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1. 发明申请

WO2010144486A1 DIHYDROPYRROLONAPHTYRIDINONE COMPOUNDS AS INHIBITORS OF JAK 审中-公开
标题翻译：作为JAK的抑制剂的二氢吡咯并吡啶酮化合物
公开(公告)号：WO2010144486A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/037822
申请日：2010-06-08
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , DONG, Qing , LAWSON, John, David , WALLACE, Michael, B. , KANOUNI, Toufike
发明人： DONG, Qing , LAWSON, John, David , WALLACE, Michael, B. , KANOUNI, Toufike
IPC分类号： C07D471/16 , A61K31/519 , A61P35/00
CPC分类号： A61K31/541 , A61K31/4375 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , C07D471/16
摘要： Disclosed are JAK inhibitors of formula (I) where G 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are defined in the specification. Also disclosed are pharmaceutical compositions, kits and articles of manufacture which contain the compounds, methods and materials for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions involving the immune system and inflammation, including rheumatoid arthritis, hematological malignancies, epithelial cancers (i.e., carcinomas), and other diseases, disorders or conditions associated with JAK.
摘要翻译：公开了式（I）的JAK抑制剂，其中G1，R1，R2，R3，R4，R5，R6和R7在说明书中定义。还公开了含有化合物的化合物，制备该化合物的方法和材料的药物组合物，试剂盒和制品，以及使用该化合物治疗涉及免疫系统和炎症的疾病，病症和病症的方法，包括类风湿性关节炎，血液学恶性肿瘤，上皮癌（即癌）以及与JAK有关的其他疾病，病症或病症。

2. 发明申请

WO2008054956A3 KINASE INHIBITORS 审中-公开
标题翻译：激酶抑制剂
公开(公告)号：WO2008054956A3
公开(公告)日：2008-09-04
申请号：PCT/US2007080714
申请日：2007-10-08
申请人： TAKEDA SAN DIEGO INC , BROWN JASON W , DONG QING , PARASELLI BHEEMA R , STAFFORD JEFFREY ALAN , WALLACE MICHAEL B , WIJESEKERA HASANTHI
发明人： BROWN JASON W , DONG QING , PARASELLI BHEEMA R , STAFFORD JEFFREY ALAN , WALLACE MICHAEL B , WIJESEKERA HASANTHI
IPC分类号： C07D213/61 , A61K31/437 , C07D471/04
CPC分类号： C07D471/04
摘要： Compounds are provided for use with kinases that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译：化合物被提供用于包含选自式（I）的化合物的激酶，其中变量如本文所定义。还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

3. 发明申请

WO2007075847A3 GLUCOKINASE ACTIVATORS 审中-公开
公开(公告)号：WO2007075847A3
公开(公告)日：2007-07-05
申请号：PCT/US2006/048714
申请日：2006-12-19
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , TAKEDA SAN DIEGO, INC. , FENG, Jun , GWALTNEY, Stephen L. , HOSFIELD, David J. , SASAKI, Shigekazu , SKENE, Robert J. , WALLACE, Michael B.
发明人： FENG, Jun , GWALTNEY, Stephen L. , HOSFIELD, David J. , SASAKI, Shigekazu , SKENE, Robert J. , WALLACE, Michael B.
IPC分类号： C07D231/56 , C07D417/12 , A61K31/427 , A61P3/10 , C07C233/64
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of wherein the variables are as defined herein.

4. 发明申请

WO2006068978A2 DIPEPTIDYL PEPTIDASE INHIBITORS 审中-公开
标题翻译： DIPEPTIDYL PEPTIDASE抑制剂
公开(公告)号：WO2006068978A2
公开(公告)日：2006-06-29
申请号：PCT/US2005/045769
申请日：2005-12-16
申请人： TAKEDA PHARMACEUTIAL COMPANY LIMITED , FENG, Jun , GWALTNEY, Stephen, L., II , STAFFORD, Jeffrey, A. , WALLACE, Michael, B. , ZHANG, Zhiyuan
发明人： FENG, Jun , GWALTNEY, Stephen, L., II , STAFFORD, Jeffrey, A. , WALLACE, Michael, B. , ZHANG, Zhiyuan
CPC分类号： C07D471/04 , C07D487/04 , C07D513/04
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a member selected from the group consisting of: (A), (B), (C) wherein E is CH or N, Q is selected from the group consisting of CO, CS, SO, SO 2 , or C=NR 4 , and L, X, Z, R 2 and R 3 are as defined herein.
摘要翻译：提供化合物，药物，试剂盒和方法用于DPP-IV和其它S9蛋白酶，其包含选自以下的成员：（A），（B），（C）其中E是CH或N，Q是选自CO，CS，SO，SO 2，或C = NR 4，且L，X，Z，R 2

5. 发明申请

WO2011008758A2 COLONIC LAVAGE CATHETER 审中-公开
标题翻译： COLONIC行走管
公开(公告)号：WO2011008758A2
公开(公告)日：2011-01-20
申请号：PCT/US2010041827
申请日：2010-07-13
申请人： MAYO FOUNDATION , WALLACE MICHAEL B
发明人： WALLACE MICHAEL B
IPC分类号： A61M25/01 , A61M1/00 , A61M3/02 , A61M27/00
CPC分类号： A61M25/0122 , A61M3/0216 , A61M3/022 , A61M3/0233 , A61M3/0283 , A61M25/0032 , A61M25/007 , A61M2025/0034 , A61M2210/1064
摘要： A colonic lavage catheter includes a head attached at an end of a suction tube and having both rearward and lateral fluid discharge openings. A pair of tubes extend along the suction tube with their ends attached to the head to place the rearward and lateral fluid discharge openings in fluid communication with a source of pressurized fluid. The suction tube includes a plurality of suction orifices through the outer wall along its length proximate the catheter head. A cleaning process may be performed by inserting the catheter head into the colon and then discharging fluid through the rearward openings to advance the catheter. At points along the colon, pressurized fluid may be discharged through the lateral discharge openings to lavage the adjacent walls of the colon, with suction being applied to draw the dislodged material into the suction tube through the suction orifices.
摘要翻译：结肠灌洗导管包括附接在吸管的端部并具有向后和向外的流体排出口的头部。一对管沿着吸管延伸，其端部附接到头部，以使后部和侧向流体排放开口与加压流体源流体连通。抽吸管包括沿着其邻近导管头的长度穿过外壁的多个抽吸孔。可以通过将导管头插入结肠，然后通过后开口排出流体以推进导管来执行清洁过程。在结肠的点处，加压流体可以通过侧向排出口排出，以冲洗结肠的相邻壁，同时施加抽吸以通过抽吸孔将移动的物质吸入抽吸管。

6. 发明申请

WO2008079814A3 MAPK/ERK KINASE INHIBITORS 审中-公开
标题翻译： MAPK / ERK激酶抑制剂
公开(公告)号：WO2008079814A3
公开(公告)日：2008-09-04
申请号：PCT/US2007087913
申请日：2007-12-18
申请人： TAKEDA PHARMACEUTICAL , DONG QING , GONG XIANCHANG , KALDOR STEPHEN W , KANOUNI TOUFIKE , SCORAH NICHOLAS , WALLACE MICHAEL B , ZHOU FENG
发明人： DONG QING , GONG XIANCHANG , KALDOR STEPHEN W , KANOUNI TOUFIKE , SCORAH NICHOLAS , WALLACE MICHAEL B , ZHOU FENG
IPC分类号： C07D471/04 , A61K31/4375 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds of the following formula are provided for use with MEK (I): wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译：提供下式的化合物与MEK（I）一起使用：其中变量如本文所定义。还提供了包含此类化合物的药物组合物，试剂盒和制品; 用于制备该化合物的方法和中间体; 和使用所述化合物的方法。

7. 发明申请

WO2008055236A3 MAPK/ERK KINASE INHIBITORS 审中-公开
公开(公告)号：WO2008055236A3
公开(公告)日：2008-05-08
申请号：PCT/US2007/083240
申请日：2007-10-31
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , ADAMS, Mark. E. , DONG, Qing , KALDOR, Stephen, W. , KANOUNI, Toufike , WALLACE, Michael, B.
发明人： ADAMS, Mark. E. , DONG, Qing , KALDOR, Stephen, W. , KANOUNI, Toufike , WALLACE, Michael, B.
IPC分类号： C07D207/34
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with MEK that comprise a compound selected from the group consisting of wherein the variables are as defined herein.

8. 发明申请

WO2008055236A2 MAPK/ERK KINASE INHIBITORS 审中-公开
标题翻译： MAPK / ERK激酶抑制剂
公开(公告)号：WO2008055236A2
公开(公告)日：2008-05-08
申请号：PCT/US2007083240
申请日：2007-10-31
申请人： TAKEDA PHARMACEUTICAL , ADAMS MARK E , DONG QING , KALDOR STEPHEN W , KANOUNI TOUFIKE , WALLACE MICHAEL B
发明人： ADAMS MARK E , DONG QING , KALDOR STEPHEN W , KANOUNI TOUFIKE , WALLACE MICHAEL B
IPC分类号： C07D207/34
CPC分类号： C07D207/34 , C07D403/04 , C07D403/06 , C07D413/12
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with MEK that comprise a compound selected from the group consisting of ##STR## wherein the variables are as defined herein.
摘要翻译：提供化合物，药物组合物，试剂盒和方法用于包含选自下组的化合物的MEK：其中变量如本文所定义。

9. 发明申请

WO2008045834A2 KINASE INHIBITORS 审中-公开
标题翻译：激酶抑制剂
公开(公告)号：WO2008045834A2
公开(公告)日：2008-04-17
申请号：PCT/US2007/080710
申请日：2007-10-08
申请人： TAKEDA SAN DIEGO, INC. , BROWN, Jason W. , DONG, Qing , PARASELLI, Bheema R. , STAFFORD, Jeffrey Alan , WALLACE, Michael B.
发明人： BROWN, Jason W. , DONG, Qing , PARASELLI, Bheema R. , STAFFORD, Jeffrey Alan , WALLACE, Michael B.
CPC分类号： C07D471/04 , C07D471/12
摘要： Compounds are provided for use with kinases that comprise a compound selected from the group consisting of (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译：化合物提供用于包含选自（I）的化合物的激酶，其中变量如本文所定义。还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

10. 发明申请

WO2007112347A1 DIPEPTIDYL PEPTIDASE INHIBITORS 审中-公开
标题翻译： DIPEPTIDYL PEPTIDASE抑制剂
公开(公告)号：WO2007112347A1
公开(公告)日：2007-10-04
申请号：PCT/US2007/064919
申请日：2007-03-26
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , FENG, Jun , GWALTNEY, Stephen L. , WALLACE, Michael B. , ZHANG, Zhiyuan
发明人： FENG, Jun , GWALTNEY, Stephen L. , WALLACE, Michael B. , ZHANG, Zhiyuan
IPC分类号： C07D215/22 , C07D217/24 , C07D241/44 , C07D237/28 , C07D237/32 , C07D239/74 , C07D239/80 , C07D239/88 , C07D239/96 , C07D241/42 , A61K31/517 , A61P35/00
CPC分类号： C07D217/24 , C07D215/227 , C07D215/233 , C07D237/28 , C07D237/32 , C07D239/74 , C07D239/80 , C07D239/88 , C07D239/96 , C07D241/42 , C07D241/44
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: (I) wherein the substituents are as defined herein.
摘要翻译：提供化合物，药物组合物，试剂盒和方法用于DPP-IV和其它S9蛋白酶，其包含下式化合物：其中取代基如本文所定义。

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