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1. 发明申请

WO2005105135A1 IL-6 FOR THERAPY OR PREVENTION OF CHEMOTHERAPY-INDUCED NEUROPATHY 审中-公开
标题翻译： IL-6治疗或预防化疗诱导的神经病变
公开(公告)号：WO2005105135A1
公开(公告)日：2005-11-10
申请号：PCT/IL2005/000444
申请日：2005-04-28
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V , EINAV, Henry , DREANO, Michel , VITTE, Pierre-Alain
发明人： DREANO, Michel , VITTE, Pierre-Alain
IPC分类号： A61K38/20
CPC分类号： A61K38/204 , A61K38/185 , A61K48/00 , C07K14/5412 , A61K2300/00
摘要： The present invention relates to the use of IL-6 in compositions and methods for therapy or prevention of chemotherapy-induced neuropathy (CIPN). More specifically, the invention relates to the use of a low dose of IL-6 for the treatment and/or prevention CIPN.
摘要翻译：本发明涉及IL-6在用于治疗或预防化学疗法诱导的神经病变（CIPN）的组合物和方法中的用途。更具体地说，本发明涉及低剂量IL-6用于治疗和/或预防CIPN的用途。

2. 发明申请

WO2005097116A1 COMPOSITION COMPRISING A JNK INHIBITOR AND CYCLOSPORIN 审中-公开
标题翻译：包含JNK抑制剂和环磷酰胺的组合物
公开(公告)号：WO2005097116A1
公开(公告)日：2005-10-20
申请号：PCT/EP2005/051572
申请日：2005-04-08
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , ROMMEL, Christian , VITTE, Pierre-Alain
发明人： ROMMEL, Christian , VITTE, Pierre-Alain
IPC分类号： A61K31/428
CPC分类号： C07D409/12 , C07D413/14 , C07D417/06 , C07D417/14
摘要： The present invention is related to a composition comprising a JNK inhibitor and a cyclosporin, in particular for the treatment of neuronal disorders, autoimmune diseases, cancer and cardiovascular diseases.
摘要翻译：本发明涉及包含JNK抑制剂和环孢菌素的组合物，特别是用于治疗神经元疾病，自身免疫疾病，癌症和心血管疾病。

3. 发明申请

WO2007014798A3 USE OF THE GLOBULAR DOMAIN OF ACRP30 FOR THE PREPARATION OF A MEDICAMENT FOR THE PREVENTION AND/OR TREATMENT OF THROMBOSIS-RELATED DISEASES 审中-公开
标题翻译： ACRP30全球领域用于制备用于预防和/或治疗与相关疾病相关的疾病的药物
公开(公告)号：WO2007014798A3
公开(公告)日：2007-08-23
申请号：PCT/EP2006063341
申请日：2006-06-20
申请人： SERONO LAB , BIHAIN BERNARD , DREANO MICHEL , HANTSON JENNIFER , OGIER VIRGINIE , VITTE PIERRE-ALAIN , YEN-POTIN FRANCES
发明人： BIHAIN BERNARD , DREANO MICHEL , HANTSON JENNIFER , OGIER VIRGINIE , VITTE PIERRE-ALAIN , YEN-POTIN FRANCES
IPC分类号： A61K38/17 , A61P7/02
CPC分类号： A61K45/06 , A61K38/1709 , A61K38/2264 , C07K16/26 , C07K2317/34 , A61K2300/00
摘要： It is the object of the present invention to provide novel means for the treatment and/or prevention of thrombosis, tumor implantation, tumor seeding and metastasis. More specifically, the present invention relates to the use of a polypeptide comprising the globular head of Acrp30 for the manufacture of a medicament for treatment and/or prevention of thombosis-related disorder, an hypertensive disorder of the pregnancy, tumor implantation, tumor seeding and metastasis.
摘要翻译：本发明的目的是提供治疗和/或预防血栓形成，肿瘤植入，肿瘤接种和转移的新手段。更具体地，本发明涉及包含Acrp30的球形头的多肽在制备用于治疗和/或预防与宫颈相关病症，妊娠高血压疾病，肿瘤植入，肿瘤种子和转移。

4. 发明申请

WO2007051785A2 USE OF SDF-1 FOR THE TREATMENT AND/OR PREVENTION OF NEUROLOGICAL DISEASES 审中-公开
标题翻译：使用SDF-1治疗和/或预防神经系统疾病
公开(公告)号：WO2007051785A2
公开(公告)日：2007-05-10
申请号：PCT/EP2006/067949
申请日：2006-10-30
申请人： Applied Research Systems ARS Holding N.V. , BOSCHERT, Ursula , PROUDFOOT, Amanda , KADI, Linda , VITTE, Pierre Alain , WOJCIK, Jérôme
发明人： BOSCHERT, Ursula , PROUDFOOT, Amanda , KADI, Linda , VITTE, Pierre Alain , WOJCIK, Jérôme
CPC分类号： A61K38/215 , A61K38/195 , A61K47/60 , A61K2300/00
摘要： The invention relates to the use of SDF-1 , or of an agonist of SDF-1 activity, for the treatment and/or prevention of a neurological disease.
摘要翻译：本发明涉及SDF-1或SDF-1活性激动剂用于治疗和/或预防神经疾病的用途。

5. 发明申请

WO2003033015A1 USE OF gp130 ACTIVATORS IN DIABETIC NEUROPATHY 审中-公开
标题翻译： gp130激活剂在糖尿病神经病变中的应用
公开(公告)号：WO2003033015A1
公开(公告)日：2003-04-24
申请号：PCT/EP2002/011364
申请日：2002-10-10
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , DREANO, Michel , VITTE, Pierre-Alain
发明人： DREANO, Michel , VITTE, Pierre-Alain
IPC分类号： A61K38/17
CPC分类号： A61K38/204 , A61K38/1793 , C07K2319/02 , C07K2319/30 , C12N2750/10011 , A61K2300/00
摘要： The invention relates to the use a substance signaling through gp130 for the manufacture of a medicament for the treatment and/or prevention of diabetic neuropathy. The use of IL-6 is preferred.
摘要翻译：本发明涉及通过gp130信号传导的物质用于制备用于治疗和/或预防糖尿病性神经病的药物。优选使用IL-6。

6. 发明申请

WO2005025558A1 SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DIABETES 审中-公开
标题翻译：用于治疗糖尿病的磺酰胺衍生物
公开(公告)号：WO2005025558A1
公开(公告)日：2005-03-24
申请号：PCT/EP2004/052143
申请日：2004-09-13
申请人： APPLIED RESERACH SYSTEMS ARS HOLDING N.V. , RUECKLE, Thomas , VITTE, Pierre-Alain , GOTTELAND, Jean-Pierre
发明人： RUECKLE, Thomas , VITTE, Pierre-Alain , GOTTELAND, Jean-Pierre
IPC分类号： A61K31/18
CPC分类号： A61K31/18 , A61K31/4535 , Y10S514/866
摘要： The present invention is related to the use of sulfonamide derivatives in the treatment of metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type II, inadequate glucose tolerance, insulin resistance, obesity, polycystic ovary syndrome (PCOS). Formula (I). R 1 is selected from the group comprising or consisting of hydrogen, C 1 -C 6 -alkoxy, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, amino, sulfanyl, sulfinyl, sulfonyl, sulfonyloxy, sulfonamide, acylamino, aminocarbonyl, C 1 -C 6 alkoxycarbonyl, aryl, heteroaryl, carboxy, cyano, halogen, hydroxy, nitro, hydrazides. R 2 is selected from the group comprising or consisting of hydrogen, COOR3, -CONR 3 R 3’ , OH, a C 1 -C 4 alkyl substituted with an OH or amino group, a hydrazido carbonyl group, a sulfate, a sulfonate, an amine or an ammonium salt. Y is an 4-12-membered saturated cyclic or bicyclic alkyl containing at least one nitrogen atom, whereby one nitrogen atom within said ring is forming a bond with the sulfonyl group of formula I thus providing the sulfonamide.
摘要翻译：本发明涉及磺酰胺衍生物在治疗由胰岛素抵抗或高血糖介导的代谢紊乱中的应用，包括II型糖尿病，葡萄糖耐量不足，胰岛素抵抗，肥胖，多囊卵巢综合征（PCOS）。式（I）。 R 1选自氢，C 1 -C 6 - 烷氧基，C 1 -C 6 - 烷基，C 2 -C 6 - 烯基，C 2 -C 6 - 炔基，氨基，硫烷基，亚磺酰基，磺酰基，磺酰氧基，磺酰胺酰基氨基，氨基羰基，C 1 -C 6烷氧基羰基，芳基，杂芳基，羧基，氰基，卤素，羟基，硝基，酰肼。 R 2选自由氢，COOR 3，-CONR 3 R 3，OH，被OH或氨基取代的C 1 -C 4烷基，酰肼基羰基，硫酸根，磺酸盐，胺或铵盐。 Y是含有至少一个氮原子的4-12元饱和环状或双环烷基，其中所述环中的一个氮原子与式I的磺酰基形成键，因此提供磺酰胺。

7. 发明申请

WO2007051785A3 USE OF SDF-1 FOR THE TREATMENT AND/OR PREVENTION OF NEUROLOGICAL DISEASES 审中-公开
标题翻译：使用SDF-1治疗和/或预防神经病变
公开(公告)号：WO2007051785A3
公开(公告)日：2007-09-07
申请号：PCT/EP2006067949
申请日：2006-10-30
申请人： SERONO LAB , BOSCHERT URSULA , PROUDFOOT AMANDA , KADI LINDA , VITTE PIERRE ALAIN , WOJCIK JEROME
发明人： BOSCHERT URSULA , PROUDFOOT AMANDA , KADI LINDA , VITTE PIERRE ALAIN , WOJCIK JEROME
IPC分类号： A61K47/48
CPC分类号： A61K38/215 , A61K38/195 , A61K47/60 , A61K2300/00
摘要： The invention relates to the use of SDF-1 , or of an agonist of SDF-1 activity, for the treatment and/or prevention of a neurological disease.
摘要翻译：本发明涉及SDF-1或SDF-1活性激动剂在治疗和/或预防神经系统疾病中的用途。

8. 发明申请

WO2007014798A2 USE OF ACRP30 FOR THE TREATMENT AND/OR PREVENTION OF THROMBOSIS AND CANCER 审中-公开
标题翻译：使用ACRP30治疗和/或预防血栓和癌症
公开(公告)号：WO2007014798A2
公开(公告)日：2007-02-08
申请号：PCT/EP2006/063341
申请日：2006-06-20
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , BIHAIN, Bernard , DREANO, Michel , HANTSON, Jennifer , OGIER, Virginie , VITTE, Pierre-Alain , YEN-POTIN, Frances
发明人： BIHAIN, Bernard , DREANO, Michel , HANTSON, Jennifer , OGIER, Virginie , VITTE, Pierre-Alain , YEN-POTIN, Frances
IPC分类号： A61K38/17 , A61P7/02
CPC分类号： A61K45/06 , A61K38/1709 , A61K38/2264 , C07K16/26 , C07K2317/34 , A61K2300/00
摘要： It is the object of the present invention to provide novel means for the treatment and/or prevention of thrombosis, tumor implantation, tumor seeding and metastasis. More specifically, the present invention relates to the use of a polypeptide comprising the globular head of Acrp30 for the manufacture of a medicament for treatment and/or prevention of thombosis-related disorder, an hypertensive disorder of the pregnancy, tumor implantation, tumor seeding and metastasis.
摘要翻译：本发明的目的是提供治疗和/或预防血栓形成，肿瘤植入，肿瘤接种和转移的新手段。更具体地说，本发明涉及包含Acrp30的球形头的多肽在制备用于治疗和/或预防肿瘤相关病症，妊娠高血压疾病，肿瘤植入，肿瘤接种和转移。

9. 发明申请

WO2007009959A1 GLEPP-1 INHIBITORS IN THE TREATMENT OF AUTOIMMUNE AND/OR INFLAMMATORY DISORDERS 审中-公开
标题翻译： GLEPP-1抑制剂治疗自身免疫和/或炎症性疾病
公开(公告)号：WO2007009959A1
公开(公告)日：2007-01-25
申请号：PCT/EP2006/064288
申请日：2006-07-14
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , BOMBRUN, Agnes , HOOFT VAN HUIJSDUIJNEN, Rob , JORAND-LEBRUN, Catherine , VITTE, Pierre-Alain , GERBER, Patrick
发明人： BOMBRUN, Agnes , HOOFT VAN HUIJSDUIJNEN, Rob , JORAND-LEBRUN, Catherine , VITTE, Pierre-Alain , GERBER, Patrick
IPC分类号： A61K31/192 , A61K31/195 , A61K31/196 , A61P29/00 , A61P37/00 , A61K31/452 , A61K31/404
CPC分类号： A61K31/404 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/4152
摘要： The present invention is related to the use of a Glepp-1 inhibitor for the manufacture of a medicament for the treatment of an autoimmune and/or an inflammatory disorder.
摘要翻译：本发明涉及Glepp-1抑制剂在制备用于治疗自身免疫和/或炎症性疾病的药物中的用途。

10. 发明申请

WO2003091249A1 PIPERAZINE BENZOTHIAZOLES AS AGENTS FOR THE TREATMENT OF CEREBRAL ISCHEMIC DISORDERS OR CNS DISORDERS 审中-公开
标题翻译：哌嗪苯唑胺作为治疗小儿间质性疾病或中枢神经疾病的药剂
公开(公告)号：WO2003091249A1
公开(公告)日：2003-11-06
申请号：PCT/EP2003/004323
申请日：2003-04-25
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , GAILLARD, Pascale , GOTTELAND, Jean-Pierre , VITTE, Pierre-Alain
发明人： GAILLARD, Pascale , GOTTELAND, Jean-Pierre , VITTE, Pierre-Alain
IPC分类号： C07D417/06
CPC分类号： C07D417/06
摘要： The present invention is related to piperazine benzothiazole derivatives, notably for use in the treatment and/or prophylaxis of cerebral ischemic disorders or CNS disorders. The present invention is furthermore related to methods of their preparation.
摘要翻译：本发明涉及哌嗪苯并噻唑衍生物，特别用于治疗和/或预防脑缺血障碍或CNS障碍。本发明还涉及它们的制备方法。

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