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1. 发明授权

US5296197A Automated sample extractor or feeder/inoculator for bioreactors and similar equipment 失效
标题翻译：用于生物反应器和类似设备的自动样品提取器或进料器/接种器
公开(公告)号：US5296197A
公开(公告)日：1994-03-22
申请号：US911052
申请日：1992-07-09
申请人： Douglas A. Newberg , Vjekoslav Pavlin , Richard R. Newberg , Jackson C. S. Yang
发明人： Douglas A. Newberg , Vjekoslav Pavlin , Richard R. Newberg , Jackson C. S. Yang
IPC分类号： G01N1/00 , C12M1/00 , C12M1/26 , F16K7/10 , F16K27/00 , F16K41/10 , F16K51/00 , G01N1/10 , G01N1/14 , G01N1/20 , G01N1/04 , F16K31/44
CPC分类号： F16K41/103 , C12M33/04 , G01N1/2035 , G01N2001/1012 , G01N2001/1445 , G01N2001/205 , Y10T137/4259 , Y10T137/4266
摘要： An apparatus can withdraw a sample from a vessel or conduit or provide a sample to this vessel or conduit. This apparatus includes a main body with an inlet passage and drain passage. The main body has a longitudinal axis with the axes of the drain passage and inlet passage being inclined relative thereto. A flexible bellows is positioned within an internal cavity of the main body. A sealing tip of the bellows is movable by a valve operating rod to close an orifice to a sample cavity within the body. A sample can be taken from the vessel or conduit, through this sample cavity and out the drain passage to a sampling device when the apparatus is used as a sampler. On the other hand, a sample can be fed through the inlet passage, sample cavity and orifice to the vessel or conduit when the apparatus is used as a feeder/inoculator. Steam, pure dry air and/or a wash medium can be provided through the inlet passage to cleanse the apparatus. Crevices and exposure to moving parts are avoided in the apparatus to prevent contamination of the sample. This apparatus can be retrofitted to existing containers or vessels and can be automatically controlled and monitored.
摘要翻译：设备可以从容器或管道中取出样品，或者将样品提供到该容器或导管。该装置包括具有入口通道和排放通道的主体。主体具有纵向轴线，排水通道和入口通道的轴线相对于其倾斜。柔性波纹管位于主体的内腔内。波纹管的密封尖端可通过阀操作杆移动以将孔口关闭到体内的样品腔。当该装置用作取样器时，样品可以从容器或管道中取出，通过该样品腔并排出通道至采样装置。另一方面，当将该装置用作进料器/接种器时，样品可以通过入口通道，样品腔和孔口进料到容器或导管。可以通过入口通道提供蒸汽，纯净的干燥空气和/或洗涤介质以清洁设备。在装置中避免了对运动部件的裂缝和暴露，以防止样品污染。该装置可以被改装成现有的容器或容器，并且可被自动控制和监控。

2. 发明授权

US5525301A Automated sample extractor or feeder/inoculator for bioreactors and similar equipment 失效
标题翻译：用于生物反应器和类似设备的自动样品提取器或进料器/接种器
公开(公告)号：US5525301A
公开(公告)日：1996-06-11
申请号：US215416
申请日：1994-03-21
申请人： Douglas A. Newberg , Vjekoslav Pavlin
发明人： Douglas A. Newberg , Vjekoslav Pavlin
IPC分类号： G01N1/00 , C12M1/00 , C12M1/26 , F16K7/10 , F16K27/00 , F16K41/10 , F16K51/00 , G01N1/10 , G01N1/14 , G01N1/20 , B01L11/00 , F16K1/00
CPC分类号： F16K41/103 , C12M33/04 , G01N1/2035 , G01N2001/1012 , G01N2001/1445 , G01N2001/205 , Y10T137/4259 , Y10T137/4266
摘要： An apparatus for inoculating a sample to or withdrawing a sample from a vessel or conduit includes a body with an internal sample cavity, a valve operating rod movable to open and close an orifice to the sample cavity a coupler to attach the body to a port of the vessel or conduit. A manual and/or automatic device can be provided for moving the valve operating rod to open and close the orifice. The manual device includes a trigger actuator. A portion of the sample cavity is formed by an endcap which includes the orifice. The sample cavity has an inner wall and outer wall with a space therebetween. The space can thermally insulate the sample cavity from the ambient environment as well as the interior of the vessel or conduit. The valve operating rod has a diaphragm attached to one end. A blunt sealing tip of the diaphragm seals the orifice when the valve operating rod moves to close the orifice. The valve operating rod has a portion which extends into the diaphragm to support the diaphragm and to form a seal at an opening to the sample cavity through which the diaphragm extends.
摘要翻译：用于将样品接收或从容器或管道中取出样品的装置包括具有内部样品腔的主体，阀操作杆，其可移动以打开和关闭到样品腔的孔，耦合器将本体附接到船只或导管。可以提供手动和/或自动装置，用于移动阀操作杆以打开和关闭孔口。手动装置包括触发器致动器。样品腔的一部分由包括孔的端盖形成。样品腔具有内壁和外壁之间的空间。该空间可以将样品空腔与周围环境以及容器或导管的内部热绝缘。阀门操作杆的一端连接一个隔膜。当阀门操作杆移动以关闭孔口时，隔膜的钝的密封尖端密封孔口。阀操作杆具有延伸到隔膜中以支撑隔膜的部分，并且在隔膜延伸穿过的样品腔的开口处形成密封。

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