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1. 发明专利

AU4238600A Beta-lactamase inhibiting compounds 未知
公开(公告)号：AU4238600A
公开(公告)日：2000-11-02
申请号：AU4238600
申请日：2000-04-14
申请人： RES CORP TECHNOLOGIES INC , JOHN D BUYNAK , SRINIVASA RAO A , GREG C ADAM , SIRISHKUMAR D NIDAMARTHY , VENKATA RAMANA DOPPALAPUDI
发明人： BUYNAK JOHN D , RAO A SRINIVASA , ADAM GREG C , NIDAMARTHY SIRISHKUMAR D , DOPPALAPUDI VENKATA RAMANA
IPC分类号： A61K31/545 , A61K31/546 , A61P31/00 , A61P31/04 , C07D501/00

2. 发明授权

US08293714B2 Anti-angiogenic compounds 有权
标题翻译：抗血管生成化合物
公开(公告)号：US08293714B2
公开(公告)日：2012-10-23
申请号：US12432528
申请日：2009-04-29
申请人： Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
发明人： Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
IPC分类号： A61K38/16
CPC分类号： A61K47/48215 , A61K47/48246 , A61K47/48415 , A61K47/48507 , A61K47/60 , A61K47/64 , A61K47/6811 , A61K47/6835 , C07K14/71
摘要： The present invention provides VEGF binding peptides. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules. Various uses of the peptides and compounds are provided, including methods to treat disorders associated with abnormal angiogenesis.
摘要翻译：本发明提供VEGF结合肽。此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽。提供肽和化合物的各种用途，包括治疗与异常血管发生相关的疾病的方法。

3. 发明授权

US07163923B2 Peptide deformylase activated prodrugs 有权
标题翻译：肽变性酶活化的前药
公开(公告)号：US07163923B2
公开(公告)日：2007-01-16
申请号：US10142089
申请日：2002-05-09
申请人： Maria V. Sergeeva , Venkata Ramana Doppalapudi
发明人： Maria V. Sergeeva , Venkata Ramana Doppalapudi
IPC分类号： C07K5/06
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/556 , A61K47/67 , C07K5/0606 , C07K5/06191 , Y02A50/473
摘要： This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting the microorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gram-negative microorganism, e.g., S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, E. cloacae, M. catarrhalis, E. coli, E. faecalis, H. influenzae and P. aeruginosa. This method can be practiced in vitro, ex vivo and in vivo. Further provided is a method for alleviating the symptoms of an infection by a Peptide Deformylase expressing microorganism in a subject by administering or delivering to the subject an effective amount of the compound described above.
摘要翻译：本发明提供了通过使微生物与有效量的本文所述化合物接触来抑制表达肽脱甲硅烷基化酶的微生物生长的方法。该方法抑制革兰氏阳性和革兰氏阴性微生物的生长，例如金黄色葡萄球菌，表皮葡萄球菌，肺炎支原体，产气肠杆菌，阴沟肠杆菌，卡他莫拉菌，大肠杆菌，粪肠球菌，H 流感嗜血杆菌和铜绿假单胞菌。该方法可以在体外，离体和体内实施。还提供了一种通过向受试者施用或递送有效量的上述化合物来减轻受试者中表达肽变态酶的微生物的感染症状的方法。

4. 发明申请

US20080152660A1 Anti-Angiogenic Compounds 审中-公开
标题翻译：抗血管生成化合物
公开(公告)号：US20080152660A1
公开(公告)日：2008-06-26
申请号：US11817668
申请日：2006-03-03
申请人： Curt W. Bradshaw , Venkata Ramana Doppalapudi , Jing-Yu Lai , John Rizzo
发明人： Curt W. Bradshaw , Venkata Ramana Doppalapudi , Jing-Yu Lai , John Rizzo
IPC分类号： A61K39/395 , C07K7/00 , A61K38/08
CPC分类号： C07K7/02 , A61K38/00 , C07K7/06 , C07K16/40 , C07K2319/30
摘要： The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
摘要翻译：本发明提供了AA靶向化合物，其包含与抗体的组合位点连接的AA靶向剂 - 接头缀合物。提供了化合物的各种用途，包括治疗与异常血管发生相关的病症的方法。

5. 发明授权

US07125986B2 Penicillanic acid derivative compounds and methods of making 有权
标题翻译：青霉烷酸衍生物及其制备方法
公开(公告)号：US07125986B2
公开(公告)日：2006-10-24
申请号：US10855053
申请日：2004-05-27
申请人： John D. Buynak , Akireddy Srinivasa Rao , Venkata Ramana Doppalapudi
发明人： John D. Buynak , Akireddy Srinivasa Rao , Venkata Ramana Doppalapudi
IPC分类号： C07D499/04 , C07D499/87
CPC分类号： C07D499/00
摘要： Compounds of formula I: wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting β-lactamase enzymes, for enhancing the activity of β-lactam antibiotics, and for treating β-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.
摘要翻译：式I的化合物：其中R 1，R 2，R 3，R 4和n具有以下任何一种：说明书中定义的值及其药学上可接受的盐可用于抑制β-内酰胺酶，用于增强β-内酰胺抗生素的活性，以及用于治疗哺乳动物中的β-内酰胺抗性细菌感染。本发明还提供药物组合物，制备式I化合物的方法和可用于合成式I化合物的新中间体。

6. 发明授权

US08937048B2 Anti-angiogenic compounds 有权
标题翻译：抗血管生成化合物
公开(公告)号：US08937048B2
公开(公告)日：2015-01-20
申请号：US13595250
申请日：2012-08-27
申请人： Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
发明人： Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
IPC分类号： A61K38/10 , C07K14/00 , C07K14/515 , A61K47/48 , C07K14/71
CPC分类号： A61K47/48215 , A61K47/48246 , A61K47/48415 , A61K47/48507 , A61K47/60 , A61K47/64 , A61K47/6811 , A61K47/6835 , C07K14/71
摘要： The present invention provides various uses of VEGF binding peptides, including methods to treat disorders associated with abnormal angiogenesis. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules.
摘要翻译：本发明提供VEGF结合肽的各种用途，包括治疗与异常血管发生相关的疾病的方法。此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽。

7. 发明授权

US06770759B2 Penicillanic acid derivative compounds and methods of making 失效
标题翻译：青霉烷酸衍生物及其制备方法
公开(公告)号：US06770759B2
公开(公告)日：2004-08-03
申请号：US10163684
申请日：2002-06-05
申请人： John D. Buynak , Akireddy Srinivasa Rao , Venkata Ramana Doppalapudi
发明人： John D. Buynak , Akireddy Srinivasa Rao , Venkata Ramana Doppalapudi
IPC分类号： C07D49904
CPC分类号： C07D499/00
摘要： Compound of formula I: wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting &bgr;-lactamase enzymes, for enhancing the activity of &bgr;-lactam antibiotics, and for treating &bgr;-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.
摘要翻译：式I化合物：其中R 1，R 2，R 3，R 4和n具有说明书中定义的任何值及其药学上可接受的盐，可用于抑制β-内酰胺酶酶，用于增强β-内酰胺抗生素的活性，以及用于治疗哺乳动物中的β-内酰胺抗性细菌感染。本发明还提供药物组合物，制备式I化合物的方法和可用于合成式I化合物的新中间体。

8. 发明授权

US6156745A 2.beta.-substituted-6-alkylidene penicillanic acid derivatives as .beta.-lactamase inhibitors 有权
标题翻译： 2β-取代-6-亚烷基青霉烷酸衍生物作为β-内酰胺酶抑制剂
公开(公告)号：US6156745A
公开(公告)日：2000-12-05
申请号：US223077
申请日：1998-12-29
申请人： John D. Buynak , Akireddy Srinivasa Rao , Venkata Ramana Doppalapudi
发明人： John D. Buynak , Akireddy Srinivasa Rao , Venkata Ramana Doppalapudi
IPC分类号： A61K31/43 , C07D499/00 , C07D499/04 , C07D499/44 , C07D499/86 , C07D499/87 , C07D499/897 , C12N9/99 , A61D31/04
CPC分类号： C07D499/00
摘要： Compounds of formula I: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting .beta.-lactamase enzymes, for enhancing the activity of .beta.-lactam antibiotics, and for treating .beta.-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.
摘要翻译：式I化合物：其中R1，R2，R3，R4和n具有说明书中定义的任何值及其药学上可接受的盐，可用于抑制β-内酰胺酶，以增强β-内酰胺抗生素的活性，并用于治疗哺乳动物中的β-内酰胺抗性细菌感染。本发明还提供药物组合物，制备式I化合物的方法和可用于合成式I化合物的新中间体。

9. 发明申请

US20110087010A1 ANTI-ANGIOGENIC COMPOUNDS 审中-公开
标题翻译：抗生素化合物
公开(公告)号：US20110087010A1
公开(公告)日：2011-04-14
申请号：US12897594
申请日：2010-10-04
申请人： Curt W. BRADSHAW , Venkata Ramana DOPPALAPUDI , Jing-Yu LAI , John RIZZO
发明人： Curt W. BRADSHAW , Venkata Ramana DOPPALAPUDI , Jing-Yu LAI , John RIZZO
IPC分类号： C07K16/00 , C07D205/08
CPC分类号： C07K7/02 , A61K38/00 , C07K7/06 , C07K16/40 , C07K2319/30
摘要： The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
摘要翻译：本发明提供了AA靶向化合物，其包含与抗体的组合位点连接的AA靶向剂 - 接头缀合物。提供了化合物的各种用途，包括治疗与异常血管发生相关的病症的方法。

10. 发明申请

US20100003267A1 ANTI-ANGIOGENIC COMPOUNDS 有权
标题翻译：抗生素化合物
公开(公告)号：US20100003267A1
公开(公告)日：2010-01-07
申请号：US12432528
申请日：2009-04-29
申请人： Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
发明人： Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
IPC分类号： A61K39/395 , C07K14/00 , C07K19/00
CPC分类号： A61K47/48215 , A61K47/48246 , A61K47/48415 , A61K47/48507 , A61K47/60 , A61K47/64 , A61K47/6811 , A61K47/6835 , C07K14/71
摘要： The present invention provides VEGF binding peptides. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules. Various uses of the peptides and compounds are provided, including methods to treat disorders associated with abnormal angiogenesis.
摘要翻译：本发明提供VEGF结合肽。此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽。提供肽和化合物的各种用途，包括治疗与异常血管发生相关的疾病的方法。

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