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1. 发明专利

LU101096B1 Natural non-pathogenic microorganisms capable of associating glycolipids or lipopeptides and use thereof 未知
公开(公告)号：LU101096B1
公开(公告)日：2020-07-21
申请号：LU101096
申请日：2019-01-21
申请人： ULSEMER PHILIPPE , GOLETZ STEFFEN , GOETZ PETER , TOUTOUNIAN KAWE
发明人： ULSEMER PHILIPPE , GOLETZ STEFFEN , GOETZ PETER , TOUTOUNIAN KAWE
IPC分类号： A61K35/74 , A61K36/06 , A61K39/02 , A61K47/00 , C07K19/00
摘要： The present invention relates to natural non-pathogenic microorganisms capable of associating glycolipids and/or lipopeptides such as e.g. binding peptides (e.g. linear or circular binding peptides, bi-cyclic peptides including a stabilizing molecule, DARPins), immunological active peptides, proteins (e.g. anti-inflammatory cytokines, binding molecules), antibodies, antibody fragments (e.g. single domain antibodies, single chain antibdoies scFv) or derivatives thereof coupled to a lipid carrier and uses thereof. The present invention further relates to naturally-occurring non-pathogenic microorganisms (e.g., bacteria, archae, yeasts or fungi) capable to physically interact with a lipid carrier (e.g., glycolipid, lipopeptide etc.) and present the carried moiety (e.g., carbohydrate, peptide or chemical molecule, etc.) to the environment (e.g., exterior surface of the cell). Among others, the invention is useful for the development of oral vaccines, oral drug delivery systems and anti-infectious agents (e.g., high-density natural display system) as well as for various topical applications and/or to inhale and/or compositions (e.g., medical and/or pharmaceutical applications and/compositions) including such for topical or inhalation applications and/or compositions for use in treatment or prevention of diseases such as diseases from the gut, digestive tract, oral cavity, skin, urogenital tract, lung and/or other sites. Furthermore, microorganisms, compositions, vaccines, adjuvants, kits, methods and uses of the present invention are useful for immunization, delivery, screening and targeting applications, e.g., particularly relating to pharmaceutically active compounds, toxins and pathogenic microorganisms. Furthermore, the present invention relates to methods of associating and/or loading and methods of displaying carbohydrates or lipopetides on microorganisms.

2. 发明公开

EP3485277A1 NATURAL MICROORGANISMS WHICH ARE NATURALLY CAPABLE OF BINDING TOXINS AND/OR TOXIN RECEPTORS 审中-公开
公开(公告)号：EP3485277A1
公开(公告)日：2019-05-22
申请号：EP17740023.1
申请日：2017-07-18
申请人： Ulsemer, Philippe , Goletz, Steffen , Goetz, Peter
发明人： Ulsemer, Philippe , Goletz, Steffen , Goetz, Peter
IPC分类号： G01N33/569 , C12R1/01

3. 发明申请

WO2008055702A1 CARBOHYDRATE SPECIFIC CELLULAR IMMUNITY INDUCING MICROORGANISMS AND FRACTIONS THEREOF 审中-公开
标题翻译：碳水化合物特异性细胞免疫诱导微生物及其分子
公开(公告)号：WO2008055702A1
公开(公告)日：2008-05-15
申请号：PCT/EP2007/009765
申请日：2007-11-12
申请人： GLYCOTOPE GMBH , GOLETZ, Steffen , ULSEMER, Philippe , LÖFFLER, Anja
发明人： GOLETZ, Steffen , ULSEMER, Philippe , LÖFFLER, Anja
IPC分类号： A61K39/02 , A61K39/40 , G01N33/53 , A61P35/00 , A23L1/30
CPC分类号： G01N33/56972 , A23L33/135 , A61K39/0011 , A61K39/02 , A61K2039/5152 , A61K2039/5154 , A61K2039/5158 , A61K2039/52 , A61K2039/521 , A61K2039/522 , A61K2039/54 , A61K2039/542 , A61K2039/57 , C07K16/3092 , C07K2317/73 , C12N1/20 , C12R1/01 , C12R1/19 , G01N33/5058 , G01N33/56911 , G01N2400/00 , G01N2469/20
摘要： The present invention relates to the field of prevention and treatment of disorders associated with the occurrence of certain carbohydrate epitopes. More particularly, the present invention relates to the prevention and treatment of carbohydrate epitope positive tumors. It relates to formulations and methods for the induction of an effective carbohydrate specific cellular immune response.
摘要翻译：本发明涉及预防和治疗与某些碳水化合物表位发生相关的病症的领域。更具体地说，本发明涉及预防和治疗碳水化合物表位阳性肿瘤。它涉及用于诱导有效的碳水化合物特异性细胞免疫应答的制剂和方法。

4. 发明申请

WO2013026886A2 MICROORGANISMS OF THE SPECIES BACTEROIDES XYLANISOLVENS 审中-公开
标题翻译：物种微生物菌株XYLANISOLVENS
公开(公告)号：WO2013026886A2
公开(公告)日：2013-02-28
申请号：PCT/EP2012/066359
申请日：2012-08-22
申请人： GLYCOTOPE GMBH , GOLETZ, Steffen , ULSEMER, Philippe , TOUTOUNIAN, Kawe
发明人： GOLETZ, Steffen , ULSEMER, Philippe , TOUTOUNIAN, Kawe
IPC分类号： A23L1/00
CPC分类号： A23L29/065 , A23C9/1203 , A23L33/135 , A23V2002/00 , C12N1/20 , C12R1/01 , A23V2200/30 , A23V2200/3204
摘要： The present invention pertains to food products comprising microorganisms of the species Bacteroides xylanisolvens, in particular fermented food and probiotic food. These microorganisms are particularly characterized as having a very low pathogenicity and a high safety for human consumption.Furthermore, methods for producing said food products, in particular by fermentation, as well as suitable bacterial strains Bacteroides xylanisolvens of are provided.
摘要翻译：本发明涉及包含拟杆菌木聚糖异构酶的微生物，特别是发酵食品和益生菌食品的食品。这些微生物的特征在于具有非常低的致病性和对人类消费的高安全性。此外，提供了用于生产所述食品，特别是通过发酵的方法以及合适的细菌菌株木霉菌木聚糖溶液。

5. 发明申请

WO2008055703A2 COREOTICS 审中-公开
标题翻译：的Coreotics
公开(公告)号：WO2008055703A2
公开(公告)日：2008-05-15
申请号：PCT/EP2007/009766
申请日：2007-11-12
申请人： GLYCOTOPE GMBH , GOLETZ, Steffen , ULSEMER, Philippe , LÖFFLER, Anja
发明人： GOLETZ, Steffen , ULSEMER, Philippe , LÖFFLER, Anja
IPC分类号： C07K16/30
CPC分类号： G01N33/56972 , A23L33/135 , A61K39/0011 , A61K39/02 , A61K2039/5152 , A61K2039/5154 , A61K2039/5158 , A61K2039/52 , A61K2039/521 , A61K2039/522 , A61K2039/54 , A61K2039/542 , A61K2039/57 , C07K16/3092 , C07K2317/73 , C12N1/20 , C12R1/01 , C12R1/19 , G01N33/5058 , G01N33/56911 , G01N2400/00 , G01N2469/20
摘要： The present invention relates to the field of prevention and treatment of tumors and gastrointestinal disorders. More particularly, the present invention relates to the prevention and treatment of Core-1 -positive carcinomas. It relates to coreotics and a method of producing the same and to a method of prevention and treatment of core-1 positive disorders using the same.
摘要翻译：本发明涉及肿瘤和胃肠疾病的预防和治疗领域。更具体地说，本发明涉及预防和治疗Core-1阳性癌。本发明涉及核糖核酸及其制备方法，以及使用其的核心-1阳性疾病的预防和治疗方法。

6. 发明申请

WO2013026887A1 MICROORGANISMS CARRYING A TUMOR ANTIGEN 审中-公开
标题翻译：携带肿瘤抗原的微生物
公开(公告)号：WO2013026887A1
公开(公告)日：2013-02-28
申请号：PCT/EP2012/066360
申请日：2012-08-22
申请人： GLYCOTOPE GMBH , GOLETZ, Steffen , ULSEMER, Philippe , TOUTOUNIAN, Kawe
发明人： GOLETZ, Steffen , ULSEMER, Philippe , TOUTOUNIAN, Kawe
IPC分类号： C12N1/20 , C12R1/01 , A61K39/00 , A61K39/02
CPC分类号： A61K39/0216 , A61K39/0011 , A61K2039/5154 , A61K2039/585 , C07K16/1257 , C12N1/20 , C12R1/01
摘要： The present invention pertains to microorganisms of the species Bacteroides xylanisolvens expressing a core-1 antigen on their surface. These microorganisms are in particular useful for the prophylaxis and treatment of core-1 positive diseases and are particularly characterized by a stable, homogenous high core-1 expression. Also provided are pharmaceutical compositions which comprise respective core-1 positive microorganisms or fractions thereof.
摘要翻译：本发明涉及在其表面表达核心-1抗原的拟杆菌木聚糖异构酶的微生物。这些微生物特别可用于预防和治疗核心-1阳性疾病，特别是特征在于稳定的，均匀的高核心-1表达。还提供了包含各自的核心-1阳性微生物或其级分的药物组合物。

7. 发明申请

WO2008055703A9 COREOTICS 审中-公开
标题翻译：的Coreotics
公开(公告)号：WO2008055703A9
公开(公告)日：2008-10-02
申请号：PCT/EP2007009766
申请日：2007-11-12
申请人： GLYCOTOPE GMBH , GOLETZ STEFFEN , ULSEMER PHILIPPE , LOEFFLER ANJA
发明人： GOLETZ STEFFEN , ULSEMER PHILIPPE , LOEFFLER ANJA
IPC分类号： C07K16/30
CPC分类号： G01N33/56972 , A23L33/135 , A61K39/0011 , A61K39/02 , A61K2039/5152 , A61K2039/5154 , A61K2039/5158 , A61K2039/52 , A61K2039/521 , A61K2039/522 , A61K2039/54 , A61K2039/542 , A61K2039/57 , C07K16/3092 , C07K2317/73 , C12N1/20 , C12R1/01 , C12R1/19 , G01N33/5058 , G01N33/56911 , G01N2400/00 , G01N2469/20
摘要： The present invention relates to the field of prevention and treatment of tumors and gastrointestinal disorders. More particularly, the present invention relates to the prevention and treatment of Core-1 -positive carcinomas. It relates to coreotics and a method of producing the same and to a method of prevention and treatment of core-1 positive disorders using the same.
摘要翻译：本发明涉及肿瘤和胃肠道疾病的预防和治疗领域。更具体地，本发明涉及预防和治疗核心-1阳性癌。本发明涉及与其相关的核心及其制备方法以及使用其的核心-1阳性病症的预防和治疗方法。

8. 发明申请

WO2018015380A1 NATURAL MICROORGANISMS WHICH ARE NATURALLY CAPABLE OF BINDING TOXINS AND/OR TOXIN RECEPTORS 审中-公开
标题翻译：天然微生物能够结合毒素和/或毒素受体
公开(公告)号：WO2018015380A1
公开(公告)日：2018-01-25
申请号：PCT/EP2017/068115
申请日：2017-07-18
申请人： ULSEMER, Philippe , GOLETZ, Steffen , GOETZ, Peter
发明人： ULSEMER, Philippe , GOLETZ, Steffen , GOETZ, Peter
IPC分类号： G01N33/569 , C12R1/01
摘要： The present invention relates to means and method for isolating naturally-occurring microorganisms (non-pathogenic bacteria, yeasts or fungi) capable of binding toxins from microorganisms such as bacteria, viruses, fungi, yeasts, or protozoans and/or receptors for these toxins on the surface of mammalian cells, thereby making these receptors inaccessible for said toxins. The naturally-occurring microorganisms that are obtainable by the means and methods of the present invention can be used for adsorbing toxins from pathogenic microorganisms and/or blocking receptors for such toxins on the surface of mammalian cells. These toxin-receptor interactions are known to be critical for disease pathogenesis, making both the toxins and receptors a target for the naturally-occurring microorganisms of the present invention.
摘要翻译：本发明涉及从微生物如细菌，病毒，真菌，酵母或原生动物中分离能够结合毒素的天然存在的微生物（非病原菌，酵母或真菌）的手段和方法和/或这些毒素在哺乳动物细胞表面上的受体，从而使这些受体对于所述毒素不可接近。可通过本发明的手段和方法获得的天然存在的微生物可用于从病原微生物吸附毒素和/或阻断哺乳动物细胞表面上的这种毒素的受体。已知这些毒素 - 受体相互作用对于疾病发病机制是关键的，使毒素和受体成为本发明的天然存在的微生物的靶标。

9. 发明申请

WO2013026886A3 MICROORGANISMS OF THE SPECIES BACTEROIDES XYLANISOLVENS 审中-公开
标题翻译：物种微生物菌株XYLANISOLVENS
公开(公告)号：WO2013026886A3
公开(公告)日：2014-03-20
申请号：PCT/EP2012066359
申请日：2012-08-22
申请人： GLYCOTOPE GMBH , GOLETZ STEFFEN , ULSEMER PHILIPPE , TOUTOUNIAN KAWE
发明人： GOLETZ STEFFEN , ULSEMER PHILIPPE , TOUTOUNIAN KAWE
IPC分类号： A23L1/30 , A23C9/12 , A23L1/03 , C12N1/20 , C12R1/01
CPC分类号： A23L29/065 , A23C9/1203 , A23L33/135 , A23V2002/00 , C12N1/20 , C12R1/01 , A23V2200/30 , A23V2200/3204
摘要： The present invention pertains to food products comprising microorganisms of the species Bacteroides xylanisolvens, in particular fermented food and probiotic food. These microorganisms are particularly characterized as having a very low pathogenicity and a high safety for human consumption.Furthermore, methods for producing said food products, in particular by fermentation, as well as suitable bacterial strains Bacteroides xylanisolvens of are provided.
摘要翻译：本发明涉及包含拟杆菌木聚糖异构酶的微生物，特别是发酵食品和益生菌食品的食品。这些微生物的特征在于具有非常低的致病性和对人类消费的高安全性。此外，提供了用于生产所述食品，特别是通过发酵的方法以及合适的细菌菌株木霉菌木聚糖溶液。

10. 发明申请

WO2009138220A1 FERMENTATION PROCESS 审中-公开
标题翻译：发酵过程
公开(公告)号：WO2009138220A1
公开(公告)日：2009-11-19
申请号：PCT/EP2009/003401
申请日：2009-05-13
申请人： GLYCOTOPE GMBH , GOLETZ, Steffen , ULSEMER, Philippe
发明人： GOLETZ, Steffen , ULSEMER, Philippe
IPC分类号： A23C9/12 , A61K39/00
CPC分类号： A23C9/1203 , A61K39/0011 , A61K2039/523 , A61K2039/542
摘要： The present invention relates to a method of producing a fermented food, wherein a raw food material is combined with a starter culture for fermentation, which is characterized in that at least one microorganism of the genus Bacteroides and/or a at least microorganism is added having at least a cell surface structure which corresponds to a human carbohydrate structure. Further disclosed are processing aids and fermented foods containing respective microorganisms.
摘要翻译：发明食品的制造方法技术领域本发明涉及一种发酵食品的制造方法，其特征在于，将原料食品与发酵用发酵培养物结合，其特征在于，添加至少一种拟杆菌属和/或至少微生物的微生物，至少一个对应于人碳水化合物结构的细胞表面结构。进一步公开的是加工助剂和含有微生物的发酵食品。

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