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1. 发明申请

WO1996012173A1 SYSTEM FOR SENSING DROPLET FORMATION TIME DELAY IN A FLOW CYTOMETER 审中-公开
标题翻译：用于在流量计中感测流道形成时间延迟的系统
公开(公告)号：WO1996012173A1
公开(公告)日：1996-04-25
申请号：PCT/US1995014624
申请日：1995-10-13
申请人： UNIVERSITY OF WASHINGTON , VAN DEN ENGH, Ger , ESPOSITO, Richard, J.
发明人： UNIVERSITY OF WASHINGTON
IPC分类号： G01N15/14
CPC分类号： G01N15/1404 , G01N2015/149 , Y10T436/11 , Y10T436/115831
摘要： A droplet flow cytometer system which includes a system to optimize the droplet formation time delay based on conditions actually experienced includes an automatic droplet sample (73) which rapidly moves a plurality of containers (75) stepwise through the droplet stream while simultaneously adjusting the droplet time delay. Through the system sampling of an actual substance to be processed can be used to minimize the effect of the substances variations or the determination of which time delay is optimal. Analysis such as cell counting and the like may be conducted manually or automatically and input to a time delay adjustement which may then act with analysis equipement to revise the time delay estimate actually applied during processing. The automatic sample (73) can be controlled through a microprocessor and approriate programming to bracket an inital droplet formation time delay estimate. When maximization counts through volume, weight, or other types of analysis exists in the containers, the increment may then be reduced for a more accurate ultimate setting. This may be accomplished while actually processing the sample without interruption.
摘要翻译：包括基于实际经历的条件来优化液滴形成时间延迟的系统的液滴流式细胞仪系统包括自动液滴样品（73），其将多个容器（75）逐步地快速移动通过液滴流，同时调节液滴时间延迟。通过对待处理的实际物质的系统采样可以用于最小化物质变化的影响或确定哪个时间延迟是最佳的。可以手动或自动地进行诸如细胞计数等的分析，并输入到时间延迟调整部，然后可以与分析装置一起操作，以修改在处理期间实际应用的时间延迟估计。自动样品（73）可以通过微处理器进行控制，并且适用于编程，以支配液滴形成时间估计。当容器中存在通过体积，重量或其他类型的分析的最大化计数时，可以减小增量以获得更准确的最终设置。这可以在不间断地实际处理样品的同时完成。

2. 发明申请

WO1996012171A3 HIGH SPEED FLOW CYTOMETER DROPLET FORMATION SYSTEM 审中-公开
公开(公告)号：WO1996012171A3
公开(公告)日：1996-04-25
申请号：PCT/US1995013308
申请日：1995-10-13
申请人： UNIVERSITY OF WASHINGTON , VAN DEN ENGH, Ger
发明人： UNIVERSITY OF WASHINGTON
IPC分类号： G01N15/14

3. 发明申请

WO2012149174A3 MULTI-WAY SORTER SYSTEM AND METHOD 审中-公开
标题翻译：多路系统和方法
公开(公告)号：WO2012149174A3
公开(公告)日：2013-01-03
申请号：PCT/US2012035233
申请日：2012-04-26
申请人： BECTON DICKINSON CO , VAN DEN ENGH GER
发明人： VAN DEN ENGH GER
IPC分类号： C12M1/00 , C12M1/18 , C12M1/24 , C12M1/34 , C12Q1/24
CPC分类号： G01N15/14 , B01L3/50853 , B01L2200/026 , B01L2300/046 , G01N2015/1081 , G01N2015/149
摘要： Provided herein are improved multi-way cell sorter systems and methods. For example, provided are systems and methods for the collection of cells that are sorted in multiple directions. The systems and methods allow for the construction of a multi-way sorter (e.g., a ten-way sorter in the space that currently only allows four-way sorting). In addition the device may actively sense the arrival of drops (with cells of interest) at a sample tube, and trigger an alarm when the drops' arrivals deviate from an expected pattern.
摘要翻译：本文提供了改进的多路细胞分选机系统和方法。例如，提供了用于收集在多个方向分类的单元的系统和方法。这些系统和方法允许构建多路分拣机（例如，目前仅允许四路分拣的空间中的十路分拣机）。此外，装置可以主动地感测液滴（与感兴趣的细胞）到达样品管，并且当液滴的到达偏离预期图案时触发警报。

4. 发明申请

WO2012148584A1 CELL SORTER SYSTEM AND METHOD 审中-公开
标题翻译：细胞分离系统和方法
公开(公告)号：WO2012148584A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/028951
申请日：2012-03-13
申请人： BECTON DICKINSON & CO. , VAN DEN ENGH, Ger
发明人： VAN DEN ENGH, Ger
IPC分类号： C12M1/42 , C12Q1/24 , C12N13/00
CPC分类号： G01N15/14 , B01L3/502715 , C12M47/04 , C12N13/00 , C12Q3/00 , G01N15/1012 , G01N15/1031 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081 , G01N2015/149
摘要： Provided herein are improved cell sorter systems and methods. Such systems and methods provide a self-stabilizing sorter jet to automate calibration, and address the issue of drift in cell sorting systems. The systems and methods presented make it possible to determine and set the charge delay interval automatically with circuitry in the cell sorter. These circuits can set, monitor, and adjust the time delay continuously, allowing for a completely automatic, autonomous, turn-key, self-stabilizing sorter jet.
摘要翻译：本文提供了改进的细胞分选机系统和方法。这种系统和方法提供自稳定分选机射流以自动校准，并解决细胞分选系统中漂移的问题。所提出的系统和方法使得可以自动确定和设置电池分选器中的电路的充电延迟时间。这些电路可以连续设置，监视和调整时间延迟，从而允许一个完全自动的，自主的，交钥匙的自稳定分拣机。

5. 发明申请

WO1996012172A1 FLOW CYTOMETER JET MONITOR SYSTEM 审中-公开
标题翻译：流量计流量监测系统
公开(公告)号：WO1996012172A1
公开(公告)日：1996-04-25
申请号：PCT/US1995013502
申请日：1995-10-13
申请人： UNIVERSITY OF WASHINGTON , VAN DEN ENGH, Ger
发明人： UNIVERSITY OF WASHINGTON
IPC分类号： G01N15/14
CPC分类号： G01N15/1404 , G01N2015/1406 , G01N2015/149
摘要： A direct jet monitor (66) illuminates the jet of a flow cytometer in a monitor wavelength band which is substantially separate from the substance wavelengthband. When a laser is used to cause fluorescence of the substance, it may be appropriate to use an infrared source (67) to illuminate the jet and thus optically monitor the conditions within the jet through a CCD camera (68) or the like. This optical monitoring may be provided to some type of controller or feedback system (34) which automatically changes either the horizontal location of the jet, the point at which droplet separation occurs, or some other condition within the jet in order to maintain optimum conditions. The direct jet monitor (66) may be operated simultaneously with the substance property sensing and analysis system so that continuous monitoring may be achieved without interfering with the substance data gathering and may be configured so as to allow the front of the analysis or free fall area (7) to be unobstructed during processing.
摘要翻译：直接喷射监视器（66）照射基本上与物质波长带分离的监测波长带中的流式细胞仪的射流。当使用激光来引起物质的荧光时，使用红外光源（67）来照射射流并因此通过CCD照相机（68）等光学地监测射流内的状况可能是合适的。这种光学监视可以被提供给某种类型的控制器或反馈系统（34），其自动地改变射流的水平位置，发生液滴分离的点或射流内的某些其他状态，以保持最佳条件。直接喷射监视器（66）可以与物质性质感测和分析系统同时操作，使得可以在不干扰物质数据收集的情况下实现连续监测，并且可以配置为允许分析前沿或自由落体区域（7）在加工过程中不受阻碍。

6. 发明申请

WO2012149174A2 MULTI-WAY SORTER SYSTEM AND METHOD 审中-公开
标题翻译：多路分离系统和方法
公开(公告)号：WO2012149174A2
公开(公告)日：2012-11-01
申请号：PCT/US2012/035233
申请日：2012-04-26
申请人： BECTON DICKINSON & CO. , VAN DEN ENGH, Ger
发明人： VAN DEN ENGH, Ger
IPC分类号： C12M1/00 , C12M1/24 , C12M1/18 , C12M1/34 , C12Q1/24
CPC分类号： G01N15/14 , B01L3/50853 , B01L2200/026 , B01L2300/046 , G01N2015/1081 , G01N2015/149
摘要： Provided herein are improved multi-way cell sorter systems and methods. For example, provided are systems and methods for the collection of cells that are sorted in multiple directions. The systems and methods allow for the construction of a multi-way sorter (e.g., a ten-way sorter in the space that currently only allows four-way sorting). In addition the device may actively sense the arrival of drops (with cells of interest) at a sample tube, and trigger an alarm when the drops' arrivals deviate from an expected pattern.
摘要翻译：本文提供了改进的多路细胞分选机系统和方法。例如，提供了用于收集在多个方向上排序的单元的系统和方法。这些系统和方法允许构建多路分拣机（例如，目前仅允许四路分拣的空间中的十路分拣机）。此外，装置可以主动地感测液滴（具有感兴趣的细胞）到达样品管，并且当液滴的到达偏离预期图案时触发报警。

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