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1. 发明申请

US20050137172A1 Haloacetamide and azide substituted compounds and methods of use thereof 审中-公开
标题翻译：卤代乙酰胺和叠氮化物取代的化合物及其使用方法
公开(公告)号：US20050137172A1
公开(公告)日：2005-06-23
申请号：US10963761
申请日：2004-10-14
申请人： James Dalton , Duane Miller , Vipin Nair , Huiping Xu
发明人： James Dalton , Duane Miller , Vipin Nair , Huiping Xu
IPC分类号： A61K31/165 , A61K31/21 , A61K31/277 , A61K31/655 , A61K31/66 , C07C235/24 , C07C255/60 , C07D207/44 , C07D207/452 , A61K31/195 , A61K31/32 , A61K31/4015
CPC分类号： C07D207/452 , C07C235/24 , C07C255/60
摘要： The present invention relates to a novel class of anti-cancer compounds, which contain a haloacetamide or azide moiety and are, in one embodiment, alkylating agents. These agents, either alone or in a composition, are useful for treating cancer, preventing cancer, delaying the progression of cancer, treating and/or preventing the recurrence of cancer, suppressing, inhibiting or reducing the incidence of cancer, or inducing apoptosis in a cancer cell. Accordingly, the present invention provides a) methods of treating cancer in a subject; b) methods of preventing cancer in a subject; c) methods of delaying the progression of cancer in a subject; d) methods of treating the recurrence of cancer in a subject; e) methods of preventing the recurrence of cancer in a subject; f) methods of suppressing, inhibiting or reducing the incidence of cancer in a subject; and g) methods of inducing apoptosis in a cancer cell; by administering to the subject an anti-cancer compound of the present invention or an analog or metabolite thereof, its N-oxide, ester, pharmaceutically acceptable salt, hydrate, or any combination thereof as described herein.
摘要翻译：本发明涉及一类新的抗癌化合物，其含有卤代乙酰胺或叠氮化物部分，在一个实施方案中是烷化剂。这些药物单独或组合物可用于治疗癌症，预防癌症，延缓癌症进展，治疗和/或预防癌症复发，抑制，抑制或降低癌症发生率或诱导癌细胞凋亡癌细胞。因此，本发明提供了a）在受试者中治疗癌症的方法; b）预防受试者癌症的方法; c）延缓受试者癌症进展的方法; d）治疗患者癌症复发的方法; e）预防受试者癌症复发的方法; f）抑制或抑制受试者癌症发病率的方法; 和g）诱导癌细胞凋亡的方法; 通过向受试者施用本文所述的抗癌化合物或其类似物或代谢物，其N-氧化物，酯，药学上可接受的盐，水合物或其任何组合。

2. 发明申请

US20050085449A1 Haloacetamide and azide substituted compounds and methods of use thereof 审中-公开
公开(公告)号：US20050085449A1
公开(公告)日：2005-04-21
申请号：US10684582
申请日：2003-10-15
申请人： James Dalton , Duane Miller , Huiping Xu , Vipin Nair
发明人： James Dalton , Duane Miller , Huiping Xu , Vipin Nair
IPC分类号： A61K31/165 , A61K31/21 , A61K31/277 , A61K31/655 , A61K31/66 , C07C235/24 , C07C255/60 , C07D207/44 , C07D207/452
CPC分类号： C07D207/452 , A61K31/165 , A61K31/21 , A61K31/277 , A61K31/655 , A61K31/66 , C07C235/24 , C07C255/60
摘要： The present invention relates to a novel class of anti-cancer compounds, which contain a haloacetamide or azide moiety and are, in one embodiment, alkylating agents. These agents, either alone or in a composition, are useful for treating cancer, preventing cancer, delaying the progression of cancer, treating and/or preventing the recurrence of cancer, suppressing, inhibiting or reducing the incidence of cancer, or inducing apoptosis in a cancer cell. Accordingly, the present invention provides a) methods of treating cancer in a subject; b) methods of preventing cancer in a subject; c) methods of delaying the progression of cancer in a subject; d) methods of treating the recurrence of cancer in a subject; e) methods of preventing the recurrence of cancer in a subject; f) methods of suppressing, inhibiting or reducing the incidence of cancer in a subject; and g) methods of inducing apoptosis in a cancer cell; by administering to the subject an anti-cancer compound of the present invention or an analog or metabolite thereof, its N-oxide, ester, pharmaceutically acceptable salt, hydrate, or any combination thereof as described herein.

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