专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2010163435A Electroprocessed collagen 审中-公开
标题翻译：电解胶
公开(公告)号：JP2010163435A
公开(公告)日：2010-07-29
申请号：JP2010015403
申请日：2010-01-27
申请人： Virginia Commonwealth Univ Intellectual Property Foundation , ヴァージニアコモンウェルスユニバーシティインテレクチュアルプロパティーファンデーション
发明人： SIMPSON DAVID G , BOWLIN GARY L , WNEK GARY E , STEVENS PETER J , CARR MARCUS E JR , MATTHEWS JAMIL A , RAJENDRAN SARAVANAMOORTHY
IPC分类号： C07K14/78 , A61K8/64 , A61K31/7088 , A61K35/12 , A61K35/39 , A61K38/22 , A61K47/42 , A61K48/00 , A61L27/00 , A61P3/08 , A61P5/48 , A61P9/00 , A61P17/02 , A61P21/00 , A61P43/00 , C12N5/07 , C12Q1/02
摘要： PROBLEM TO BE SOLVED: To provide a collagen material which can be used in forming a biocompatible graft which possesses structural perfection and maintains such perfection after implantation. SOLUTION: Micropipettes 10 filled with a collagen-containing solution are arranged above a grounded target 11 and a wire 12 is placed in the solution to charge the solution in each pipette tip 13 to a high voltage, and a collagen stream 14 is directed towards the grounded target to produce an electroprocessed collagen. The electroprocessed collagen can be constituted or formed from, for example, natural collagen, collagen produced by genetic engineering or collagen modified by conservative amino acid substitutions or non-conservative amino acid substitutions or non-naturally occurring amino acid substitutions. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供可用于形成具有结构完整性并在植入后保持这种完美性的生物相容性移植物的胶原材料。
解决方案：填充有含胶原蛋白溶液的微量移液器10布置在接地靶11上方，并且将线12放置在溶液中以将每个移液管尖端13中的溶液充电至高电压，并且胶原流14 针对接地靶产生电加工胶原。电加工胶原蛋白可以由例如天然胶原蛋白，通过基因工程产生的胶原或通过保守氨基酸取代或非保守氨基酸取代或非天然存在的氨基酸取代而修饰的胶原构成或形成。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2009007357A New bis-platinum complex with polyamine ligand as antitumor agent 有权
标题翻译：具有聚氨基甲酸丁酯的新型双酚钠复合物作为抗菌剂
公开(公告)号：JP2009007357A
公开(公告)日：2009-01-15
申请号：JP2008156473
申请日：2008-06-16
申请人： F Hoffmann La Roche Ag , Virginia Commonwealth Univ , ヴァージニアコモンウェルスユニバーシティ , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人： FARRELL NICHOLAS P , MENTA ERNESTO , DI DOMENICO ROBERTO , SPINELLI SILVANO
IPC分类号： A61P35/00 , C07C269/06 , A61K31/282 , C07C209/08 , C07C209/50 , C07C211/09 , C07C211/14 , C07C237/10 , C07C269/04 , C07C271/16 , C07C271/20 , C07F15/00
CPC分类号： C07C209/50 , C07C269/04 , C07F15/0093 , Y02P20/55 , C07C211/09 , C07C211/14 , C07C271/16
摘要： PROBLEM TO BE SOLVED: To provide a method for producing an intermediate for bis-platinum (II) complex. SOLUTION: The method produces a polyamine represented by formula (III): NH 2 -(CH 2 ) n -A'-(CH 2 ) m -NH 2 . The method includes steps of protecting the nitrogen atom of an ω-aminoacid with a first protecting group, followed by the treatment with a mineral acid, to obtain the free acid first intermediate, reacting the first intermediate with a second intermediate obtained by carrying out mono-protection of a diamine with a second protecting group to produce an amide intermediate, removing the first protecting group and the second protecting group from the amide intermediate to produce a fourth intermediate, reducing the amide moieties of the fourth intermediate to a secondary amine, protecting the primary amine with a third protecting group, protecting the secondary amine with a fourth protecting groups to produce a fifth intermediate, removing the third protecting group from the primary amine in the fifth intermediate to produce a compound represented by formula (III). COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种制备双 - 铂（II）络合物的中间体的方法。解决方案：该方法产生由式（III）表示的多胺：NH 2 -S-（CH 2 SBR） - （CH 2 SBR）（CH 2 ） -NH SB 2。该方法包括用第一保护基保护ω-氨基酸的氮原子，然后用无机酸处理以获得游离酸的第一中间体，使第一中间体与通过进行单体保护具有第二保护基团的二胺以产生酰胺中间体，从酰胺中间体除去第一保护基团和第二保护基团以产生第四中间体，将第四中间体的酰胺部分还原成仲胺，保护伯胺与第三保护基团，用第四保护基团保护仲胺以产生第五中间体，从第五中间体中的伯胺除去第三保护基以制备由式（III）表示的化合物。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2008303216A New bis-platinum complex with polymethylene derivative as ligand having antitumor activity 审中-公开
标题翻译：具有聚甲基衍生物的新型双 - 铂络合物作为具有抗肿瘤活性的配体
公开(公告)号：JP2008303216A
公开(公告)日：2008-12-18
申请号：JP2008135734
申请日：2008-05-23
申请人： F Hoffmann La Roche Ag , Virginia Commonwealth Univ , ヴァージニアコモンウェルスユニバーシティ , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人： FARRELL NICHOLAS P , MENTA ERNESTO , DI DOMENICO ROBERTO , SPINELLI SILVANO
IPC分类号： A61P35/00 , C07C231/12 , A61K31/282 , A61P35/02 , C07C231/02 , C07C231/14 , C07C233/56 , C07C237/10 , C07C273/18 , C07C275/14 , C07C277/08 , C07C279/12 , C07C279/24 , C07C303/34 , C07C307/06 , C07F15/00
CPC分类号： C07C277/08 , C07C231/02 , C07C231/12 , C07C231/14 , C07C273/1809 , C07C273/1818 , C07C303/34 , C07F15/0093 , C07C307/06 , C07C233/56 , C07C237/10 , C07C275/14 , C07C279/12 , C07C279/24
摘要： PROBLEM TO BE SOLVED: To provide a method for producing an intermediate for a bis-platinum (II) complex.
SOLUTION: The method for producing a polymethylene derivative of chemical formula (III) comprises a step of protecting the nitrogen atom of an ω-amino acid with a tert-butyloxycarbonyl group and treating with an inorganic acid to form the first intermediate which is not a chlorinated acid, a step of reacting the first intermediate with a second intermediate formed by a diamine having one amino group protected with about 0.3-0.5 mol of a tert-butyloxycarbonyl group based on 1 mol of the diamine to form the second intermediate, and a step of removing the tert-butyloxycarbonyl group from the second intermediate.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种双 - 铂（II）络合物的中间体的制备方法。解决方案：制备化学式（III）的聚亚甲基衍生物的方法包括用叔丁氧基羰基保护ω-氨基酸的氮原子并用无机酸处理以形成第一中间体的步骤不是氯化酸，使第一中间体与由具有一个氨基的二胺形成的第二中间体反应的步骤，所述二胺具有用约0.3-0.5摩尔叔丁氧基羰基保护的基于1摩尔二胺保护，形成第二中间体，以及从第二中间体除去叔丁氧基羰基的步骤。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2013040340A Electroprocessed phenolic resin material and method 有权
标题翻译：电化学酚醛树脂材料与方法
公开(公告)号：JP2013040340A
公开(公告)日：2013-02-28
申请号：JP2012220702
申请日：2012-10-02
申请人： Virginia Commonwealth Univ , ヴァージニアコモンウェルスユニヴァーシティーVirginia Commonwealth University , Philip Morris Usa Inc , フィリップモリスユーエスエーインコーポレイテッドPhilip Morris Usa Inc.
发明人： GEE DIANE , WNEK GARY , LAYMAN JOHN , KARLES GEORGIOS D , ZHUANG MARK
IPC分类号： C08J3/12 , A24B15/28 , A24D3/16 , C01B31/08 , C08J9/26 , D01D5/00 , D01F9/20
CPC分类号： D01F9/24 , A24D3/163 , C01B32/30 , D01D5/0007 , D01D5/003 , D01F1/10 , D01F6/50 , D01F6/76
摘要： PROBLEM TO BE SOLVED: To provide a method for preparing a minute phenolic resin bead capable of having micropores on carbonization.SOLUTION: This method for preparing a phenolic resin bead includes: (a) a step of providing a phenolic polymeric system; and (b) a step of preparing a phenolic resin bead having 100 nm to 10 μm diameter by electrostatically spraying the phenolic polymeric system.
摘要翻译：要解决的问题：提供一种制备能够在碳化上具有微孔的微小酚醛树脂珠粒的方法。酚醛树脂珠粒的制备方法包括：（a）提供酚醛聚合体系的步骤; 和（b）通过静电喷涂酚醛聚合物体系制备直径为100nm至10μm的酚醛树脂珠粒的步骤。版权所有（C）2013，JPO＆INPIT

5. 发明专利

JP2011131076A Engineered muscle 审中-公开
标题翻译：工程肌肉
公开(公告)号：JP2011131076A
公开(公告)日：2011-07-07
申请号：JP2011069980
申请日：2011-03-28
申请人： Virginia Commonwealth Univ Intellectual Property Foundation , ヴァージニアコモンウェルスユニバーシティインテレクチュアルプロパティーファンデーション
发明人： BOWLIN GARY , WNEK GARY , SIMPSON DAVID , TERRACIO LOUIS
IPC分类号： A61L27/00 , A61F2/08 , A61L27/18 , A61L27/24 , A61L27/34 , A61L27/38 , A61L27/50
CPC分类号： A61L27/383 , A61F2/08 , A61L27/18 , A61L27/24 , A61L27/34 , A61L27/3817 , A61L27/3826 , A61L27/3843 , A61L27/507 , A61L2430/30 , C08L67/04 , C08L89/06
摘要： PROBLEM TO BE SOLVED: To provide a muscle implant to a host in need thereof. SOLUTION: An extracellular matrix includes a matrix of electroaerosol droplets. The droplets are discharged from one or more electrically charged orifice to a grounded substrate to form the matrix. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：为有需要的宿主提供肌肉植入物。解决方案：细胞外基质包括电溶质液滴的基质。液滴从一个或多个充电孔排出到接地的基板上以形成基体。版权所有（C）2011，JPO＆INPIT

6. 发明专利

AU2007219278A1 Electroprocessed fibrin-based matrices and tissues 未知
公开(公告)号：AU2007219278A1
公开(公告)日：2007-10-18
申请号：AU2007219278
申请日：2007-09-24
申请人： VIRGINIA COMMONWEALTH UNIV INTELLECTUAL PROPERTY FOUNDATION
发明人： CARR MARCUS E JR , SIMPSON DAVID G , LAM PHILIPPE , BOWLIN GARY L , WNEK GARY E
IPC分类号： C12Q1/02 , A61K8/64 , A61K8/96 , A61K35/12 , A61K38/36 , A61K47/42 , A61L15/32 , A61L27/00 , A61L27/22 , A61L27/24 , A61L27/26 , A61L27/38 , A61L31/04 , A61P7/04 , A61P17/02 , B29C41/00 , C07K1/00 , C07K14/75 , C07K14/78 , C12N5/00 , C12N5/06

7. 发明专利

PT623213E 未知
公开(公告)号：PT623213E
公开(公告)日：2000-10-31
申请号：PT93904657
申请日：1993-01-15
申请人： VIRGINIA COMMONWEALTH UNIV INT
发明人： CARR MARCUS E JR
IPC分类号： G01N33/487 , G01N33/49 , G01N33/86 , G01N33/48 , G01N3/08
摘要： The performance of platelets can be best understood by monitoring both the force development and the elastic modulus of the blood clot during both clotting and dissolution of the blood clot. Intermittent application and removal of a compressive force on a blood sample (8) positioned between a pair of plates (12 and 14) throughout clot formation and dissolution provides a standard for using voltage output from a transducer (22) to determine force and elastic modulus parameters. Force development arises from the internal actions of the platelets during clot retraction. Elastic modulus provides a measure of the stiffness of the clot. Clotting can be measured as an increase in force development and clot elastic modulus. Clot dissolution can be determined by a dramatic decrease in force development and in elastic modulus. Providing the blood sample with a clot dissolving agent such as tPA allows determining the fibrinolytic potential of whole blood and, thus, aids in identifying patients at risk for thrombosis due to a decreased ability to dissolve clots. Clot elastic modulus provides a measure of erythrocyte flexibility.

8. 发明专利

CA3096484A1 IRON OXIDE NANOWIRES BASED FILTER FOR THE INACTIVATION OF PATHOGENS 未知
公开(公告)号：CA3096484A1
公开(公告)日：2019-10-24
申请号：CA3096484
申请日：2019-04-18
申请人： VIRGINIA COMMONWEALTH UNIV INTELLECTUAL PROPERTY FOUNDATION
发明人： WANG WEINING , WANG DAWEI , XU PING , ZHU BIN
IPC分类号： B82Y30/00 , C01G49/02
摘要： Disclosed herein are embodiments of filtration systems and iron oxide nanowire-based filter meshes that can capture and inactivate pathogens in air. The filter meshes can include a porous lattice of iron metal and iron oxide nanowires radiating from the porous lattice of iron metal. The iron oxide nanowires radiating from the porous lattice of iron metal can be created by processing the filter mesh using the disclosed method. Pathogens can be inactivated by passing a sample containing the pathogens through the filter mesh and inactivating at least a portion of the pathogens as the sample passes through the filter mesh.

9. 发明专利

AU2011204877A1 Electroprocessing in drug delivery and cell encapsulation 未知
公开(公告)号：AU2011204877A1
公开(公告)日：2011-08-11
申请号：AU2011204877
申请日：2011-07-20
申请人： VIRGINIA COMMONWEALTH UNIV INTELLECTUAL PROPERTY FOUNDATION
发明人： DAVID SIMPSON , BOWLIN GARY L , WNEK GARY E
IPC分类号： C07K14/75 , A61K9/00 , A61K31/65 , A61K35/12 , A61K38/22 , A61K41/00 , A61K45/00 , A61K47/16 , A61K47/26 , A61K47/30 , A61K47/42 , A61L15/32 , A61L27/22 , A61L27/24 , A61L27/26 , A61L27/38 , A61L31/04 , A61P3/10 , A61P17/02 , A61P19/00 , A61P31/04 , A61P43/00 , B29C41/00 , B29C67/00 , C07K14/78 , C12N5/00
摘要： The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more natural materials, one or more synthetic materials, or a combination thereof. The substance can be one or more therapeutic or cosmetic substances or other compounds, molecules, cells, vesicles. The compositions can be used in substance delivery, including drug delivery within an organism by, for example, releasing substances or containing cells that release substances. The compositions can be used for other purposes, such as prostheses or similar implants.

10. 发明专利

AU2011203262A1 Electroprocessed fibrin-based matrices and tissues 未知
公开(公告)号：AU2011203262A1
公开(公告)日：2011-07-21
申请号：AU2011203262
申请日：2011-07-04
申请人： VIRGINIA COMMONWEALTH UNIV INTELLECTUAL PROPERTY FOUNDATION
发明人： SIMPSON DAVID G , WNEK GARY E , PHILIPPE LAM , CARR JR MARCUS E , BOWLIN GARY L
IPC分类号： C12Q1/02 , A61K8/64 , A61K8/96 , A61K35/12 , A61K38/36 , A61K47/42 , A61L15/32 , A61L27/00 , A61L27/22 , A61L27/24 , A61L27/26 , A61L27/38 , A61L31/04 , A61P7/04 , A61P17/02 , B29C41/00 , C07K1/00 , C07K14/75 , C07K14/78 , C12N5/00
摘要： The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed fibrin may also be combined with other molecules in order to deliver the molecules to the site of application or implantation of the electroprocessed fibrin. The fibrin or fibrin/cell suspension is electrodeposited onto a substrate to form the tissues and organs.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式