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1. 发明申请

WO2006021903A1 AUTONOMOUS CALIBRATION FOR OPTICAL ANALYSIS SYSTEM 审中-公开
标题翻译：光学分析系统的自动校准
公开(公告)号：WO2006021903A1
公开(公告)日：2006-03-02
申请号：PCT/IB2005/052558
申请日：2005-07-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SCHUURMANS, Franck, Jeroen, Pieter , VAN BEEK, Michael, Cornelis , VAN DER VOORT, Marjolein
发明人： SCHUURMANS, Franck, Jeroen, Pieter , VAN BEEK, Michael, Cornelis , VAN DER VOORT, Marjolein
IPC分类号： G01J3/36 , G01J3/04
CPC分类号： G01J3/28 , G01J3/04 , G01J3/36 , G01J2003/047 , G01J2003/1278
摘要： The present invention provides an autonomous calibration of a multivariate based spectroscopic system that is preferably implemented as a multivariate based spectrometer. The spectroscopic system is based on a multivariate optical element that provides a spectral weighting of an incident optical signal. Spectral weighting is performed on the basis of spatial separation of spectral components and subsequent spatial filtering by means of a spatial light modulator. Calibration of the spectroscopic system is based on a dedicated calibration segment of the spatial light modulator, whose position corresponds to a characteristic calibration or reference wavelength of the incident optical signal. Preferably, the calibration or reference wavelength is given by the wavelength of the excitation radiation generated by the optical source that serves to induce scattering processes in a volume of interest.
摘要翻译：本发明提供了一种基于多变量的光谱仪的多变量光谱系统的自主校准，其优选地被实现为基于多变量的光谱仪。光谱系统基于提供入射光信号的光谱加权的多元光学元件。基于光谱分量的空间分离和随后的空间光调制器的空间滤波进行光谱加权。分光系统的校准基于空间光调制器的专用校准段，其位置对应于入射光信号的特征校准或参考波长。优选地，校准或参考波长由用于感兴趣的体积中的散射过程的光源产生的激发辐射的波长给出。

2. 发明申请

WO2005104932A1 PROBE HEAD FOR SPECTROSCOPIC ANALYSIS OF A FLUID 审中-公开
标题翻译：用于流体光谱分析的探头
公开(公告)号：WO2005104932A1
公开(公告)日：2005-11-10
申请号：PCT/IB2005/050564
申请日：2005-02-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , LUCASSEN, Gerhardus Wilhelmus , RENSEN, Wouter Harry Jacinth , VAN BEEK, Michael Cornelis , VAN DER VOORT, Marjolein , BAKKER, Bernardus Leonardus Gerardus
发明人： LUCASSEN, Gerhardus Wilhelmus , RENSEN, Wouter Harry Jacinth , VAN BEEK, Michael Cornelis , VAN DER VOORT, Marjolein , BAKKER, Bernardus Leonardus Gerardus
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/489 , A61B2562/0242
摘要： The present invention provides a spectroscopic system for determining a property of a fluid flowing through a volume of interest underneath the surface of the skin of a patient. The spectroscopic system comprises a probe head that has at least an objective for directing an excitation beam into the volume of interest and for collecting return radiation. The spectroscopic system has further a base station having at least a spectroscopic analysis unit and a power supply. The system makes use of a beam combination unit, a filter unit and a focusing unit for combining and separating a variety of different optical signals and for precisely positioning the optical signals inside the volume of interest. The beam combination unit, the filter unit and the focusing unit can be variably implemented inside the probe head or inside the base station depending on a specific applications of the spectroscopic system, thereby allowing for a flexible and compact design of the probe head.
摘要翻译：本发明提供了一种用于确定流过患者皮肤表面下方的感兴趣体积的流体的性质的光谱系统。分光系统包括探头，该探头至少具有将激发光束引导到感兴趣体积中并用于收集返回辐射的目的。光谱系统还具有至少具有光谱分析单元和电源的基站。该系统利用光束组合单元，滤光器单元和聚焦单元，用于组合和分离各种不同的光信号，并将光信号精确地定位在感兴趣的体积内。根据分光系统的具体应用，光束组合单元，滤光器单元和聚焦单元可以可变地实现在探头内部或基站内部，从而允许探头的灵活且紧凑的设计。

3. 发明申请

WO2007119126A2 SELF-LEARNING LIGHTING SYSTEM 审中-公开
标题翻译：自学习照明系统
公开(公告)号：WO2007119126A2
公开(公告)日：2007-10-25
申请号：PCT/IB2006/050888
申请日：2006-03-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , U.S. PHILIPS CORPORATION , VERBRUGH, Stefan Marcus , VAN BEEK, Michael Cornelis , FRUMAU, Constantinus Carolus Franciscus
发明人： VERBRUGH, Stefan Marcus , VAN BEEK, Michael Cornelis , FRUMAU, Constantinus Carolus Franciscus
CPC分类号： H05B37/029 , H05B37/02
摘要： A system (120) and/or corresponding method introduces a minor change to a given set of parameters (110) that affect an ambiance (130) associated with an environment, and collects the user's response to the change. Based on the user's response, the system learns which changes to which parameters lead to an improved effect. By repeating the change- feedback sessions, the system approaches an optimal setting for achieving the desired ambiance in the given environment. Preferably, the change-feedback session is non- obtrusive, and occurs, for example, each time a light is turned on, and the feedback is collected when the light is turned off, using a multiple switch arrangement. If the light is turned off using one switch, the feedback is positive; if the light is turned off using an alternative switch, the feedback is negative. Alternatively, the system can be placed in a rapid-learning mode, wherein the change-feedback cycles occur more frequently.
摘要翻译：系统（120）和/或相应的方法对影响与环境相关联的氛围（130）的给定参数集（110）引入微小变化，并且收集用户对更改。根据用户的反应，系统知道哪些参数导致改进效果的哪些改变。通过重复变化反馈会话，系统接近用于在给定环境中实现期望氛围的最佳设置。优选地，变化反馈会话是非突兀的，并且例如在每次打开灯时发生，并且当灯关闭时采用多开关装置收集反馈。如果使用一个开关关闭灯，则反馈为正; 如果使用替代开关关闭灯，则反馈是否定的。或者，可以将系统置于快速学习模式，其中变化反馈周期更频繁地发生。

4. 发明申请

WO2006021903A9 AUTONOMOUS CALIBRATION FOR OPTICAL ANALYSIS SYSTEM 审中-公开
标题翻译：光学分析系统的自动校准
公开(公告)号：WO2006021903A9
公开(公告)日：2007-06-14
申请号：PCT/IB2005052558
申请日：2005-07-29
申请人： KONINKL PHILIPS ELECTRONICS NV , SCHUURMANS FRANCK JEROEN PIETE , VAN BEEK MICHAEL CORNELIS , VAN DER VOORT MARJOLEIN
发明人： SCHUURMANS FRANCK JEROEN PIETE , VAN BEEK MICHAEL CORNELIS , VAN DER VOORT MARJOLEIN
IPC分类号： G01J3/36 , G01J3/04
CPC分类号： G01J3/28 , G01J3/04 , G01J3/36 , G01J2003/047 , G01J2003/1278
摘要： The present invention provides an autonomous calibration of a multivariate based spectroscopic system that is preferably implemented as a multivariate based spectrometer. The spectroscopic system is based on a multivariate optical element that provides a spectral weighting of an incident optical signal. Spectral weighting is performed on the basis of spatial separation of spectral components and subsequent spatial filtering by means of a spatial light modulator. Calibration of the spectroscopic system is based on a dedicated calibration segment of the spatial light modulator, whose position corresponds to a characteristic calibration or reference wavelength of the incident optical signal. Preferably, the calibration or reference wavelength is given by the wavelength of the excitation radiation generated by the optical source that serves to induce scattering processes in a volume of interest.
摘要翻译：本发明提供了基于多变量的光谱仪的多变量光谱系统的自主校准，其优选地被实现为基于多变量的光谱仪。光谱系统基于提供入射光信号的光谱加权的多元光学元件。基于光谱分量的空间分离和随后的空间光调制器的空间滤波进行光谱加权。光谱系统的校准基于空间光调制器的专用校准段，其位置对应于入射光信号的特征校准或参考波长。优选地，校准或参考波长由用于感兴趣的体积中的散射过程的光源产生的激发辐射的波长给出。

5. 发明申请

WO2005107578A1 PROTECTION MECHANISM FOR SPECTROSCOPIC ANALYSIS OF BIOLOGICAL TISSUE 审中-公开
标题翻译：生物组织光谱分析保护机制
公开(公告)号：WO2005107578A1
公开(公告)日：2005-11-17
申请号：PCT/IB2005/051266
申请日：2005-04-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , VAN BEEK, Michael Cornelis , RENSEN, Wouter Harry Jacinth , VAN DER VOORT, Marjolein
发明人： VAN BEEK, Michael Cornelis , RENSEN, Wouter Harry Jacinth , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0531 , A61B2090/065
摘要： The present invention provides a protection mechanism for a spectroscopic analysis system being adapted to determine a property of a biological structure in a volume of interest of a patient. The spectroscopic system preferably makes use of high power radiation, and provides a protection mechanism for preventing an accidental exposure of light sensitive tissue of a body. The invention provides a variety of approaches to detect whether a measurement head of the spectroscopic system is in a measurement position. The measurement position of the measurement head can effectively be determined by making use of e.g. a pressure sensor, a sensor measuring the electric resistance of the skin of the patient, or even by optical means analyzing the intensity or the spatial structure of a monitoring beam providing a visual image of the volume of interest.
摘要翻译：本发明提供了一种用于光谱分析系统的保护机制，其适于确定患者感兴趣体积的生物结构的性质。光谱系统优选利用高功率辐射，并且提供用于防止身体的感光组织的意外暴露的保护机构。本发明提供了多种方法来检测分光系统的测量头是否处于测量位置。测量头的测量位置可以有效地通过使用例如测量头来确定。压力传感器，测量患者皮肤电阻的传感器，或者甚至通过分析提供感兴趣体积的视觉图像的监测光束的强度或空间结构的光学装置来测量。

6. 发明申请

WO2005124423A1 AUTOFOCUS MECHANISM FOR SPECTROSCOPIC SYSTEM 审中-公开
标题翻译：用于光谱系统的自动机械机构
公开(公告)号：WO2005124423A1
公开(公告)日：2005-12-29
申请号：PCT/IB2005/051848
申请日：2005-06-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , VAN BEEK, Michael Cornelis , LUCASSEN, Gerald , VAN DER VOORT, Marjolein , RENSEN, Wouter Harry Jacinth , DE VRIES, Durk Jolmer
发明人： VAN BEEK, Michael Cornelis , LUCASSEN, Gerald , VAN DER VOORT, Marjolein , RENSEN, Wouter Harry Jacinth , DE VRIES, Durk Jolmer
IPC分类号： G02B21/24
CPC分类号： G02B21/247 , G01J3/02 , G01J3/0237 , G01J3/44 , G01N21/645 , G01N21/65 , G01N2021/6463 , G01N2021/653 , G01N2021/655
摘要： The present invention provides an autofocus mechanism for a spectroscopic system (400) that is adapted to determine a property of a volume of interest. The volume of interest has an optical property that varies with time. The invention provides measurement means that are adapted to measure the fluctuations of the optical property of the volume of interest for determining the position (428) of the volume of interest. The spectroscopic system being further adapted to focus an excitation beam (418) into the determined volume of interest and for collecting return radiation (420) emanating from the volume of interest for spectroscopic analysis. Preferably, inelastically scattered radiation of an excitation beam (428) is separated from elastically scattered radiation for spectroscopic analysis. The elastically scattered radiation of the excitation beam is in turn exploited in order to measure the fluctuations of the optical property of the volume of interest. Making use of a control loop allows for maximization of the amplitude and/or intensity of the fluctuation inherently specifying the position of a volume of interest e.g. the center of a capillary vessel (450).
摘要翻译：本发明提供一种用于分光系统（400）的自动对焦机构，其适于确定感兴趣体积的性质。感兴趣的体积随着时间而变化。本发明提供了测量装置，其适于测量感兴趣体积的光学性质的波动，以确定感兴趣体积的位置（428）。光谱系统还适于将激发光束（418）聚焦到所确定的感兴趣体积中并且用于收集从用于光谱分析的感兴趣体积发出的返回辐射（420）。优选地，激发光束（428）的非弹性散射辐射与用于光谱分析的弹性散射辐射分离。激发光束的弹性散射辐射又被利用来测量感兴趣体积的光学特性的波动。利用控制回路允许最大化固有地指定感兴趣体积的位置的波动的幅度和/或强度，毛细血管的中心（450）。

7. 发明申请

WO2005107579A1 MEASUREMENT HEAD FOR NON-INVASIVE BLOOD ANALYSIS 审中-公开
标题翻译：非侵入性血液分析的测量头
公开(公告)号：WO2005107579A1
公开(公告)日：2005-11-17
申请号：PCT/IB2005/051430
申请日：2005-05-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VOORT, Marjolein , BAKKER, Bernadus, Leonardus, Gerardus , LUCASSEN, Gerald , COMPEN, Hendrikus, Antonius, Cornelus, Maria , VAN BEEK, Michael, Cornelis , RENSEN, Wouter, Harry, Jacinth
发明人： VOORT, Marjolein , BAKKER, Bernadus, Leonardus, Gerardus , LUCASSEN, Gerald , COMPEN, Hendrikus, Antonius, Cornelus, Maria , VAN BEEK, Michael, Cornelis , RENSEN, Wouter, Harry, Jacinth
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0062 , A61B5/68 , A61B5/6843
摘要： The present invention provides an efficient approach of attaching and fixing a measurement head for a spectroscopic system to a variety of different parts of the skin of a patient. The measurement head preferably features a compact design providing a flexible handling and offering a huge variety of application areas taking into account the plurality of properties of various portions of the skin. Furthermore, the measurement head features a robust and uncomplicated optical design not requiring a lateral shifting of the optical axis of the objective. Such transverse relative movements between the objective and a capillary vessel in the skin are preferably performed by mechanically shifting the skin with respect to the objective of the measurement head. Moreover, the measurement head is adapted to host one or more pressure sensors measuring the contact pressure between the measurement head and the skin. This pressure information can further be exploited in order to calibrate the spectroscopic analysis means, to regulate the contact pressure within predefined margins specifying an optimum range of contact pressure for spectroscopic examination of capillary vessels.
摘要翻译：本发明提供了将用于分光系统的测量头附接和固定到患者皮肤的各种不同部分的有效方法。测量头优选地具有紧凑的设计，提供灵活的处理，并且考虑到皮肤的各个部分的多个性质，提供了各种各样的应用领域。此外，测量头具有坚固且不复杂的光学设计，不需要物镜的光轴的横向偏移。物体和皮肤中的毛细血管之间的这种横向相对移动优选通过相对于测量头的目标机械地移动皮肤来执行。此外，测量头适于承载测量测量头与皮肤之间的接触压力的一个或多个压力传感器。可以进一步利用该压力信息来校准光谱分析装置，以调节预定余量内的接触压力，从而规定用于毛细血管的光谱检查的最佳接触压力范围。

8. 发明申请

WO2005062006A1 OPTICAL ANALYSIS SYSTEM USING MULTIVARIATE OPTICAL ELEMENTS 审中-公开
标题翻译：使用多种光学元件的光学分析系统
公开(公告)号：WO2005062006A1
公开(公告)日：2005-07-07
申请号：PCT/IB2004/052832
申请日：2004-12-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , VAN BEEK, Michael Cornelis , SCHUURMANS, Frank Jeroen Pieter , BAKKER, Levinus Pieter
发明人： VAN BEEK, Michael Cornelis , SCHUURMANS, Frank Jeroen Pieter , BAKKER, Levinus Pieter
IPC分类号： G01J3/36
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/14552 , G01J3/36 , G01N21/65 , G01N33/49
摘要： The present invention provides an optical analysis system for determining an amplitude of a principal component of an optical signal. The principal component is indicative of the concentration of a particular compound or various compounds of a substance that is subject to spectroscopic analysis. The optical signal is subject to wavelength selective weighting and wavelength selective spatial separation specified by a weighting function. The optical signal is preferably separated into two parts that corresponding to a positive and negative spectral band of the weighting function, respectively. The separation provides separate detection of the separated parts of the optical signal without significant loss of intensity, thereby providing an improved signal to noise ratio of the determined principal component. Separation and weighting of the optical signal is realized by two multivariate optical elements.
摘要翻译：本发明提供了一种用于确定光信号的主分量的幅度的光学分析系统。主要成分指示特定化合物或受光谱分析的物质的各种化合物的浓度。光信号经受由加权函数指定的波长选择加权和波长选择性空间分离。光信号优选分为对应于加权函数的正和负光谱带的两部分。分离提供对光信号的分离部分的单独检测，而没有明显的强度损失，从而提供确定的主要分量的改善的信噪比。光信号的分离和加权由两个多元光学元件实现。

9. 发明申请

WO2007119126A3 SELF-LEARNING LIGHTING SYSTEM 审中-公开
标题翻译：自学习照明系统
公开(公告)号：WO2007119126A3
公开(公告)日：2007-12-21
申请号：PCT/IB2006050888
申请日：2006-03-22
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS CORP , VERBRUGH STEFAN MARCUS , VAN BEEK MICHAEL CORNELIS , FRUMAU CONSTANTINUS CAROLUS FR
发明人： VERBRUGH STEFAN MARCUS , VAN BEEK MICHAEL CORNELIS , FRUMAU CONSTANTINUS CAROLUS FR
IPC分类号： H05B37/02
CPC分类号： H05B37/029 , H05B37/02
摘要： A system (120) and/or corresponding method introduces a minor change to a given set of parameters (110) that affect an ambiance (130) associated with an environment, and collects the user's response to the change. Based on the user's response, the system learns which changes to which parameters lead to an improved effect. By repeating the change- feedback sessions, the system approaches an optimal setting for achieving the desired ambiance in the given environment. Preferably, the change-feedback session is non- obtrusive, and occurs, for example, each time a light is turned on, and the feedback is collected when the light is turned off, using a multiple switch arrangement. If the light is turned off using one switch, the feedback is positive; if the light is turned off using an alternative switch, the feedback is negative. Alternatively, the system can be placed in a rapid-learning mode, wherein the change-feedback cycles occur more frequently.
摘要翻译：系统（120）和/或相应的方法对影响与环境相关联的环境（130）的给定参数集（110）引入次要改变，并且收集用户对该变化的响应。根据用户的回应，系统会学习哪些参数导致更改效果的变化。通过重复改变反馈会话，系统接近一个最佳设置，以在给定的环境中实现所需的氛围。优选地，变化反馈会话是非突出的，并且例如在每次开启光时发生，并且当使用多重开关布置关闭光时收集反馈。如果使用一个开关关闭指示灯，则反馈为正; 如果使用替代开关关闭指示灯，则反馈为负。或者，系统可以被置于快速学习模式中，其中变化反馈循环更频繁地出现。

10. 发明申请

WO2006000939A1 ABERRATION CORRECTION FOR SPECTROSCOPIC ANALYSIS 审中-公开
标题翻译：光谱分析的校正校正
公开(公告)号：WO2006000939A1
公开(公告)日：2006-01-05
申请号：PCT/IB2005/051944
申请日：2005-06-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , VAN BEEK, Michael Cornelis , RENSEN, Wouter Harry Jacinth , LUCASSEN, Gerald , VAN DER VOORT, Marjolein , BAKKER, Bernardus Leonardus Gerardus
发明人： VAN BEEK, Michael Cornelis , RENSEN, Wouter Harry Jacinth , LUCASSEN, Gerald , VAN DER VOORT, Marjolein , BAKKER, Bernardus Leonardus Gerardus
IPC分类号： G02B21/00
CPC分类号： G02B27/0025 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/28
摘要： The present invention provides a spectroscopic system (100) for determining of a property of a biological structure in a volume of interest (120) of a person. The spectroscopic system (100) comprises a low cost objective lens (118) for directing an excitation beam into a volume of interest (120) and for collecting return radiation (124) from the volume of interest (120). After detection of the return radiation (124), i.e. the spectroscopic signals, a correction unit (106) performs the compensation of the aberrations of the spectroscopic signals introduced by the low cost objective lens (118). Since the aberrations of the objective lens (118) strongly depend on the lateral distance (122) of the volume of interest (120) from the optical axis (116) of the objective lens (118), the correction unit (106) makes effective use of a correction table (110) providing an assignment between correction values and various lateral positions (122) of the volume of interest (120).
摘要翻译：本发明提供一种用于确定人的感兴趣体积（120）中的生物结构的性质的光谱系统（100）。分光系统（100）包括用于将激发光束引导到感兴趣体积（120）中并用于从感兴趣体积（120）收集返回辐射（124）的低成本物镜（118）。在检测到返回辐射（124）即分光信号之后，校正单元（106）执行由低成本物镜（118）引入的分光信号的像差的补偿。由于物镜（118）的像差强烈地取决于物镜（118）的光轴（116）的感兴趣体积（120）的横向距离（122），所以校正单元（106）有效使用校正表（110）提供校正值与感兴趣体积（120）的各种侧向位置（122）之间的分配。

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