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1. 发明申请

WO1995031969A1 PHARMACEUTICAL COMPOSITIONS DERIVED FROM MICROELMULSION-BASED GELS, METHOD FOR THEIR PREPARATION AND NEW MICROEMULSION-BASED GELS 审中-公开
标题翻译：由基于微胶囊的凝胶衍生的药物组合物，其制备方法和新的基于微乳液的凝胶
公开(公告)号：WO1995031969A1
公开(公告)日：1995-11-30
申请号：PCT/FI1995000234
申请日：1995-04-28
申请人： LEIRAS OY , BACKLUND, Sune , ERIKSSON, Folke , RANTALA, Maria , RANTALA, Pertti , VARHO, Kari
发明人： LEIRAS OY
IPC分类号： A61K09/107
CPC分类号： A61K9/06 , A61K9/1075 , Y10S514/937 , Y10S514/938 , Y10S514/944
摘要： The invention relates to a pharmaceutical composition comprising a microemulsion made up of a hydrophilic component, a lipophilic component, a surfactant and a drug, wherein the hydrophilic component, the lipophilic component and the surfactant form, when examined on a macroscopic scale, a one-phase solution. The hydrophilic component is dispersed as colloidal droplets in the lipophilic component, or the lipophilic component is dispersed as colloidal droplets in the hydrophilic component. According to still another alternative the hydrophilic and the lipophilic components form a microemulsion with bicontinuous structure wherein said components form elongated adjacent channels. The drug is dissolved in the dispersed component or, in case of a microemulsion with a bicontinuous structure, in the hydrophilic or the lipophilic component. The microemulsion is stabilized by means of the surfactant. It is characteristic that a gelatinizer and water are added to the microemulsion thereby bringing the microemulsion into a gel form.
摘要翻译：本发明涉及一种药物组合物，其包含由亲水组分，亲脂性组分，表面活性剂和药物组成的微乳液，其中亲水组分，亲油性组分和表面活性剂形式在宏观尺度上检查时，相溶液。亲水性成分作为胶体液滴分散在亲油性成分中，或者亲油性成分作为胶体液滴分散在亲水性成分中。根据另一替代方案，亲水和亲油组分形成具有双连续结构的微乳液，其中所述组分形成细长的相邻通道。将该药物溶解在分散组分中，或在具有双连续结构的微乳液的情况下溶解在亲水或亲油组分中。微乳液通过表面活性剂稳定。特征在于，将微凝胶和水加入到微乳液中，从而使微乳液成为凝胶形式。

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