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1. 发明授权

US5169967A Aluminum magnesium hydroxy fatty acid compounds and thermostable lipogels including same 失效
标题翻译：含镁镁盐的脂肪酸化合物和包含其的可热固化的脂肪酸
公开(公告)号：US5169967A
公开(公告)日：1992-12-08
申请号：US588575
申请日：1990-09-26
申请人： Uwe Assmus , Klaus Schanz , Bruno Kaumann
发明人： Uwe Assmus , Klaus Schanz , Bruno Kaumann
IPC分类号： A61K8/02 , A61K8/26 , A61K8/36 , A61K9/00 , A61K31/19 , A61K31/20 , A61K47/12 , A61Q15/00 , A61Q19/00 , C07C51/41 , C07C53/126
CPC分类号： A61K8/26 , A61K47/12 , A61K8/042 , A61K8/361 , A61K9/0014 , A61Q15/00 , A61Q19/00 , C07C53/126
摘要： A novel aluminum magnesium hydroxy fatty acid compound is disclosed having a general formula, Al.sub.x Mg.sub.y (OH).sub.3x+2y-z R.sub.z.nH.sub.2 O, wherein R is at least one aliphatic monocarboxylic acid group having the formula RCOO.sup.- and comprising from 12 to 22 carbon atoms, and wherein x=2, 2.ltoreq.y.ltoreq.10, z=2, and n is an integer greater than zero. The compound is prepared by a process including placing water and a salt which is one of an alkali metal salt or an ammonium salt of at least one aliphatic monocarboxylic acid having from 12 to 22 carbon atoms in a reactor fitted with heating and stirring means. The salt is dissolved by intensive stirring and by heating to a temperature ranging from 20.degree. to 90.degree. C. to provide a salt solution. The pH of the salt solution in the reactor is maintained at a pH of at least 8 to provide an alkaline solution. A solution comprised of water, an aluminum salt, and a magnesium salt is added to the reactor under constant stirring to cause reaction and precipitation of a precipitate comprised of the novel aluminum magnesium hydroxy fatty acid compound. The precipitate is separated and washed with substantially demineralized water until substantially no anions of the aluminum salt and the magnesium salt are detectable. A lipogel with improved thermal stability is formed using the novel compound and organic lipophilic compounds which are liquid at room temperature, and is useful in cosmetic or pharmaceutical preparations.
摘要翻译：公开了一种新型的铝镁羟基脂肪酸化合物，其具有通式Al x M y（OH）3 x + 2y-z R z.nH 2 O，其中R是至少一个具有式RCOO-并且包含12-22个碳原子的脂肪族单羧酸基团，并且其中x = 2,2，y = 10，z = 2，并且n是大于零的整数。该化合物通过包括在装有加热和搅拌装置的反应器中放置水和盐的方法制备，所述盐和盐是至少一种具有12至22个碳原子的脂肪族单羧酸的碱金属盐或铵盐之一。通过剧烈搅拌和加热至20〜90℃的温度使盐溶解，得到盐溶液。将反应器中的盐溶液的pH保持在至少8的pH以提供碱性溶液。将水，铝盐和镁盐组成的溶液在恒定搅拌下加入到反应器中，引起由新的铝镁羟基脂肪酸化合物组成的沉淀物的反应和沉淀。将沉淀物分离并用基本上软化的水洗涤直到基本上不检测到铝盐和镁盐的阴离子。使用在室温下为液体的新化合物和有机亲脂性化合物形成具有改善的热稳定性的脂凝胶，并且可用于化妆品或药物制剂。

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