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1. 发明申请

US20120130057A1 Compounds related to assays 有权
标题翻译：与测定相关的化合物
公开(公告)号：US20120130057A1
公开(公告)日：2012-05-24
申请号：US13374995
申请日：2012-01-27
申请人： Jianjun He , Anita Hong , Qingheng Wang , Raman Khosrow Afshar , Ming Zhu , Vera Rakhmanova
发明人： Jianjun He , Anita Hong , Qingheng Wang , Raman Khosrow Afshar , Ming Zhu , Vera Rakhmanova
IPC分类号： C07D311/90
CPC分类号： C09B7/00 , Y10T436/18 , Y10T436/182
摘要： The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair.
摘要翻译：本发明一般涉及硫醇定量测定，进行测定的方法和用于测定中的化合物。更具体地涉及包括一种或多种二硫化物和相关分子和方法的测定。二硫化物含有FRET对。

2. 发明申请

US20100279328A1 Fret assays, methods for performing the assays and compounds relevant to the assays 审中-公开
标题翻译： Fret测定，用于进行测定的方法和与测定相关的化合物
公开(公告)号：US20100279328A1
公开(公告)日：2010-11-04
申请号：US12658447
申请日：2010-02-05
申请人： Anita Hong , Vera Rakhmanova , Xiao-He Tong
发明人： Anita Hong , Vera Rakhmanova , Xiao-He Tong
IPC分类号： C12Q1/34 , C12N9/48
CPC分类号： G01N33/542 , C07K7/06 , G01N33/582 , G01N2333/95
摘要： The present invention is generally directed to biological assays. More specifically it is directed to FRET-based assays using particularly effecting FRET pairs, methods for performing such assays and the molecules utilized in the assays. In a composition aspect, the present invention is directed to a FRET-based protease substrate selected from the list of substrates shown in the Detailed Description section above. In a method aspect, the present invention is directed to a method of performing a FRET-based assay, where the assay includes the following steps: adding a solution or suspension containing one or more different proteins to a reaction vessel; adding a liquid comprising a FRET-substrate to the reaction vessel, wherein the FRET-substrate is selected from the list of substrates shown in the Detailed Description section above. In a kit aspect, the present invention is directed to a kit for performing a FRET-based assay, wherein the kit comprises a protease substrate. The protease substrate is selected from the list of substrates shown in the Detailed Description section above.
摘要翻译：本发明一般涉及生物测定。更具体地，其涉及使用特别有效的FRET对的FRET-测定法，用于进行此类测定的方法和用于测定中的分子。在组合物方面，本发明涉及选自上述详细描述部分中所示的基材列表的基于FRET的蛋白酶底物。在方法方面，本发明涉及一种进行基于FRET的测定法，其中测定法包括以下步骤：向反应容器中加入含有一种或多种不同蛋白质的溶液或悬浮液; 向反应容器中加入包含FRET-底物的液体，其中FRET-基材选自上述详细描述部分所示的基材列表。在试剂盒方面，本发明涉及用于进行基于FRET的测定的试剂盒，其中所述试剂盒包含蛋白酶底物。蛋白酶底物选自上述详细描述部分中所示的底物列表。

3. 发明申请

US20080108630A1 SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION 审中-公开
标题翻译：取代三唑作为PPAR的调节剂及其制备方法
公开(公告)号：US20080108630A1
公开(公告)日：2008-05-08
申请号：US11932755
申请日：2007-10-31
申请人： Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine Gregoire , Vera Rakhmanova
发明人： Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine Gregoire , Vera Rakhmanova
IPC分类号： A61K31/497 , A61P3/06 , A61P3/10 , A61K31/4192 , C07D403/06 , C07D249/04
CPC分类号： C07D249/06 , C07D409/10
摘要： The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.
摘要翻译：本发明涉及由式I表示的某些新颖的三唑化合物及其药学上可接受的盐，溶剂合物，水合物和前药。本发明还涉及制备和使用这些化合物和含有这些化合物的药物组合物的方法，以治疗或控制PPAR介导的许多疾病，例如葡萄糖代谢，脂质代谢和胰岛素分泌，特别是2型糖尿病，高胰岛素血症，高脂血症高尿酸血症，高胆固醇血症，动脉粥样硬化，心血管疾病的一个或多个危险因素，X综合征，高甘油三酯血症，高血糖症，肥胖症和进食障碍。

4. 发明申请

US20060014809A1 Substituted triazoles as modulators of PPAR and methods of their preparation 有权
标题翻译：取代三唑作为PPAR的调节剂及其制备方法
公开(公告)号：US20060014809A1
公开(公告)日：2006-01-19
申请号：US11137678
申请日：2005-05-24
申请人： Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine Gregoire , Vera Rakhmanova
发明人： Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine Gregoire , Vera Rakhmanova
IPC分类号： A61K31/4192 , C07D249/04
CPC分类号： C07D249/06 , C07D409/10
摘要： The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.
摘要翻译：本发明涉及由式I表示的某些新颖的三唑化合物及其药学上可接受的盐，溶剂合物，水合物和前药。本发明还涉及制备和使用这些化合物和含有这些化合物的药物组合物的方法，以治疗或控制PPAR介导的许多疾病，例如葡萄糖代谢，脂质代谢和胰岛素分泌，特别是2型糖尿病，高胰岛素血症，高脂血症高尿酸血症，高胆固醇血症，动脉粥样硬化，心血管疾病的一个或多个危险因素，X综合征，高甘油三酯血症，高血糖症，肥胖症和进食障碍。

5. 发明申请

US20110027900A1 Thiol quantitation assays and related methods 有权
标题翻译：硫醇定量测定及相关方法
公开(公告)号：US20110027900A1
公开(公告)日：2011-02-03
申请号：US12804739
申请日：2010-07-28
申请人： Jianjun He , Anita Hong , Qingzheng Wang , Raman Khosrow Afshar , Ming Zhu , Vera Rakhmanova
发明人： Jianjun He , Anita Hong , Qingzheng Wang , Raman Khosrow Afshar , Ming Zhu , Vera Rakhmanova
IPC分类号： G01N33/00 , C09B29/36
CPC分类号： C09B7/00 , Y10T436/18 , Y10T436/182
摘要： The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair.
摘要翻译：本发明一般涉及硫醇定量测定，进行测定的方法和用于测定中的化合物。更具体地涉及包括一种或多种二硫化物和相关分子和方法的测定。二硫化物含有FRET对。

6. 发明申请

US20060014785A1 BICYCLIC, SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION 审中-公开
标题翻译：作为PPAR的调节剂的双相，取代三唑类及其制备方法
公开(公告)号：US20060014785A1
公开(公告)日：2006-01-19
申请号：US11137679
申请日：2005-05-24
申请人： Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine Gregoire , Vera Rakhmanova
发明人： Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine Gregoire , Vera Rakhmanova
IPC分类号： A61K31/4709 , C07D403/02
CPC分类号： C07D403/12 , C07D403/06 , C07D403/14 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.
摘要翻译：本发明涉及由式I表示的某些新颖的三唑化合物及其药学上可接受的盐，溶剂合物，水合物和前药。本发明还涉及制备和使用这些化合物和含有这些化合物的药物组合物的方法，以治疗或控制PPAR介导的许多疾病，例如葡萄糖代谢，脂质代谢和胰岛素分泌，特别是2型糖尿病，高胰岛素血症，高脂血症高尿酸血症，高胆固醇血症，动脉粥样硬化，心血管疾病的一个或多个危险因素，X综合征，高甘油三酯血症，高血糖症，肥胖症和进食障碍。

7. 发明授权

US08420402B2 Compounds related to assays 有权
标题翻译：与测定相关的化合物
公开(公告)号：US08420402B2
公开(公告)日：2013-04-16
申请号：US13374995
申请日：2012-01-27
申请人： Jianjun He , Anita Hong , Qingheng Wang , Raman Khosrow Afshar , Ming Zhu , Vera Rakhmanova
发明人： Jianjun He , Anita Hong , Qingheng Wang , Raman Khosrow Afshar , Ming Zhu , Vera Rakhmanova
IPC分类号： C09B29/16 , G01N33/52 , C07D311/82 , C07D311/86 , C07D311/88
CPC分类号： C09B7/00 , Y10T436/18 , Y10T436/182
摘要： The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair.
摘要翻译：本发明一般涉及硫醇定量测定，进行测定的方法和用于测定中的化合物。更具体地涉及包括一种或多种二硫化物和相关分子和方法的测定。二硫化物含有FRET对。

8. 发明授权

US08129193B2 Thiol quantitation assays and related methods 有权
标题翻译：硫醇定量测定及相关方法
公开(公告)号：US08129193B2
公开(公告)日：2012-03-06
申请号：US12804739
申请日：2010-07-28
申请人： Jianjun He , Anita Hong , Qingzheng Wang , Raman Khosrow Afshar , Ming Zhu , Vera Rakhmanova
发明人： Jianjun He , Anita Hong , Qingzheng Wang , Raman Khosrow Afshar , Ming Zhu , Vera Rakhmanova
IPC分类号： G01N33/52 , C09B29/16 , C07D311/82 , C07D311/86 , C07D311/88
CPC分类号： C09B7/00 , Y10T436/18 , Y10T436/182
摘要： The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair.
摘要翻译：本发明一般涉及硫醇定量测定，进行测定的方法和用于测定中的化合物。更具体地涉及包括一种或多种二硫化物和相关分子和方法的测定。二硫化物含有FRET对。

9. 发明申请

US20060058301A1 Modulators of PPAR and methods of their preparation 失效
公开(公告)号：US20060058301A1
公开(公告)日：2006-03-16
申请号：US11202963
申请日：2005-08-11
申请人： Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine Gregoire , Vera Rakhmanova
发明人： Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine Gregoire , Vera Rakhmanova
IPC分类号： A61K31/4965 , A61K31/50 , A61K31/506 , A61K31/53 , C07D403/02
CPC分类号： C07D263/57 , C07D249/06 , C07D249/20 , C07D403/12 , C07D409/10
摘要： The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulinemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity and eating disorders.

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