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1. 发明申请

US20100047313A1 MEDICAL DEVICES HAVING A COATING FOR ELECTROMAGNETICALLY-CONTROLLED RELEASE OF THERAPEUTIC AGENTS 审中-公开
标题翻译：具有用于电磁控制释放治疗剂的涂层的医疗装置
公开(公告)号：US20100047313A1
公开(公告)日：2010-02-25
申请号：US12544577
申请日：2009-08-20
申请人： Tom PRIEBE , Umang ANAND , Lance GIBSON , Les CLAPP , Michael KUEHLING
发明人： Tom PRIEBE , Umang ANAND , Lance GIBSON , Les CLAPP , Michael KUEHLING
IPC分类号： A61F2/04 , A61K31/337 , A61P7/00
CPC分类号： A61L27/34 , A61L27/50 , A61L27/54 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/606 , C08L101/12
摘要： Medical devices having a coating comprising an ionic polymer for electromagnetically-controlled release of a therapeutic agent. Release of the therapeutic agent from the coating is facilitated or modulated by the application of an electromagnetic field to the medical device. Exposure to the electromagnetic field may cause the release of the therapeutic agent in various ways, including electrochemical changes in the ionic polymer, structural changes in the coating and/or ionic polymers, changes in the permeability of the coating, changes in the orientation of the ionic polymers, or motion of the ionic polymers. Also disclosed are methods for delivering a therapeutic agent using electromagnetic fields.
摘要翻译：具有包含用于电磁控制释放治疗剂的离子聚合物的涂层的医疗装置。通过向医疗装置施加电磁场来促进或调节治疗剂从涂层的释放。暴露于电磁场可能导致治疗剂以各种方式释放，包括离子聚合物的电化学变化，涂层和/或离子聚合物的结构变化，涂层渗透性的变化，离子聚合物或离子聚合物的运动。还公开了使用电磁场递送治疗剂的方法。

2. 发明授权

US07976915B2 Endoprosthesis with select ceramic morphology 失效
标题翻译：具有选择陶瓷形态的内假体
公开(公告)号：US07976915B2
公开(公告)日：2011-07-12
申请号：US11752772
申请日：2007-05-23
申请人： Torsten Scheuermann , Michael Kuehling , Umang Anand , Jaydeep Y. Kokate , Samuel Robaina
发明人： Torsten Scheuermann , Michael Kuehling , Umang Anand , Jaydeep Y. Kokate , Samuel Robaina
IPC分类号： A47G19/22 , B32B1/08 , A61F2/06
CPC分类号： A47G19/22 , A61F2/0077 , A61F2/82 , A61F2/91 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/606 , Y10T428/131 , Y10T428/1321
摘要： An endoprosthesis, such as a stent, includes a ceramic, such as IROX, having a select morphology and composition.
摘要翻译：内置假体，例如支架，包括具有选择形态和组成的陶瓷，例如IROX。

3. 发明申请

US20120053678A1 INERT HEAT TREATMENT TO IMPROVE COATING ADHESION AND PRODUCT PERFORMANCE CHARACTERISTICS FOR BIODEGRADEABLE COATINGS 审中-公开
标题翻译：用于改善涂层粘合剂的耐热处理和可生物降解涂料的产品性能特性
公开(公告)号：US20120053678A1
公开(公告)日：2012-03-01
申请号：US13208142
申请日：2011-08-11
申请人： Umang Anand , Liliana Atanasoska , Pankaj Gupta , Steve Kangas
发明人： Umang Anand , Liliana Atanasoska , Pankaj Gupta , Steve Kangas
IPC分类号： A61F2/06 , B32B15/08 , B05D3/02 , B32B15/04 , B05D5/00 , B05D7/00
CPC分类号： A61L31/022 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2420/08 , B05D7/546 , B05D2202/00 , Y10T428/31678 , Y10T428/31692
摘要： An implantable metallic medical device having a dual-layered coating with a primer layer having functional groups capable of forming an organo-metallic complex with iron species and a second biocompatible polymer layer. The primer layer is baked onto the metallic medical device functioning as a tie layer between the surface of the medical device and a second biocompatible polymer layer disposed on the primer layer. Baking improves tie layer adhesion and in some cases provides an organo-metallic complex with the metal substrate. The second biocompatible polymer may can a therapeutic agent.
摘要翻译：一种具有双层涂层的可植入金属医疗装置，其具有能够形成与铁物质的有机金属络合物的官能团的底漆层和第二生物相容性聚合物层。底漆层被烘烤到用作医疗装置的表面和设置在底漆层上的第二生物相容性聚合物层之间的连接层的金属医疗装置上。烘烤改善粘结层粘合性，并且在一些情况下提供与金属基材的有机金属络合物。第二生物相容性聚合物可以是治疗剂。

4. 发明申请

US20100145437A1 Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface 审中-公开
标题翻译：支架设计允许药物的扩展释放和/或增强的聚合物粘附到OD表面
公开(公告)号：US20100145437A1
公开(公告)日：2010-06-10
申请号：US12706881
申请日：2010-02-17
申请人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuchling
发明人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuchling
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2210/0076 , A61F2220/0066 , A61F2220/0083 , A61F2250/0067 , A61F2250/0068
摘要： The invention is directed to mechanisms and methods that reduce the delamination of a therapeutic agent from a stent. The mechanisms include holes (channels, wells, and other hole configurations), protrusions, sintered metal cores, clamps/staples, pins, and stainless steel shields.
摘要翻译：本发明涉及减少治疗剂从支架分层的机制和方法。这些机构包括孔（通道，孔和其他孔构造），突起，烧结金属芯，夹/钉，销和不锈钢屏蔽。

5. 发明申请

US20090076591A1 Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface 审中-公开
标题翻译：支架设计允许药物的扩展释放和/或增强的聚合物粘附到OD表面
公开(公告)号：US20090076591A1
公开(公告)日：2009-03-19
申请号：US11857736
申请日：2007-09-19
申请人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuehling
发明人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuehling
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2210/0076 , A61F2220/0066 , A61F2220/0083 , A61F2250/0067 , A61F2250/0068
摘要： The invention is directed to mechanisms and methods that reduce the delamination of a therapeutic agent from a stent. The mechanisms include holes (channels, wells, and other hole configurations), protrusions, sintered metal cores, clamps/staples, pins, and stainless steel shields.
摘要翻译：本发明涉及减少治疗剂从支架分层的机制和方法。这些机构包括孔（通道，孔和其他孔构造），突起，烧结金属芯，夹/钉，销和不锈钢屏蔽。

6. 发明申请

US20080294236A1 Endoprosthesis with Select Ceramic and Polymer Coatings 审中-公开
标题翻译：选择陶瓷和聚合物涂层的内置假体
公开(公告)号：US20080294236A1
公开(公告)日：2008-11-27
申请号：US11752735
申请日：2007-05-23
申请人： Umang Anand , Torsten Scheuermann , Michael Kuehling
发明人： Umang Anand , Torsten Scheuermann , Michael Kuehling
IPC分类号： A61F2/00
CPC分类号： C23C14/08 , A61F2/91 , A61F2210/0076 , A61L31/088 , A61L31/10 , A61L2420/04 , C23C14/06 , C23C14/12 , C23C14/28
摘要： An endoprosthesis, such as a stent, includes a ceramic, such as IROX, having a select morphology and composition and a polymer coating, both of which are deposited by pulsed laser deposition.
摘要翻译：内置假体，例如支架，包括具有选择形态和组成的陶瓷，例如IROX，以及通过脉冲激光沉积沉积的聚合物涂层。

7. 发明授权

US06837775B2 Porous, lubricated mixing tube for abrasive, fluid jet 失效
标题翻译：多孔润滑混合管用于磨料，流体喷射
公开(公告)号：US06837775B2
公开(公告)日：2005-01-04
申请号：US10010663
申请日：2001-12-06
申请人： Umang Anand , Joseph Katz
发明人： Umang Anand , Joseph Katz
IPC分类号： B24C1/04 , B24C5/04 , B24B1/00
CPC分类号： B24C5/04 , B24C1/045
摘要： An abrasive, fluid jet cutting apparatus, and its method of construction and operation, are disclosed that reduce the wear and erosion problems typically experienced in the cutting jet's mixing tube. This improved fluid jet cutting apparatus comprises (a) a chamber having an inlet for receiving a pressurized fluid jet, a port for receiving a flow of abrasive particles which are entrained into the fluid jet, and an exit through which the fluid jet and entrained abrasives exit the chamber, (b) a mixing tube having an entry port for receiving said fluid jet and entrained abrasives, an inner wall for directing the flow of said fluid jet and entrained abrasives, and an outlet port through which said fluid jet and entrained abrasives exit said tube, wherein the tube entry port is proximate the chamber exit, (c) a lubricating fluid reservoir that surrounds at least a portion of the outer wall of the mixing tube, (d) wherein at least a portion of the mixing tube wall is porous, and (e) wherein the lubricating fluid passes from the lubricating reservoir and through the porous wall to lubricate at least a portion of the surface of the mixing tube wall so as to resist erosion of the tube wall when the fluid jet and entrained abrasives flow through the mixing tube.

8. 发明申请

US20080294246A1 Endoprosthesis with Select Ceramic Morphology 失效
标题翻译：选择陶瓷形态的内置假体
公开(公告)号：US20080294246A1
公开(公告)日：2008-11-27
申请号：US11752772
申请日：2007-05-23
申请人： Torsten Scheuermann , Michael Kuehling , Umang Anand , Jaydeep Y. Kokate , Samuel Robaina
发明人： Torsten Scheuermann , Michael Kuehling , Umang Anand , Jaydeep Y. Kokate , Samuel Robaina
IPC分类号： A61F2/06
CPC分类号： A47G19/22 , A61F2/0077 , A61F2/82 , A61F2/91 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/606 , Y10T428/131 , Y10T428/1321
摘要： An endoprosthesis, such as a stent, includes a ceramic, such as IROX, having a select morphology and composition.
摘要翻译：内置假体，例如支架，包括具有选择形态和组成的陶瓷，例如IROX。

9. 发明授权

US06688947B2 Porous, lubricated nozzle for abrasive fluid suspension jet 失效
标题翻译：用于研磨液悬浮喷嘴的多孔润滑喷嘴
公开(公告)号：US06688947B2
公开(公告)日：2004-02-10
申请号：US10067591
申请日：2002-02-05
申请人： Umang Anand , Joseph Katz
发明人： Umang Anand , Joseph Katz
IPC分类号： B24B100
CPC分类号： B24C1/045 , Y10T83/0591 , Y10T137/0469
摘要： A nozzle apparatus for use with an abrasive fluid jet cutting system, and its method of construction and operation, are disclosed that reduce the wear and erosion problems typically experienced in the cutting jet's nozzle. This improved nozzle apparatus comprises (a) a nozzle having an entry port for receiving a slurry consisting of a carrier fluid and abrasive particles, an inner wall for directing the flow of the slurry, and an outlet port through which the slurry exits the nozzle, (b) wherein at least a portion of the nozzle wall is porous, and (c) a lubricating fluid chamber that surrounds the porous portion of the outer wall of the nozzle, the chamber having a port where a lubricating fluid enters the chamber, with the chamber port connecting to an input pipe which connects to a filter for filtering contaminants that might clog the pores of the porous portion of the nozzle. The nozzle operates by having the lubricating fluid pass from the lubricating reservoir and through the porous wall to lubricate at least a portion of the surface of the nozzle inner wall so as to resist erosion of the wall, as well as result in an abrasive slurry jet with improved coherence and cutting efficiency.
摘要翻译：公开了一种用于磨料流体射流切割系统的喷嘴装置及其结构和操作方法，其减少了切割喷嘴喷嘴中通常经历的磨损和侵蚀问题。这种改进的喷嘴装置包括（a）喷嘴，其具有用于接收由载体流体和磨料颗粒组成的浆料的入口，用于引导浆料流动的内壁和浆料离开喷嘴的出口，（b）其中所述喷嘴壁的至少一部分是多孔的，以及（c）围绕所述喷嘴的外壁的多孔部分的润滑流体室，所述室具有润滑流体进入所述室的端口，连接到输入管的室口连接到过滤器，用于过滤可能堵塞喷嘴的多孔部分的孔的污染物。喷嘴通过使润滑流体从润滑储存器通过并穿过多孔壁以润滑喷嘴内壁的表面的至少一部分以便抵抗壁的侵蚀，并且导致磨料浆料喷射具有改进的一致性和切割效率。

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