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1. 发明申请

WO2022223063A1 PROBIOTIC PRODUCT AND USE THEREOF 审中-公开
公开(公告)号：WO2022223063A1
公开(公告)日：2022-10-27
申请号：PCT/CZ2022/050031
申请日：2022-03-22
申请人： VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V. V. I.
发明人： RYCHLIK, Ivan , FALDYNOVA, Marcela , KUBASOVA, Tereza , VOLF, Jiri , JURICOVA, Helena , MATIASOVICOVA, Jitka , KARASOVA, Daniela , CRHANOVA, Magdalena , SEBKOVA, Alena , SEIDLEROVA, Zuzana , CIZEK, Alois
IPC分类号： C12N1/20 , A61K35/741
摘要： The invention provides a probiotic product for poultry, which contains a mixture of bacteria Bacteroides caecicola, Bacteroides caecigallinarum, Megasphaera sp. and Mediterranea sp. as an active ingredient. The product is destined for use for therapeutic or prophylactic treatment or improvement of physiological condition of the gastrointestinal tract of poultry.

2. 发明申请

WO2013104346A1 LIPOPOLYAMINES OF SPERMINE TYPE FOR CONSTRUCTION OF LIPOSOMAL TRANSFECTION SYSTEMS 审中-公开
标题翻译：用于构建脂肪转运系统的脂质体类型的磷脂酰胺
公开(公告)号：WO2013104346A1
公开(公告)日：2013-07-18
申请号：PCT/CZ2013/000004
申请日：2013-01-14
申请人： USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. , VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V.V.I.
发明人： DRASAR, Lukas , LEDVINA, Miroslav , KORVASOVA, Zina , TURANEK, Jaroslav
IPC分类号： C07C233/18 , C07C233/35 , C07J41/00 , A61K9/127
CPC分类号： A61K9/1272 , A61K47/18 , C07C233/18 , C07C233/35 , C07J9/00 , C07J41/0055 , C12N15/88
摘要： The invention provides new lipopolyamines of spermine type of the general formula I, wherein X is C-N bond or aminopolyethyleneglycolcarboxamide linker or o-hydroxy- alkylcarboxamide linker or ω-hydroxyalkylcarboxamidopolyethyleneglycol- carboxamide linker, and wherein a hydrophobic domain Y is an acyl symmetrically branched in the position C(2) or cholesteryl. The invention further provides a method of preparation of said lipopolyamines and their use for construction of polycationic liposomal drug carriers.
摘要翻译：本发明提供了通式I的精胺类型的新的脂多胺，其中X是CN键或氨基聚乙二醇甲酰胺接头或邻羟基 - 烷基羧酰胺接头或ω-羟烷基羧甲基聚乙二醇 - 甲酰胺接头，其中疏水结构域Y是在位置C（2）或胆固醇基。本发明还提供了所述脂多胺的制备方法及其用于构建聚阳离子脂质体药物载体的用途。

3. 发明申请

WO2015169271A1 VACCINE FOR PREVENTION OF LYME BORRELIOSIS 审中-公开
标题翻译：用于预防LYME BORRELIOSIS的疫苗
公开(公告)号：WO2015169271A1
公开(公告)日：2015-11-12
申请号：PCT/CZ2015/000042
申请日：2015-05-11
申请人： VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V.V.I. , UNIVERZITA PALACKEHO V OLOMOUCI , BIOVETA, A.S. , USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. , FYZIKALNI USTAV AV CR, V.V.I.
发明人： TURANEK, Jaroslav , MASEK, Josef , RASKA, Milan , WEIGL, Evzen , KRUPKA, Michal , BITTNER, Libor , NEPERENY, Jiri , VRZAL, Vladimir , LEDVINA, Miroslav , KRATOCHVILOVA, Irena
IPC分类号： A61K39/02 , C07K14/20 , A61K39/00
CPC分类号： C07K16/1207 , A61K39/0225 , A61K2039/70 , C07K16/18 , C07K2319/00 , Y02A50/401
摘要： The invention provides a vaccine for prevention of Lyme borreliosis containing at least two types of chimeric poly epitope recombinant antigens, comprising immunodominant regions of OspA and OspC antigens, and at least one adjuvant and/or ferritin II.
摘要翻译：本发明提供了一种用于预防含有至少两种类型的嵌合型多表位重组抗原的莱姆硼酸血症疫苗，其包含OspA和OspC抗原的免疫显性区域，以及至少一种佐剂和/或铁蛋白II。

4. 发明申请

US20210292275A1 AMINOOXYLIPIDS FOR THE CONSTRUCTION OF SELF-ASSEMBLING LIPOSOMAL SYSTEMS ENABLING THEIR SUBSEQUENT MODIFICATION BY BIOLOGICALLY FUNCTIONAL MOLECULES 有权
公开(公告)号：US20210292275A1
公开(公告)日：2021-09-23
申请号：US16336844
申请日：2017-11-02
申请人： VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE , VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V.V.I. , APIGENEX S.R.O.
发明人： Mirolav LEDVINA , Roman EFFENBERG , Jaroslav TURANEK , Elissa BARTHELDYOVA , Ladislav DROZ , Josef MASEK , Frantisek HUBATKA
IPC分类号： C07C239/20 , A61K9/127 , A61K47/69 , A61K47/68 , A61K47/54 , A61K47/61
摘要： New aminooxylipids of general formula I, wherein n1=5-30 and X is polymethylene linker of the general formula II where n2=2-10, or X is polyethylene glycol linker of the general formula III, wherein n3=1-14 are provided. A method of preparation of the aminooxylipids of general formula I characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH3)3C—O—(C═O)—HN—(CH2)n—NH2, n=2-13}, or N-tert-butoxycarbonyl-polyethyleglycoldiamine {(CH3)3C—O—(C═O)—HN—(CH2)2—[O—(CH2)]n—O—(CH2)2NH2, n=1-14} with in position C(2) symmetrically branched fatty acids of general formula IV, wherein n1=5-30, in the presence of condensation reagent, or from acid of general formula IV derived acylchloride of general formula V wherein n1=5-30, produces N-Boc-aminolipids of general formula VI, wherein n1=5-30 a X is polymethylene linker of the general formula II or X is polyethylene glycol linker of the general formula III.

5. 发明授权

US09393200B2 Lipopolyamines of spermine type for construction of liposomal transfection systems 有权
标题翻译：用于构建脂质体转染系统的精胺型脂多糖
公开(公告)号：US09393200B2
公开(公告)日：2016-07-19
申请号：US14370526
申请日：2013-01-14
申请人： USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. , VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V.V.I.
发明人： Lukas Drasar , Miroslav Ledvina , Zina Korvasova , Jaroslav Turanek
IPC分类号： A61K9/127 , C07C233/18 , C07C233/35 , C07J41/00 , A61K47/18 , C12N15/88 , C07J9/00
CPC分类号： A61K9/1272 , A61K47/18 , C07C233/18 , C07C233/35 , C07J9/00 , C07J41/0055 , C12N15/88
摘要： The invention provides new lipopolyamines of spermine type of the general formula I, wherein X is C—N bond or aminopolyethyleneglycolcarboxamide linker or o-hydroxy-alkylcarboxamide linker or ω-hydroxyalkylcarboxamidopolyethyleneglycol-carboxamide linker, and wherein a hydrophobic domain Y is an acyl symmetrically branched in the position C(2) or cholesteryl. The invention further provides a method of preparation of said lipopolyamines and their use for construction of polycationic liposomal drug carriers.
摘要翻译：本发明提供了通式I的精胺类型的新的脂多胺，其中X是C-N键或氨基聚乙二醇羧酰胺接头或邻羟基烷基羧酰胺接头或ω-羟烷基羧甲基聚乙二醇 - 甲酰胺接头，其中疏水域Y是对称支化的酰基位于C（2）或胆固醇基。本发明还提供了所述脂多胺的制备方法及其用于构建聚阳离子脂质体药物载体的用途。

6. 发明申请

WO2018082723A1 AMINOOXYLIPIDS FOR THE CONSTRUCTION OF SELF-ASSEMBLING LIPOSOMAL SYSTEMS ENABLING THEIR SUBSEQUENT MODIFICATION BY BIOLOGICALLY FUNCTIONAL MOLECULES 审中-公开
标题翻译：用于构建自组装脂质体系统的氨基甲酰脂质使其能够通过生物功能分子进行后续修饰
公开(公告)号：WO2018082723A1
公开(公告)日：2018-05-11
申请号：PCT/CZ2017/050054
申请日：2017-11-02
申请人： VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE , VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V. V. I. , APIGENEX S.R.O.
发明人： LEDVINA, Miroslav , EFFENBERG, Roman , TURANEK, Jaroslav , BARTHELDYOVA, Elissa , DROZ, Ladislav , MASEK, Josef , HUBATKA, Frantisek
IPC分类号： C07C235/08 , A61K9/127 , C07C235/10 , A61K47/50
CPC分类号： C07C235/10 , A61K9/1271 , A61K47/543 , A61K47/61 , A61K47/6835 , A61K47/6911 , A61K47/6913 , C07C235/08
摘要： New aminooxylipids of general formula (I), wherein n 1 = 5-30 and X is polymethylene linker of the general formula (II) where n 2 = 2 -10, or X is polyethylene glycol linker of the general formula (III), wherein n 3 = 1-14, are provided. A method of preparation of the aminooxylipids of general formula (I) characterized in that the acylation of N -tert-butoxycarbonyl-polymethylenediamine {(CH 3 ) 3 C-0-(C=0)-HN-(CH 2 ) n -N H 2 , n = 2 -13}, or N -tert- butoxycarbonyl-polyethyleglycoldiamine {(CH 3 ) 3 C-0-(C=0)-HN-(CH 2 ) 2 -[0-(CH 2 )] n -0-(CH 2 ) 2 NH 2 , n = 1-14} with in position C(2) symmetrically branched fatty acids of general formula (IV), wherein n 1 = 5-30, in the presence of condensation reagent, or from acid of general formula (IV) derived acylchloride of general formula (V) wherein n 1 = 5-30, produces N -Boc-aminolipids of general formula (VI), wherein n 1 = 5-30 a X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III). These are converted by debocylation to aminolipids of general formula (VII), wherein n 1 = 5-30 and X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III). By their condensation with N -terf-butoxycarbonyl-aminooxyacetic acid in the presence of condensation reagent, N -Boc-aminooxylipids of general formula (VIII), where in n 1 = 5- 30 and X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III), are obtained, which by debocylation afford aminooxylipids of general formula (I). Acylchlorides of general formula (V) are prepared by reaction of acid of general formula (IV) with oxalylchloride in the presence of catalytic amount of N, N -dimethylformamide in organic aprotic solvent. The use of nontoxic aminooxylipids of the general formula I for construction of nontoxic self-assembly liposomal carriers of therapeutics presenting aminooxy groups and so-called "post-liposomal" modification of these carriers with biologically functional molecules using oxime ligation technique (binding counterparts: aminooxy group and aldehyde or ketone group).
摘要翻译：通式（I）的新的氨氧基脂类（其中n 1 = 5-30且X是通式（II）的聚亚甲基连接基，其中n 2 = / X =通式（III）的聚乙二醇接头，其中n 3 = 1-14。制备通式（I）的氨氧基脂类的方法，其特征在于N-叔丁氧基羰基 - 多亚甲基二胺{（CH 3）3} （C = O）-HN-（CH 2）n -N 2 H 2，n = 2 -13 }或N'-叔丁氧基羰基 - 聚乙二醇二胺{（CH 3）3 C-O-（C = O）-HN-（ CH <子> 2 ）<子> 2 - [O-（CH <子> 2 ）] <子>名词 -O-（CH <子> （2）对称支链脂肪酸的通式（IV）的化合物，其中n（n）为1或2，其中n （IV）衍生的通式（V）的酰氯中，其中n1 = 5- 30产生通式（VI）的N-Boc-氨基脂质，其中n1 = 5-30，X是通式（II）的聚亚甲基连接体或X 是通式（III）的聚乙二醇接头。通过去核作用将它们转化为通式（VII）的氨基脂质，其中n 1 = 5-30，X是通式（II）的聚亚甲基连接基或X是通式（III）。通过它们在缩合剂存在下与N-叔丁氧羰基氨基氧乙酸缩合，得到通式（VIII）的N-Boc-氨氧基脂类，其中n

7. 发明申请

WO2009115782A3 COMPOUNDS DERIVED FROM MURAMYLDIPEPTIDE 审中-公开
公开(公告)号：WO2009115782A3
公开(公告)日：2009-09-24
申请号：PCT/GB2009/000703
申请日：2009-03-17
申请人： IMUTHES LIMITED , INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AV CR, v.v.i. , VYZKUMNY USTAV VETERINARNIHO , HIPLER, Karsten , MILLER, Andrew , TURANEK, Jaroslav , LEDVINA, Miroslav
发明人： HIPLER, Karsten , MILLER, Andrew , TURANEK, Jaroslav , LEDVINA, Miroslav
IPC分类号： C07K9/00 , A61K38/04
摘要： The invention provides a compound (which can act as an adjuvant) of Formula I or Formula (Il), wherein R 1 R 4 R 5 R 6 and R 7 are each independently selected from hydrogen, acetyl, hydrocarbyl, a lipid moiety and a lipid acyl moiety; R 2 is a hydroxyl, a hydrocarbyl, a lipid moiety, a lipid acyl moiety; or an amino hydrocarbyl group optionally substituted with a hydrocarbyl, a lipid moiety or a lipid acyl moiety; R 3 and R 8 are each independently selected from acetyl, a hydrocarbyl, a lipid moiety and a lipid acyl moiety; X is a peptide chain; The above normuramylglycopeptide compounds can be located in liposomes and micelles and can function as immunomodulators, along with a desired antigen (or DNA encloding the antigen), in (e.g. DNA) vaccines.

8. 发明授权

US11492327B2 Aminooxylipids for the construction of self-assembling liposomal systems enabling their subsequent modification by biologically functional molecules 有权
公开(公告)号：US11492327B2
公开(公告)日：2022-11-08
申请号：US16336844
申请日：2017-11-02
申请人： VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE , VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V. V. I. , APIGENEX S.R.O.
发明人： Miroslav Ledvina , Roman Effenberg , Jaroslav Turanek , Elissa Bartheldyova , Ladislav Droz , Josef Masek , Frantisek Hubatka
IPC分类号： C07C239/20 , A61K47/69 , A61K47/61 , A61K47/54 , A61K47/68 , A61K9/127
摘要： New aminooxylipids of general formula I, wherein n1=5-30 and X is polymethylene linker of the general formula II where n2=2-10, or X is polyethylene glycol linker of the general formula III, wherein n3=1-14 are provided. A method of preparation of the aminooxylipids of general formula I characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH3)3C—O—(C═O)—HN—(CH2)n—NH2, n=2-13}, or N-tert-butoxycarbonyl-polyethyleglycoldiamine {(CH3)3C—O—(C═O)—HN—(CH2)2—[O—(CH2)]n—O—(CH2)2NH2, n=1-14} with in position C(2) symmetrically branched fatty acids of general formula IV, wherein n1=5-30, in the presence of condensation reagent, or from acid of general formula IV derived acylchloride of general formula V wherein n1=5-30, produces N-Boc-aminolipids of general formula VI, wherein n1=5-30 a X is polymethylene linker of the general formula II or X is polyethylene glycol linker of the general formula III.

9. 发明申请

US20150018436A1 LIPOPOLYAMINES OF SPERMINE TYPE FOR CONSTRUCTION OF LIPOSOMAL TRANSFECTION SYSTEMS 有权
标题翻译：用于构建脂肪转运系统的脂质体类型的磷脂酰胺
公开(公告)号：US20150018436A1
公开(公告)日：2015-01-15
申请号：US14370526
申请日：2013-01-14
申请人： USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. , VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V.V.I.
发明人： Lukas Drasar , Miroslav Ledvina , Zina Korvasova , Jaroslav Turanek
IPC分类号： A61K9/127
CPC分类号： A61K9/1272 , A61K47/18 , C07C233/18 , C07C233/35 , C07J9/00 , C07J41/0055 , C12N15/88
摘要： The invention provides new lipopolyamines of spermine type of the general formula I, wherein X is C—N bond or aminopolyethyleneglycolcarboxamide linker or o-hydroxy-alkylcarboxamide linker or ω-hydroxyalkylcarboxamidopolyethyleneglycol-carboxamide linker, and wherein a hydrophobic domain Y is an acyl symmetrically branched in the position C(2) or cholesteryl. The invention further provides a method of preparation of said lipopolyamines and their use for construction of polycationic liposomal drug carriers.
摘要翻译：本发明提供了通式I的精胺类型的新的脂多胺，其中X是C-N键或氨基聚乙二醇羧酰胺接头或邻羟基烷基羧酰胺接头或ω-羟烷基羧甲基聚乙二醇 - 甲酰胺接头，其中疏水域Y是对称支化的酰基位于C（2）或胆固醇基。本发明还提供了所述脂多胺的制备方法及其用于构建聚阳离子脂质体药物载体的用途。

10. 发明公开

EP2271661A2 COMPOUNDS DERIVED FROM MURAMYLDIPEPTIDE 有权
标题翻译：胞壁酰二肽衍生物
公开(公告)号：EP2271661A2
公开(公告)日：2011-01-12
申请号：EP09721749.1
申请日：2009-03-17
申请人： IMUTHES LIMITED , Institute Of Organic Chemistry And Biochemistry Av CR, v.v.i. , Vyzkumny Ustav Veterinarniho lékarstvi, v.v.i.
发明人： HIPLER, Karsten , MILLER, Andrew , TURANEK, Jaroslav , LEDVINA, Miroslav
IPC分类号： C07K9/00 , A61K38/04
CPC分类号： C07K9/005 , A61K9/127 , A61K39/39 , A61K2039/5555 , A61K2039/55583
摘要： The invention provides a compound (which can act as an adjuvant) of Formula I or Formula (Il), wherein R
1 R
4 R
5 R
6 and R
7 are each independently selected from hydrogen, acetyl, hydrocarbyl, a lipid moiety and a lipid acyl moiety; R
2 is a hydroxyl, a hydrocarbyl, a lipid moiety, a lipid acyl moiety; or an amino hydrocarbyl group optionally substituted with a hydrocarbyl, a lipid moiety or a lipid acyl moiety; R
3 and R
8 are each independently selected from acetyl, a hydrocarbyl, a lipid moiety and a lipid acyl moiety; X is a peptide chain; The above normuramylglycopeptide compounds can be located in liposomes and micelles and can function as immunomodulators, along with a desired antigen (or DNA encloding the antigen), in (e.g. DNA) vaccines.

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