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1. 发明申请

WO2007131972A1 NICOTINE-CARRIER VACCINE FORMULATION 审中-公开
标题翻译： NICOTINE-CARRIER VACCINE配方
公开(公告)号：WO2007131972A1
公开(公告)日：2007-11-22
申请号：PCT/EP2007/054604
申请日：2007-05-11
申请人： CYTOS BIOTECHNOLOGY AG , LUDWIG MAXIMILIANS UNIVERSITÄT MÜNCHEN , LANG, Rainer , WINTER, Gerhard , VOGT, Lorenz
发明人： LANG, Rainer , WINTER, Gerhard , VOGT, Lorenz
IPC分类号： A61K39/385 , A61K47/06
CPC分类号： A61K39/0013 , A61K9/19 , A61K2039/5258
摘要： The present invention is in the fields of medicine, public health, vaccine and drug formulation. The invention provides composition formulat ions comprising a nicotine- carrier conjugate and a stabilizer, wherein said stabilizer comprises a non-reducing disaccharide and a non-ionic surfactant. The composition formulations are stable after a long time of storage at room temperature.
摘要翻译：本发明在医药，公共卫生，疫苗和药物制剂领域。本发明提供了包含尼古丁 - 载体缀合物和稳定剂的组合物制剂，其中所述稳定剂包含非还原性二糖和非离子表面活性剂。组合物制剂在室温下长时间储存后是稳定的。

2. 发明申请

WO2004022594A3 IMMUNE MODULATORY COMPOUNDS AND METHODS 审中-公开
标题翻译：免疫调节化合物和方法
公开(公告)号：WO2004022594A3
公开(公告)日：2004-06-24
申请号：PCT/EP0309970
申请日：2003-09-08
申请人： CYTOS BIOTECHNOLOGY AG , VOGT LORENZ , BACHMANN MARTIN
发明人： VOGT LORENZ , BACHMANN MARTIN
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , G01N33/50 , A61K38/17 , A61K39/395 , C07K16/28 , C12N5/12 , C12N15/62 , G01N33/68
CPC分类号： G01N33/505 , A61K38/00 , C07K14/70532 , C07K2319/00 , G01N33/5052 , G01N2500/10
摘要： The present invention relates to nucleic acids encoding novel polypeptides that modulate immune responses as well as corresponding recombinant vectors and host cells comprising said vectors. The invention also encompasses the above mentioned polypeptides, derivatives thereof, antibodies directed against said polypeptides and corresponding hybridoma cell lines. Furthermore, the invention is directed at pharmaceutical compositions comprising the above mentioned nucleic acids, vectors, polypeptides and/or antibodies. In addition, the present invention is directed to a method of identifying a compound that modulates a cell response, and a method of treating and/or preventing a disease in a mammal, wherein said disease benefits from an enhanced or reduced immune response. A further aspect provides a method of producing a polypeptide, nucleic acid, vector or antibody according to the invention.
摘要翻译：本发明涉及编码调节免疫应答的新型多肽的核酸以及相应的重组载体和包含所述载体的宿主细胞。本发明还包括上述多肽，其衍生物，针对所述多肽的抗体和相应的杂交瘤细胞系。此外，本发明涉及包含上述核酸，载体，多肽和/或抗体的药物组合物。此外，本发明涉及鉴定调节细胞应答的化合物的方法，以及治疗和/或预防哺乳动物疾病的方法，其中所述疾病受益于增强或降低的免疫应答。另一方面提供了制备根据本发明的多肽，核酸，载体或抗体的方法。

3. 发明申请

WO0222819A3 CALCIUM BINDING PROTEINS 审中-公开
标题翻译：钙结合蛋白
公开(公告)号：WO0222819A3
公开(公告)日：2003-10-30
申请号：PCT/IB0101662
申请日：2001-09-13
申请人： UNIV ZUERICH , SONDEREGGER PETER , HINTSCH GUSTAV , KINTER JOCHEN , MESKENAITE VIRGINIJA , SCHRIMPF SABINE , VOGT LORENZ , ZURLINDEN ANDREAS
发明人： SONDEREGGER PETER , HINTSCH GUSTAV , KINTER JOCHEN , MESKENAITE VIRGINIJA , SCHRIMPF SABINE , VOGT LORENZ , ZURLINDEN ANDREAS
IPC分类号： A01K67/027 , A61K31/7088 , A61K31/713 , A61K38/00 , A61K38/17 , A61K38/46 , A61K39/00 , A61K48/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P35/04 , A61P43/00 , C07K14/47 , C12N5/06 , C12N9/48 , C12N15/09 , C12N15/12 , C12N15/85 , C12Q1/02 , C12Q1/37 , C12Q1/68
CPC分类号： C07K14/4728 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： There is described a novel class of calcium binding proteins of the nervous system, in particular calsyntenin-1-3. Calsyntenin proteins are valuable agents in the treatment of disorders of the nervous system, in particular the central nervous system. They are very useful for the development of drugs for the treatment of disorders of the nervous system.
摘要翻译：描述了一类新型的神经系统钙结合蛋白，特别是钙调蛋白1-3。卡介素蛋白是治疗神经系统疾病，特别是中枢神经系统的有价值的药剂。它们对于开发用于治疗神经系统疾病的药物非常有用。

4. 发明申请

WO2009056651A1 ANGIOTENSIN-CARRIER FORMULATION 审中-公开
标题翻译：血管紧张素转运酶制剂
公开(公告)号：WO2009056651A1
公开(公告)日：2009-05-07
申请号：PCT/EP2008/064894
申请日：2008-11-03
申请人： CYTOS BIOTECHNOLOGY AG , LANDOLT, Stefan , VOGT, Lorenz , ZUERCHER, Alexander
发明人： LANDOLT, Stefan , VOGT, Lorenz , ZUERCHER, Alexander
IPC分类号： A61K39/00 , A61K9/19 , C07K7/14 , C07K14/08 , A61P9/12
CPC分类号： A61K39/0005 , A61K9/19 , A61K9/5184 , A61K47/6901 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K2319/00
摘要： The present invention is in the fields of medicine, vaccine and pharmaceutical formulation. The invention provides formulations comprising an angiotensin-virus-like particle conjugate and a stabilizer, wherein said stabilizer comprises a non-reducing disaccharide and a non-ionic surfactant. The lyophilized formulations are stable after a long time of storage at room temperature.
摘要翻译：本发明涉及药物，疫苗和药物制剂领域。本发明提供了包含血管紧张素 - 病毒样颗粒缀合物和稳定剂的制剂，其中所述稳定剂包含非还原性二糖和非离子表面活性剂。冻干制剂在室温下长时间储存后是稳定的。

5. 发明申请

WO2004022594A2 IMMUNE MODULATORY COMPOUNDS AND METHODS 审中-公开
标题翻译：免疫调节化合物和方法
公开(公告)号：WO2004022594A2
公开(公告)日：2004-03-18
申请号：PCT/EP2003/009970
申请日：2003-09-08
申请人： CYTOS BIOTECHNOLOGY AG , VOGT, Lorenz , BACHMANN, Martin
发明人： VOGT, Lorenz , BACHMANN, Martin
IPC分类号： C07K14/705
CPC分类号： G01N33/505 , A61K38/00 , C07K14/70532 , C07K2319/00 , G01N33/5052 , G01N2500/10
摘要： The present invention relates to nucleic acids encoding novel polypeptides that modulate immune responses as well as corresponding recombinant vectors and host cells comprising said vectors. The invention also encompasses the above mentioned polypeptides, derivatives thereof, antibodies directed against said polypeptides and corresponding hybridoma cell lines. Furthermore, the invention is directed at pharmaceutical compositions comprising the above mentioned nucleic acids, vectors, polypeptides and/or antibodies. In addition, the present invention is directed to a method of identifying a compound that modulates a cell response, and a method of treating and/or preventing a disease in a mammal, wherein said disease benefits from an enhanced or reduced immune response. A further aspect provides a method of producing a polypeptide, nucleic acid, vector or antibody according to the invention.
摘要翻译：本发明涉及编码调节免疫应答的新多肽的核酸以及包含所述载体的相应重组载体和宿主细胞。本发明还包括上述多肽，其衍生物，针对所述多肽的抗体和相应的杂交瘤细胞系。此外，本发明涉及包含上述核酸，载体，多肽和/或抗体的药物组合物。另外，本发明涉及鉴定调节细胞应答的化合物的方法，和治疗和/或预防哺乳动物疾病的方法，其中所述疾病受益于增强的或降低的免疫应答。另一方面提供了生产根据本发明的多肽，核酸，载体或抗体的方法。

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