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1. 发明授权

US07759134B2 Magnetostrictive ligand sensor 有权
标题翻译：磁致伸缩配体传感器
公开(公告)号：US07759134B2
公开(公告)日：2010-07-20
申请号：US10923414
申请日：2004-08-20
申请人： Bryan A. Chin , Zhongyang Cheng , Vitaly J. Vodyanoy , James Barbaree , Valery A. Petrenko , Tung-Shi Huang , Howard C. Wikle, III
发明人： Bryan A. Chin , Zhongyang Cheng , Vitaly J. Vodyanoy , James Barbaree , Valery A. Petrenko , Tung-Shi Huang , Howard C. Wikle, III
IPC分类号： G01N33/553
CPC分类号： G01N27/745 , G01N33/5434
摘要： A magnetostrictive ligand sensor device (MLSD), system and method are provided having at least one magnetostrictive particle (MSP) to which is bound at least one binding element. The MSP may be dispersed in a sample containing a target ligand such that the target ligand binds thereto. A driver is also provided to emit a varying magnetic field such that the MSP produces a resonance response detectable by a measurement device configured to receive and detect changes in the resonance response that are due to alterations of the binding element. The MLSD and assays find use in identifying and quantitating ligands as well as chemicals and environmental conditions in a sample or patient.
摘要翻译：提供了具有至少一个磁致伸缩颗粒（MSP）的磁致伸缩配体传感器装置（MLSD），系统和方法，其结合至少一个结合元件。 MSP可以分散在含有靶配体的样品中，使得靶配体与其结合。还提供驱动器以发射变化的磁场，使得MSP产生由测量装置可检测的共振响应，该测量装置被配置为接收和检测由于绑定元件的改变而引起的共振响应的变化。 MLSD和测定法用于鉴定和定量配体以及样品或患者中的化学物质和环境条件。

2. 发明授权

US07542203B2 Microscope illumination device and adapter 有权
标题翻译：显微镜照明设备和适配器
公开(公告)号：US07542203B2
公开(公告)日：2009-06-02
申请号：US11487551
申请日：2006-07-14
申请人： Vitaly J. Vodyanoy , Oleg M. Pustovyy , Arnold Vainrub
发明人： Vitaly J. Vodyanoy , Oleg M. Pustovyy , Arnold Vainrub
IPC分类号： G02B21/06
CPC分类号： G02B21/125
摘要： The present invention is a dark field illumination system including a light source which is fixed on an entrance slit of a condenser and an objective aligned with the condenser such that the objective and the condenser are adjusted to find a focus spot on a sample. The present invention essentially uses structured illumination to achieve an improved illumination system. The present invention also includes a system and method wherein the objective is coupled to an iris and aligned with the condenser such that when the iris is closed only dark field images are produced, and when the iris is open, direct entrance of light is allowed into the objective and bright field illumination is produced.
摘要翻译：本发明是一种暗场照明系统，其包括固定在冷凝器的入口狭缝上的光源和与冷凝器对准的物镜，使得调节物镜和聚光镜以在样品上找到焦点。本发明基本上使用结构照明来实现改进的照明系统。本发明还包括一种系统和方法，其中物镜耦合到虹膜并与冷凝器对准，使得当虹膜闭合时，仅产生暗场图像，并且当虹膜打开时，允许光直接进入产生客观和明亮的场景照明。

3. 发明授权

US06788071B2 Method and apparatus for generating a voltage across a membrane 失效
标题翻译：用于在膜上产生电压的方法和装置
公开(公告)号：US06788071B2
公开(公告)日：2004-09-07
申请号：US10201746
申请日：2002-07-23
申请人： Vitaly J. Vodyanoy , Solomon Yilma , Ting To Lo , Alexander Samoylov
发明人： Vitaly J. Vodyanoy , Solomon Yilma , Ting To Lo , Alexander Samoylov
IPC分类号： G01R2702
CPC分类号： G01N33/48728
摘要： A method and apparatus for generating a transmembrane voltage, including a semiconductive substrate having a surface for receiving a membrane thereon, and a light source for illuminating at least a portion of the semiconductive substrate. Measurement of current through the membrane addresses ion channels through the membrane at the location illuminated by the light source.
摘要翻译：一种用于产生跨膜电压的方法和装置，包括具有用于在其上接收膜的表面的半导体衬底和用于照射半导电衬底的至少一部分的光源。通过膜的电流的测量通过光源照射的位置处的离子通道通过膜。

4. 发明授权

US07872108B2 Processes for isolating proteon nucleation centers (PNCs) from a biological sample obtained from an animal 有权
标题翻译：从动物获得的生物样品中分离蛋白质成核中心（PNC）的过程
公开(公告)号：US07872108B2
公开(公告)日：2011-01-18
申请号：US12107477
申请日：2008-04-22
申请人： Vitaly J. Vodyanoy , Alexandre M. Samoylov , Oleg M. Pustovyy
发明人： Vitaly J. Vodyanoy , Alexandre M. Samoylov , Oleg M. Pustovyy
IPC分类号： C07K1/00
CPC分类号： G01N33/68
摘要： Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form. In another aspect of the invention, the PNCs are comprised of metallic nanoclusters.
摘要翻译：提供了用于分离和操作存在于血液和其他生物材料中的错误折叠或部分错误折叠的蛋白质的组合物和方法。在本发明的一个方面，组合物（以下称为“蛋白质”）由错误折叠的蛋白质组成。还提供了用于分离和操纵在血液和其他生物材料中形成本发明蛋白质的蛋白质成核中心（PNC）的组合物和方法。在本发明的另一方面，PNC由金属纳米团簇组成。

5. 发明授权

US07871772B2 Methods for detecting misfolded proteins in biological samples 有权
标题翻译：检测生物样品中错误折叠的蛋白质的方法
公开(公告)号：US07871772B2
公开(公告)日：2011-01-18
申请号：US11601423
申请日：2006-11-16
申请人： Vitaly J. Vodyanoy , Alexandre M. Samoylov , Oleg M. Pustovyy
发明人： Vitaly J. Vodyanoy , Alexandre M. Samoylov , Oleg M. Pustovyy
IPC分类号： C12Q1/68
CPC分类号： G01N33/5002
摘要： Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form. In another aspect of the invention, the PNCs are comprised of metallic nanoclusters.
摘要翻译：提供了用于分离和操作存在于血液和其他生物材料中的错误折叠或部分错误折叠的蛋白质的组合物和方法。在本发明的一个方面，组合物（以下称为“蛋白质”）由错误折叠的蛋白质组成。还提供了用于分离和操纵在血液和其他生物材料中形成本发明蛋白质的蛋白质成核中心（PNC）的组合物和方法。在本发明的另一方面，PNC由金属纳米团簇组成。

6. 发明授权

US07670765B2 Method of forming monolayers of phage-derived products and used thereof 失效
标题翻译：形成噬菌体衍生产物的单层及其用途的方法
公开(公告)号：US07670765B2
公开(公告)日：2010-03-02
申请号：US11604537
申请日：2006-11-27
申请人： Valery A. Petrenko , Vitaly J. Vodyanoy , Jennifer Cannon Sykora
发明人： Valery A. Petrenko , Vitaly J. Vodyanoy , Jennifer Cannon Sykora
IPC分类号： C12Q1/70
CPC分类号： G01N33/54373 , B82Y5/00 , B82Y30/00
摘要： Methods and compositions for identifying and characterizing the affinity of one or more ligands of a peptide are provided. In particular, a “stripped phage ligand sensor device” (SPLSD) is provided comprising a sensor coupled to a binding element of interest. Binding elements of the invention comprise phage which in most embodiments express a peptide of interest on the phage surface. Assays using the SPLSD allow detection and quantitation of ligands. Also provided are improved methods for forming monolayers using phage. In particular, methods for the formation of monolayers using “stripped phage” are provided. Further provided are monolayers and Langmuir-Blodgett films formed by the methods of the invention as well as substrates having deposited thereon the films of the invention. The monolayers, films and substrates of the invention are useful as components of biosensors and/or chemosensors.
摘要翻译：提供了用于鉴定和表征肽的一个或多个配体的亲和力的方法和组合物。特别地，提供了“剥离的噬菌体配体传感器装置”（SPLSD），其包括耦合到感兴趣的结合元件的传感器。本发明的结合元件包含噬菌体，其在大多数实施方案中在噬菌体表面上表达感兴趣的肽。使用SPLSD的测定允许检测和定量配体。还提供了使用噬菌体形成单层的改进方法。特别地，提供了使用“剥离噬菌体”形成单层的方法。还提供了通过本发明的方法形成的单层和Langmuir-Blodgett膜以及在其上沉积有本发明的膜的基底。本发明的单层，薄膜和底物可用作生物传感器和/或化学传感器的组分。

7. 发明授权

US07267993B2 Phage ligand sensor devices and uses thereof 失效
标题翻译：噬菌体配体传感器装置及其用途
公开(公告)号：US07267993B2
公开(公告)日：2007-09-11
申请号：US10289725
申请日：2002-11-07
申请人： Valery A. Pentrenko , Vitaly J. Vodyanoy , Alexandre M. Samoylov , Iryna Sorokulova , Viswaprakash Nanduri , Bryan A. Chin , James M. Barbaree , W. Charles Neely
发明人： Valery A. Pentrenko , Vitaly J. Vodyanoy , Alexandre M. Samoylov , Iryna Sorokulova , Viswaprakash Nanduri , Bryan A. Chin , James M. Barbaree , W. Charles Neely
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , G01N33/569
摘要： Methods and compositions for identifying and characterizing one or more ligands of a peptide are provided. In particular, the invention provides a phage ligand sensor device (PLSD) comprising a sensor coupled to a binding element of interest. Binding elements of interest comprise phage displaying at least one foreign peptide. The PLSD and assays find particular use in identifying and characterizing ligand-peptide interactions.
摘要翻译：提供了用于鉴定和表征肽的一个或多个配体的方法和组合物。特别地，本发明提供了一种包含耦合到感兴趣的结合元件的传感器的噬菌体配体传感器装置（PLSD）。感兴趣的结合元件包括显示至少一种外源肽的噬菌体。 PLSD和测定法特别用于鉴定和表征配体 - 肽相互作用。

8. 发明授权

US06979298B2 Apparatus and method for the measurement of the aerodynamics of olfaction in animals and man 失效
标题翻译：用于测量动物和人的嗅觉空气动力学的装置和方法
公开(公告)号：US06979298B2
公开(公告)日：2005-12-27
申请号：US10159800
申请日：2002-05-31
申请人： Vitaly J. Vodyanoy , Edward E. Morrison
发明人： Vitaly J. Vodyanoy , Edward E. Morrison
IPC分类号： A01K15/02 , A01K29/00 , A61B5/00 , A61B7/00
CPC分类号： A61B7/003 , A01K15/02 , A01K15/021 , A01K29/00 , A61B5/0002 , A61B5/082 , A61B5/4017 , A61B5/4818
摘要： A system and method for observing, collecting and analyzing olefactory characteristics of a human or animal subject, such as sniffing, breathing and respiratory patterns and sounds. Example applications include the evaluation and training of dogs for explosive and drug detection, clinical diagnostics, scientific research, and identification.
摘要翻译：用于观察，收集和分析人类或动物受试者的嗅觉特征的系统和方法，例如嗅闻，呼吸和呼吸模式和声音。示例应用包括用于爆炸和药物检测，临床诊断，科学研究和鉴定的狗的评估和培训。

9. 发明授权

US08298793B2 Methods for isolating proteons from plasma samples 有权
标题翻译：从血浆样品中分离蛋白质的方法
公开(公告)号：US08298793B2
公开(公告)日：2012-10-30
申请号：US11523250
申请日：2006-09-19
申请人： Vitaly J. Vodyanoy , Alexandre M. Saamoylov , Oleg M. Pustovyy
发明人： Vitaly J. Vodyanoy , Alexandre M. Saamoylov , Oleg M. Pustovyy
IPC分类号： C12P19/34
CPC分类号： G01N33/553 , G01N33/6893 , G01N33/6896 , G01N2510/00 , G01N2800/2828
摘要： Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are misfolded or partially misfolded proteins surrounding a metallic nanocluster, termed “proteon nucleation center” (PNC). Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form.
摘要翻译：提供了用于分离和操作存在于血液和其他生物材料中的错误折叠或部分错误折叠的蛋白质的组合物和方法。在本发明的一个方面，组合物，以下称为蛋白质，被称为蛋白质成核中心（PNC）的金属纳米簇周围的错误折叠或部分错误折叠的蛋白质。还提供了用于分离和操纵在血液和其他生物材料中形成本发明蛋白质的蛋白质成核中心（PNC）的组合物和方法。

10. 发明授权

US07138255B2 Method of isolation and self-assembly of small protein particles from blood and other biological materials 失效
标题翻译：从血液和其他生物材料中分离和自组装小蛋白质颗粒的方法
公开(公告)号：US07138255B2
公开(公告)日：2006-11-21
申请号：US10674750
申请日：2003-09-30
申请人： Vitaly J. Vodyanoy , Alexandre M. Samoylov , Oleg M. Pustovyy
发明人： Vitaly J. Vodyanoy , Alexandre M. Samoylov , Oleg M. Pustovyy
IPC分类号： C12P19/34
CPC分类号： G01N33/5002
摘要： Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form. In another aspect of the invention, the PNCs are comprised of metallic nanoclusters.
摘要翻译：提供了用于分离和操作存在于血液和其他生物材料中的错误折叠或部分错误折叠的蛋白质的组合物和方法。在本发明的一个方面，组合物（以下称为“蛋白质”）由错误折叠的蛋白质组成。还提供了用于分离和操纵在血液和其它生物材料中形成本发明蛋白质的蛋白质成核中心（PNC）的组合物和方法。在本发明的另一方面，PNC由金属纳米团簇组成。

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