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1. 发明公开

EP3700538A1 METHODS OF TREATING CANCER AND/OR ENHANCING SENSITIVITY TO CANCER TREATMENT BY INCREASING TUMOR MUTATION BURDEN OR TUMOR INDELS 审中-公开
公开(公告)号：EP3700538A1
公开(公告)日：2020-09-02
申请号：EP18869815.3
申请日：2018-10-23
申请人： Vincent, Mark David
发明人： Vincent, Mark David
IPC分类号： A61K31/7088 , A61K31/713 , A61P35/00 , A61P37/02 , C12N15/00 , C12N15/11 , C12N15/113

2. 发明专利

RS37804A UPOTREBA N,N-DIETIL-2-/4-(FENILMETIL)-FENOKSI/ETANAMIN MONOHIDROHLORIDA (DPPE) U TERAPIJI RAKA 未知
公开(公告)号：RS37804A
公开(公告)日：2006-12-15
申请号：YUP37804
申请日：2002-11-01
申请人： VINCENT MARK
发明人： VINCENT MARK
IPC分类号： A61K31/138 , A61K31/337 , A61K31/704 , A61K45/00 , A61P35/00 , A61P43/00
摘要： Ovaj pronalazak opisuje upotrebu N,N-dietil-2-[-4-(fenilmetil)-fenoksi]etanamin monohidrohlorida (DPPE) u lečenju od raka. DPPE se koristi u lečenju pacijenata koji su oboleli ili postoji sumnja da su oboleli od invazivnog tumora. Ovaj pronalazak se dalje bavi upotrebom DPPE u lečenju pacijenata kod kojih se sumnja na prethodno postojeći tumor, gde upotreba sledi nakon hirurškog lečenja primarnog karcinoma koji ne ispoljava estrogenski receptor. Takođe su opisane farmacetuske kompozicije koje sadrže DPPE za upotrebu u lečenju pacijenata koji imaju ili se sumnja da imaju invazivni tumor kao i komercijalni kitovi koji sadrže ovakve kompozicije.

3. 发明专利

CA3079907A1 METHODS OF TREATING CANCER AND/OR ENHANCING SENSITIVITY TO CANCER TREATMENT BY INCREASING TUMOR MUTATION BURDEN OR TUMOR INDELS 未知
公开(公告)号：CA3079907A1
公开(公告)日：2019-05-02
申请号：CA3079907
申请日：2018-10-23
申请人： VINCENT MARK DAVID
发明人： VINCENT MARK DAVID
IPC分类号： A61K31/7088 , A61K31/713 , A61P35/00 , A61P37/02 , C12N15/00 , C12N15/11 , C12N15/113
摘要： Methods of treating cancer or enhancing sensitivity to cancer therapies, including immunotherapies by increasing tumor mutation burden, are provided. The methods use therapeutics directed against DNA polymerase proofreading and/or mismatch repair enzymes such as MLH1, MSH2, MSH6 or PMS2. The therapeutics can be used alone, in tandem or in combination with other cancer therapies, in particular with immunotherapies. Also provided are antisense therapeutics targeting DNA polymerase proofreading and/or mismatch repair enzymes.

4. 发明申请

WO2011094571A8 METHOD FOR IMPROVING THE FUEL EFFICIENCY OF ENGINE OIL COMPOSITIONS FOR LARGE LOW AND MEDIUM SPEED ENGINES BY REDUCING THE TRACTION COEFFICIENT 审中-公开
标题翻译：通过减少牵引系数来提高大型低速和中速发动机的机油组合物的燃料效率的方法
公开(公告)号：WO2011094571A8
公开(公告)日：2011-08-04
申请号：PCT/US2011/022965
申请日：2011-01-28
申请人： EXXONMOBIL RESEARCH AND ENGINEERING COMPANY , TELLIER, Kathleen, H. , CAREY, Vincent, Mark , CROUTHAMEL, Kevin, Louis
发明人： TELLIER, Kathleen, H. , CAREY, Vincent, Mark , CROUTHAMEL, Kevin, Louis
IPC分类号： C10M111/04 , C10N30/06 , C10N40/25 , C10N40/26
摘要： The present invention is directed to a method for improving the fuel efficiency of low and medium speed engine oil compositions by reducing the traction coefficient of the oil by formulating the oil using at least two base stocks of different kinematic viscosity wherein the differences in kinematic viscosity between the base stocks is at least 30 mm 2 /s.
摘要翻译：本发明涉及一种通过使用至少两种不同运动学的基础油配制油来降低油的牵引系数来提高低速和中速发动机油组合物的燃料效率的方法其中基础油料之间的运动粘度差异至少为30mm 2 / s。

5. 发明申请

WO2007012795A1 EXTRACTION DEVICE FOR USE WHEN EXTRACTING A CERAMIC FOAM FILTER 审中-公开
标题翻译：提取陶瓷泡沫过滤器时使用的萃取装置
公开(公告)号：WO2007012795A1
公开(公告)日：2007-02-01
申请号：PCT/GB2006/002232
申请日：2006-06-19
申请人： PYROTEK INCORPORATED , VINCENT, Mark
发明人： VINCENT, Mark
IPC分类号： F16B25/10 , C22B9/02 , C22B21/06
CPC分类号： C22B21/066 , C22B9/023 , F16B25/103 , Y02P10/234 , Y10T29/49815 , Y10T29/53 , Y10T29/53687
摘要： An extraction device is provided for use when extracting a ceramic foam filter, as used for example in the production and processing of aluminium. The extraction device includes an anchor device (1) having an anchor body (2) suitable for driving into the filter, and a screw thread (8) that extends along at least part of the length of the anchor body, for engagement with the filter.
摘要翻译：提取提取装置用于提取陶瓷泡沫过滤器时，例如在铝的生产和加工中使用。提取装置包括具有适于驱动到过滤器中的锚固体（2）的锚定装置（1）和沿着锚固体长度的至少一部分延伸的螺纹（8），用于与过滤器。

6. 发明申请

WO2006113987A1 SYSTEM FOR DEVELOPMENT OF INDIVIDUALISED TREATMENT REGIMENS 审中-公开
标题翻译：发展个体化治疗方案制度
公开(公告)号：WO2006113987A1
公开(公告)日：2006-11-02
申请号：PCT/CA2006/000653
申请日：2006-04-25
申请人： CADUCEUS INFORMATION SYSTEMS INC. , DRANITSARIS, George , VINCENT, Mark
发明人： DRANITSARIS, George , VINCENT, Mark
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： G16H50/70 , G06F19/00 , G16H10/20 , G16H50/20 , G16H50/30 , G16H50/50
摘要： A system is provided for facilitating the development of an individualised treatment regimen for a patient based on an evaluation of the risk(s) associated with a disease and/or associated with known treatment options. In order to evaluate these risk(s), the system utilises clinical data from a plurality of patients having the disease in question. The clinical data includes information for each of the plurality of patients relating to the presence, absence and/or severity of one or more negative events. The negative event(s) can be disease-related, for example, a complication such as metastasis of a cancer to bone or the brain, or the negative event(s) can be treatment-related, for example a toxicity associated with the treatment. The system can also include prediction models that allow the probability that a patient will develop a toxicity or complication to be assessed. Methods for developing prediction models are provided.
摘要翻译：提供了一种系统，用于基于与疾病相关的风险的评估和/或与已知治疗选择相关联的方式促进针对患者的个体化治疗方案的开发。为了评估这些风险，该系统利用来自患有该疾病的多个患者的临床数据。临床数据包括与一个或多个阴性事件的存在，不存在和/或严重性相关的多个患者中的每一个的信息。阴性事件可以是疾病相关的，例如，诸如癌症对骨或脑的转移的并发症，或者阴性事件可以是治疗相关的，例如与治疗相关的毒性。该系统还可以包括允许患者发生毒性或并发症评估的可能性的预测模型。提供了开发预测模型的方法。

7. 发明申请

WO2004082867A3 CONTINUOUS CASTING INSTALLATION & PROCESS 审中-公开
标题翻译：连续铸造安装和工艺
公开(公告)号：WO2004082867A3
公开(公告)日：2004-11-11
申请号：PCT/GB2004001164
申请日：2004-03-18
申请人： PYROTEK ENGINEERING MATERIALS , VINCENT MARK
发明人： VINCENT MARK
IPC分类号： B22D11/117 , B22D11/119 , B22D41/01 , F27B17/00 , F27D3/14 , F27D11/00 , F27D21/00 , F27D99/00 , B22D41/005 , B22D11/06 , F27B14/06 , F27D23/00 , H05B3/62
CPC分类号： F27D99/0006 , B22D11/117 , B22D11/119 , B22D41/01 , F27B17/00 , F27D3/14 , F27D11/00 , F27D21/0014
摘要： A continuous casting installation includes a furnace (2) for heating metal to a first liquid metal temperature, a degassing unit (4), a filter (6), a heating unit (8) and a casting machine (10). The casting machine (10) includes a pair of casting rollers and a nozzle arranged to deliver liquid metal into a nip between the casting rollers, such that the metal solidifies as it passes through the nip. The heating unit (8) is located between the furnace and the casting machine, and is thermostatically controlled to heat the liquid metal to a second liquid metal temperature.
摘要翻译：一种连铸设备包括用于将金属加热至第一液态金属温度的炉（2），脱气单元（4），过滤器（6），加热单元（8）和浇铸机（10）。铸造机（10）包括一对铸造辊和喷嘴，该喷嘴布置成将液态金属输送到铸造辊之间的辊隙中，使得金属在通过辊隙时凝固。加热单元（8）位于熔炉和铸造机之间，并被恒温控制以加热液态金属至第二液态金属温度。

8. 发明申请

WO2004082867A2 CONTINUOUS CASTING INSTALLATION & PROCESS 审中-公开
标题翻译：连续铸造安装和工艺
公开(公告)号：WO2004082867A2
公开(公告)日：2004-09-30
申请号：PCT/GB2004/001164
申请日：2004-03-18
申请人： PYROTEK ENGINEERING MATERIALS LIMITED , VINCENT, Mark
发明人： VINCENT, Mark
IPC分类号： B22D
CPC分类号： F27D99/0006 , B22D11/117 , B22D11/119 , B22D41/01 , F27B17/00 , F27D3/14 , F27D11/00 , F27D21/0014
摘要： A continuous casting installation includes a furnace (2) for heating metal to a first liquid metal temperature, a degassing unit (4), a filter (6), a heating unit (8) and a casting machine (10). The casting machine (10) includes a pair of casting rollers and a nozzle arranged to deliver liquid metal into a nip between the casting rollers, such that the metal solidifies as it passes through the nip. The heating unit (8) is located between the furnace and the casting machine, and is thermostatically controlled to heat the liquid metal to a second liquid metal temperature.
摘要翻译：连续铸造设备包括用于将金属加热到第一液态金属温度的炉（2），脱气单元（4），过滤器（6），加热单元（8）和浇铸机（10）。铸造机（10）包括一对铸辊和喷嘴，其布置成将液态金属输送到铸辊之间的辊隙中，使得金属在其通过辊隙时固化。加热单元（8）位于炉和铸造机之间，并被恒温控制以将液态金属加热至第二液态金属温度。

9. 发明申请

WO2003093291A3 ANTISENSE OLIGONUCLEOTIDES FOR IDENTIFYING DRUG TARGETS AND ENHANCING CANCER THERAPIES 审中-公开
公开(公告)号：WO2003093291A3
公开(公告)日：2003-11-13
申请号：PCT/CA2003/000610
申请日：2003-05-01
申请人： SARISSA INC. , VINCENT, Mark, D. , KOROPATNICK, D., James , BERG, Randall, W.
发明人： VINCENT, Mark, D. , KOROPATNICK, D., James , BERG, Randall, W.
IPC分类号： C12N15/11
摘要： The present invention provides antisense oligonucleotides useful for identifying drug targets for cancer therapies and for enhancing current cancer therapies. The oligonucleotides of the invention are complementary to thymidylate synthase mRNA and affect expression of at least one other gene. For the enhancement of cancer therapies, such antisense oligonucleotides can be used in conjunction with standard chemotherapeutic agents in order to target thymidylate synthase, as well as other appropriate targets. The antisense oligonucleotides and the methods of the invention constitute improved antisense therapies with application to a variety of cancers.

10. 发明申请

WO2003037318A1 USE OF N,N-DIETHYL-2-[-4-(PHENYLMETHYL)-PHENOXY]ETHANAMINE MONOHYDROCHLORIDE (DPPE) IN CANCER THERAPY 审中-公开
标题翻译： N，N-二乙基-2 - [ - 4-（苯基甲基） - 苯氧基]乙酰胺单盐酸盐（DPPE）在癌症治疗中的应用
公开(公告)号：WO2003037318A1
公开(公告)日：2003-05-08
申请号：PCT/CA2002/001651
申请日：2002-11-01
申请人： VINCENT, Mark
发明人： VINCENT, Mark
IPC分类号： A61K31/138
CPC分类号： A61K31/704 , A61K31/138 , A61K2300/00
摘要： The present invention provides for the use of N,N-diethyl-2-[-4-(phenylmethyl)-phenoxy]ethanamine monohydrochloride (DPPE) in cancer therapy. DPPE is used in the treatment of patients having, or suspected of having, an aggressive cancer. The present invention further provides for the use of DPPE in the treatment of a patient suspected of having an existing cancer, wherein the use follows a surgery for treatment of a primary cancer that is estrogen-receptor negative. Also provided are pharmaceutical compositions comprising DPPE for use in the treatment of patients having, or suspected of having, an aggressive cancer and pharmaceutical kits comprising such compositions.
摘要翻译：本发明提供N，N-二乙基-2- [ - 4-（苯基甲基） - 苯氧基]乙胺单盐酸盐（DPPE）在癌症治疗中的用途。 DPPE用于治疗患有或怀疑患有侵袭性癌症的患者。本发明进一步提供DPPE用于治疗疑似患有现有癌症的患者，其中所述用途遵循用于治疗雌激素受体阴性的原发性癌症的手术。还提供了包含DPPE的药物组合物，其用于治疗患有侵袭性癌症的患者或怀疑具有侵袭性癌症的患者以及包含该组合物的药物试剂盒。

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