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1. 发明授权

US4725619A Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments 失效
标题翻译：芳基和杂芳基醚作为治疗过敏性疾病的药剂
公开(公告)号：US4725619A
公开(公告)日：1988-02-16
申请号：US877568
申请日：1986-06-23
申请人： Utpal R. Chakraborty , Raymond D. Youssefyeh
发明人： Utpal R. Chakraborty , Raymond D. Youssefyeh
IPC分类号： C07C43/23 , C07D215/14 , C07D257/04 , C07D309/22 , C07D401/12 , C07D405/12 , A61K31/38 , A61K31/385
CPC分类号： C07D257/04 , C07C43/23 , C07D215/14 , C07D309/22 , C07D401/12 , C07D405/12
摘要： The present invention is concerned with the therapeutic composition comprising as an active ingredient a compound of the formula:(R.sub.1)(R.sub.2) Ar--Z--M--Ar.sub.1 (R.sub.3)(R.sub.4) Iand salts thereof; whereinAr and Ar.sub.1 are independently phenyl, naphthyl or a nitrogen, oxygen, or sulfur heterocyclic ring;Z is an alkylene chain containing from 1 to 5 carbon atoms in the principal chain and up to a total of 10 carbon atoms;M is oxygen, sulfur, or NR.sub.5 ;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently H, lower alkyl, lower alkoxy, hydroxy, halo, trihalomethyl, hydroxy lower alkyl, carboxy, formyl, aryl, aryloxy, benzyloxy, lower alkanoyl, carboxy lower alkoxy, nitro, amino, lower alkylamino, dilower alkylamino, cyano, lower alkanoyloxy, carbamoyl, lower alkoxy-alkoxy, carbo-lower-alkoxy-alkoxy, or tetrahydropyranylmethyl; andR.sub.5 is hydrogen or lower alkyl.
摘要翻译：本发明涉及包含下式化合物作为活性成分的治疗组合物：（R1）（R2）Ar-Z-M-Ar1（R3）（R4）I及其盐; 其中Ar和Ar 1独立地是苯基，萘基或氮，氧或硫杂环; Z是在主链中含有1至5个碳原子并且总共10个碳原子的亚烷基链; M是氧，硫或NR5; R 1，R 2，R 3和R 4各自独立地为H，低级烷基，低级烷氧基，羟基，卤素，三卤甲基，羟基低级烷基，羧基，甲酰基，芳基，芳氧基，苄氧基，低级烷酰基，羧基低级烷氧基，硝基，烷基氨基，二元烷基氨基，氰基，低级烷酰氧基，氨基甲酰基，低级烷氧基 - 烷氧基，碳 - 低级 - 烷氧基 - 烷氧基或四氢吡喃基甲基。 R5是氢或低级烷基。

2. 发明授权

US5514602A Method of producing a metal sol reagent containing colloidal metal particles 失效
标题翻译：制备含有胶体金属颗粒的金属溶胶试剂的方法
公开(公告)号：US5514602A
公开(公告)日：1996-05-07
申请号：US22544
申请日：1993-02-25
申请人： Houston G. Brooks, Jr. , Chi-Deu Chang , Utpal R. Chakraborty , Henry A. Graham, Jr. , Lloyd L. Hollenbeck, Jr. , Sharon R. Lawler , Jennifer Nasser , Ernest G. Schutt , Albert Venturini
发明人： Houston G. Brooks, Jr. , Chi-Deu Chang , Utpal R. Chakraborty , Henry A. Graham, Jr. , Lloyd L. Hollenbeck, Jr. , Sharon R. Lawler , Jennifer Nasser , Ernest G. Schutt , Albert Venturini
IPC分类号： B01J13/00 , G01N33/543 , G01N33/558 , G01N33/58 , G01N33/74 , G01N33/553
CPC分类号： G01N33/587 , B01J13/0004 , B01J13/0043 , G01N33/54326 , G01N33/54386 , G01N33/558 , G01N33/74 , Y10S435/975
摘要： A method and test kit useful in a wide variety of immunoassay systems. A method of producing metal sol reagents containing metal sol particles of a preselected size is provided. A metal containing solution is reduced under optimized pH conditions to produce metal sol particles of a preselected size, the particles are coated with a coupling compound and then bound with at least one selected immunochemically reactive component. Particles having different immunochemical specificities are also mixed to produce reagents having multiple selected immunochemical specificities.
摘要翻译：用于各种免疫测定系统的方法和测试试剂盒。提供一种制备含有预选尺寸的金属溶胶颗粒的金属溶胶试剂的方法。在优化的pH条件下还原含金属溶液以制备预选尺寸的金属溶胶颗粒，用偶联化合物涂覆颗粒，然后与至少一种选择的免疫化学反应性组分结合。具有不同免疫化学特异性的颗粒也混合以产生具有多种选择的免疫化学特异性的试剂。

3. 发明授权

US4794188A Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity 失效
标题翻译：某些具有抗炎和抗过敏活性的不对称喹啉基醚
公开(公告)号：US4794188A
公开(公告)日：1988-12-27
申请号：US810868
申请日：1985-12-19
申请人： John H. Musser , Utpal R. Chakraborty
发明人： John H. Musser , Utpal R. Chakraborty
IPC分类号： C07C29/40 , C07C33/20 , C07C37/11 , C07C39/11 , C07C43/23 , C07C45/30 , C07C45/44 , C07C45/67 , C07C45/71 , C07C47/575 , C07C49/782 , C07C49/796 , C07C49/825 , C07C49/84 , C07C50/32 , C07C59/68 , C07C65/24 , C07C229/38 , C07D213/30 , C07D213/79 , C07D213/84 , C07D215/14 , C07D215/22 , C07D215/227 , C07D307/42 , C07D333/16 , C07D333/56 , C07D217/24
CPC分类号： C07D213/30 , C07C229/38 , C07C255/00 , C07C29/40 , C07C309/00 , C07C37/20 , C07C41/30 , C07C45/305 , C07C45/44 , C07C45/673 , C07C45/71 , C07C47/575 , C07C49/782 , C07C49/796 , C07C49/825 , C07C49/84 , C07C50/32 , C07C59/68 , C07C65/24 , C07D213/79 , C07D213/84 , C07D215/14 , C07D215/227 , C07D307/42 , C07D333/16 , C07D333/56
摘要： Compounds of the formula:Ar.sub.1 -X-Ar-Z-(R).sub.n'and salts thereof, whereinAr.sub.1 is a nitrogen, sulfur or oxygen heterocyclic ring;Ar is a phenyl ring or a nitrogen, oxygen or sulfur heterocyclic ring;Ar and Ar.sub.1 may be fully substituted or less than fully substituted with H, CH.sub.3, lower alkyl, aryl, aralkyl, halo, hydroxy, lower alkoxy, CF.sub.3, carboxy, alkylcarboxy, arylcarboxy, alkylcarbalkoxy, alkanoyl, formyl, oxo, nitrilo, amino, aminoalkyl, alkylamine, carboxamide, aryloxy, nitro, sulfonyl, sulfonamide, thio, alkylthio, hydroxyalkyl or oxyalkylcarbalkoxy;X= ##STR1## of up to 2 carbon atoms in the principal chain and up to a total of 4 carbon atoms, ##STR2## Z is an alkylene chain containing up to 10 carbon atoms in the principal chain and a total of up to 12 carbon atoms and from 0 to 2 double bonds and the said alkylene chain may be attached to Ar through an oxygen, sulfur or amino nitrogen atom, and when n'=2, one of the R substituents may be halogen on an omega carbon of the alkylene chain Z;when n'=1, R is a substituent attached to one of the carbon atoms of Z selected from the group consisting of .dbd.O, OR.sub.3, SR.sub.3, N(R.sub.2).sub.2 and R.sub.1, --COR.sub.4 and when n'=2 one R is previously defined and the additional R is a substituent attached to one of the carbon atoms of Z selected from the group consisting of .dbd.O, OR.sub.3, SR.sub.3, N(R.sub.2).sub.2, --COR.sub.4, lactone and halo;R.sub.1 is H or CH.sub.3 ;R.sub.2 is H, lower alkyl, aryl or aralkyl;R.sub.3 is H, lower alkyl, lower alkanoyl, aryl, aralkyl or substituted aryl in which the substituent is halo, lower alkyl or lower alkoxy;R.sub.4 is OR.sub.2 or N(R.sub.2).sub.2 ;n=0 or 1;n'=1 to 7; andn"=0, 1 or 2.
摘要翻译：式：Ar1-X-Ar-Z-（R）n'的化合物及其盐，其中Ar 1是氮，硫或氧杂环; Ar是苯环或氮，氧或硫杂环; Ar和Ar 1可以被完全取代或少于完全被H，CH 3，低级烷基，芳基，芳烷基，卤素，羟基，低级烷氧基，CF 3，羧基，烷基羧基，芳基羧基，烷基烷氧基，烷酰基，甲酰基，氧代，次氮基，氨基，氨基烷基，烷基胺，甲酰胺，芳氧基，硝基，磺酰基，磺酰胺，硫代，烷硫基，羟基烷基或氧烷基碳烷氧基; 在主链中最多2个碳原子的X = ，最多总共4个碳原子，Z是在主链中含有至多10个碳原子的亚烷基链，总共多达12个碳原子和0至2个双键，并且所述亚烷基链可以通过氧，硫或氨基氮原子连接到Ar上，当n'= 2时，R取代基之一可以是卤素亚烷基链Z的ω碳; 当n'= 1时，R是与选自= O，OR 3，SR 3，N（R 2）2和R 1，-COR 4的Z的一个碳原子连接的取代基，当n'= 2时，R 并且附加的R是与选自= O，OR 3，SR 3，N（R 2）2，-COR 4，内酯和卤素的Z的一个碳原子连接的取代基。 R1是H或CH3; R2是H，低级烷基，芳基或芳烷基; R3是H，低级烷基，低级烷酰基，芳基，芳烷基或取代芳基，其中取代基是卤素，低级烷基或低级烷氧基; R4是OR2或N（R2）2; n = 0或1; n'= 1至7; 和n“= 0,1或2。

4. 发明授权

US4778931A Certain [3-(1-hydroxy hexyl-tetrahydro)naphthalenes], the corresponding naphthalenes having anti-inflammatory and anti-allergic activity 失效
标题翻译：某些[3-（1-羟基己基 - 四氢）萘]，相应的萘具有抗炎和抗过敏活性
公开(公告)号：US4778931A
公开(公告)日：1988-10-18
申请号：US803122
申请日：1985-11-29
申请人： John H. Musser , Utpal R. Chakraborty
发明人： John H. Musser , Utpal R. Chakraborty
IPC分类号： C07C29/40 , C07C33/20 , C07C37/11 , C07C39/11 , C07C43/23 , C07C45/30 , C07C45/44 , C07C45/67 , C07C45/71 , C07C47/575 , C07C49/782 , C07C49/796 , C07C49/825 , C07C49/84 , C07C50/32 , C07C59/68 , C07C65/24 , C07C69/773 , C07C229/38 , C07D213/30 , C07D213/79 , C07D213/84 , C07D215/14 , C07D215/22 , C07D215/227 , C07D307/42 , C07D333/16 , C07D333/56 , C07C43/20 , C07C43/257 , C07C43/295
CPC分类号： C07D213/30 , C07C229/38 , C07C255/00 , C07C29/40 , C07C309/00 , C07C37/11 , C07C37/20 , C07C43/23 , C07C45/305 , C07C45/44 , C07C45/673 , C07C45/71 , C07C47/575 , C07C49/782 , C07C49/796 , C07C49/825 , C07C49/84 , C07C50/32 , C07C59/68 , C07C65/24 , C07D213/79 , C07D213/84 , C07D215/14 , C07D215/227 , C07D307/42 , C07D333/16 , C07D333/56
摘要： The invention relates to several aryloxy-alkane alcohols, for example 1-(3-(1-hydroxy-1-methylhexyl) phenoxy methyl)-2-methoxy-naphthalene, 2-(1-(3-(1-hydroxy-2,2-dimethylhexyl)phenoxy)ethyl naphthalene, 1-(3-6-phenoxy-1-hydroxyhexyl)phenoxy methyl)-4-methoxy naphthalene, 2-(3-(1-hydroxyhexyl) phenoxymethyl) naphthalene and 2-(3-(1-hydroxyhexyl)phenoxymethyl)-1,2,3,4-tetrahydro naphthalene, methods for their preparation and their use for treating inflammatory and allergic conditions in a mammal.
摘要翻译：本发明涉及几种芳氧基 - 烷烃，例如1-（3-（1-羟基-1-甲基己基）苯氧基甲基）-2-甲氧基 - 萘，2-（1-（3-（1-羟基-2- （3-（1-羟基己基）苯氧基甲基）萘和2-（3-（1-羟基己基）苯氧基甲基）萘，2-（3- - （1-羟基己基）苯氧基甲基）-1,2,3,4-四氢萘，其制备方法及其用于治疗哺乳动物的炎性和过敏状况。

5. 发明授权

US4567184A Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies 失效
标题翻译：某些用于治疗炎症和过敏的1-羟基戊烷或1-羟基己烷的芳基或杂芳基衍生物
公开(公告)号：US4567184A
公开(公告)日：1986-01-28
申请号：US530811
申请日：1983-09-09
申请人： John H. Musser , Utpal R. Chakraborty
发明人： John H. Musser , Utpal R. Chakraborty
IPC分类号： C07C29/40 , C07C33/20 , C07C37/11 , C07C39/11 , C07C43/23 , C07C45/30 , C07C45/44 , C07C47/575 , C07C49/84 , C07C59/68 , C07C65/24 , C07C229/38 , C07D213/30 , C07D213/79 , C07D215/14 , A61K31/44 , A61K31/47
CPC分类号： C07D213/30 , C07C229/38 , C07C29/40 , C07C309/00 , C07C37/20 , C07C43/23 , C07C45/305 , C07C45/44 , C07C47/575 , C07C49/84 , C07C59/68 , C07C65/24 , C07D213/79 , C07D215/14
摘要： Compounds of the structure ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen, alkyl, carboxy, alkylcarboxy, arylcarboxy, alkyl carbalkoxy, alkanoyl, formyl, nitrile, amino, amino alkyl, alkylamine, carboxamide, halo, trihalomethyl, hydroxy, alkoxy, aryloxy, nitro, sulfonyl, sulfonamide, thio, alkylthio, or R.sub.1 and R.sub.2 can be taken together to form a phenyl ring;B is C or N, in which N can be in any position of the ring;X is O, S, NR.sub.4, CH.sub.2 Z, CH.dbd.N, CH.dbd.CH, C.tbd.C, CH.sub.2 ZCH.sub.2, C.dbd.O, C.dbd.CR or WC.dbd.O;Y is CHCH.sub.2, C.dbd.CH, C--CH.sub.2, CHCHR.sub.5, CHC(R.sub.5).sub.2 or CC(R.sub.5).sub.2 ;R.sub.3 is O, OH, OR.sub.4, SH, SR.sub.4, NH, HNR.sub.4 or N(R.sub.4).sub.2 ; andM is an integer from 0 to 10; wherein Z is O, S or NR.sub.4 ; R.sub.4 is H, alkyl or aryl;W is O, S or NR.sub.4 ; and R.sub.5 is H, alkyl or fluoro have antiinflammatory and antiallergic activities.
摘要翻译：结构化合物及其药学上可接受的盐，其中R 1和R 2独立地是氢，烷基，羧基，烷基羧基，芳基羧基，烷基烷氧基，烷酰基，甲酰基，腈，氨基，氨基烷基，烷基胺，甲酰胺，卤素，三卤甲基，羟基，烷氧基，芳氧基，硝基，磺酰基，磺酰胺，硫代，烷硫基，或R 1和R 2可以一起形成苯环; B是C或N，其中N可以在环的任何位置; X是O，S，NR4，CH2Z，CH = N，CH = CH，C 3BOND C，CH2ZCH2，C = O，C = CR或WC = O; Y是CHCH2，C = CH，C-CH2，CHCHR5，CHC（R5）2或CC（R5）2; R3是O，OH，OR4，SH，SR4，NH，HNR4或N（R4）2; M为0〜10的整数。其中Z是O，S或NR4; R4是H，烷基或芳基; W是O，S或NR4; R5是H，烷基或氟具有抗炎和抗过敏活性。

6. 发明授权

US4631287A Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments 失效
标题翻译：芳基和杂芳基醚作为治疗过敏性疾病的药剂
公开(公告)号：US4631287A
公开(公告)日：1986-12-23
申请号：US723781
申请日：1985-04-16
申请人： Utpal R. Chakraborty , Raymond D. Youssefyeh
发明人： Utpal R. Chakraborty , Raymond D. Youssefyeh
IPC分类号： A61K31/47 , A61K31/472 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C43/14 , C07C43/18 , C07C43/20 , C07C43/23 , C07C43/257 , C07C45/00 , C07C47/228 , C07C47/52 , C07C49/215 , C07C49/84 , C07C51/00 , C07C59/58 , C07C59/76 , C07C65/21 , C07C67/00 , C07C69/003 , C07C69/007 , C07C201/00 , C07C205/38 , C07C209/00 , C07C213/00 , C07C215/48 , C07C215/74 , C07C217/48 , C07C231/00 , C07C235/42 , C07C237/30 , C07C313/00 , C07C323/24 , C07D215/14 , C07D215/20 , C07D217/16 , C07D257/04 , C07D257/06 , C07D307/28 , C07D307/38 , C07D309/04 , C07D309/20 , C07D309/22 , C07D333/16 , C07D333/18 , C07D401/12 , C07D405/12 , C12N9/99
CPC分类号： C07D257/04 , C07C43/23 , C07D215/14 , C07D309/22 , C07D401/12 , C07D405/12
摘要： The present invention is concerned with the therapeutic composition comprising as an active ingredient a compound of the formula:(R.sub.1)(R.sub.2)Ar--Z--M--Ar.sub.1 (R.sub.3)(R.sub.4) Iand salts thereof;whereinAr and Ar.sub.1 are independently phenyl, naphthyl or a nitrogen, oxygen, or sulfur heterocyclic ring;Z is an alkylene chain containing from 1 to 5 carbon atoms in the principal chain and up to a total of 10 carbon atoms;M is oxygen, sulfur, or NR.sub.5 ;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently H, lower alkyl, lower alkoxy, hydroxy, halo, trihalomethyl, hydroxy lower alkyl, carboxy, formyl, aryl, aryloxy, benzyloxy, lower alkanoyl, carboxy lower alkoxy, nitro, amino, lower alkylamino, dilower alkylamino, cyano, lower alkanoyloxy, carbamoyl, lower alkoxy-alkoxy, carbo-lower-alkoxy-alkoxy, or tetrahydropyranylmethyl; andR.sub.5 is hydrogen or lower alkyl.
摘要翻译：本发明涉及包含下式化合物作为活性成分的治疗组合物：（R1）（R2）Ar-Z-M-Ar1（R3）（R4）I及其盐; 其中Ar和Ar 1独立地是苯基，萘基或氮，氧或硫杂环; Z是在主链中含有1至5个碳原子并且总共10个碳原子的亚烷基链; M是氧，硫或NR5; R 1，R 2，R 3和R 4各自独立地为H，低级烷基，低级烷氧基，羟基，卤素，三卤甲基，羟基低级烷基，羧基，甲酰基，芳基，芳氧基，苄氧基，低级烷酰基，羧基低级烷氧基，硝基，烷基氨基，二元烷基氨基，氰基，低级烷酰氧基，氨基甲酰基，低级烷氧基 - 烷氧基，碳 - 低级 - 烷氧基 - 烷氧基或四氢吡喃基甲基。 R5是氢或低级烷基。

7. 发明授权

US5597688A Cell fixative and method of analyzing virally infected cells 失效
标题翻译：细胞固定剂和分析病毒感染细胞的方法
公开(公告)号：US5597688A
公开(公告)日：1997-01-28
申请号：US467799
申请日：1995-06-06
申请人： Mark C. Connelly , Utpal R. Chakraborty , Houston G. Brooks, Jr.
发明人： Mark C. Connelly , Utpal R. Chakraborty , Houston G. Brooks, Jr.
IPC分类号： C12Q1/00 , G01N1/30 , G01N15/14 , G01N33/48 , G01N33/533 , G01N33/545 , G01N33/569 , C12Q1/70 , G01N33/53
CPC分类号： G01N33/56988 , G01N1/30 , G01N33/56972 , G01N33/56983 , G01N2001/305 , Y10S435/975 , Y10S436/805 , Y10T436/10 , Y10T436/101666 , Y10T436/108331 , Y10T436/25
摘要： The present invention provides a novel cellular fixative composition and method of cellular fixing and cellular analysis wherein cells may be fixed for further analysis without destroying the cell's surface markers, cellular morphology, and the cell's light scattering properties. Treatment of cells with the fixative as described herein also allows antibodies or .other desired components to enter the cell through the cellular membrane, without allowing important contents of the cell to escape. As an added benefit, the fixative composition of the invention may also kill or at least inactivate or reduce the activity of deadly virus contained in the cell. In its broadest aspect, the presently claimed fixative composition comprises at least three components, and in more preferred embodiments, four components. In a particularly preferred embodiment, the fixative composition described herein comprises at least one compound suitable for increasing the permeability of a cellular membrane, at least one compound that facilitates transportation of components across cellular membranes, at least one detergent, and at least one compound having the structure:R.sub.1 R.sub.2 R.sub.3 R.sub.4 R.sub.5 --Ar--X
摘要翻译：本发明提供了一种新的细胞固定组合物和细胞固定和细胞分析方法，其中细胞可以固定用于进一步分析，而不破坏细胞的表面标志物，细胞形态和细胞的光散射性质。用本文所述的固定剂处理细胞还允许抗体或其它所需组分通过细胞膜进入细胞，而不允许细胞的重要内容物逸出。作为额外的益处，本发明的固定组合物还可以杀死或至少灭活或降低细胞中包含的致命病毒的活性。在其最广泛的方面，目前要求的固定剂组合物包含至少三种组分，在更优选的实施方案中包含四种组分。在一个特别优选的实施方案中，本文描述的固定剂组合物包含至少一种适合于增加细胞膜的渗透性的化合物，至少一种促进组分跨细胞膜运输的化合物，至少一种洗涤剂和至少一种具有结构：R1R2R3R4R5-Ar-X

8. 发明授权

US5571726A Kit containing glutaraldehyde coated colloidal metal particles of a preselected size 失效
标题翻译：含有预选大小的含戊二醛涂层胶体金属颗粒的试剂盒
公开(公告)号：US5571726A
公开(公告)日：1996-11-05
申请号：US446533
申请日：1995-05-19
申请人： Houston G. Brooks, Jr. , Chi-Deu Chang , Utpal R. Chakraborty , Henry A. Graham, Jr. , Lloyd L. Hollenbeck, Jr. , Sharon R. Lawler , Jennifer Nasser , Ernest G. Schutt , Albert Venturini
发明人： Houston G. Brooks, Jr. , Chi-Deu Chang , Utpal R. Chakraborty , Henry A. Graham, Jr. , Lloyd L. Hollenbeck, Jr. , Sharon R. Lawler , Jennifer Nasser , Ernest G. Schutt , Albert Venturini
IPC分类号： B01J13/00 , G01N33/543 , G01N33/558 , G01N33/58 , G01N33/74 , G01N33/551 , G01N33/553
CPC分类号： G01N33/587 , B01J13/0004 , B01J13/0043 , G01N33/54326 , G01N33/54386 , G01N33/558 , G01N33/74 , Y10S435/975
摘要： A method and test kit useful in a wide variety of immunoassay systems. A method of producing metal sol reagents containing metal sol particles of a preselected size is provided. A metal containing solution is reduced under optimized pH conditions to produce metal sol particles of a preselected size, the particles are coated with a coupling compound and then bound with at least one selected immunochemically reactive component. Particles having different immunochemical specificities are also mixed to produce reagents having multiple selected immunochemical specificities.
摘要翻译：用于各种免疫测定系统的方法和测试试剂盒。提供一种制备含有预选尺寸的金属溶胶颗粒的金属溶胶试剂的方法。在优化的pH条件下还原含金属溶液以制备预选尺寸的金属溶胶颗粒，用偶联化合物涂覆颗粒，然后与至少一种选择的免疫化学反应性组分结合。具有不同免疫化学特异性的颗粒也混合以产生具有多种选择的免疫化学特异性的试剂。

9. 发明授权

US5422277A Cell fixative composition and method of staining cells without destroying the cell surface 失效
标题翻译：细胞固定组合物和染色细胞的方法，而不破坏细胞表面
公开(公告)号：US5422277A
公开(公告)日：1995-06-06
申请号：US859212
申请日：1992-03-27
申请人： Mark C. Connelly , Utpal R. Chakraborty , Houston G. Brooks, Jr.
发明人： Mark C. Connelly , Utpal R. Chakraborty , Houston G. Brooks, Jr.
IPC分类号： C12Q1/00 , G01N1/30 , G01N15/14 , G01N33/48 , G01N33/533 , G01N33/545 , G01N33/569 , G01N31/00 , C12Q1/02 , G01N1/00
CPC分类号： G01N33/56988 , G01N1/30 , G01N33/56972 , G01N33/56983 , G01N2001/305 , Y10S435/975 , Y10S436/805 , Y10T436/10 , Y10T436/101666 , Y10T436/108331 , Y10T436/25
摘要： A cell fixative composition for fixing the internal components of a cell without disrupting the cell surface components is disclosed. The composition contains a compound for preserving intracellular morphology, a compound for fixing internal components of the cell, a compound which facilitates transportation of components across the cellular membrane, and a compound for increasing permeability of cell membranes. Methods for analyzing cells which have been fixed using the composition are also disclosed.
摘要翻译：公开了用于固定电池的内部组分而不破坏电池表面组分的电池固定组合物。该组合物含有用于保留细胞内形态的化合物，用于固定细胞内部组分的化合物，促进组分跨细胞膜运输的化合物和用于增加细胞膜渗透性的化合物。还公开了使用该组合物固定的细胞分析方法。

10. 发明授权

US4728668A Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments 失效
标题翻译：芳基和杂芳基醚作为治疗过敏性疾病的药剂
公开(公告)号：US4728668A
公开(公告)日：1988-03-01
申请号：US877570
申请日：1986-06-23
申请人： Utpal R. Chakraborty , Raymond D. Youssefyeh
发明人： Utpal R. Chakraborty , Raymond D. Youssefyeh
IPC分类号： C07C43/23 , C07D215/14 , C07D257/04 , C07D309/22 , C07D401/12 , C07D405/12 , A61K31/36
CPC分类号： C07D257/04 , C07C43/23 , C07D215/14 , C07D309/22 , C07D401/12 , C07D405/12
摘要： The present invention is concerned with the therapeutic composition comprising as an active ingredient a compound of the formula:(R.sub.1)(R.sub.2) Ar--Z--M--Ar.sub.1 (R.sub.3)(R.sub.4) Iand salts thereof;whereinAr and Ar.sub.1 are independently phenyl, naphthyl or a nitrogen, oxygen, or sulfur heterocyclic ring;Z is an alkylene chain containing from 1 to 5 carbon atoms in the principal chain and up to a total of 10 carbon atoms;M is oxygen, sulfur, or NR.sub.5 ;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently H, lower alkyl, lower alkoxy, hydroxy, halo, trihalomethyl, hydroxy lower alkyl, carboxy, formyl, aryl, aryloxy, benzyloxy, lower alkanoyl, carboxy lower alkoxy, nitro, amino, lower alkylamino, dilower alkylamino, cyano, lower alkanoyloxy, carbamoyl, lower alkoxy-alkoxy, carbo-lower alkoxy-alkoxy, or tetrahydropyranylmethyl; andR.sub.5 is hydrogen or lower alkyl.
摘要翻译：本发明涉及包含下式化合物作为活性成分的治疗组合物：（R1）（R2）Ar-Z-M-Ar1（R3）（R4）I及其盐; 其中Ar和Ar 1独立地是苯基，萘基或氮，氧或硫杂环; Z是在主链中含有1至5个碳原子并且总共10个碳原子的亚烷基链; M是氧，硫或NR5; R 1，R 2，R 3和R 4各自独立地为H，低级烷基，低级烷氧基，羟基，卤素，三卤甲基，羟基低级烷基，羧基，甲酰基，芳基，芳氧基，苄氧基，低级烷酰基，羧基低级烷氧基，硝基，烷基氨基，二元烷基氨基，氰基，低级烷酰氧基，氨基甲酰基，低级烷氧基 - 烷氧基，碳 - 低级烷氧基 - 烷氧基或四氢吡喃基甲基; R5是氢或低级烷基。

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