUTHERLAND, Hamish, Scott , DENNY, William, Alexander
IPC分类号： C07D498/04 , A61P31/04 , A61P31/06 , A61K31/5365
摘要： The current invention provides a series of bicyclic nitroimidazole- substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild- type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis .

5. 发明申请

WO2009120789A1 BICYCLIC NITROIMIDAZOLES COVALENTLY LINKED TO SUBSTITUTED PHENYL OXAZOLIDINONES 审中-公开
标题翻译：双相纳米微星共同连接到取代的苯基氧杂环己烷
公开(公告)号：WO2009120789A1
公开(公告)日：2009-10-01
申请号：PCT/US2009038266
申请日：2009-03-25
申请人： GLOBAL ALLIANCE FOR TB DRUG DE , DING CHARLES Z , LU GENLIANG , COMBRINK KEITH , CHEN DIAJUN D , SONG MINSOO , WANG JIANCHENG , MA ZHENKUN , PALMER BRIAN DESMOND , BLASER ADRIAN , THOMPSON ANDREW M , KMENTOVA IVETA , SUTHERLAND HAMISH SCOTT , DENNY WILLIAM ALEXANDER
发明人： DING CHARLES Z , LU GENLIANG , COMBRINK KEITH , CHEN DIAJUN D , SONG MINSOO , WANG JIANCHENG , MA ZHENKUN , PALMER BRIAN DESMOND , BLASER ADRIAN , THOMPSON ANDREW M , KMENTOVA IVETA , SUTHERLAND HAMISH SCOTT , DENNY WILLIAM ALEXANDER
IPC分类号： C07D498/04 , A61K31/5365 , A61P31/04 , A61P31/06
CPC分类号： C07D498/04
摘要： The current invention provides a series of bicyclic nitroimidazole- substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild- type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.
摘要翻译：本发明提供了一系列双环硝基咪唑取代的苯基恶唑烷酮，其中双环硝基咪唑药效团与苯基恶唑烷酮共价结合，其药物组合物，以及该组合物用于预防和治疗细菌感染的方法。双环硝基咪唑取代的苯基恶唑烷酮对野生型和抗性病原体菌株具有惊人的抗菌活性，因此可用于预防，控制和治疗由这些病原体引起的许多人和兽医细菌感染，如结核分枝杆菌。

6. 发明申请

WO2006124748A2 MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE 审中-公开
标题翻译：多种化合物及其使用方法
公开(公告)号：WO2006124748A2
公开(公告)日：2006-11-23
申请号：PCT/US2006/018682
申请日：2006-05-12
申请人： LEXICON GENETICS INCORPORATED , BARBOSA, Joseph , DONG, Li , FINK, Cynthia Ann , WANG, Jiancheng , ZIPP, G. Gregory
发明人： BARBOSA, Joseph , DONG, Li , FINK, Cynthia Ann , WANG, Jiancheng , ZIPP, G. Gregory
CPC分类号： C07D239/42 , C07D277/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04 , C07D451/02 , C07D471/08 , C07D487/04
摘要： This invention relates to multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use in, for example, the treatment of cognitive disorders.
摘要翻译：本发明涉及多环化合物，包含它们的药物组合物及其用于例如认知障碍治疗的方法。

7. 发明申请

WO2007024789A1 PYRROLOPYRIDINE, PYRROLOPYRIMIDINE AND PYRAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE 审中-公开
标题翻译：吡咯啉，吡咯烷酮和吡唑并吡啶化合物，包含它们的组合物及其使用方法
公开(公告)号：WO2007024789A1
公开(公告)日：2007-03-01
申请号：PCT/US2006/032620
申请日：2006-08-22
申请人： LEXICON GENETICS INCORPORATED , FINK, Cynthia, Ann , BARBOSA, Joseph , ZIPP, G., Gregory , WANG, Jiancheng
发明人： FINK, Cynthia, Ann , BARBOSA, Joseph , ZIPP, G., Gregory , WANG, Jiancheng
IPC分类号： A61K31/519 , A61K31/437 , C07D487/04 , C07D471/04 , A61P25/28
CPC分类号： C07D471/04 , A61K31/437 , A61K31/519 , C07D487/04
摘要： Disclosed are pyrrolopyridine, pyrrolopyrimidine and pyrazolopyridine compounds, compositions comprising them, and methods of their use.
摘要翻译：公开了吡咯并吡啶，吡咯并嘧啶和吡唑并吡啶化合物，包含它们的组合物及其用途。

8. 发明申请

WO2006124897A3 METHODS AND COMPOSITIONS FOR IMPROVING COGNITION 审中-公开
公开(公告)号：WO2006124897A3
公开(公告)日：2006-11-23
申请号：PCT/US2006/018917
申请日：2006-05-12
申请人： LEXICON GENETICS INCORPORATED , BARBOSA, Joseph , DONG, Li , FINK, Cynthia Ann , LANTHORN, Thomas Herbert , WANG, Jiancheng , ZIPP, G. Gregory
发明人： BARBOSA, Joseph , DONG, Li , FINK, Cynthia Ann , LANTHORN, Thomas Herbert , WANG, Jiancheng , ZIPP, G. Gregory
IPC分类号： A61K31/506 , A61K31/497 , A61K31/551 , A61K31/519 , A61K31/437 , A61K48/00 , A61P25/28
摘要： This invention encompasses methods of improving cognitive performance and of treating, preventing and managing various diseases and disorders, such as Alzheimer's disease, autism, cognitive disorders, dementia, learning disorders, and short- and long-term memory loss.

9. 发明申请

WO2008008480A2 NITROHETEROARYL-CONTAINING RIFAMYCIN DERIVATIVES 审中-公开
标题翻译：含有硝基的含有RIFAMYCIN衍生物
公开(公告)号：WO2008008480A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/015970
申请日：2007-07-12
申请人： CUMBRE PHARMACEUTICALS INC. , DING, Charles, Z. , KIM, In, Ho , WANG, Jiancheng , MA, Zhenkun , JIN, Yafei , COMBRINK, Keith, D. , LU, Genliang , LYNCH, A., Simon
发明人： DING, Charles, Z. , KIM, In, Ho , WANG, Jiancheng , MA, Zhenkun , JIN, Yafei , COMBRINK, Keith, D. , LU, Genliang , LYNCH, A., Simon
IPC分类号： C07D498/08 , C07D498/18 , C07D498/22 , C07D519/00 , A61K31/395
CPC分类号： C07D498/18 , C07D498/08 , C07D498/22 , C07D519/00
摘要： Substituted rifamycin derivatives in which a nitroimidazole, nitrothiazole or nitrofuran pharmacophore is covalently bonded to a rifamycin, methods of using the rifamycin derivatives, and pharmaceutical compositions containing the rifamycin derivatives are disclosed. Methods of synthesizing these substituted rifamycin derivatives are also disclosed. The rifamycin derivatives possess antibacterial activity, and are effective against a number of human and veterinary pathogens in the treatment of bacterial diseases.
摘要翻译：公开了其中硝基咪唑，硝基噻唑或硝基呋喃药效团与利福霉素共价结合的取代的利福霉素衍生物，使用利福霉素衍生物的方法和含有利福霉素衍生物的药物组合物。还公开了合成这些取代的利福霉素衍生物的方法。利福霉素衍生物具有抗菌活性，并且在治疗细菌性疾病中对许多人和兽医病原体有效。

10. 发明申请

WO2008008480A3 NITROHETEROARYL-CONTAINING RIFAMYCIN DERIVATIVES 审中-公开
标题翻译：含有硝基的含有RIFAMYCIN衍生物
公开(公告)号：WO2008008480A3
公开(公告)日：2008-03-13
申请号：PCT/US2007015970
申请日：2007-07-12
申请人： CUMBRE PHARMACEUTICALS INC , DING CHARLES Z , KIM IN HO , WANG JIANCHENG , MA ZHENKUN , JIN YAFEI , COMBRINK KEITH D , LU GENLIANG , LYNCH A SIMON
发明人： DING CHARLES Z , KIM IN HO , WANG JIANCHENG , MA ZHENKUN , JIN YAFEI , COMBRINK KEITH D , LU GENLIANG , LYNCH A SIMON
IPC分类号： C07D498/08 , A61K31/395 , C07D498/18 , C07D498/22 , C07D519/00
CPC分类号： C07D498/18 , C07D498/08 , C07D498/22 , C07D519/00
摘要： Substituted rifamycin derivatives of formula I uses thereof and pharmaceutical compositions containing the rifamycin derivatives are disclosed. Methods of synthesizing these substituted rifamycin derivatives are also disclosed. The rifamycin derivatives possess antibacterial activity, and are effective against a number of human and veterinary pathogens in the treatment of bacterial diseases.or their pharmaceutically acceptable salt thereof, wherein R 1 is a hydrogen or acetyl group, G is a structure of formula (II, III, IV or V): wherein, in formula (II, III, IV or V), Q is N- or CR 2 . which is bonded to a linkage, group "L", which in turn is bonded to a structure A-NO 2 ,and R 2 is a group selected from hydrogen, substituted or unsubstituted (C 1 -C 6 )alkyl, aryl, heteroaryl, or heterocycloalkyl group; The structure A-NO 2 is a structural formula (VI1 VII, VIII or IX): wherein Y is a bond which is bonded to linkage group "L", defined as above; and Z is a carbon (-CR 7 R 8 -), carbonyl (-C(O)-), amide (-C(O)N-), sulfonamide (-S(O 2 )N-), or a heteroatom selected from N, O, S, SO or SO 2 ; wherein R 5 , R 6 , R 7 , and R 8 are independently a group selected from hydrogen, substituted or unsubstituted (C 1 -C 6 )alkyl, aryl. heteroaryl. or heterocycloalkyl group; R 5 and R 6 R 7 and R 8 can join together to form a five to seven-member ring system optionally containing one to three heteroatoms.
摘要翻译：公开了其取代的利福霉素衍生物的用途，并且公开了含有利福霉素衍生物的药物组合物。还公开了合成这些取代的利福霉素衍生物的方法。利福霉素衍生物具有抗细菌活性，并且在治疗细菌性疾病中对许多人和兽医病原体有效。或其药学上可接受的盐，其中R 1是氢或乙酰基，G 是式（II，III，IV或V）的结构：其中，在式（II，III，IV或V）中，Q是N-或CR 2。其键合到键，组“L”，其又结合于结构A-NO 2，并且R 2是选自氢，取代的基团或未取代的（C 1 -C 6 -C 6）烷基，芳基，杂芳基或杂环烷基; 结构A-NO 2结构式（VI1 VII，VIII或IX）：其中Y是与上述定义的连接基团“L”键合的键; （C（O） - ），酰胺（-C（O）N-），磺酰胺（C（O）（-S（O）2 - ）N-）或选自N，O，S，SO或SO 2的杂原子; 其中R 5，R 6，R 7和R 8独立地是选自氢，取代的或未取代的（C 1 -C 6 -C 6）烷基，芳基。杂。或杂环烷基; R 5和R 6 R 7和R 8可以连接在一起以形成五至七元环系统任选地含有一至三个杂原子。

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