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1. 发明申请

WO2013008062A1 NON COVALENT MOLECULAR STRUCTURE, COMPRISING A PYRENE BASED GLYCOCONJUGATE, DEVICE COMPRISING THE SAME AND ITS USE FOR DETECTION OF LECTIN 审中-公开
标题翻译：非共价分子结构，包含基于聚苯乙烯的甘油三酯，其包含其的装置及其用于检测LECTIN
公开(公告)号：WO2013008062A1
公开(公告)日：2013-01-17
申请号：PCT/IB2011/053100
申请日：2011-07-12
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITÉ CLAUDE BERNARD LYON 1 (UCBL) , INSA LYON , University of Pittsburgh - Of the Commonwealth System of Higher Education , STAR, Alexander , VIDAL, Sébastien , IMBERTY, Anne
发明人： STAR, Alexander , VIDAL, Sébastien , IMBERTY, Anne
IPC分类号： G01N27/414 , B82Y5/00 , G01N33/543 , C07H15/26
CPC分类号： G01N33/566 , C07H15/26 , G01N33/5438 , G01N2333/42 , G01N2333/4724
摘要： The present invention relates to a non covalent molecular structure comprising a carbon nanostructure and a pyrene based glycoconjugate (I) which is linked to the said carbon nanostructure by a non covalent link, the said glycoconjugate (I) having the formula : wherein B is a group which is present on any of the ten carbon atoms of the pyrene structure represented in ( I ) susceptible to bear a substituent, and is represented by the following group : -(CH2) n -CO-NH-A, wherein n is an integer from 1 to 9, A is a group of formula : The present invention also relates to an electronic device comprising the said non covalent molecular structure, and to the use of this device for the detection of a lectin involved in bacterial or viral infections. Thus the invention also relates to a method for detecting the presence of a lectin in a sample to be analysed.
摘要翻译：本发明涉及包含碳纳米结构和芘基糖缀合物（I）的非共价分子结构，其通过非共价键与所述碳纳米结构连接，所述糖缀合物（I）具有下式：其中B是存在于易于承载取代基的（I）中表示的芘结构的十个碳原子中的任何一个的基团，并且由以下基团表示： - （CH 2）n -CO-NH-A，其中n是 A为1至9的整数，A为下式的基团：本发明还涉及包含所述非共价分子结构的电子器件，以及该装置用于检测涉及细菌或病毒感染的凝集素的用途。因此，本发明还涉及用于检测待分析样品中凝集素的存在的方法。

2. 发明申请

WO2012076934A1 GLYCOMIMETIC COMPOUNDS AS ANTI-INFECTIOUS AGAINST PATHOGENS LECTINS 审中-公开
标题翻译：作为抗病原体的抗感染药物的胶体化合物
公开(公告)号：WO2012076934A1
公开(公告)日：2012-06-14
申请号：PCT/IB2010/055741
申请日：2010-12-10
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE CLAUDE BERNARD LYON 1 , IMBERTY, Anne , VIDAL, Sébastien , MATTHEWS, Susan , FAURE, Karine , GUERY, Benoit , CECIONI, Samy
发明人： IMBERTY, Anne , VIDAL, Sébastien , MATTHEWS, Susan , FAURE, Karine , GUERY, Benoit , CECIONI, Samy
IPC分类号： C07H3/06 , C07H5/06 , A61K31/7028 , A61P31/04
CPC分类号： C07H17/08 , C07H3/06 , C07H5/06 , C07H17/02
摘要： The present invention relates to a calixarene-based glycosylated compound (I) having the formula : (I) wherein D is independently selected in the group comprising a –CH 2 –group, an oxygen atom, a sulphur atom, a sulfinyl group or a sulfonyl group, E is independently selected in the group comprising a hydrogen, an alkyl having from 1 to 10 carbon atoms, an aryl having from 6 to 20 carbon atoms, a nitrogen dioxide group, an azide group, an amino group, a guanidinium group,a halogen atom, a –CH 2 R group wherein R is a hydroxyl, a halogen, an amino group, a N(alkyl) 2 group, a NH(alkyl) group, or E represents a –CO-R' wherein R' is a hydrogen atom, a hydroxyl group or an amino, B represents a A–C group wherein A is independently selected in the group comprising an oxygen atom, a sulfur atom, a NH group or a (CH 2 ) i group, i being an integer from 1 to 10, C is independently selected in the group comprising a hydrogen, an alkyl, an alkenyl, an alkynyl, or C is a group of formula (II). The present invention also relates to a pharmaceutical composition characterized in that it comprises the said calixarene-based glycosylated compound (I), in combination with pharmaceutically acceptable carriers or diluents. The present invention also relates to the use of the said calixarene-based glycosylated compound (I) or the said pharmaceutical composition, for the manufacture of a drug intended to prevent or treat bacterial infections from pathogens that use lectins in the first steps of infection.
摘要翻译：本发明涉及具有下式的杯芳烃类糖基化化合物（I）：（I）其中D独立地选自-CH 2 - 基，氧原子，硫原子，亚磺酰基或磺酰基基团，E独立地选自包含氢，具有1至10个碳原子的烷基，具有6至20个碳原子的芳基，二氧化氮基，叠氮基，氨基，胍基，卤素原子，-CH 2 R基团，其中R是羟基，卤素，氨基，N（烷基）2基团，NH（烷基）基团或E表示-CO-R'，其中R' 氢原子，羟基或氨基，B表示其中A独立地选自氧原子，硫原子，NH基或（CH 2）i基团中的A基团，i为1的整数，至10，C独立地选自包含氢，烷基，烯基，炔基或C是式（II）的基团。本发明还涉及药物组合物，其特征在于其包含所述基于杯芳烃的糖基化化合物（I），与药学上可接受的载体或稀释剂组合。本发明还涉及所述基于杯芳烃的糖基化化合物（I）或所述药物组合物在制备用于预防或治疗在感染的第一步中使用凝集素的病原体的细菌感染的药物中的用途。

3. 发明申请

WO2011158200A1 NON COVALENT MOLECULAR STRUCTURE, DEVICE COMPRISING THE SAME AND ITS USE FOR THE DETECTION OF A LECTIN 审中-公开
标题翻译：非共价分子结构，包含它的设备及其用于检测LECTIN
公开(公告)号：WO2011158200A1
公开(公告)日：2011-12-22
申请号：PCT/IB2011/052617
申请日：2011-06-16
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE CLAUDE BERNARD LYON 1 (UCBL) , UNIVERSITY OF PITTSBURGH , IMBERTY, Anne , VIDAL, Sébastien , STAR, Alexander
发明人： IMBERTY, Anne , VIDAL, Sébastien , STAR, Alexander
IPC分类号： G01N33/68 , G01N33/72 , G01N33/531 , G01N33/543
CPC分类号： G01N33/56911 , C01B32/174 , G01N33/5438 , G01N33/72 , G01N2333/4724
摘要： The present invention relates to a non covalent molecular structure comprising a carbon nanostructure and a porphyrin based glycoconjugate (I) which is linked to the said carbon nanostructure by a non covalent link, the said glycoconjugate (I) having the formula (I): wherein M is a metal selected in the group comprising Fe, Ni, Zn, Cu, Mn, Cr or Co, B is a group which is present on at least one of the four phenyl group (C 6 H 5 ) represented in (I), n is an integer from 1 to 3, that is to say that one to three B group(s) may be present on each phenyl group, and B is represented by a -A-C group wherein A is selected in the group comprising an oxygen atom, a sulfur atom, a N H group or a (CH 2 ) n1 group, n 1 being an integer from 1 to 10, C is a group of formula (II). The present invention also relates to an electronic device comprising the said non covalent molecular structure, and to the use of this device for the detection of a lectin involved in bacterial or viral infections. Thus the invention also relates to a method for detecting the presence of a lectin in a sample to be analysed.
摘要翻译：本发明涉及一种非共价分子结构，其包含碳纳米结构和基于卟啉的糖缀合物（I），其通过非共价键与所述碳纳米结构连接，所述糖缀合物（I）具有式（I）：其中 M是选自Fe，Ni，Zn，Cu，Mn，Cr或Co的金属，B是存在于（I）中所表示的四个苯基（C 6 H 5）中的至少一个上的基团，n是 1〜3的整数，也就是说，可以在每个苯基上存在一至三个B基团，B由-AC基团表示，其中A选自氧原子，硫原子，NH基或（CH 2）n1基，n1为1〜10的整数，C为式（II）的基团。本发明还涉及包含所述非共价分子结构的电子器件，以及该装置用于检测涉及细菌或病毒感染的凝集素的用途。因此，本发明还涉及用于检测待分析样品中凝集素的存在的方法。

4. 发明申请

WO2011158068A1 NON COVALENT MOLECULAR STRUCTURE, DEVICE COMPRISING THE SAME AND ITS USE FOR DETECTION OF LECTIN 审中-公开
标题翻译：非共价分子结构，包含它的装置及其用于检测LECTIN
公开(公告)号：WO2011158068A1
公开(公告)日：2011-12-22
申请号：PCT/IB2010/052754
申请日：2010-06-18
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , IMBERTY, Anne , VIDAL, Sébastien , STAR, Alexander
发明人： IMBERTY, Anne , VIDAL, Sébastien , STAR, Alexander
IPC分类号： G01N33/68 , G01N33/72 , G01N33/531 , G01N33/543
CPC分类号： G01N33/56911 , C01B32/174 , G01N33/5438 , G01N33/72 , G01N2333/4724
摘要： The present invention relates to a non covalent molecular structure comprising a carbon nanostructure and a porphyrin based glycoconjugate (I) which is linked to the said carbon nanostructure by a non covalent link, the said glycoconjugate (I) having the Formula (I) : wherein M is a metal selected in the group comprising Fe, Ni, Zn, Cu, Mn, Cr or Co, B is a group which is present on at least one of the four phenyl group (C 6 H 5 ) represented in (I), n is an integer from 1 to 3, that is to say that one to three B group(s) may be present on each phenyl group, and B is represented by a -A-C group wherein A is selected in the group comprising an oxygen atom, a sulfur atom, a NH group or a (CH 2 ) n1 group, n 1 being an integer from 1 to 10, C is a group of Formula (II) : The present invention also relates to an electronic device comprising the said non covalent molecular structure, and to the use of this device for the detection of a lectin involved in bacterial or viral infections. Thus the invention also relates to a method for detecting the presence of a lectin in a sample to be analysed.
摘要翻译：本发明涉及一种非共价分子结构，其包含碳纳米结构和基于卟啉的糖缀合物（I），其通过非共价键与所述碳纳米结构连接，所述糖缀合物（I）具有式（I）：其中 M是选自Fe，Ni，Zn，Cu，Mn，Cr或Co组成的金属，B是存在于（I）中表示的四个苯基（C 6 H 5）中的至少一个上的基团，n是 1〜3的整数，也就是说，可以在每个苯基上存在一至三个B基团，B由-AC基团表示，其中A选自氧原子，硫原子，NH基或（CH 2）n1基，n1为1至10的整数，C为式（II）的基团：本发明还涉及包含所述非共价分子结构的电子器件，以及使用该装置来检测涉及细菌或病毒感染的凝集素。因此，本发明还涉及用于检测待分析样品中凝集素的存在的方法。

5. 发明申请

WO2007125429A2 METHOD FOR THE SYNTHESIS OF OLIGONUCLEOTIDE DERIVATIVES 审中-公开
标题翻译：寡核苷酸衍生物的合成方法
公开(公告)号：WO2007125429A2
公开(公告)日：2007-11-08
申请号：PCT/IB2007/002486
申请日：2007-04-26
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , MORVAN, François , MEYER, Albert , VASSEUR, Jean-Jacques , VIDAL, Sébastien , CLOAREC, Jean-Pierre , CHEVOLOT, Yann , SOUTEYRAND, Eliane
发明人： MORVAN, François , MEYER, Albert , VASSEUR, Jean-Jacques , VIDAL, Sébastien , CLOAREC, Jean-Pierre , CHEVOLOT, Yann , SOUTEYRAND, Eliane
CPC分类号： C07H21/00 , Y10T436/143333
摘要： Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a "click chemistry" reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.
摘要翻译：合成核苷酸衍生物的方法，其中目的分子在寡核苷酸上接枝，借助于目标分子上的叠氮化物官能团与寡核苷酸上的炔官能团之间的“点击化学”反应，或者在目标分子和寡核苷酸上的叠氮基功能。中间分子，特别是炔官能化寡核苷酸，接枝寡核苷酸，叠氮化物官能化寡核苷酸，含有它们的寡核苷酸微阵列以及这些接枝寡核苷酸用于生物学研究和用于细胞靶向的用途。

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