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    • 1. 发明申请
    • Haloacetamide and azide substituted compounds and methods of use thereof
    • 卤代乙酰胺和叠氮化物取代的化合物及其使用方法
    • US20050137172A1
    • 2005-06-23
    • US10963761
    • 2004-10-14
    • James DaltonDuane MillerVipin NairHuiping Xu
    • James DaltonDuane MillerVipin NairHuiping Xu
    • A61K31/165A61K31/21A61K31/277A61K31/655A61K31/66C07C235/24C07C255/60C07D207/44C07D207/452A61K31/195A61K31/32A61K31/4015
    • C07D207/452C07C235/24C07C255/60
    • The present invention relates to a novel class of anti-cancer compounds, which contain a haloacetamide or azide moiety and are, in one embodiment, alkylating agents. These agents, either alone or in a composition, are useful for treating cancer, preventing cancer, delaying the progression of cancer, treating and/or preventing the recurrence of cancer, suppressing, inhibiting or reducing the incidence of cancer, or inducing apoptosis in a cancer cell. Accordingly, the present invention provides a) methods of treating cancer in a subject; b) methods of preventing cancer in a subject; c) methods of delaying the progression of cancer in a subject; d) methods of treating the recurrence of cancer in a subject; e) methods of preventing the recurrence of cancer in a subject; f) methods of suppressing, inhibiting or reducing the incidence of cancer in a subject; and g) methods of inducing apoptosis in a cancer cell; by administering to the subject an anti-cancer compound of the present invention or an analog or metabolite thereof, its N-oxide, ester, pharmaceutically acceptable salt, hydrate, or any combination thereof as described herein.
    • 本发明涉及一类新的抗癌化合物,其含有卤代乙酰胺或叠氮化物部分,在一个实施方案中是烷化剂。 这些药物单独或组合物可用于治疗癌症,预防癌症,延缓癌症进展,治疗和/或预防癌症复发,抑制,抑制或降低癌症发生率或诱导癌细胞凋亡 癌细胞。 因此,本发明提供了a)在受试者中治疗癌症的方法; b)预防受试者癌症的方法; c)延缓受试者癌症进展的方法; d)治疗患者癌症复发的方法; e)预防受试者癌症复发的方法; f)抑制或抑制受试者癌症发病率的方法; 和g)诱导癌细胞凋亡的方法; 通过向受试者施用本文所述的抗癌化合物或其类似物或代谢物,其N-氧化物,酯,药学上可接受的盐,水合物或其任何组合。