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1. 发明申请

WO2011158162A1 AN IMAGE PROCESSING METHOD IN MICROSCOPY 审中-公开
标题翻译：微观图像处理方法
公开(公告)号：WO2011158162A1
公开(公告)日：2011-12-22
申请号：PCT/IB2011/052546
申请日：2011-06-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , MUELLER, Dan , VOSSEN, Dirk , HULSKEN, Bas
发明人： MUELLER, Dan , VOSSEN, Dirk , HULSKEN, Bas
IPC分类号： G06T3/00
CPC分类号： G06K9/0014 , G06T3/0068 , G06T2200/24 , G06T2207/10056 , G06T2207/20016 , G06T2207/20104
摘要： The invention pertains to the field of image processing in digital pathology. It notably proposes a method for processing a first digital image, representing a sample in a region, and which image has been acquired from the sample by means of a microscopic imaging system (1) and is stored in a multi-resolution image data structure (80), comprising the steps of: - retrieving (104) a sub-region of the first digital image at a first resolution, -executing (105) a transform function on the retrieved sub-region, the transform function modifying a content of the sub-region according to at least one metric derived from a second resolution representation of the first digital image.
摘要翻译：本发明涉及数字病理学中的图像处理领域。特别提出了一种用于处理第一数字图像的方法，其表示区域中的样本，并且已经通过显微镜成像系统（1）从样本获取了哪个图像，并且被存储在多分辨率图像数据结构中 80），包括以下步骤：以第一分辨率检索（104）第一数字图像的子区域， - 对所检索的子区域执行（105）变换函数，所述变换函数修改所述第一数字图像的内容根据从第一数字图像的第二分辨率表示导出的至少一个量度的子区域。

2. 发明申请

WO2009022245A3 MECHANICAL RESONANCE DETECTION SYSTEM 审中-公开
标题翻译：机械共振检测系统
公开(公告)号：WO2009022245A3
公开(公告)日：2009-08-20
申请号：PCT/IB2008052972
申请日：2008-07-24
申请人： KONINKL PHILIPS ELECTRONICS NV , VOSSEN DIRK L J , VLUTTERS RUUD , CIUHU CALINA , DE BRUIJN FREDERIK J
发明人： VOSSEN DIRK L J , VLUTTERS RUUD , CIUHU CALINA , DE BRUIJN FREDERIK J
IPC分类号： G01H13/00
CPC分类号： G01H13/00
摘要： In a mechanical resonance detection system, a vibration applicator (VFO, EMT) imposes a mechanical vibration (MV) at various different frequencies onto at least a portion of a physical object (S). An imaging assembly (IAS) captures images (IM) within an imaging frame that lies in at least a portion of the physical object (S), which undergoes the mechanical vibration (MV). At least one element of the imaging assembly (IAS) equally undergoes the mechanical vibration (MV) so that the imaging frame moves in synchronization with the mechanical vibration (MV). An analyzer (BLA, DTA) analyzes the images so as to provide an indication of a frequencyofthe mechanical vibration whereby an image has a relatively high degree of blur.
摘要翻译：在机械共振检测系统中，振动施加器（VFO，EMT）将各种不同频率的机械振动（MV）施加到物理对象（S）的至少一部分上。成像组件（IAS）捕获位于物理对象（S）的至少一部分中的成像帧内的图像（IM），其经历机械振动（MV）。成像组件（IAS）的至少一个元件同样经历机械振动（MV），使得成像框架与机械振动（MV）同步移动。分析仪（BLA，DTA）分析图像以提供机械振动频率的指示，由此图像具有相对较高的模糊度。

3. 发明申请

WO2009066253A2 MULTI-MODAL SPOT GENERATOR AND MULTI-MODAL MULTI-SPOT SCANNING MICROSCOPE 审中-公开
标题翻译：多模光斑发生器和多模多光斑扫描显微镜
公开(公告)号：WO2009066253A2
公开(公告)日：2009-05-28
申请号：PCT/IB2008054861
申请日：2008-11-19
申请人： KONINKL PHILIPS ELECTRONICS NV , STALLINGA SJOERD , VOSSEN DIRK L J , BAKKER LEVINUS P , HULSKEN BAS
发明人： STALLINGA SJOERD , VOSSEN DIRK L J , BAKKER LEVINUS P , HULSKEN BAS
IPC分类号： G02B3/00 , G02B5/18 , G02B21/00 , G02B27/00 , G02B27/09
CPC分类号： G02B21/0032 , G02B27/0087 , G02B27/0905
摘要： The invention relates to a spot generator (10) having: -an entrysurface (12) for receiving an incident light beam (20) and an exit surface (14) for transmitting the light beam, the entry surface defining an entryside (16) and the exit surface defining an exit side (18). According to the invention, the spot generator is designed to modulate the incident light beam to generate on the exit side a first plurality (22) and a second plurality (24) of separate light spots, each light spot belonging to the first plurality having a first angular spectrum and each light spot belonging to the second plurality having a second angular spectrum different than the first angular spectrum. Advantageously, the spot generator comprises a periodic binary phase structure. The invention further relates to a multi-spot scanning microscope and to a method of imaging a microscopic sample.
摘要翻译：本发明涉及一种点发生器（10），其具有： - 用于接收入射光束（20）的表面（12）和用于透射光束的出射表面（14），所述入射表面限定了农庄（16）;以及出口表面限定出口侧（18）。根据本发明，点发生器被设计为调制入射光束以在出射侧产生第一多个（22）和第二多个（24）分离的光点，属于第一多个的每个光点具有第一角谱和属于第二多个谱的每个光斑具有不同于第一角谱的第二角谱。有利地，点发生器包括周期性二元相位结构。本发明还涉及一种多点扫描显微镜和一种对显微镜样品成像的方法。

4. 发明申请

WO2008152568A3 METHOD AND DEVICE FOR ANALYZING A SAMPLE 审中-公开
标题翻译：用于分析样品的方法和装置
公开(公告)号：WO2008152568A3
公开(公告)日：2009-02-19
申请号：PCT/IB2008052267
申请日：2008-06-09
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN ALEM TOON , BIERHOFF WALTHERUS C J , HELWEGEN IVON F , MIHAJLOVIC NENAD , STALLINGA SJOERD , VOSSEN DIRK L J
发明人： VAN ALEM TOON , BIERHOFF WALTHERUS C J , HELWEGEN IVON F , MIHAJLOVIC NENAD , STALLINGA SJOERD , VOSSEN DIRK L J
IPC分类号： G01N21/27 , G02B21/00
CPC分类号： G02B21/002 , G02B21/0024
摘要： The invention relates to an optical device for analyzing a sample (8), comprising: - means for irradiating the sample (8) with at least one light beam, - a reference marker (12) placed on a light path (P) of the light beam so that the reference marker (12) is irradiated by said light beam simultaneously with the sample (8), - means for simultaneously detecting light interacted with the sample (8), for analyzing the sample (8), and with the reference marker (12), for at least one of calibrating, aligning or adjusting the optical device.
摘要翻译：本发明涉及一种用于分析样品（8）的光学装置，包括： - 用于用至少一个光束照射所述样品（8）的装置， - 放置在所述样品（8）的光路（P）上的参考标记（12）光束，使得参考标记（12）与样品（8）同时被所述光束照射， - 用于同时检测与样品（8）相互作用的光，用于分析样品（8）以及参考的装置标记（12），用于校准，对准或调整光学装置中的至少一个。

5. 发明申请

WO2009066252A3 MULTI-FOCAL SPOT GENERATOR AND MULTI-FOCAL MULTI-SPOT SCANNING MICROSCOPE 审中-公开
公开(公告)号：WO2009066252A3
公开(公告)日：2009-05-28
申请号：PCT/IB2008/054860
申请日：2008-11-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , STALLINGA, Sjoerd , BAKKER, Levinus, P. , VOSSEN, Dirk, L. J.
发明人： STALLINGA, Sjoerd , BAKKER, Levinus, P. , VOSSEN, Dirk, L. J.
IPC分类号： G02B3/00 , G02B27/00 , G02B21/00
摘要： The invention relates to a spot-generator (10) having: an entrance surface (12) for receiving an incident light beam (20) and an exit surface (14) for transmitting the light beam, the entrance surface defining an entrance side (16) and the exit surface defining an exit side (18), wherein the spot generator is designed to modulate the incident light beam to generate on the exit side a plurality of separate light spots. According to the invention, the plurality of light spots comprises a first light spot (22) generated in a first focal plane (24) and a second light spot (26) generated in a second focal plane (28), the first focal plane and the second focal plane being essentially perpendicular to the mean propagation direction of the exit light beam, and wherein the first light spot (22) differs from every other light spot generated on the exit side by the spot generator in the projection of its position on a plane essentially perpendicular to the mean propagation direction of the exit light beam. Advantageously, the light spots of the plurality of separate light spots have identical spectra. The invention further relates to a multi-spot scanning microscope and to a method of generating an image of a microscopic sample. Advantageously, the method comprises the step of generating a three- dimensional image of the sample.

6. 发明申请

WO2009022289A3 A METHOD OF IMAGING A SAMPLE 审中-公开
标题翻译：一种成像方法
公开(公告)号：WO2009022289A3
公开(公告)日：2009-05-28
申请号：PCT/IB2008053218
申请日：2008-08-12
申请人： KONINKL PHILIPS ELECTRONICS NV , VOSSEN DIRK , BAKKER LEVINUS , HULSKEN BAS , STALLINGA SJOERD
发明人： VOSSEN DIRK , BAKKER LEVINUS , HULSKEN BAS , STALLINGA SJOERD
IPC分类号： G02B21/00 , G02B21/08 , G02B21/14
CPC分类号： G02B21/002 , G02B21/004 , G02B21/008 , G02B21/086 , G02B21/14
摘要： A method of imaging a sample comprises the steps of: -providing S1 a reference array of spots 104, -illuminating the sample 106 with the reference array of spots 104 and acquiring S2 at least one sample image IMSi comprising a sample related array of spots 107 resulting from the reference array of spots interacting with the sample 106, -determining S3 a spot characterizing parameter for each of a plurality of sample related spots, and -constructing S4 an image of the sample IMs By plotting the spot characterizing parameter for each of the plurality of sample related spots at the respective sample related spot position.
摘要翻译：一种对样本进行成像的方法包括以下步骤： - 提供斑点104的参考阵列， - 用点104的参考阵列照亮样本106，并获取S2至少一个样本图像IMSi，其包括样本相关的点阵列107 由与样品106相互作用的点的参考阵列产生的， - 确定S3是多个样本相关斑点中的每一个的斑点特性参数，以及 - 构造样品IM的图像。通过绘制样品IM的图像在相应样品相关斑点位置处的多个样品相关斑点。

7. 发明申请

WO2009022289A2 A METHOD OF IMAGING A SAMPLE 审中-公开
标题翻译：成像样品的方法
公开(公告)号：WO2009022289A2
公开(公告)日：2009-02-19
申请号：PCT/IB2008/053218
申请日：2008-08-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VOSSEN, Dirk , BAKKER, Levinus , HULSKEN, Bas , STALLINGA, Sjoerd
发明人： VOSSEN, Dirk , BAKKER, Levinus , HULSKEN, Bas , STALLINGA, Sjoerd
IPC分类号： G02B21/00 , G02B21/14 , G02B21/08
CPC分类号： G02B21/002 , G02B21/004 , G02B21/008 , G02B21/086 , G02B21/14
摘要： A method of imaging a sample comprises the steps of: -providing S1 a reference array of spots 104, -illuminating the sample 106 with the reference array of spots 104 and acquiring S2 at least one sample image IM Si comprising a sample related array of spots 107 resulting from the reference array of spots interacting with the sample 106, -determining S3 a spot characterizing parameter for each of a plurality of sample related spots, and -constructing S4 an image of the sample IM s By plotting the spot characterizing parameter for each of the plurality of sample related spots at the respective sample related spot position.
摘要翻译：成像样品的方法包括以下步骤：为S1提供斑点104的参考阵列;利用点104的参考阵列照亮样品106;以及获取S2至少一个样品图像IM 包括从与样本106相互作用的参考点阵列产生的样本相关的点阵列107， - 确定S3针对多个样本相关点中的每一个的点表征参数，以及 - 构建S4 样品IM的图像通过在各个样品相关斑点位置绘制多个样品相关斑点中的每一个的斑点表征参数。

8. 发明申请

WO2008146226A1 SAMPLE HOLDER FOR AN OPTICAL DEVICE 审中-公开
标题翻译：用于光学设备的样品座
公开(公告)号：WO2008146226A1
公开(公告)日：2008-12-04
申请号：PCT/IB2008/052050
申请日：2008-05-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VOSSEN, Dirk, L. J , STALLINGA, Sjoerd
发明人： VOSSEN, Dirk, L. J , STALLINGA, Sjoerd
IPC分类号： G02B21/34 , G02B21/18 , G02B21/00
CPC分类号： G02B21/18 , G02B21/0032 , G02B21/0056 , G02B21/32 , G02B21/34 , G02B2207/113
摘要： The invention relates to an optical device which comprises at least three objectives (24, 25, 26, 27), each objective (24, 25, 26, 27) comprising an optical axis ((24', 25', 26', 27'), the device further comprising a polyhedron-shaped sample holder (28, 36, 38), comprising a plurality of faces defining a volume within which the sample is to be placed, each objective (24, 25, 26, 27) facing one corresponding face of the polyhedron-shaped sample holder (28, 36, 38), said face being substantially perpendicular to the optical axis (24', 25', 26',27') of the corresponding objective (24, 25, 26, 27).
摘要翻译：本发明涉及一种光学装置，其包括至少三个物镜（24,25,26,27），每个物镜（24,25,26,27）包括光轴（（24'，25'，26'，27 '），所述装置还包括多面体样品保持器（28,36,38），其包括限定待放置样品的体积的多个面，每个物镜（24,25,26,27）面向所述多面体样品保持器（28,36,38）的一个对应的表面基本上垂直于相应物镜（24,25,26）的光轴（24'，25'，26'，27'），27）。

9. 发明申请

WO2009066252A2 MULTI-FOCAL SPOT GENERATOR AND MULTI-FOCAL MULTI-SPOT SCANNING MICROSCOPE 审中-公开
标题翻译：多焦点发生器和多焦点多点扫描显微镜
公开(公告)号：WO2009066252A2
公开(公告)日：2009-05-28
申请号：PCT/IB2008054860
申请日：2008-11-19
申请人： KONINKL PHILIPS ELECTRONICS NV , STALLINGA SJOERD , BAKKER LEVINUS P , VOSSEN DIRK L J
发明人： STALLINGA SJOERD , BAKKER LEVINUS P , VOSSEN DIRK L J
IPC分类号： G02B3/00 , G02B21/00 , G02B27/00
CPC分类号： G02B27/0087 , G02B3/0006 , G02B21/004
摘要： The invention relates to a spot-generator (10) having: an entrance surface (12) for receiving an incident light beam (20) and an exit surface (14) for transmitting the light beam, the entrance surface defining an entrance side (16) and the exit surface defining an exit side (18), wherein the spot generator is designed to modulate the incident light beam to generate on the exit side a plurality of separate light spots. According to the invention, the plurality of light spots comprises a first light spot (22) generated in a first focal plane (24) and a second light spot (26) generated in a second focal plane (28), the first focal plane and the second focal plane being essentially perpendicular to the mean propagation direction of the exit light beam, and wherein the first light spot (22) differs from every other light spot generated on the exit side by the spot generator in the projection of its position on a plane essentially perpendicular to the mean propagation direction of the exit light beam. Advantageously, the light spots of the plurality of separate light spots have identical spectra. The invention further relates to a multi-spot scanning microscope and to a method of generating an image of a microscopic sample. Advantageously, the method comprises the step of generating a three- dimensional image of the sample.
摘要翻译：本发明涉及点光发生器（10），其具有：用于接收入射光束（20）的入射表面（12）和用于透射光束的出射表面（14），入射面限定入射侧（16 ）和所述出射表面限定出射侧（18），其中所述光斑发生器被设计成调制所述入射光束，以在所述出射侧产生多个单独的光斑。根据本发明，多个光点包括在第一焦平面（24）中产生的第一光点（22）和在第二焦平面（28）中产生的第二光点（26），第一焦平面和所述第二焦平面基本上垂直于所述出射光束的平均传播方向，并且其中所述第一光点（22）在其位置的投影中由所述光点发生器在出射侧产生的每隔一个光点不同平面基本上垂直于出射光束的平均传播方向。有利地，多个分开的光点中的光点具有相同的光谱。本发明还涉及多点扫描显微镜和产生微观样品图像的方法。有利地，该方法包括产生样本的三维图像的步骤。

10. 发明申请

WO2008152605A1 MULTI-SPOT SCANNING OPTICAL DEVICE FOR IMAGING OF A SAMPLE 审中-公开
标题翻译：用于成像成像的多点扫描光学装置
公开(公告)号：WO2008152605A1
公开(公告)日：2008-12-18
申请号：PCT/IB2008/052338
申请日：2008-06-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VOSSEN, Dirk, L. J. , BAKKER, Levinus, P.
发明人： VOSSEN, Dirk, L. J. , BAKKER, Levinus, P.
IPC分类号： G02B21/36 , G02B21/00
CPC分类号： G02B21/0032 , G02B21/008 , G02B21/367
摘要： The invention relates to a method for imaging a sample (5) with a multi-spot scanning microscope, comprising: - generating an array (4) of light spots (S), - irradiating the sample (5) with the array (4) of light spots (S), the light spots (S) interacting with the sample (5) and being imaged on a detector (8), forming an array of image light spots (S'), - scanning the array (4) of light spots (S) into a plurality of positions (Pl, P2, P3) in the sample, - for each position (Pl, P2, P3) of the array (4) of light spots (S) in the sample (5), recording an image of the corresponding array (7) of image light spots (S') on the detector (8), - calculating the relative positions of the array (7) of image light spots (S') on the detector (8) between the recorded images, - calculating the relative positions of the array (4) of light spots (S) in the sample (5) between the recorded images, on the basis of the calculated relative positions of the array (7) of image light spots (S') on the detector (8), and - constructing a complete image of the sample (5) on the basis of the images recorded on the detector (8), the recorded images being attributed to corresponding positions of the array (4) of light spots (S) in the sample (5), these positions taking into account the calculated relative positions of the array (7) of light spots (S) in the sample (5).
摘要翻译：本发明涉及一种用多点扫描显微镜对样品（5）进行成像的方法，包括： - 产生光斑阵列（4）， - 用阵列（4）照射样品（5）的光斑（S），与样品（5）相互作用并在检测器（8）上成像的光点（S），形成图像光斑（S'）的阵列， - 扫描阵列（4） - 样品中的多个位置（P1，P2，P3）中的光点（S） - 对于样品（5）中的光斑（S）的阵列（4）的每个位置（P1，P2，P3）将图像光点（S'）的相应阵列（7）的图像记录在检测器（8）上， - 计算检测器（8）上的图像光点（S'）的阵列（7）的相对位置）， - 基于所计算的图像阵列（7）的相对位置，计算记录图像之间的样本（5）中的光点阵列（4）的相对位置（4）检测器上的光斑（S'）（8），并且 - 基于记录在检测器（8）上的图像构建样本（5）的完整图像，所记录的图像归因于光点阵列（4）的相应位置，在样品（5）中，这些位置考虑到样品（5）中的光斑（S）的阵列（7）的计算的相对位置。

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