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1. 发明申请

WO2008057410A2 ELECTRIC PLASMA-MEDIATED CUTTING AND COAGULATION OF TISSUE AND SURGICAL APPARATUS 审中-公开
标题翻译：电子等离子体介质切割和组织和组织装置
公开(公告)号：WO2008057410A2
公开(公告)日：2008-05-15
申请号：PCT/US2007/023130
申请日：2007-11-01
申请人： PEAK SURGICAL, INC. , PALANKER, Daniel, V. , DAVISON, Paul, O. , VANKOV, Alexander, B.
发明人： PALANKER, Daniel, V. , DAVISON, Paul, O. , VANKOV, Alexander, B.
IPC分类号： A61B18/14
CPC分类号： A61B18/1402 , A61B2018/00589 , A61B2018/00601 , A61B2018/00607
摘要： Electrosurgery method and apparatus. In the method, tissue is cut or coagulated, with an electrically low conductive liquid providing cooling. In another method, skin is cut by electrosurgery in a dry field using a low duty cycle signal energizing the cutting electrode, minimizing tissue charring. A combination coagulation and cutting electrode performs both functions. The cutting is performed by a blade edge generating a local plasma adapted for cutting. Superimposed on the blade edge is an electrode of greater surface area electrically insulated from the cutting electrode, for coagulation. In another version, a single component cutting/coagulation blade (electrode) has a cutting and a flat partially insulated portion defining through holes in the insulation for coagulation. Also provided is an electrical circuit whereby each electrode is isolated by a filter from cross talk and feedback of the RF signal from the other electrode, minimizing arcing.
摘要翻译：电外科手术方法及装置。在该方法中，组织被切割或凝结，具有提供冷却的低电导率液体。在另一种方法中，通过在干燥场中的电外切切割皮肤，使用对切割电极通电的低占空比信号，使组织炭化最小化。组合凝结切割电极执行两种功能。通过产生适于切割的局部等离子体的叶片边缘进行切割。叠置在刀片边缘上的是与切割电极电绝缘的较大表面积的电极，用于凝结。在另一种形式中，单组分切割/凝结叶片（电极）具有切割和平坦的部分绝缘部分，其限定用于凝固的绝缘体中的孔。还提供了一种电路，其中每个电极通过滤波器与串扰隔离并且来自另一电极的RF信号的反馈，从而最小化电弧。

2. 发明申请

WO2007126906A2 DEVICES AND METHODS FOR TISSUE WELDING 审中-公开
标题翻译：用于组织焊接的装置和方法
公开(公告)号：WO2007126906A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/007704
申请日：2007-03-29
申请人： PEAK SURGICAL, INC. , PALANKER, Daniel, V. , VANKOV, Alexander, B.
发明人： PALANKER, Daniel, V. , VANKOV, Alexander, B.
IPC分类号： A61F2/06 , A61N1/04
CPC分类号： A61F2/82 , A61B18/14 , A61B2017/00504 , A61B2018/00619 , A61F2220/0008 , A61F2250/0001 , A61F2250/0069
摘要： Tissue implants configured to adhere to biological tissues when activated by electrical energy may include an electrically conductive structure, a connector releasably connected to the electrically conductive structure, and a thermally crosslinkable coating covering at least the exposed portion of the electrically conductive structure. These tissue implants may be used for welding tissues to other tissues, or for welding tissue to the implant, and thus may be used to attach implants within a body, or for therapeutic uses. These implants may be used for wound closure or to create occlusions. Thermal damage to the tissue may be minimized by use of the thermally-crosslinkable material having a resistivity higher than that of the adjacent tissue.
摘要翻译：构造成当由电能激活时被附着到生物组织上的组织植入物可以包括导电结构，可释放地连接到导电结构的连接器以及至少覆盖导电结构的暴露部分的热交联涂层。这些组织植入物可以用于将组织焊接到其他组织，或用于将组织焊接到植入物，并且因此可以用于将植入物附接到体内或用于治疗用途。这些植入物可用于伤口闭合或产生闭塞。通过使用具有比相邻组织的电阻率高的电阻率的热交联材料，可以使组织的热损伤最小化。

3. 发明申请

WO2012054771A3 SYNCHRONIZING DATA STREAMS OVER A LOCAL AREA NETWORK 审中-公开
标题翻译：在本地区域网络上同步数据流
公开(公告)号：WO2012054771A3
公开(公告)日：2012-07-05
申请号：PCT/US2011057164
申请日：2011-10-20
申请人： UNIV CALIFORNIA , VANKOV ANDRE , MAKEIG SCOTT
发明人： VANKOV ANDRE , MAKEIG SCOTT
IPC分类号： H04L7/00 , H04L12/56
CPC分类号： H04L69/28
摘要： In an aspect there is provided a method. The method may include receiving, from a first sender, a first plurality of packets, each of the first plurality of packets including at least a first time stamp representative of a first time local to the first sender of the first plurality of packets; retrieving a first correction factor determined for the first sender; correcting, at the receiver, each of the first time stamps based on the first correction factor, the corrected first time stamps providing a time local to the receiver; receiving, from a second sender, a second plurality of packets, each of the second plurality of packets including a second time stamp representative of a second time local to the second sender of the second plurality of packets; retrieving a second correction factor determined for the second sender; and correcting, at the receiver, each of the second time stamps based on the second correction factor, the corrected second time stamps providing the time local to the receiver, the corrected first time stamps and the corrected second time stamps being corrected to the same time local to the receiver. Related apparatus, systems, techniques, and articles are also described.
摘要翻译：在一方面，提供了一种方法。该方法可以包括从第一发送方接收第一多个分组，第一多个分组中的每一个分组至少包括表示第一多个分组的第一发送者本地的第一时间的第一时间戳; 检索为所述第一发送者确定的第一校正因子; 在接收机处基于第一校正因子校正每个第一时间戳，校正的第一时间戳提供接收器的本地时间; 从第二发送方接收第二多个分组，所述第二多个分组中的每一个分组包括表示所述第二多个分组的第二发送方本地的第二时间的第二时间戳; 检索为所述第二发送者确定的第二校正因子; 并且在所述接收机处，基于所述第二校正因子校正所述第二时间标记中的每一个，所述校正后的第二时间戳提供接收机本地的时间，所述校正的第一时间戳和所述校正的第二时间戳被校正到相同时间本地接收器。还描述了相关装置，系统，技术和制品。

4. 发明申请

WO2008130525A2 ELECTROSURGICAL SYSTEM WITH UNIFORMLY ENHANCED ELECTRIC FIELD AND MINIMAL COLLATERAL DAMAGE 审中-公开
标题翻译：具有均匀增强电场和最小束缚损伤的电磁系统
公开(公告)号：WO2008130525A2
公开(公告)日：2008-10-30
申请号：PCT/US2008/004806
申请日：2008-04-11
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , PALANKER, Daniel, V. , VANKOV, Alexander, B.
发明人： PALANKER, Daniel, V. , VANKOV, Alexander, B.
IPC分类号： A61B18/14
CPC分类号： A61B18/1402 , A61B2018/00083 , A61B2018/1407
摘要： The present invention is directed towards an electrosurgical cutting system. The system comprises an electrically conductive blade, having an uninsulated cutting edge that is surrounded by an insulator. A source of pulsed electrical energy may be coupled to the electrically conductive blade to provide a substantially uniform and highly enhanced electric field along a cutting portion of the blade edge. The blade may have a uniform rate of erosion during use, so that both the conductive metal edge and the surrounding insulation layer erode at approximately the same rate. Also described are methods of fabricating insulated cutting electrodes, particularly blade electrodes.
摘要翻译：本发明涉及电外科切割系统。该系统包括导电叶片，其具有被绝缘体包围的非绝缘切割边缘。脉冲电能源可以耦合到导电叶片，以沿叶片边缘的切割部分提供基本均匀且高度增强的电场。刀片在使用期间可能具有均匀的侵蚀速率，使得导电金属边缘和周围绝缘层两者以大致相同的速率腐蚀。还描述了制造绝缘切割电极，特别是刀片电极的方法。

5. 发明申请

WO2008124103A2 METHOD AND APPARATUS FOR PLASMA-MEDIATED THERMO-ELECTRICAL ABLATION 审中-公开
标题翻译：用于等离子体介导的热电收缩的方法和装置
公开(公告)号：WO2008124103A2
公开(公告)日：2008-10-16
申请号：PCT/US2008/004460
申请日：2008-04-04
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , PALANKER, Daniel, V. , VANKOV, Alexander, B.
发明人： PALANKER, Daniel, V. , VANKOV, Alexander, B.
IPC分类号： A61B18/12
CPC分类号： A61B18/042 , A61B2018/00601 , A61B2018/00625 , A61B2018/00726 , A61B2018/122 , A61B2018/1472

6. 发明专利

UA8392U ROLL BEARING 未知
公开(公告)号：UA8392U
公开(公告)日：2005-08-15
申请号：UA20040806663
申请日：2004-08-10
申请人： BURIA OLEKSANDR IVANOVYCH , DUDIN VOLODYMYR YURIIOVYCH , VANKOV OLEKSANDR YURIIOVYCH
发明人： BURIA OLEKSANDR IVANOVYCH , DUDIN VOLODYMYR YURIIOVYCH , VANKOV OLEKSANDR YURIIOVYCH
IPC分类号： F16C19/00
摘要： A roll bearing has the inner and the outer rings, solids of revolution and separator, sealing of the cavities made of polymer composite material on the basis of poly-tetra-fluoroethylene.

7. 发明专利

BG41018A1 MAGNETIC DEVICE FOR GRASPING DURING STRETCHING OF STEEL ROPES 未知
公开(公告)号：BG41018A1
公开(公告)日：1987-04-15
申请号：BG7323386
申请日：1986-01-24
申请人： GEORGIEV , STOJANOV , CANEV , ANDREEV , VANKOV
发明人： GEORGIEV , STOJANOV , CANEV , ANDREEV , VANKOV
IPC分类号： B66C1/04

8. 发明专利

BG37719A1 METHOD AND DEVICE FOR MIXING MATERIALS IN BULK 未知
公开(公告)号：BG37719A1
公开(公告)日：1985-08-15
申请号：BG6492484
申请日：1984-04-02
申请人： NIKOLOV , SENDOV , KOLCHEV , MIRCHEV , NACHEVA , JJONOV , BOGDANOV , VANKOV
发明人： NIKOLOV , SENDOV , KOLCHEV , MIRCHEV , NACHEVA , JJONOV , BOGDANOV , VANKOV
IPC分类号： B01F3/12

9. 发明申请

WO2007022403A3 OCULAR GENE THERAPY USING AVALANCHE-MEDIATED TRANSFECTION 审中-公开
标题翻译：使用AVALANCHE-MEDIATED TRANSFECTION的OCULAR GENE THERAPY
公开(公告)号：WO2007022403A3
公开(公告)日：2010-04-22
申请号：PCT/US2006032249
申请日：2006-08-15
申请人： UNIV LELAND STANFORD JUNIOR , CHALBERG THOMAS W JR , BLUMENKRANZ MARK , PALANKER DANIEL V , VANKOV ALEXANDER , HUIE PHILIP JR , MARMOR MICHAEL F , CALOS MICHELE P
发明人： CHALBERG THOMAS W JR , BLUMENKRANZ MARK , PALANKER DANIEL V , VANKOV ALEXANDER , HUIE PHILIP JR , MARMOR MICHAEL F , CALOS MICHELE P
IPC分类号： C12N15/87
CPC分类号： C12N15/87 , C07K14/811
摘要： The present invention provides a method of treating an ocular disease in a subject. In a first step, a nucleic acid is introduced into cells or a tissue. The nucleic acid is introduced by electron avalanche transfection. With this technique, a high electric field induces a vapor bubble and plasma discharge between an electrode and the surrounding medium. The formation of a vapor bubble generates mechanical stress. Plasma discharge through the ionized vapor in the bubble enables connectivity between the electrode and the surrounding medium, so that mechanical stress and electric field are applied simultaneously, which results in permeabilization of the cells or tissue. This permeabilization in turn allows the nucleic acid to enter the cell or tissue. Cells or tissue containing the nucleic acid are then transplanted into an ocular region of the subject.
摘要翻译：本发明提供了治疗受试者眼部疾病的方法。在第一步骤中，将核酸引入细胞或组织。通过电子雪崩转染引入核酸。利用这种技术，高电场在电极和周围介质之间引起蒸汽气泡和等离子体放电。气泡的形成产生机械应力。通过气泡中的电离蒸汽的等离子体放电使得电极和周围介质之间能够连接，使得同时施加机械应力和电场，这导致细胞或组织的透化。这种渗透反过来又允许核酸进入细胞或组织。然后将含有核酸的细胞或组织移植到受试者的眼部区域。

10. 发明申请

WO2007106136A3 METHOD AND APPARATUS FOR AVALANCHE-MEDIATED TRANSFER OF AGENTS INTO CELLS 审中-公开
标题翻译：用于将细胞转移到细胞中的方法和装置
公开(公告)号：WO2007106136A3
公开(公告)日：2009-04-23
申请号：PCT/US2006037010
申请日：2006-09-22
申请人： UNIV LELAND STANFORD JUNIOR , VANKOV ALEXANDER , CHALBERG THOMAS W JR , HUIE PHILIP JR , PALANKER DANIEL V
发明人： VANKOV ALEXANDER , CHALBERG THOMAS W JR , HUIE PHILIP JR , PALANKER DANIEL V
IPC分类号： C12M1/42 , C12N15/64 , C12N15/87
CPC分类号： C12N13/00 , A61K48/00 , C12N15/87
摘要： The present invention provides a method and apparatus for transferring an agent into a cell. The method includes the steps of providing an agent outside of a cell and generating a vapor bubble and a plasma discharge between an avalanche electrode and a conductive fluid surrounding the cell. The vapor bubble and plasma discharge generate a mechanical stress wave and an electric field, respectively. The combination of this mechanical stress wave and electric field results in permeabilization of the cell, which in turn results in transfer of the agent into the cell.
摘要翻译：本发明提供了一种将药剂转移到细胞中的方法和装置。该方法包括以下步骤：在电池外部提供一种试剂，并在雪崩电极和围绕电池的导电流体之间产生蒸气泡和等离子体放电。蒸气泡和等离子体放电分别产生机械应力波和电场。这种机械应力波和电场的组合导致电池的透化，这进而导致试剂转移到电池中。

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