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1. 发明专利

AU3731400A Methods and compositions useful in inhibiting apoptosis 未知
公开(公告)号：AU3731400A
公开(公告)日：2000-09-21
申请号：AU3731400
申请日：2000-03-03
申请人： TRUSTEES OF UNIVERSITY TECHNOLOGY CORPORATION THE
发明人： SHAPIRO LELAND
IPC分类号： A61K38/08 , A61K38/55 , A61K38/57 , A61K38/00
摘要： The instant invention provides a method of treating an animal suffering a disease characterized by excessive apoptosis by administering a therapeutically effective amount of at least one serine protease inhibitor and thereafter monitoring a decrease in apoptosis. The inhibitor of the invention includes α1-antitrypsin or an α1-antitrypsin-like agent, including, but not limited to oxidation-resistant variants of α1-antitrypsin, and peptoids with antitrypsin activity. The diseases treatable by the invention include cancer, autoimmune disease, sepsis neurodegenerative disease, myocardial infarction, stroke, ischemia-reperfusion injury, toxin induced liver injury and AIDS. The method of the invention is also suitable for the prevention or amelioration of diseases characterized by excessive apoptosis.

2. 发明专利

AU3511500A Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions 未知
公开(公告)号：AU3511500A
公开(公告)日：2000-09-21
申请号：AU3511500
申请日：2000-03-03
申请人： TRUSTEES OF UNIVERSITY TECHNOLOGY CORPORATION THE
发明人： SHAPIRO LELAND
IPC分类号： A61K38/08 , A61K38/55 , A61K38/57 , A61K38/00
摘要： A novel method of treating and preventing diseases is provided. In particular, compositions and methods of blocking diseases associated with aberrant levels of nitric oxide and facilitated by a serine proteolytic (SP) activity are disclosed, which consist of administering to a subject a therapeutically effective amount of a compound having a serine protease inhibitory activity. Among effective compounds are alpha1-antitrypsin and synthetic drugs mimicking some or all of the actions of alpha1-antitrypsin.

4. 发明申请

WO2002095920A1 ELECTRON TUNNELING DEVICE 审中-公开
标题翻译：电子隧道设备
公开(公告)号：WO2002095920A1
公开(公告)日：2002-11-28
申请号：PCT/US2002/015417
申请日：2002-05-17
申请人： UNIVERSITY TECHNOLOGY CORPORATION , ELIASSON, Blake, J. , MODDEL, Garret
发明人： ELIASSON, Blake, J. , MODDEL, Garret
IPC分类号： H02N6/00
CPC分类号： H01L31/06 , B82Y20/00 , H01L31/035236 , H01L31/101 , H01L45/00 , Y02E10/50
摘要： The electron tunneling device (110) includes first and second non-insulating layers (112 and 114) spaced apart such that a given voltage can be provided therebetween. The device also includes an arrangement disposed between the non-insulating layers and configured to serve as a transport of electrons between the non-insulating layers. This arrangement includes a first layer (116) of an amorphous material such that using only the first layer of amorphous material in the arrangement would result in a given value of a parameter in the transport of electrons, with respect to the given voltage. The arrangement further includes a second layer (118) of material, which is configured to cooperate with the first layer (116) of amorphous material such that the transport of electrons includes, at least in part, transport by tunneling, and such that the parameter, with respect to the given voltage, is increased above the given value of the parameter.
摘要翻译：电子隧穿装置（110）包括间隔开的第一和第二非绝缘层（112和114），使得可以在其间提供给定的电压。该装置还包括设置在非绝缘层之间并被配置为用作非绝缘层之间的电子传输的布置。这种布置包括非晶材料的第一层（116），使得仅使用该布置中的第一非晶材料层将导致相对于给定电压的电子传输中的参数的给定值。该装置还包括材料的第二层（118），其被配置为与非晶材料的第一层（116）协作，使得电子的传输至少部分地包括通过隧道传输，并且使得参数，相对于给定的电压，增加到高于参数的给定值。

5. 发明申请

WO2001032222A1 SELECTIVE TOXIN EXPRESSION IN ANGIOGENIC ENDOTHELIAL CELLS 审中-公开
标题翻译：在生殖内皮细胞中的选择性毒素表达
公开(公告)号：WO2001032222A1
公开(公告)日：2001-05-10
申请号：PCT/US2000/030471
申请日：2000-11-03
申请人： MBT MUNICH BIOTECHNOLOGY GMBH , UNIVERSITY TECHNOLOGY CORPORATION , MAXWELL, Ian, H. , MAXWELL, Francoise , KALETTA, Cortina , NAUJOKS, Kurt, W.
发明人： MAXWELL, Ian, H. , MAXWELL, Francoise , KALETTA, Cortina , NAUJOKS, Kurt, W.
IPC分类号： A61K48/00
CPC分类号： C07K14/34 , A61K48/00 , C12N15/85 , C12N2799/027 , C12N2830/00 , C12N2830/002 , C12N2830/008 , C12N2830/60 , C12N2830/85
摘要： The present invention relates to pharmaceutical compositions capable of specifically inducing cell death in the proliferating angiogenic endothelial cells associated with solid tumors and other angiogenesis associated diseases. More specifically, the present invention relates to nucleotide constructs that are selectively active in angiogenic endothelial cells and that encode highly toxic agents, such as diphtheria toxin, for expression in such cells.
摘要翻译：本发明涉及能够在与实体瘤和其他血管生成相关疾病相关的增殖性血管生成内皮细胞中特异性诱导细胞死亡的药物组合物。更具体地，本发明涉及在血管生成内皮细胞中选择性活性并且编码高毒性剂如白喉毒素用于在这样的细胞中表达的核苷酸构建体。

6. 发明申请

WO1998028971A2 BETA-AMYLOID TOXICITY 审中-公开
标题翻译： β-淀粉样毒性
公开(公告)号：WO1998028971A2
公开(公告)日：1998-07-09
申请号：PCT/US1997023819
申请日：1997-12-31
申请人： UNIVERSITY TECHNOLOGY CORPORATION , LINK, Christopher
发明人： UNIVERSITY TECHNOLOGY CORPORATION
IPC分类号： A01K67/027
CPC分类号： A01K67/0336 , A01K2217/05 , A01K2217/20 , A01K2227/703 , A01K2267/0312 , A01K2267/0337 , A01K2267/0393 , C07K14/43595 , C07K14/4711 , C12N15/8509 , C12N2830/008
摘要： The present invention relates to methods and compositions for visualization of the toxic effects of transgenes in vivo. In particular, the present invention provides methods and compositions for the production and use of transgenic, including dually transgenic, Caenorhabditis elegans for visualization of the toxic effects of beta -amyloid accumulation in vivo.
摘要翻译：本发明涉及用于可视化转基因在体内的毒性作用的方法和组合物。特别地，本发明提供了用于生产和使用转基因的方法和组合物，包括双重转基因秀丽隐杆线虫，用于可视化体内β-淀粉样蛋白积累的毒性作用。

7. 发明申请

WO2003006223A1 DEVICES AND METHODS FOR THE PRODUCTION OF PARTICLES 审中-公开
标题翻译：用于生产颗粒的装置和方法
公开(公告)号：WO2003006223A1
公开(公告)日：2003-01-23
申请号：PCT/US2002/022300
申请日：2002-07-10
申请人： UNIVERSITY TECHNOLOGY CORPORATION , GROTHE, Willy , JARMER, Daniel , LENGSFELD, Corinne , RANDOLPH, Theodore
发明人： GROTHE, Willy , JARMER, Daniel , LENGSFELD, Corinne , RANDOLPH, Theodore
IPC分类号： B29B9/00
CPC分类号： B01J2/04 , B01D11/0403 , B01D11/0407 , B01D11/0473 , B01F5/0057 , B01F2003/0064
摘要： The present invention provides methods and devices for producing particles with an average diameter less than about 15μm using the precipitation with compressed fluid-antisolvent (PCA) process and the carbon-dioxide assisted nebulization with a bubble dryer (CAN-BD) process. In the methods and nozzles of the invention, at least one jet of supercritical or near-supercritical fluid and at least one jet of solution interact to mix the supercritical or near-supercritical fluid and the solution within a chamber. The solution contains at least one solvent and at least one solute. At least one of the jets is a swirling jet. To form particles, the solvent and supercritical or near-supercritical fluid are then injected into a PCA or a CAN-BD process chamber. The degree of mixing depends in part on the power input into the mixing chamber. Power inputs of about 6.5xl0 9 W/m 3 enhance the degree of mixing and allow production of nanoscale particles with the PCA process. The nanoscale particles have a size distribution so that polydispersity is less than about 1.75.
摘要翻译：本发明提供了使用压缩流体 - 反溶剂（PCA）沉淀法和用气泡干燥器（CAN-BD）方法进行二氧化碳辅助雾化来生产平均直径小于约15μm的颗粒的方法和装置。在本发明的方法和喷嘴中，至少一个超临界或近超临界流体射流和至少一个溶液射流相互作用以将超临界或近超临界流体和溶液混合在腔室内。该溶液含有至少一种溶剂和至少一种溶质。至少有一架喷气式飞机是旋流式飞机。为了形成颗粒，然后将溶剂和超临界或近临界流体注入PCA或CAN-BD处理室中。混合程度部分取决于输入混合室的功率。约6.5×10 9 W / m 3的功率输入增强了混合的程度，并允许用PCA工艺生产纳米级颗粒。纳米级颗粒具有尺寸分布，使得多分散性小于约1.75。

8. 发明申请

WO1998014593A3 HUMAN TELOMERASE CATALYTIC SUBUNIT 审中-公开
公开(公告)号：WO1998014593A3
公开(公告)日：1998-04-09
申请号：PCT/US1997017885
申请日：1997-10-01
申请人： GERON CORPORATION , UNIVERSITY TECHNOLOGY CORPORATION , CECH, Thomas, R. , LINGNER, Joachim , NAKAMURA, Toru , CHAPMAN, Karen, B. , MORIN, Gregg, B. , HARLEY, Calvin, B. , ANDREWS, William, H.
发明人： GERON CORPORATION , UNIVERSITY TECHNOLOGY CORPORATION
IPC分类号： C12N15/54

9. 发明申请

WO1997039143A3 METHODS FOR THE IDENTIFICATION OF NOVEL ANTIFUNGAL AGENTS 审中-公开
公开(公告)号：WO1997039143A3
公开(公告)日：1997-10-23
申请号：PCT/US1997006304
申请日：1997-04-17
申请人： ABBOTT LABORATORIES , UNIVERSITY TECHNOLOGY CORPORATION
发明人： ABBOTT LABORATORIES , UNIVERSITY TECHNOLOGY CORPORATION , FOSTEL, Jennifer, Marion , WINEY, Mark, Edward , STEINER, Estelle, Marthe , LUCA, Francis, Conrad
IPC分类号： C12Q01/48

10. 发明申请

WO1997038698A1 METHODS FOR TREATING MIDDLE AND INNER EAR DISORDERS 审中-公开
标题翻译：用于治疗中度和内脏疾病的方法
公开(公告)号：WO1997038698A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006507
申请日：1997-04-18
申请人： UNIVERSITY TECHNOLOGY CORPORATION , MANNING, Mark, C. , SHEFTER, Eli , HART, Michael, J.
发明人： UNIVERSITY TECHNOLOGY CORPORATION
IPC分类号： A61K31/715
CPC分类号： A61K9/0046 , A61K31/7036 , A61K47/36
摘要： Provided are methods to deliver drugs to the middle or inner ear of a mammal in need of such drug comprising inserting a composition comprising a biocompatible polymer and at least one pharmacologically active agent. More particularly, the invention relates to a method for treating Meniere's disease using a composition of hyaluronic acid and gentamicin.
摘要翻译：提供了将药物递送到需要这种药物的哺乳动物的中耳或内耳的方法，包括插入包含生物相容性聚合物和至少一种药理活性剂的组合物。更具体地，本发明涉及使用透明质酸和庆大霉素组合物治疗梅尼埃病的方法。

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