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1. 发明申请

WO2009126289A3 POSITIVE MAGNETIC RESONANCE IMAGING CONTRAST METHODS AND APPARATUS USING CHEMICAL EXCHANGE SATURATION TRANSFER 审中-公开
标题翻译：积极磁共振成像对比方法和使用化学交换饱和转移的装置
公开(公告)号：WO2009126289A3
公开(公告)日：2009-12-30
申请号：PCT/US2009002221
申请日：2009-04-09
申请人： BETH ISRAEL HOSPITAL , VINOGRADOV ELENA , LENKINSKI ROBERT E
发明人： VINOGRADOV ELENA , LENKINSKI ROBERT E
IPC分类号： A61B5/055 , G05F1/00
CPC分类号： G01R33/485 , G01N24/087 , G01R33/5601
摘要： In one aspect, an apparatus for performing chemical exchange saturation transfer (CEST) magnetic resonance imaging on a region of an object being imaged is provided. The method comprises at least one coil capable of being operated to emit radio frequency (RF) signals, at least one detector capable of detecting nuclear magnetic resonance signals, and at least one controller to operate the at least one coil to provide at least one inversion sequence to the region to flip at least some spins in the region by a desired flip-angle, operate the at least one coil to provide at least one first pulse sequence at a first frequency offset from a peak resonant frequency of water by a first amount in a first direction to magnetize at least one exchange group in the region, operate the at least one coil to provide at least one second pulse sequence at a second frequency offset from the peak resonant frequency of water by the first amount in a second direction opposite the first direction, operate the at least one detector to measure a first signal emitted from the region as a result of providing the at least one first pulse sequence after a predetermined time interval after applying the first inversion sequence, and operate the at least one detector to measure a second signal emitted from the region as a result of providing the at least one second sequence at the predetermined time interval after applying the at least one inversion sequence, wherein the predetermined time interval is selected such that positive contrast is achieved with respect to the first signal relative to the second signal.
摘要翻译：在一个方面，提供了一种用于在被成像物体的区域上进行化学交换饱和转移（CEST）磁共振成像的装置。该方法包括能够被操作以发射射频（RF）信号的至少一个线圈，能够检测核磁共振信号的至少一个检测器，以及至少一个控制器，用于操作至少一个线圈以提供至少一个反转序列到所述区域以使所述区域中的至少一些自旋翻转所需的翻转角度，操作所述至少一个线圈以提供至少一个第一脉冲序列，所述至少一个第一脉冲序列以水的峰值共振频率偏移第一量在第一方向上磁化该区域中的至少一个交换组，操作该至少一个线圈以提供至少一个第二脉冲序列，该第二脉冲序列以与水的峰值共振频率偏移的第二频率相反的第二方向第一方向，操作至少一个检测器，以测量从该区域发射的第一信号，作为在预定时间之后提供至少一个第一脉冲序列的结果并且在应用第一反转序列之后操作至少一个检测器以测量从该区域发射的第二信号，作为在施加至少一个反转序列之后以预定时间间隔提供至少一个第二序列的结果，其中选择预定时间间隔使得相对于第二信号相对于第一信号获得正对比度。

2. 发明申请

WO2007149454A2 IMAGING AGENTS FOR USE IN MAGNETIC RESONANCE BLOOD FLOW/PERFUSION IMAGING 审中-公开
标题翻译：成像剂用于磁共振血液/灌注成像
公开(公告)号：WO2007149454A2
公开(公告)日：2007-12-27
申请号：PCT/US2007014310
申请日：2007-06-19
申请人： BETH ISREAL DEACONESS MEDICAL , ALSOP DAVID , VINOGRADOV ELENA , GRANT AARON , LENKINSKI ROBERT
发明人： ALSOP DAVID , VINOGRADOV ELENA , GRANT AARON , LENKINSKI ROBERT
IPC分类号： A61K49/10
CPC分类号： A61K49/10
摘要： . In one aspect, a method of imaging blood flow in a region of interest of a subject using magnetic resonance imaging (MRI) is provided. The method includes introducing an imaging agent into the subject, the imaging agent including a compound having at least one hyperpolarized nucleus having a T 1 greater than 15 seconds and a water-octanol partition coefficient between -1 and 1, providing at least one excitation signal to the region of interest, the at least one excitation signal configured to invoke a nuclear magnetic resonance (NMR) effect at least in the introduced imaging agent, and detecting an NMR signal emitted by the region of interest in response to the at least one excitation signal. In another aspect, a method of imaging blood flow in a region of interest of a subject using magnetic resonance imaging (MRI) is provided. The method includes introducing an imaging agent into the subject, the imaging agent including a carbon- 13 enriched alcohol, providing at least one excitation signal to the region of interest, the at least one excitation signal configured to invoke a nuclear magnetic resonance (NMR) effect at least in the introduced imaging agent, and detecting an NMR signal emitted by the region of interest in response to the at least one excitation signal.
摘要翻译：。一方面，提供了使用磁共振成像（MRI）对受试者的感兴趣区域中的血液流动进行成像的方法。该方法包括将成像剂引入受试者，成像剂包括具有至少一个具有大于15秒的T 1 S的超极化核的化合物和-1和1之间的水 - 辛醇分配系数向所述感兴趣区域提供至少一个激励信号，所述至少一个激励信号被配置成至少在引入的成像剂中调用核磁共振（NMR）效应，并且检测由感兴趣区域发射的NMR信号响应于所述至少一个激励信号。在另一方面，提供了一种使用磁共振成像（MRI）对受试者感兴趣区域中的血液流动进行成像的方法。该方法包括将成像剂引入受试者，成像剂包括富含碳的富含醇的醇，向感兴趣区域提供至少一个激发信号，所述至少一个激发信号被配置成调用核磁共振（NMR）至少在引入的成像剂中起作用，并且响应于至少一个激发信号，检测由感兴趣区域发射的NMR信号。

3. 发明申请

WO2007149454A3 IMAGING AGENTS FOR USE IN MAGNETIC RESONANCE BLOOD FLOW/PERFUSION IMAGING 审中-公开
公开(公告)号：WO2007149454A3
公开(公告)日：2007-12-27
申请号：PCT/US2007/014310
申请日：2007-06-19
申请人： BETH ISREAL DEACONESS MEDICAL CENTER, INC. , ALSOP, David , VINOGRADOV, Elena , GRANT, Aaron , LENKINSKI, Robert
发明人： ALSOP, David , VINOGRADOV, Elena , GRANT, Aaron , LENKINSKI, Robert
IPC分类号： A61K49/10
摘要： . In one aspect, a method of imaging blood flow in a region of interest of a subject using magnetic resonance imaging (MRI) is provided. The method includes introducing an imaging agent into the subject, the imaging agent including a compound having at least one hyperpolarized nucleus having a T 1 greater than 15 seconds and a water-octanol partition coefficient between -1 and 1, providing at least one excitation signal to the region of interest, the at least one excitation signal configured to invoke a nuclear magnetic resonance (NMR) effect at least in the introduced imaging agent, and detecting an NMR signal emitted by the region of interest in response to the at least one excitation signal. In another aspect, a method of imaging blood flow in a region of interest of a subject using magnetic resonance imaging (MRI) is provided. The method includes introducing an imaging agent into the subject, the imaging agent including a carbon- 13 enriched alcohol, providing at least one excitation signal to the region of interest, the at least one excitation signal configured to invoke a nuclear magnetic resonance (NMR) effect at least in the introduced imaging agent, and detecting an NMR signal emitted by the region of interest in response to the at least one excitation signal.

4. 发明申请

WO2009126289A2 POSITIVE MAGNETIC RESONANCE IMAGING CONTRAST METHODS AND APPARATUS USING CHEMICAL EXCHANGE SATURATION TRANSFER 审中-公开
标题翻译：利用化学交换饱和转移的正磁共振成像对比方法和装置
公开(公告)号：WO2009126289A2
公开(公告)日：2009-10-15
申请号：PCT/US2009/002221
申请日：2009-04-09
申请人： BETH ISRAEL DEACONESS MEDICAL CENTER, INC. , VINOGRADOV, Elena , LENKINSKI, Robert, E.
发明人： VINOGRADOV, Elena , LENKINSKI, Robert, E.
IPC分类号： A61B5/055
CPC分类号： G01R33/485 , G01N24/087 , G01R33/5601
摘要： In one aspect, an apparatus for performing chemical exchange saturation transfer (CEST) magnetic resonance imaging on a region of an object being imaged is provided. The method comprises at least one coil capable of being operated to emit radio frequency (RF) signals, at least one detector capable of detecting nuclear magnetic resonance signals, and at least one controller to operate the at least one coil to provide at least one inversion sequence to the region to flip at least some spins in the region by a desired flip-angle, operate the at least one coil to provide at least one first pulse sequence at a first frequency offset from a peak resonant frequency of water by a first amount in a first direction to magnetize at least one exchange group in the region, operate the at least one coil to provide at least one second pulse sequence at a second frequency offset from the peak resonant frequency of water by the first amount in a second direction opposite the first direction, operate the at least one detector to measure a first signal emitted from the region as a result of providing the at least one first pulse sequence after a predetermined time interval after applying the first inversion sequence, and operate the at least one detector to measure a second signal emitted from the region as a result of providing the at least one second sequence at the predetermined time interval after applying the at least one inversion sequence, wherein the predetermined time interval is selected such that positive contrast is achieved with respect to the first signal relative to the second signal.
摘要翻译：在一个方面，提供了一种用于在正被成像的物体的区域上执行化学交换饱和转移（CEST）磁共振成像的装置。该方法包括至少一个能够被操作以发射射频（RF）信号的线圈，至少一个能够检测核磁共振信号的检测器以及至少一个控制器以操作至少一个线圈以提供至少一个反转序列到该区域以翻转该区域中的至少一些自旋达期望的翻转角，操作该至少一个线圈以提供至少一个第一脉冲序列，该第一脉冲序列在距水的峰值谐振频率第一频率偏移第一量在使所述区域中的至少一个交换组磁化的第一方向上，操作所述至少一个线圈以提供至少一个第二脉冲序列，所述第二脉冲序列在相对于水的峰值谐振频率的第二频率偏移第一量的第二方向作为在预定时间之后提供所述至少一个第一脉冲序列的结果，所述第一方向操作所述至少一个检测器以测量从所述区域发射的第一信号在施加所述至少一个反转序列之后，作为在所述预定时间间隔提供所述至少一个第二序列的结果，操作所述至少一个检测器以测量从所述区域发射的第二信号，其中，预定时间间隔被选择为使得相对于第一信号相对于第二信号实现正对比度。

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