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1. 发明专利

IL291562D0 Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis 未知
公开(公告)号：IL291562D0
公开(公告)日：2022-05-01
申请号：IL29156222
申请日：2022-03-21
申请人： ADARE PHARMACEUTICALS INC , GOSSELIN MICHAEL A , LAI JIN WANG , VENKATESH GOPI M
发明人： GOSSELIN MICHAEL A , LAI JIN-WANG , VENKATESH GOPI M
IPC分类号： A61K31/56 , A61K45/06 , A61P29/00 , B29C43/00
摘要： The present invention is directed to orally administered compositions of topically acting corticosteroids for the treatment of inflammation of the gastrointestinal tracts such as eosinophilic esophagitis. The present invention also provides a method for treating conditions associated with inflammation of the gastrointestinal tract in an individual. The method comprises administering to an individual in need thereof a pharmaceutical composition of the present invention as orally disintegrating tablets comprising a topically active corticosteroid adsorbed onto a pharmaceutically acceptable carrier such as silicified microcrystalline cellulose.

2. 发明专利

IL291562A Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis 未知
公开(公告)号：IL291562A
公开(公告)日：2022-05-01
申请号：IL29156222
申请日：2022-03-21
申请人： ADARE PHARMACEUTICALS INC , GOSSELIN MICHAEL A , LAI JIN WANG , VENKATESH GOPI M
发明人： GOSSELIN MICHAEL A , LAI JIN-WANG , VENKATESH GOPI M
摘要： The present invention is directed to orally administered compositions of topically acting corticosteroids for the treatment of inflammation of the gastrointestinal tracts such as eosinophilic esophagitis. The present invention also provides a method for treating conditions associated with inflammation of the gastrointestinal tract in an individual. The method comprises administering to an individual in need thereof a pharmaceutical composition of the present invention as orally disintegrating tablets comprising a topically active corticosteroid adsorbed onto a pharmaceutically acceptable carrier such as silicified microcrystalline cellulose.

3. 发明申请

WO2011041509A1 ORALLY ADMINISTERED CORTICOSTEROID COMPOSITIONS 审中-公开
公开(公告)号：WO2011041509A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/050860
申请日：2010-09-30
申请人： EURAND, INC. , VENKATESH, Gopi M. , PERRETT, Stephen , COHEN, Fredric Jay
发明人： VENKATESH, Gopi M. , PERRETT, Stephen , COHEN, Fredric Jay
IPC分类号： A61K31/56
CPC分类号： A61K9/0065 , A61K9/0053 , A61K9/0056 , A61K9/006 , A61K9/06 , A61K9/08 , A61K31/56 , A61K31/569 , A61K31/58 , A61K45/06 , A61K47/38 , A61K2300/00
摘要： Orally administered corticosteroid compositions and methods for treating a condition associated with inflammation of the gastrointestinal tract in an individual, comprising administering to an individual said orally administered corticosteriod composition are disclosed.
摘要翻译：口服给药皮质类固醇组合物和治疗与个体中胃肠道炎症有关的病症的方法，包括给予个体所述口服给药的皮质类固醇组合物。

4. 发明申请

WO2011035079A1 PANCREATIC ENZYME COMPOSITIONS AND METHODS FOR TREATING PANCREATITIS AND PANCREATIC INSUFFICIENCY 审中-公开
标题翻译：胰蛋白酶组合物和治疗胰腺癌和胰腺癌的方法
公开(公告)号：WO2011035079A1
公开(公告)日：2011-03-24
申请号：PCT/US2010/049203
申请日：2010-09-17
申请人： EURAND, INC. , VENKATESH, Gopi M. , PERRETT, Stephen , THIEROFF-EKERDT, Ruth , EFTHYMIOPOULOS, Konstantino
发明人： VENKATESH, Gopi M. , PERRETT, Stephen , THIEROFF-EKERDT, Ruth , EFTHYMIOPOULOS, Konstantino
IPC分类号： A61K38/43
CPC分类号： A61K9/16 , A61K9/2813 , A61K9/2866 , A61K9/4808 , A61K9/5084 , A61K38/00 , A61K38/465 , A61K38/48
摘要： Compositions of the present invention, comprising the combination of enterically coated and uncoated pancreatic enzyme-containing beads are useful for treating or preventing pancreatitis pain, and optionally disorders associated with digestive enzyme deficiencies.
摘要翻译：包含肠溶包衣和未包被胰酶的珠的组合的本发明的组合物可用于治疗或预防胰腺炎疼痛，以及任选与消化酶缺陷相关的病症。

5. 发明申请

WO2010127345A3 ORALLY DISINTEGRATING TABLET COMPOSITIONS COMPRISING COMBINATIONS OF HIGH AND LOW-DOSE DRUGS 审中-公开
公开(公告)号：WO2010127345A3
公开(公告)日：2010-11-04
申请号：PCT/US2010/033389
申请日：2010-05-03
申请人： EURAND, INC. , VENKATESH, Gopi, M. , CLEVENGER, James , GOSSELLIN, Michael , LAI, Jin-Wang
发明人： VENKATESH, Gopi, M. , CLEVENGER, James , GOSSELLIN, Michael , LAI, Jin-Wang
IPC分类号： A61K9/00
摘要： The present invention is directed to pharmaceutical compositions comprising a plurality of taste-masked high-dose/low-dose drug-containing microparticles, dosage forms comprising such pharmaceutical compositions (such as an orally disintegrating tablet), and methods of making the pharmaceutical compositions and dosage forms of the present invention. Dosage forms comprising the pharmaceutical compositions of the present invention are improved homogeneous blends of high-dose and low-dose drugs which provide for more convenient and palatable administration of drug combinations, for example for treating pain, hyperglycemia, cardiovascular disease, and allergies.

6. 发明申请

WO2005105049A8 ORALLY DISINTEGRATING TABLETS AND METHODS OF MANUFACTURE 审中-公开
标题翻译： ORALLY DISINCATTATTING TABLETS AND METHODS OF MANUFACTURE
公开(公告)号：WO2005105049A8
公开(公告)日：2006-03-30
申请号：PCT/US2005010901
申请日：2005-03-31
申请人： EURAND PHARMACEUTICALS LTD , VENKATESH GOPI M , QIAN KEN KANGYI , VANGALA SHYAM , CLEVENGER JAMES M , GUENTHER DONALD
发明人： VENKATESH GOPI M , QIAN KEN KANGYI , VANGALA SHYAM , CLEVENGER JAMES M , GUENTHER DONALD
IPC分类号： A61K9/20 , A61K9/00 , A61K9/16 , A61K9/46 , A61K9/50 , A61K31/34
CPC分类号： A61K9/2081 , A61K9/0056 , A61K9/1623 , A61K9/1635 , A61K9/2018 , A61K9/2027 , A61K9/2095 , A61K9/5042 , A61K31/34 , A61K31/341 , A61K31/4045
摘要： A tablet that rapidly disintegrates in the oral cavity comprising a compressed blend of rapidly dispersing microgranules prepared by granulating a sugar alcohol or a saccharide or a mixture thereof having an average particle size less than about 30 microns and a disintegrant, and a taste-masked microcapsule containing at least one drug, the microcapsule being prepared by granulating a pharmaceutically acceptable formulation comprising at least one drug in a therapeutically effective amount and at least one polymeric binder that improves resilience of the microgranules, wet milling the granulated mass, and microencapsulating the milled granules to provide microcapsules.
摘要翻译：一种在口腔内快速崩解的片剂，其包含通过将平均粒度小于约30微米的糖醇或糖或其混合物制成的快速分散的微粒的压缩共混物和崩解剂，以及掩味微胶囊含有至少一种药物，所述微胶囊通过将包含至少一种治疗有效量的药物的药学上可接受的制剂和至少一种改善微粒回弹性的聚合物粘合剂制粒，湿法研磨造粒物质，并将研磨的颗粒微胶囊化以提供微胶囊。

7. 发明申请

WO2011082426A1 CONTROLLED RELEASE COMPOSITIONS COMPRISING MECLIZINE OR RELATED PIPERAZINE DERIVATIVES 审中-公开
标题翻译：包含梅毒或相关哌嗪衍生物的受控释放组合物
公开(公告)号：WO2011082426A1
公开(公告)日：2011-07-07
申请号：PCT/US2011/020130
申请日：2011-01-04
申请人： EURAND, INC. , VENKATESH, Gopi, M. , HARMON, Troy, M.
发明人： VENKATESH, Gopi, M. , HARMON, Troy, M.
IPC分类号： A61K31/497
CPC分类号： A61K31/497 , A61K9/0056 , A61K9/2081 , A61K9/5042 , A61K9/5047 , A61K9/5078
摘要： The present invention provides pharmaceutically acceptable compositions for once-daily dosing comprising a piperazine derivative of H 1 -receptor antagonists, or its salt, and/or solvate and methods of making and using the compositions in the treatment of treating vertigo and other diseases. The present invention also provides once-a-day dosage forms as orally disintegrating tablets comprising compositions of the present invention.
摘要翻译：本发明提供了包含H1-受体拮抗剂或其盐的哌嗪衍生物，和/或溶剂化物以及制备和使用该组合物治疗眩晕和其他疾病的方法的药物可接受的组合物。本发明还提供了包含本发明组合物的口服崩解片剂的一日剂型。

8. 发明申请

WO2011005671A1 METHODS OF TREATING PDNV AND PONV WITH EXTENDED RELEASE ONDANSETRON COMPOSITIONS 审中-公开
标题翻译：用扩展释放的ONDANSETRON组合物处理PDNV和PONV的方法
公开(公告)号：WO2011005671A1
公开(公告)日：2011-01-13
申请号：PCT/US2010/040868
申请日：2010-07-02
申请人： EURAND, INC. , VENKATESH, Gopi M. , PERRETT, Stephen , THIEROFF-EKERDT, Ruth
发明人： VENKATESH, Gopi M. , PERRETT, Stephen , THIEROFF-EKERDT, Ruth
IPC分类号： A01N43/50 , A61K31/415
CPC分类号： A61K31/4178 , A61K9/5073 , A61K9/5078 , A61K31/00 , A61K45/06 , A61K2300/00
摘要： Extended release ondansetron compositions of the present invention are useful for treating postoperative nausea and vomiting (PONV) and/or postdischarge nausea and vomiting (PDNV).
摘要翻译：本发明的延长释放昂丹司琼组合物可用于治疗术后恶心呕吐（PONV）和/或放电后恶心呕吐（PDNV）。

9. 发明申请

WO2009006516A1 ORALLY DISINTEGRATING TABLET COMPOSITIONS OF LAMOTRIGINE 审中-公开
标题翻译：洛伐他汀的片剂组合物的ORALLY DISINCAGE
公开(公告)号：WO2009006516A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/069000
申请日：2008-07-02
申请人： EURAND, INC. , VENKATESH, Gopi M. , VYAS, Nehal H. , GOSSELIN, Michael , LAI, Jin-wang
发明人： VENKATESH, Gopi M. , VYAS, Nehal H. , GOSSELIN, Michael , LAI, Jin-wang
IPC分类号： A01N43/64 , A61K31/53
CPC分类号： A61K31/53 , A61K9/0007 , A61K9/0056 , A61K9/2072 , A61K9/2077 , A61K9/2081 , A61K9/2095 , A61K9/5005 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5042 , A61K9/5047 , A61K9/5084 , A61K9/5089
摘要： The compositions of the present invention composition comprise a therapeutically effective amount of particles comprising lamotrigine, in combination with granules comprising a disintegrant, and a sugar alcohol and/or a saccharide. These compositions are useful in treating epilepsy and bipolar disorder, particularly for patients with dysphagia, and to improve compliance with bipolar patients.
摘要翻译：本发明组合物的组合物包含治疗有效量的包含拉莫三嗪的颗粒，以及包含崩解剂和糖醇和/或糖类的颗粒。这些组合物可用于治疗癫痫和双相障碍，特别是对于吞咽困难的患者，并改善对双相患者的依从性。

10. 发明申请

WO2007090091A2 DRUG DELIVERY SYSTEMS COMPRISING WEAKLY BASIC DRUGS AND ORGANIC ACIDS 审中-公开
标题翻译：包含弱碱性药物和有机酸的药物递送系统
公开(公告)号：WO2007090091A2
公开(公告)日：2007-08-09
申请号：PCT/US2007061237
申请日：2007-01-29
申请人： EURAND INC , VENKATESH GOPI M
发明人： VENKATESH GOPI M
CPC分类号： A61K9/2077 , A61K9/0056 , A61K9/5047 , A61K9/5078 , A61K9/5084
摘要： A pharmaceutical dosage form such as a capsule, a conventional or orally disintegrating tablet capable of delivering a nitrogen (N)-containing therapeutic agent having a pKa in the range of from about 5 to 14 into the body in a sustained- released fashion, in order to be suitable for a twice- or once-daily dosing regimen, comprises at least one organic acid, which solubilizes the therapeutic agent the drug prior to releasing it into the hostile intestinal environment wherein said weakly basic drug is practically insoluble. The unit dosage form is composed of a multitude of multicoated particulates (i.e., immediate-release beads, sustained- release beads and/or one or more timed, pulsatile-release bead populations) is designed in such a way that said weakly basic drug and said organic acid do not come into close contact during processing and/or storage for in-situ formation of acid addition compounds while ensuring that the acid is not depleted prior to completion of the drug release.
摘要翻译：药物剂型例如胶囊，常规或口腔崩解片剂，其能够以缓释方式将pKa为约5至14的含有氮（N）的治疗剂以持续释放的方式递送至体内，为了适用于每日两次或每天一次的给药方案，包含至少一种有机酸，其在药物释放到其中所述弱碱性药物实际上不可溶的恶劣肠环境中之前溶解药物的治疗剂。单位剂型由多种多层颗粒（即，立即释放珠，缓释珠和/或一种或多种定时，脉冲释放珠粒群）组成，使得所述弱碱性药物和所述有机酸在处理和/或储存过程中不会紧密接触以原位形成酸加成化合物，同时确保酸在药物释放完成之前不被耗尽。

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