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1. 发明申请

WO2011146444A1 METHOD OF MAKING NUTRITIONAL EMULSIONS CONTAINING ENCAPSULATED OILS 审中-公开
标题翻译：生产含营养油的营养乳液的方法
公开(公告)号：WO2011146444A1
公开(公告)日：2011-11-24
申请号：PCT/US2011/036761
申请日：2011-05-17
申请人： ABBOTT LABORATORIES , LAI, Chron-si , WALTON, Joseph, E. , HELMKE, Charles, R , SHEARER, Kati, E
发明人： LAI, Chron-si , WALTON, Joseph, E. , HELMKE, Charles, R , SHEARER, Kati, E
IPC分类号： A23L1/09 , A23L1/30 , A23L1/305 , A23L1/308 , A23L1/00
CPC分类号： A23D7/04 , A23D7/003 , A23D7/0053 , A23D7/011 , A23L29/10 , A23L29/35 , A23L33/105 , A23L33/115 , A23L33/12 , A23L33/17 , A23L33/21 , A23L33/40 , A23P10/30 , A23V2002/00 , A23V2250/1882
摘要： Disclosed is a method of making nutritional emulsions, comprising: (A) heating and blending together an emulsifying agent having a melt point above about 25 C and oil having hydrophobic off-notes (e.g. non-encapsulated polyunsaturated fatty acid) in a weight ratio of at least about 1:15; (B) adding the heated blend to a fat, protein, and carbohydrate mixture comprising a maltodextrin (DE of about 10 or less), in a weight ratio of the maltodextrin to the oil having hydrophobic off-notes of at least about 1:2; and (C) homogenizing, and then cooling the combination below the melt point of the emulsifying agent to form a nutritional emulsion comprising from about 0.01% to about 5% by weight of process-encapsulated polyunsaturated fatty acid. The resulting nutritional emulsions effectively mask off-notes commonly associated with certain oils, e.g., polyunsaturated fatty acids, soy oil, beta-hydroxy-beta-methylbutyrate oils.
摘要翻译：公开了一种制备营养乳液的方法，其包括：（A）将熔点高于约25℃的乳化剂和具有疏水离析物的油（例如非包封的多不饱和脂肪酸）加热并共混在一起，其重量比为至少约1:15; （B）将加热的共混物加入到包含麦芽糖糊精（DE约10或更低）的脂肪，蛋白质和碳水化合物混合物中，麦芽糖糊精与具有至少约1:2的疏水离析纸的油的重量比 ; 和（C）均化，然后将组合物冷却至低于乳化剂的熔点，以形成包含约0.01重量％至约5重量％的工艺包封的多不饱和脂肪酸的营养乳液。所得的营养乳液有效地掩盖通常与某些油相关的纸币，例如多不饱和脂肪酸，大豆油，β-羟基-β-甲基丁酸油。

2. 发明申请

WO2010120772A1 HIGH FIBER NUTRITIONAL EMULSIONS WITH GLYCERIN 审中-公开
标题翻译：高糖纤维营养乳液
公开(公告)号：WO2010120772A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/030884
申请日：2010-04-13
申请人： ABBOTT LABORATORIES , MUSTAD, Vikkie, A. , EDENS, Neile, K. , WALTON, Joseph, E. , WOLF, David, R.
发明人： MUSTAD, Vikkie, A. , EDENS, Neile, K. , WALTON, Joseph, E. , WOLF, David, R.
IPC分类号： A23L1/30 , A23L1/308
CPC分类号： A23D7/0056 , A23L33/10 , A23L33/115 , A23L33/19 , A23L33/21 , A23L33/40 , A61K31/715
摘要： Disclosed are nutritional aqueous emulsions having high fiber content. An aqueous emulsion comprising fat, protein, and carbohydrate, which includes from about 0.5% to about 9.0% by weight of a milk protein concentrate; from about 2.0% to about 6.0% by weight of glycerin, from about 2.3% to about 9.0% by weight of a fiber, and fructose and at least about 0.15% by weight of leucrose in a weight ratio of fructose to leucrose of at least 2:1, wherein the aqueous emulsion has a viscosity of less than about 300 centipoise at 20°C. These high fiber emulsions are stable and deliver desirable hedonics, rheologies, blunted glycemic profiles, and gastrointestinal tolerance. These high fiber emulsions provide beneficial features, including one or more of stability, desirable hedonics, rheology, and product performance, including a blunted glycemic response profile and or minimal or no gastrointestinal intolerance.
摘要翻译：公开了具有高纤维含量的营养水性乳液。包含脂肪，蛋白质和碳水化合物的水乳液，其包含约0.5％至约9.0％重量的乳蛋白浓缩物; 约2.0重量％至约6.0重量％的甘油，约2.3重量％至约9.0重量％的纤维，果糖和至少约0.15重量％的白糖与果糖的重量比至少为 2：1，其中所述水性乳液在20℃下的粘度小于约300厘泊。这些高纤维乳液是稳定的并且提供期望的升高，流变学，钝化血糖曲线和胃肠道耐受性。这些高纤维乳液提供有益的特征，包括一种或多种稳定性，期望的嗜酸性，流变性和产品性能，包括钝性血糖反应曲线和/或最小或无胃肠道不耐受。

3. 发明申请

WO2006102451A3 AMINO ACID COMPOSITION FOR IMPROVING GLUCOSE TOLERANCE 审中-公开
公开(公告)号：WO2006102451A3
公开(公告)日：2006-09-28
申请号：PCT/US2006/010468
申请日：2006-03-21
申请人： ABBOTT LABORATORIES , MAZER, Terry , EDENS, Neile , BERGANA, Marti , SHEARER, Kati , WOLF, David , WALTON, Joseph
发明人： MAZER, Terry , EDENS, Neile , BERGANA, Marti , SHEARER, Kati , WOLF, David , WALTON, Joseph
IPC分类号： A61K31/223
摘要： Disclosed are compositions, including low-calorie beverages or liquids, comprising isoleucine, leucine, valine, cysteine, and methionine, in specified amounts, weight ratios, or both. The compositions are especially useful in treating individuals afflicted with impaired glucose tolerance or diabetes.

4. 发明申请

WO2011146443A1 NUTRITIONAL EMULSIONS CONTAINING ENCAPSULATED OILS 审中-公开
标题翻译：含营养油的营养乳液
公开(公告)号：WO2011146443A1
公开(公告)日：2011-11-24
申请号：PCT/US2011/036760
申请日：2011-05-17
申请人： ABBOTT LABORATORIES , LAI, Chron-si , SHEARER, Kati, E , HELMKE, Charles, R , WALTON, Joseph, E.
发明人： LAI, Chron-si , SHEARER, Kati, E , HELMKE, Charles, R , WALTON, Joseph, E.
IPC分类号： A23L1/09 , A23L1/30 , A23L1/305 , A23L1/308 , A23L1/00
CPC分类号： A23L1/3008 , A23L29/35 , A23L33/105 , A23L33/115 , A23L33/12 , A23L33/17 , A23L33/21 , A23L33/40 , A23V2002/00 , A23V2200/16 , A23V2200/224 , A23V2250/1882 , A23V2250/5114
摘要： Disclosed are nutritional emulsions comprising fat, protein, and carbohydrate, including from about 0.01% to about 5% by weight of an oil having hydrophobic off-notes that is process-encapsulated by an emulsifying agent having a melt point above about 25 C, and maltodextrin having a DE of about 10 or less, wherein the weight ratio of the emulsifying agent to the process-encapsulated oil is at least about 1:15 and the weight ratio of the maltodextrin to the process-encapsulated oil is at least about 1:2. The nutritional emulsions effectively mask off-notes commonly associated with certain oils, e.g., polyunsaturated fatty acids, soy oil, beta-hydroxy-beta-methylbutyrate oils.
摘要翻译：公开了包含脂肪，蛋白质和碳水化合物的营养乳液，包括约0.01重量％至约5重量％的油，其具有疏水性纸屑，其通过熔点高于约25℃的乳化剂进行工艺包封，以及 DE为约10或更小的麦芽糖糊精，其中乳化剂与工艺包封的油的重量比至少为约1:15，麦芽糖糊精与工艺包封的油的重量比为至少约1： 2。营养乳液有效地遮蔽通常与某些油相关的纸币，例如多不饱和脂肪酸，大豆油，β-羟基-β-甲基丁酸油。

5. 发明申请

WO2010120736A1 HIGH FIBER NUTRITIONAL EMULSIONS FOR BLOOD GLUCOSE CONTROL 审中-公开
标题翻译：用于血液葡萄糖控制的高纤维营养乳液
公开(公告)号：WO2010120736A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/030837
申请日：2010-04-13
申请人： ABBOTT LABORATORIES , EDENS, Neile, K. , MUSTAD, Vikkie, A. , WALTON, Joseph, E. , WOLF, David, R.
发明人： EDENS, Neile, K. , MUSTAD, Vikkie, A. , WALTON, Joseph, E. , WOLF, David, R.
IPC分类号： A23L1/30 , A23L1/304 , A23L1/308 , A61K31/715 , A61P3/10
CPC分类号： A61K31/715 , A23D7/0053 , A23L33/10 , A23L33/115 , A23L33/165 , A23L33/19 , A23L33/21 , A23L33/40
摘要： Disclosed are nutritional aqueous emulsions having high fiber content. These emulsions comprise fat, protein, and carbohydrate, including (a) from 1.75% to about 4.0% by weight of a diacylglycerol oil; (b) from about 0.5% to about 9.0% by weight of a milk protein concentrate; (c) from about 2.0% to about 9.0% by weight of fiber; and (d) fructose and from about 0.15% by weight of leucrose in a weight ratio of fructose to leucrose of at least 2:1, wherein the aqueous emulsion has a viscosity of less than about 300 centipoise at 20°C. These high fiber emulsions provide beneficial features, including one or more of stability, desirable hedonics, rheology, and product performance, including a blunted glycemic response profile and or minimal or no gastrointestinal intolerance.
摘要翻译：公开了具有高纤维含量的营养水性乳液。这些乳液包括脂肪，蛋白质和碳水化合物，包括（a）1.75％至约4.0％的二酰基甘油油; （b）约0.5％至约9.0％重量的乳蛋白浓缩物; （c）约2.0％至约9.0％的纤维; 和（d）果糖和约0.15重量％的白糖与果糖的重量比至少为2:1，其中所述水性乳液在20℃下的粘度小于约300厘泊。这些高纤维乳液提供有益的特征，包括一种或多种稳定性，期望的嗜酸性，流变性和产品性能，包括钝性血糖反应曲线和/或最小或无胃肠道不耐受。

6. 发明申请

WO2010120734A2 HIGH FIBER NUTRITIONAL EMULSIONS 审中-公开
标题翻译：高纤维营养乳
公开(公告)号：WO2010120734A2
公开(公告)日：2010-10-21
申请号：PCT/US2010/030834
申请日：2010-04-13
申请人： ABBOTT LABORATORIES , WALTON, Joseph, E. , WOLF, David, R. , EDENS, Neile, K. , MUSTAD, Vikkie, A.
发明人： WALTON, Joseph, E. , WOLF, David, R. , EDENS, Neile, K. , MUSTAD, Vikkie, A.
IPC分类号： E04G1/32 , A47F5/12 , F16M11/06 , E04G1/24
CPC分类号： A23D7/011 , A23D7/0053 , A23L29/10 , A23L33/115 , A23L33/21 , A23L33/40
摘要： Disclosed are nutritional aqueous emulsions having high fiber content. These emulsions comprise fat, protein, and carbohydrate, which includes from 1.75% to about 4.0% by weight of diacylglycerol oil and from about 1.5% to about 9.0% by weight of fiber. These emulsions may also comprise fat, protein, and carbohydrate, which includes from 1% to about 4.0% of diacylglycerol oil by weight of the aqueous emulsion and from about 2.0 % to about 9.0% of fiber by weight of the aqueous emulsion, wherein the aqueous emulsion has a viscosity of less than about 300 centipoise at 200C. These high fiber emulsions provide beneficial features, including one or more of stability, desirable hedonics, rheology, and product performance, including a blunted glycemic response profile and or minimal or no gastrointestinal intolerance.
摘要翻译：公开了具有高纤维含量的营养水性乳液。这些乳液包括脂肪，蛋白质和碳水化合物，其包括1.75％至约4.0％的二酰基甘油油和约1.5％至约9.0％的纤维。这些乳剂还可以包含脂肪，蛋白质和碳水化合物，其包括按重量计含水乳液的1％至约4.0％的二酰基甘油油和约20％至约9.0％的水溶液乳液重量的纤维，其中水性乳液在200℃下的粘度小于约300厘泊。这些高纤维乳液提供有益的特征，包括一种或多种稳定性，期望的嗜酸性，流变性和产品性能，包括钝性血糖反应曲线和/或最小或无胃肠道不耐受。

7. 发明申请

WO2018191729A1 DEVICE FOR TARGETED FEATURE-SPECIFIC SENSORY THERAPY 审中-公开
公开(公告)号：WO2018191729A1
公开(公告)日：2018-10-18
申请号：PCT/US2018/027676
申请日：2018-04-13
申请人： EDDINS, David , WALTON, Joseph
发明人： EDDINS, David , WALTON, Joseph
IPC分类号： G09B19/04 , G09B5/00 , G09B21/00 , G10L15/00 , H04R25/00
CPC分类号： A61M21/00 , A61M2021/0027 , H04R25/70
摘要： A device and method that supplements sensory input, thereby providing a supplemented sensory environment, to induce plasticity within the central nervous system that effectively overcomes sensory-neural processing deficits or strengthens specific sensory-neural abilities. In one implementation, ear-level hearing devices are used to deliver therapeutic sound with specific acoustic features that serve as archetypes of stimulus features for which sensory-neural processing is compromised by a sensory-neural deficit.

8. 发明申请

WO2010120734A3 HIGH FIBER NUTRITIONAL EMULSIONS 审中-公开
标题翻译：高纤维营养乳
公开(公告)号：WO2010120734A3
公开(公告)日：2011-09-09
申请号：PCT/US2010030834
申请日：2010-04-13
申请人： ABBOTT LAB , WALTON JOSEPH E , WOLF DAVID R , EDENS NEILE K , MUSTAD VIKKIE A
发明人： WALTON JOSEPH E , WOLF DAVID R , EDENS NEILE K , MUSTAD VIKKIE A
IPC分类号： A23L1/30
CPC分类号： A23D7/011 , A23D7/0053 , A23L29/10 , A23L33/115 , A23L33/21 , A23L33/40
摘要： Disclosed are nutritional aqueous emulsions having high fiber content. These emulsions comprise fat, protein, and carbohydrate, which includes from 1.75% to about 4.0% by weight of diacylglycerol oil and from about 1.5% to about 9.0% by weight of fiber. These emulsions may also comprise fat, protein, and carbohydrate, which includes from 1% to about 4.0% of diacylglycerol oil by weight of the aqueous emulsion and from about 2.0 % to about 9.0% of fiber by weight of the aqueous emulsion, wherein the aqueous emulsion has a viscosity of less than about 300 centipoise at 200C. These high fiber emulsions provide beneficial features, including one or more of stability, desirable hedonics, rheology, and product performance, including a blunted glycemic response profile and or minimal or no gastrointestinal intolerance.
摘要翻译：公开了具有高纤维含量的营养水性乳液。这些乳液包括脂肪，蛋白质和碳水化合物，其包括1.75％至约4.0％的二酰基甘油油和约1.5％至约9.0％的纤维。这些乳剂还可以包含脂肪，蛋白质和碳水化合物，其包含按重量计含水乳液的1％至约4.0％的二酰基甘油油和约20％至约9.0％的水溶液乳液重量的纤维，其中水性乳液在200℃下的粘度小于约300厘泊。这些高纤维乳液提供有益的特征，包括一种或多种稳定性，期望的嗜酸性，流变性和产品性能，包括钝性血糖反应曲线和/或最小或无胃肠道不耐受。

9. 发明申请

WO2015120453A1 HORMONE TREATMENT FOR AGE-RELATED HEARING LOSS-PRESBYCUSIS 审中-公开
标题翻译：用于与年龄相关的听力损失预测的霍尔姆曼治疗
公开(公告)号：WO2015120453A1
公开(公告)日：2015-08-13
申请号：PCT/US2015/015216
申请日：2015-02-10
申请人： UNIVERSITY OF SOUTH FLORIDA , FRISINA, Robert Dana , WALTON, Joseph Paul , DING, Bo , ZHU, Xiaoxia
发明人： FRISINA, Robert Dana , WALTON, Joseph Paul , DING, Bo , ZHU, Xiaoxia
IPC分类号： A61K31/56 , A61K31/58 , A61K31/44
CPC分类号： A61K31/573 , A61K31/192 , A61K31/616 , A61K33/02 , A61K45/06 , A61K2300/00
摘要： Permanent hearing loss or deafness affects about 15% of people worldwide, about 40 million in the US alone, with no available treatment options. Age-related hearing loss (ARHL) is one of the most common forms of permanent hearing loss and deafness. ARHL is the most prevalent neurodegenerative and communication disorder, and a top 3 chronic medical conditions of our aged population. The incidence of ARHL is increasing, and cumulative effects of lifetime noise exposure, and widespread use of ototoxic chemotherapeutic and antibiotic drugs, have ototoxic side effects. A new drug is disclosed to prevent or slow the progression of ARHL, based upon natural, existing compounds. When given in the proper dosage the compounds have few, if any side effects, with in vitro experiments, and in vivo studies of aging mice, indicating is usefulness in preventing/treating one of the most pervasive forms of permanent hearing loss.
摘要翻译：永久性听力损失或耳聋影响全球约15％的人，仅在美国约4000万，没有可用的治疗方案。年龄相关性听力损失（ARHL）是永久性听力损失和耳聋的最常见形式之一。 ARHL是最常见的神经退行性疾病和沟通障碍，是我们老年人口的三大慢性疾病。 ARHL的发病率正在上升，一生噪声暴露的累积效应和耳毒性化疗药物和抗生素药物的广泛使用具有耳毒性副作用。根据天然的现有化合物，公开了一种新药来预防或减缓ARHL的发展。当以适当的剂量给予时，化合物在体外实验和老化小鼠的体内研究中几乎没有任何副作用，表明在预防/治疗永久性听力损失中最普遍形式之一是有用的。

10. 发明申请

WO2009086054A1 CHILLED NUTRITIONAL EMULSIONS 审中-公开
标题翻译：冷冻营养乳
公开(公告)号：WO2009086054A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/087597
申请日：2008-12-19
申请人： ABBOTT LABORATORIES , LAI, Chron-si , WALTON, Joseph , SHEARER, Kati , MAZER, Terry , WEN-LIU, James , STEPP, Emily, A.
发明人： LAI, Chron-si , WALTON, Joseph , SHEARER, Kati , MAZER, Terry , WEN-LIU, James , STEPP, Emily, A.
IPC分类号： A23L1/29 , A23L1/035 , A23L1/302 , A23L1/304 , A23L1/305 , A23L2/38 , A23L2/52
CPC分类号： A23L2/52 , A23L2/38 , A23L29/10 , A23L29/35 , A23L33/15 , A23L33/16 , A23L33/17 , A23L33/40
摘要： Disclosed are nutritional emulsions comprising fat, protein and carbohydrate. The emulsions include a V-complex or aqueous phase comprising a food grade surfactant complexed with a polydextrose having an average degree of polymerization of at least about 10; wherein the nutritional emulsion has a first viscosity at 20° C of less than about 300 cps and a second viscosity at a temperature of from 0° C to 8° C that is at least about 50 cps higher than said first viscosity. Also disclosed is a process for the making the nutritional emulsion. The nutritional emulsions develop a surprisingly thick, creamy texture when chilled prior to use.
摘要翻译：公开了包含脂肪，蛋白质和碳水化合物的营养乳液。所述乳液包括V-络合物或水相，其包含与平均聚合度至少约10的聚右旋糖络合的食品级表面活性剂; 其中所述营养乳液在20℃下的第一粘度小于约300cps，在0℃至8℃的温度下具有比所述第一粘度高至少约50cps的第二粘度。还公开了制备营养乳液的方法。营养乳液在使用前冷冻时会产生令人惊讶的厚实的乳状质地。

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