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1. 发明申请

WO1996003914A1 CALIBRATION OF SEGMENTAL BLOOD VOLUME CHANGES IN ARTERIES AND VEINS FOR PULSE VOLUME RECORDERS 审中-公开
标题翻译：脉冲体积记录仪的动脉和血管内分泌血液体积变化的校正
公开(公告)号：WO1996003914A1
公开(公告)日：1996-02-15
申请号：PCT/US1995009725
申请日：1995-08-02
申请人： VASOCOR, INC.
发明人： VASOCOR, INC. , RAINES, Jeffrey, K. , SNYDER, Leon, T. , HOFFMAN, John
IPC分类号： A61B05/02
CPC分类号： A61B5/02141 , A61B5/022 , A61B5/742 , A61B2560/0223
摘要： The calibration device includes a controllable pneumatic pump (44), a pressure sensor (48), a computerized device (72) for determining when a representative number of blood volume change signals are substantially similar and thereafter generating a calibration signal. The calibration system also includes a device which changes the volume in the closed peumatic system by a predetermined calibrated amount in the presence of the calibration trigger signal. This volume changing device may be a series of valves (V1, V2) coupled by a chamber (50) having a known volumetric size or a positive displacement pump driven by a stepper motor. The calibration system also includes a computerized device for correcting representative blood volume change signals based on the pressure signals at each discrete level of cuff pressure as corrected by the calibration signals represented by detected pressure signals obtained substantially simultaneously with the change of the volume at each discrete level of cuff pressure.
摘要翻译：校准装置包括可控气动泵（44），压力传感器（48），计算机化装置（72），用于确定代表数量的血容量变化信号何时基本相似，然后产生校准信号。校准系统还包括一种在存在校准触发信号的情况下将闭合的皮肤系统中的体积改变预定校准量的装置。该体积改变装置可以是由具有已知体积尺寸的室（50）和由步进电动机驱动的容积式泵耦合的一系列阀（V1，V2）。该校准系统还包括一个计算机化装置，用于根据每个离散级别的袖带压力下的压力信号来校正代表性的血容量变化信号，所述压力信号由校准信号校正，所述校准信号由检测到的压力信号表示，袖带压力水平。

2. 发明专利

AU3922000A Calibrated measurement of blood vessels and endothelium after reactive hyperemiaand method therefor 未知
公开(公告)号：AU3922000A
公开(公告)日：2000-10-16
申请号：AU3922000
申请日：2000-03-24
申请人： VASOCOR INC
发明人： RAINES JEFFREY K , INSULL WILLIAM
IPC分类号： A61B5/0295 , A61B5/022 , A61B5/026 , A61B5/02
摘要： Calibrated method characterizing blood flow in a patient's limb during reactive hyperemia episode utilizes a blood pressure cuff, establishes a predetermined, near diastolic, pressure in the cuff during the episode, continually senses the pressure cuff and periodically changes the internal volume of the cuff by a predetermined volumetric amount to calibrate the system with a calibration pressure pulse. The method may determine the condition of blood vessels and endothelium by determining, for each calibration cycle, a blood volume peak and comparing the peak with peak volume values for healthy blood vessels and endothelium (potentially waveform analysis). The method, implemented as a system, inflates, during pre-test, the cuff to a suprasystolic pressure, and establishes the near diastolic pressure in the cuff during the episode. A sensor generates a pressure signal and a subsystem periodically changes the volume during calibration such that a corrected and calibrated blood volume signal is calculated.

3. 发明专利

CA2367663C CALIBRATED MEASUREMENT OF BLOOD VESSELS AND ENDOTHELIUM AFTER REACTIVE HYPEREMIA AND METHOD THEREFOR 未知
公开(公告)号：CA2367663C
公开(公告)日：2003-02-18
申请号：CA2367663
申请日：2000-03-24
申请人： VASOCOR INC
发明人： RAINES JEFFREY K , INSULL WILLIAM JR
IPC分类号： A61B5/0295 , A61B5/022 , A61B5/026 , A61B5/02
摘要： The calibrated method for characterizing blood flow in a limb of a patient during reactive hyperemia utilizes a blood pressure cuff (14). The method establishes a predetermined, near diastolic, pressure in the blood pressure cuff (14) during the reactive hyperemic episode, continually senses via a sensor (68) the pressure in the cuff, and periodically changes the internal volume of the blood pressure cuff by a predetermined volumetric amount to calibrate the system. The resultant change in the pressure is a calibration pressure pulse (P-cal), and is used to calculate pulsatile blood volume through the blood vessel. A calibrated method for determining the condition of blood vessels, and endothelium includes determining, for each calibration cycle, a respective peak value (t-P) for the blood volume, and comparing the peak blood volume values with peak blood volume values for healthy blood vessels, and endothelium. The comparison preferably utlizes a waveform (W1).

4. 发明专利

AU752781B2 Calibrated measurement of blood vessels and endothelium after reactive hyperemia and method therefor 未知
公开(公告)号：AU752781B2
公开(公告)日：2002-10-03
申请号：AU3922000
申请日：2000-03-24
申请人： VASOCOR INC
发明人： RAINES JEFFREY K , INSULL WILLIAM
IPC分类号： A61B5/0295 , A61B5/022 , A61B5/026 , A61B5/02

5. 发明专利

AU3236195A Calibration of segmental blood volume changes in arteries and veins for pulse volume recorders 未知
公开(公告)号：AU3236195A
公开(公告)日：1996-03-04
申请号：AU3236195
申请日：1995-08-02
申请人： VASOCOR INC
发明人： RAINES JEFFREY K , SNYDER LEON T , HOFFMAN JOHN
IPC分类号： A61B5/022 , A61B5/02
摘要： The method of calibrating includes selecting discrete levels of cuff pressure and placing the artery or vein under study under discrete levels of induced pressure with a closed pneumatic system contained by the pressure cuff, substantially continually sensing cuff pressures at each discrete level and thereby sensing blood volume change through the artery, electronically determining when a certain number of representative time-based blood volume change signals are substantially equivalent, changing the volume in the closed pneumatic system at each discrete cuff pressure by a pre-determined volumetric amount after determining substantial equivalency, electronically generating a calibration signal at each discrete cuff pressure based upon the calibrated volume change and, correcting the blood volume representative signal based upon the calibration signal at each discrete level of pressure. The calibration device includes, in one embodiment, a controllable pneumatic pump, a pressure sensor, a computerized device for determining when a representative number of blood volume change signals (based on the pressure sensor signals) are substantially similar and thereafter generating a calibration signal. The calibration system also includes a device which changes the volume in the closed pneumatic system by a predetermined calibrated amount in the presence of the calibration trigger signal. This volume changing device may be a series of valves coupled by a chamber having a known volumetric size or a positive displacement pump driven by a stepper motor. The calibration system also includes a computerized device for correcting representative blood volume change signals based on the pressure signals at each discrete level of cuff pressure as corrected by the calibration signals represented by detected pressure signals obtained substantially simultaneously with the change of the volume at each discrete level of cuff pressure.

6. 发明专利

CA2367663A1 CALIBRATED MEASUREMENT OF BLOOD VESSELS AND ENDOTHELIUM AFTER REACTIVE HYPEREMIA AND METHOD THEREFOR 未知
公开(公告)号：CA2367663A1
公开(公告)日：2000-10-05
申请号：CA2367663
申请日：2000-03-24
申请人： VASOCOR INC
发明人： INSULL WILLIAM JR , RAINES JEFFREY K
IPC分类号： A61B5/0295 , A61B5/022 , A61B5/026 , A61B5/02
摘要： The calibrated method for characterizing blood flow in a limb of a patient during reactive hyperemia utilizes a blood pressure cuff (14). The method establishes a predetermined, near diastolic, pressure in the blood pressure cuff (14) during the reactive hyperemic episode, continually senses via a sensor (68) the pressure in the cuff, and periodically changes the internal volume of the blood pressure cuff by a predetermined volumetric amount to calibrate the system. The resultant change in the pressure is a calibration pressure pulse (P-cal), and is used to calculate pulsatile blood volume through the blood vessel. A calibrated method for determining the condition of blood vessels, and endothelium includes determining, for each calibration cycle, a respective peak value (t-P) for the blood volume, and comparing the peak blood volume values with peak blood volume values for healthy blood vessels, and endothelium. The comparison preferably utlizes a waveform (W1).

7. 发明公开

EP1178752A1 CALIBRATED MEASUREMENT OF BLOOD VESSELS AND ENDOTHELIUM AFTER REACTIVE HYPEREMIA AND METHOD THEREFOR 审中-公开
标题翻译：血管和后反应性充血内皮细胞和相关方法校准测量
公开(公告)号：EP1178752A1
公开(公告)日：2002-02-13
申请号：EP00918400.3
申请日：2000-03-24
申请人： Vasocor, Inc.
发明人： RAINES, Jeffrey, K. , INSULL, William
IPC分类号： A61B5/02
CPC分类号： A61B5/02007 , A61B5/02141 , A61B5/022 , A61B5/026 , A61B5/0295 , A61B5/7239 , A61B5/742
摘要： The calibrated method for characterizing blood flow in a limb of a patient during reactive hyperemia utilizes a blood pressure cuff (14). The method establishes a predetermined, near diastolic, pressure in the blood pressure cuff (14) during the reactive hyperemic episode, continually senses via a sensor (68) the pressure in the cuff, and periodically changes the internal volume of the blood pressure cuff by a predetermined volumetric amount to calibrate the system. The resultant change in the pressure is a calibration pressure pulse (P-cal), and is used to calculate pulsatile blood volume through the blood vessel. A calibrated method for determining the condition of blood vessels, and endothelium includes determining, for each calibration cycle, a respective peak value (t-P) for the blood volume, and comparing the peak blood volume values with peak blood volume values for healthy blood vessels, and endothelium. The comparison preferably utlizes a waveform (W1).

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