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1. 发明公开

EP3212283A1 ADJUSTABLE HEADPIECE WITH ANATOMICAL MARKERS AND METHODS OF USE THEREOF 审中-公开
标题翻译：具有解剖标记的可调整头罩及其使用方法
公开(公告)号：EP3212283A1
公开(公告)日：2017-09-06
申请号：EP15855806.4
申请日：2015-09-30
申请人： Highland Instruments, Inc. , Wagner, Timothy Andrew , Edelman, William , Dipietro, Laura , Mulhauser, Paul James , Lee, Kyungmin, Andy
发明人： WAGNER, Timothy Andrew , EDELMAN, William , DIPIETRO, Laura , MULHAUSER, Paul James , LEE, Kyungmin, Andy
IPC分类号： A61N2/00 , A61N7/00 , A61B18/00
CPC分类号： A61B90/39 , A61B2090/3937 , A61B2090/502 , A61N1/0456 , A61N1/0472 , A61N1/0484 , A61N7/00 , A61N2007/0021 , A61N2007/0026 , F16M13/04
摘要： The invention generally relates to an adjustable headpiece with anatomical markers and methods of use thereof. In certain embodiments, the invention provides an apparatus that includes a headpiece configured to be worn on a head of a user. The headpiece includes at least a first receptacle configured to receive and retain a first energy source, and the headpiece is adjustable in at least one direction. There is at least one anatomical marker coupled to the headpiece. In that manner, a position of the receptacle can be adjustably aligned to a region of neural tissue in the head based on an alignment of the at least one anatomical marker with its designated anatomical structure.
摘要翻译：本发明总体上涉及一种具有解剖学标记的可调节头盔及其使用方法。在某些实施例中，本发明提供了一种装置，该装置包括配置成佩戴在用户头部上的头戴件。机头包括至少一个第一插座，该第一插座被配置为接收和保持第一能量源，并且该机头可以在至少一个方向上调节。至少有一个解剖学标记耦合到头盔。以此方式，基于所述至少一个解剖标记与其指定的解剖结构的对齐，容器的位置可以可调节地与头部中的神经组织的区域对齐。

2. 发明公开

EP3212283A4 ADJUSTABLE HEADPIECE WITH ANATOMICAL MARKERS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：EP3212283A4
公开(公告)日：2018-07-11
申请号：EP15855806
申请日：2015-09-30
申请人： HIGHLAND INSTRUMENTS INC , WAGNER TIMOTHY ANDREW , EDELMAN WILLIAM , DIPIETRO LAURA , MULHAUSER PAUL JAMES , LEE KYUNGMIN ANDY
发明人： WAGNER TIMOTHY ANDREW , EDELMAN WILLIAM , DIPIETRO LAURA , MULHAUSER PAUL JAMES , LEE KYUNGMIN ANDY
IPC分类号： A61N2/00 , A61B18/00 , A61N7/00
CPC分类号： A61B90/39 , A61B2090/3937 , A61B2090/502 , A61N1/0456 , A61N1/0472 , A61N1/0484 , A61N7/00 , A61N2007/0021 , A61N2007/0026 , F16M13/04
摘要： The invention generally relates to an adjustable headpiece with anatomical markers and methods of use thereof. In certain embodiments, the invention provides an apparatus that includes a headpiece configured to be worn on a head of a user. The headpiece includes at least a first receptacle configured to receive and retain a first energy source, and the headpiece is adjustable in at least one direction. There is at least one anatomical marker coupled to the headpiece. In that manner, a position of the receptacle can be adjustably aligned to a region of neural tissue in the head based on an alignment of the at least one anatomical marker with its designated anatomical structure.

3. 发明申请

WO2012118598A1 METHODS OF STIMULATING TISSUE BASED UPON FILTERING PROPERTIES OF THE TISSUE 审中-公开
标题翻译：基于组织过滤特性刺激组织的方法
公开(公告)号：WO2012118598A1
公开(公告)日：2012-09-07
申请号：PCT/US2012/023951
申请日：2012-02-06
申请人： HIGHLAND INSTRUMENTS , WAGNER, Timothy, Andrew , EDEN, Uri, T.
发明人： WAGNER, Timothy, Andrew , EDEN, Uri, T.
IPC分类号： A61N7/00
CPC分类号： A61N1/36025 , A61H23/0236 , A61H23/0245 , A61H2201/10 , A61N1/36082 , A61N5/02 , A61N5/06 , A61N2007/0026
摘要： The invention generally relates to methods of stimulating tissue based upon filtering properties of the tissue. In certain aspects, the invention provides methods for stimulating tissue that involve analyzing at least one filtering property of a region of at least one tissue, and providing a dose of energy to the at least one region of tissue based upon results of the analyzing step.
摘要翻译：本发明一般涉及基于组织的过滤性质刺激组织的方法。在某些方面，本发明提供了刺激组织的方法，所述方法涉及分析至少一个组织的区域的至少一个过滤性质，并且基于分析步骤的结果向组织的至少一个区域提供一定量的能量。

4. 发明申请

WO2012054560A1 METHODS FOR DETECTING A CONDITION 审中-公开
标题翻译：检测条件的方法
公开(公告)号：WO2012054560A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/056816
申请日：2011-10-19
申请人： HIGHLAND INSTRUMENTS, INC. , WAGNER, Timothy, Andrew
发明人： WAGNER, Timothy, Andrew
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0033 , A61B5/0051 , A61B5/031 , A61B5/0531 , A61B5/4064 , A61B5/4884 , A61B5/6814 , A61B5/7282
摘要： The invention generally relates to methods for measuring impedance change detecting a condition. In certain embodiments, the invention provides a method for detecting a condition that involves measuring impedance change over time in a region of tissue suspected to be associated with a condition to obtain an impedance signature, and comparing the impedance signature to a reference signature, thereby detecting the condition.
摘要翻译：本发明一般涉及用于测量阻挡变化的方法来检测条件。在某些实施例中，本发明提供了一种用于检测涉及在怀疑与获得阻抗特征的条件相关联的组织的区域中随时间测量阻抗变化以及将阻抗特征与参考签名进行比较的条件的检测方法，条件。

5. 发明申请

WO2010017392A9 INTERFACE APPARATUS FOR STIMULATION OF BIOLOGICAL TISSUE 审中-公开
标题翻译：用于刺激生物组织的界面装置
公开(公告)号：WO2010017392A9
公开(公告)日：2010-04-08
申请号：PCT/US2009053006
申请日：2009-08-06
申请人： HIGHLAND INSTRUMENTS INC , WAGNER TIMOTHY ANDREW , EDEN URI T
发明人： WAGNER TIMOTHY ANDREW , EDEN URI T
IPC分类号： A61N1/36 , A61N1/04 , A61N2/00
CPC分类号： A61N1/0484 , A61N1/0408 , A61N1/0452 , A61N1/0456 , A61N1/0472 , A61N1/36014 , A61N1/36025 , A61N1/40 , A61N7/00
摘要： An apparatus for interfacing between tissues being stimulated is provided. The apparatus includes an electric source capable of generating an applied electric Held across a region of tissue and/or a means for altering at least one electromagnetic characteristic of the region of tissue relative to the applied electric field and an interface component, such interface component creating an interface between the region of tissue and the applied electric field or the means for altering at least one electromagnetic characteristic of the region of tissue.
摘要翻译：提供了用于在被刺激的组织之间接口的设备。该装置包括能够产生穿过组织区域的施加电的电源和/或用于改变组织区域相对于施加的电场的至少一个电磁特性的装置和界面组件，该界面组件创建组织区域与施加的电场之间的界面或用于改变组织区域的至少一个电磁特性的装置。

6. 发明申请

WO2007103475A3 TRANSCRANIAL MAGNETIC STIMULATION (TMS) METHODS AND APPARATUS 审中-公开
标题翻译：转移磁性刺激（TMS）方法和装置
公开(公告)号：WO2007103475A3
公开(公告)日：2008-01-17
申请号：PCT/US2007005893
申请日：2007-03-07
申请人： BETH ISRAEL HOSPITAL , PASCUAL-LEONE ALVARO , WAGNER TIMOTHY ANDREW
发明人： PASCUAL-LEONE ALVARO , WAGNER TIMOTHY ANDREW
IPC分类号： A61N2/00
CPC分类号： A61N2/006 , A61B90/14 , A61N2/008
摘要： In one aspect, a portable transcranial magnetic stimulation (TMS) device for delivering a TMS procedure is provided. The portable TMS device comprises at least one coil that, when energized, generates electromagnetic energy, a helmet adapted to fit a user's head and configured to hold the at least one coil in a predetermined position with respect to the user's head, and a port having at least one power connection coupled to the at least one coil, the at least one power connection adapted to connect the at least one coil to a power source capable of energizing the at least one coil, the port further comprising at least one data connection adapted to exchange data with at least one external component, the port being located on the helmet. In another aspect a method of positioning a coil with respect to a person's head to target a desired region of the person's brain with transcranial magnetic stimulation (TMS) is provided. The method comprises obtaining a dielectric property map of a portion of the brain, the dielectric map indicating a spatial distribution of at least one dielectric property over the portion of the brain, determining a location for the coil based, at least in part, on the dielectric property map, the location being such that when the coil is positioned at the location, magnetic energy generated by the coil is focused on the desired region, and positioning the coil at the determined location.
摘要翻译：在一个方面，提供了一种用于递送TMS程序的便携式经颅磁刺激（TMS）装置。所述便携式TMS装置包括至少一个线圈，所述至少一个线圈当被激励时产生电磁能量，头盔适于装配使用者的头部并被配置为将所述至少一个线圈保持在相对于所述用户头部的预定位置，以及具有耦合到所述至少一个线圈的至少一个电源连接器，所述至少一个电源连接器适于将所述至少一个线圈连接到能够激励所述至少一个线圈的电源，所述端口还包括适于与至少一个外部组件交换数据，该端口位于头盔上。在另一方面，提供了一种通过经颅磁刺激（TMS）将线圈相对于人的头部定位以靶向人的大脑的期望区域的方法。该方法包括获得脑的一部分的介电特性图，电介质图表示大脑部分上的至少一种电介质的空间分布，至少部分地基于所述线圈确定线圈的位置介电特性图，该位置使得当线圈位于该位置时，由线圈产生的磁能聚焦在期望的区域上，并将线圈定位在所确定的位置处。

7. 发明申请

WO2010017392A3 INTERFACE APPARATUS FOR STIMULATION OF BIOLOGICAL TISSUE 审中-公开
公开(公告)号：WO2010017392A3
公开(公告)日：2010-05-27
申请号：PCT/US2009053006
申请日：2009-08-06
申请人： HIGHLAND INSTRUMENTS INC , WAGNER TIMOTHY ANDREW , EDEN URI T
发明人： WAGNER TIMOTHY ANDREW , EDEN URI T
IPC分类号： A61N1/36 , A61N1/04 , A61N2/00
CPC分类号： A61N1/0484 , A61N1/0408 , A61N1/0452 , A61N1/0456 , A61N1/0472 , A61N1/36014 , A61N1/36025 , A61N1/40 , A61N7/00
摘要： An apparatus for interfacing between tissues being stimulated is provided. The apparatus includes an electric source capable of generating an applied electric Held across a region of tissue and/or a means for altering at least one electromagnetic characteristic of the region of tissue relative to the applied electric field and an interface component, such interface component creating an interface between the region of tissue and the applied electric field or the means for altering at least one electromagnetic characteristic of the region of tissue.

8. 发明申请

WO2013028262A3 SYSTEMS AND METHODS FOR STIMULATING CELLULAR FUNCTION IN TISSUE 审中-公开
标题翻译：用于刺激组织中细胞功能的系统和方法
公开(公告)号：WO2013028262A3
公开(公告)日：2014-05-08
申请号：PCT/US2012044664
申请日：2012-06-28
申请人： HIGHLAND INSTR , WAGNER TIMOTHY ANDREW
发明人： WAGNER TIMOTHY ANDREW
IPC分类号： A61H1/00 , A61N1/00
CPC分类号： A61N1/36025 , A61B2018/00994 , A61F7/00 , A61N1/205 , A61N1/325 , A61N1/326 , A61N1/327 , A61N1/36 , A61N1/36021 , A61N7/00 , A61N2007/0021 , A61N2007/0026
摘要： Systems and methods for stimulating cellular function in biological tissue are disclosed. A method for stimulating cellular function within tissue involves providing a first type of energy to a region of tissue, in which the first type is provided in an amount that inhibits cellular function within the region of tissue, and providing a second type of energy to the region of tissue, in which the second type is provided in an amount that facilitates cellular function within the region of tissue, wherein the combined effect stimulates cellular function within the tissue.
摘要翻译：公开了用于刺激生物组织中的细胞功能的系统和方法。用于刺激组织内的细胞功能的方法包括向组织区域提供第一类型的能量，其中以抑制组织区域内的细胞功能的量提供第一类型，并向组织提供第二类型的能量组织的区域，其中以促进组织区域内的细胞功能的量提供第二类型，其中组合效应刺激组织内的细胞功能。

9. 发明申请

WO2012054573A3 SYSTEMS FOR DETECTING A CONDITION 审中-公开
标题翻译：用于检测条件的系统
公开(公告)号：WO2012054573A3
公开(公告)日：2014-04-03
申请号：PCT/US2011056841
申请日：2011-10-19
申请人： HIGHLAND INSTR , WAGNER TIMOTHY ANDREW
发明人： WAGNER TIMOTHY ANDREW
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0033 , A61B5/0051 , A61B5/031 , A61B5/0531 , A61B5/4064 , A61B5/4884 , A61B5/6814 , A61B5/7282
摘要： The invention generally relates to systems for measuring impedance change in order to detect a condition. In certain aspects, the invention provides systems for monitoring tissue and detecting a condition that include at least one energy source, a transduction unit, and a pattern recognition component that compares impedance signatures recorded from the transduction unit with a database of impedance signatures associated with medical conditions.
摘要翻译：本发明一般涉及用于测量阻抗变化以便检测条件的系统。在某些方面，本发明提供了用于监测组织和检测包括至少一个能量源，转导单元和模式识别组件的系统的系统，其将从转导单元记录的阻抗特征与与医学相关联的阻抗特征数据库进行比较条件。

10. 发明申请

WO2013028262A2 SYSTEMS AND METHODS FOR STIMULATING CELLULAR FUNCTION IN TISSUE 审中-公开
标题翻译：用于刺激组织中细胞功能的系统和方法
公开(公告)号：WO2013028262A2
公开(公告)日：2013-02-28
申请号：PCT/US2012/044664
申请日：2012-06-28
申请人： HIGHLAND INSTRUMENTS , WAGNER, Timothy, Andrew
发明人： WAGNER, Timothy, Andrew
IPC分类号： A61N1/36 , A61N7/00
CPC分类号： A61N1/36025 , A61B2018/00994 , A61F7/00 , A61N1/205 , A61N1/325 , A61N1/326 , A61N1/327 , A61N1/36 , A61N1/36021 , A61N7/00 , A61N2007/0021 , A61N2007/0026
摘要： The invention generally relates to systems and methods for stimulating cellular function in biological tissue. In certain embodiments, the invention provides a method for stimulating cellular function within tissue that involves providing a first type of energy to a region of tissue, in which the first type is provided in an amount that inhibits cellular function within the region of tissue, and providing a second type of energy to the region of tissue, in which the second type is provided in an amount that facilitates cellular function within the region of tissue, wherein the combined effect stimulates cellular function within the tissue.
摘要翻译：本发明一般涉及用于刺激生物组织中的细胞功能的系统和方法。在某些实施方案中，本发明提供了一种刺激组织内的细胞功能的方法，其涉及向组织区域提供第一类型的能量，其中第一类型以抑制组织区域内的细胞功能的量提供，以及向组织区域提供第二类型的能量，其中以促进组织区域内的细胞功能的量提供第二类型，其中组合效应刺激组织内的细胞功能。

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