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1. 发明专利

CA472758A EXHAUST SILENCERS FOR INTERNAL COMBUSTION ENGINES 未知
公开(公告)号：CA472758A
公开(公告)日：1951-04-10
申请号：CA472758D
申请人： WALLINGFORD JOHN
发明人： WALLINGFORD JOHN

2. 发明申请

WO9901763A3 p53 AS A REGULATOR OF CELL DIFFERENTIATION 审中-公开
标题翻译： p53作为细胞分化的调控因子
公开(公告)号：WO9901763A3
公开(公告)日：1999-03-25
申请号：PCT/US9813797
申请日：1998-07-01
申请人： UNIV TEXAS , VIZE PETER D , WALLINGFORD JOHN B
发明人： VIZE PETER D , WALLINGFORD JOHN B
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/68 , G01N33/5011 , G01N2333/47 , G01N2333/4703
摘要： The present invention involves the role of p53 in the differentiation of embryonic tissues. More particularly, the present invention provides methods of the blocking of p53 function in embryonic tissues, and the use of these tissues as screening tools for substances that are capable of overcoming the p53-related block in differentiation, both in vitro and in vivo. The similarities between undifferentiated embryonic cells and tumor cells is evident, and thus these assays serve as a model for possible cancer therapeutics. In addition, methods for identifying additional cellular components that interact p53 or p53-related pathways are provided.
摘要翻译：本发明涉及p53在胚胎组织分化中的作用。更具体地说，本发明提供了在胚胎组织中阻断p53功能的方法，以及这些组织在体外和体内在分化中能够克服p53相关阻断的物质作为筛选工具的用途。未分化的胚胎细胞和肿瘤细胞之间的相似性是显而易见的，因此这些测定法可用作可能的癌症治疗剂的模型。另外，提供了用于鉴定与p53或p53相关的通路相互作用的另外的细胞组分的方法。

3. 发明申请

WO2011008769A3 ORTHOLOGOUS PHENOTYPES AND NON-OBVIOUS HUMAN DISEASE MODELS 审中-公开
标题翻译：正确的基因和非特异性人类疾病模型
公开(公告)号：WO2011008769A3
公开(公告)日：2011-05-19
申请号：PCT/US2010041840
申请日：2010-07-13
申请人： UNIV TEXAS , MARCOTTE EDWARD , MCGARY KRISTON , WALLINGFORD JOHN , PARK TAE JOO , CHA HYE JI , WOODS JOHN O
发明人： MARCOTTE EDWARD , MCGARY KRISTON , WALLINGFORD JOHN , PARK TAE JOO , CHA HYE JI , WOODS JOHN O
IPC分类号： C12Q1/68 , G06F17/00
CPC分类号： G06F19/18
摘要： A method for the quantification of equivalence between mutational phenotypes to develop non-obvious human disease models is described herein. The present inventors discover candidate genes for diseases of interest by : first, identifying orthologous phenotypes (called phenologs) involving the phenotype of interest (the first phenotype), in which a set of genes is associated with the first phenotype in the first organism, a set of genes is associated with a second phenotype in a second organism, the first and second phenotypes not having one or more common characteristics, and the second phenotype is selected such that at least one gene belongs to both the first and second phenotype gene sets; second, selecting from the second organism one or more second phenotype genes, other than the genes known to overlap the first and second phenotypes, as candidates for also belonging to the first phenotype in the first organism.
摘要翻译：本文描述了用于定量突变表型之间的等同性以开发非明显的人类疾病模型的方法。本发明人通过以下方法发现感兴趣疾病的候选基因：首先，鉴定涉及感兴趣的表型（第一表型）的直系同源异型（称为表型），其中一组基因与第一生物体中的第一表型相关，一组基因与第二生物体中的第二表型相关联，第一和第二表型不具有一个或多个共同特征，并且选择第二表型使得至少一个基因属于第一和第二表型基因组; 第二，从第二生物体中选择除了已知与第一和第二表型重叠的基因之外的一个或多个第二表型基因作为也属于第一生物体中的第一表型的候选物。

4. 发明申请

WO2011008769A2 ORTHOLOGOUS PHENOTYPES AND NON-OBVIOUS HUMAN DISEASE MODELS 审中-公开
标题翻译： ORTHOLOGOUS表型和不明显的人类疾病模型
公开(公告)号：WO2011008769A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/041840
申请日：2010-07-13
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , MARCOTTE, Edward , MCGARY, Kriston , WALLINGFORD, John , PARK, Tae, Joo , CHA, Hye, Ji , WOODS, John, O.
发明人： MARCOTTE, Edward , MCGARY, Kriston , WALLINGFORD, John , PARK, Tae, Joo , CHA, Hye, Ji , WOODS, John, O.
IPC分类号： C12Q1/68 , G06F17/00
CPC分类号： G06F19/18
摘要： A method for the quantification of equivalence between mutational phenotypes to develop non-obvious human disease models is described herein. The present inventors discover candidate genes for diseases of interest by : first, identifying orthologous phenotypes (called phenologs) involving the phenotype of interest (the first phenotype), in which a set of genes is associated with the first phenotype in the first organism, a set of genes is associated with a second phenotype in a second organism, the first and second phenotypes not having one or more common characteristics, and the second phenotype is selected such that at least one gene belongs to both the first and second phenotype gene sets; second, selecting from the second organism one or more second phenotype genes, other than the genes known to overlap the first and second phenotypes, as candidates for also belonging to the first phenotype in the first organism.
摘要翻译：本文描述了用于定量突变表型以产生非显而易见的人类疾病模型的等同性的方法。本发明人通过以下方式发现了感兴趣疾病的候选基因：首先鉴定涉及感兴趣表型（第一表型）的直系同源表型（称为表型），其中一组基因与第一生物中的第一表型相关联，第二表型与第二生物体中的第二表型相关联，第一表型和第二表型不具有一个或多个共同特征，并且第二表型被选择为使得至少一个基因属于第一和第二表型基因集合; 其次，从第二生物体中选择除了已知与第一和第二表型重叠的基因以外的一个或多个第二表型基因作为也属于第一生物体中第一表型的候选物。

5. 发明授权

US3084443A Directional indicia and ocular device 失效
标题翻译：方向标记和眼睛装置
公开(公告)号：US3084443A
公开(公告)日：1963-04-09
申请号：US86229459
申请日：1959-12-28
申请人： KAATZ RONALD E , WALLINGFORD JOHN S
发明人： KAATZ RONALD E , WALLINGFORD JOHN S
IPC分类号： G01C17/00
CPC分类号： G01C17/00

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