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    • 8. 发明申请
    • METHOD AND APPARATUS FOR ESTIMATING THE CONTENT OF AN ANALYTE IN A MULTI-LAYER MEDIUM
    • 用于估计多层介质中分析物含量的方法和装置
    • WO2009037644A2
    • 2009-03-26
    • PCT/IB2008/053761
    • 2008-09-17
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBHWU, RunzeHOOFT, Gert 'tVOLLMER, Thomas
    • WU, RunzeHOOFT, Gert 'tVOLLMER, Thomas
    • G01N21/49A61B5/0059A61B5/441A61B5/7239G01N21/359
    • The invention relates to an apparatus for non-invasively estimating the content of an analyte in a multi-layer medium, based on spectral measurements. The apparatus comprises: a radiation source adapted to generate spectrums of electromagnetic radiation and to transmit the spectrums to the multi-layer medium; a detector adapted to detect spectrums of reflected radiation from the multi-layer medium and to generate detection signals representing the detected radiation; and a data processing means adapted to derive from the detected signals a plurality of quantities representing the effective attenuation coefficients of the multi-layer medium, and to estimate the content of the analyte from the plurality of quantities, based on a regression model. As the estimation of the content of the analyte is based on a plurality of quantities representing the effective attenuation coefficients, which change with the incident wavelengths of the spectrum of the electromagnetic radiation and the source-detector distance between irradiation areas and detection areas, the invention improves the precision of the estimation of the analyte content in a multi-layer medium.
    • 本发明涉及一种用于基于光谱测量非侵入性地估计多层介质中的分析物的含量的装置。 该设备包括:辐射源,适于产生电磁辐射的光谱并将光谱传输到多层介质; 检测器,适于检测来自多层介质的反射辐射的光谱并产生表示检测到的辐射的检测信号; 以及数据处理装置,其适于从检测到的信号中导出表示多层介质的有效衰减系数的多个量,并且基于回归模型来估计来自多个量的分析物的含量。 由于分析物含量的估计是基于表示有效衰减系数的多个量,所述有效衰减系数随着电磁辐射的光谱的入射波长和照射区域和检测区域之间的源 - 检测器距离而变化,所以本发明 提高了多层介质中分析物含量的估算精度。