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1. 发明申请

US20050074477A1 Method for the treatment of diseased, degenerated, or damaged tissue using three dimensional tissue produced in vitro in combination with tissue cells and/or exogenic factors 审中-公开
标题翻译：使用体外结合组织细胞和/或外源因子产生的三维组织治疗患病，退化或损伤的组织的方法
公开(公告)号：US20050074477A1
公开(公告)日：2005-04-07
申请号：US10501520
申请日：2003-11-07
申请人： Olivera Josimovic-Alasevic , Jeannette Libera , Hans-Peter Wiesmann , Ulrich Joos , Gordana Vunjak-Novakovic
发明人： Olivera Josimovic-Alasevic , Jeannette Libera , Hans-Peter Wiesmann , Ulrich Joos , Gordana Vunjak-Novakovic
IPC分类号： A61K35/12 , C12N5/077 , C12N13/00 , C12N5/08 , A61F2/00
CPC分类号： C12N5/0655 , A61K35/12 , C12N13/00
摘要： The invention relates to a tissue replacement structure comprising (a) a preformed three-dimensional tissue which can be produced by obtaining cells from a human or animal organism and culturing them in a stationary fashion as a suspension culture in cell culture vessels with hydrophobic surface and tapering bottom until a cell aggregate is formed which has differentiated cells embedded therein and has an outer region wherein cells capable of proliferation and migration are present; (b) (i) an autologous cell suspension which can be produced from endogenous cells, with endogenous serum being added, with no addition of growth-promoting compounds, (ii) implants or support materials and/or (iii) growth factors; and/or (c) can be obtained by exposure of the tissue according to (a) to electromagnetic fields, mechanical stimulation and/or ultrasound.
摘要翻译：本发明涉及一种组织置换结构，其包括（a）预先形成的三维组织，其可以通过从人或动物生物获得细胞并以静止方式将其作为悬浮培养物在具有疏水性表面的细胞培养容器中培养而制备，逐渐变细的底部，直到形成细胞聚集体，其具有嵌入其中的分化细胞，并且具有其中存在能够增殖和迁移的细胞的外部区域; （b）（i）可以从内源细胞产生的自体细胞悬浮液，加入内源血清，不加生长促进化合物，（ii）植入物或支持材料和/或（iii）生长因子; 和/或（c）可以通过根据（a）将组织暴露于电磁场，机械刺激和/或超声波来获得。

2. 发明授权

US6053919A Bone fragment-fixing device 失效
标题翻译：骨碎片固定装置
公开(公告)号：US6053919A
公开(公告)日：2000-04-25
申请号：US981102
申请日：1998-06-11
申请人： Gilbert Talos , Ulrich Joos
发明人： Gilbert Talos , Ulrich Joos
IPC分类号： A61B17/58 , A61B17/80
CPC分类号： A61B17/8071
摘要： A bone fragment-fixing device including a longitudinal bone plate which is provided at each of its ends with two through-holes for screws and which is also provided with a central longitudinal hole extending in the direction of the longitudinal axis of the plate. In addition, a slide is provided and arranged on stems which laterally limit the central longitudinal hole, in such a way that the slide is movable in the direction of the longitudinal axis of the plate. The slide is provided with a longitudinal hole extending cross-wise to the longitudinal axis of the plate when the slide is mounted, thus permitting a three-dimensional adaptability of the device.
摘要翻译： PCT No.PCT / EP95 / 02567 Sec。 371日期：1998年6月11日 102（e）1998年6月11日PCT PCT 1995年7月3日PCT公布。出版物WO97 / 01991 日本1997年1月23日一种骨碎片固定装置，包括纵骨板，其每端设有两个用于螺钉的通孔，并且还具有沿纵轴方向延伸的中心纵向孔碟子。此外，滑块被设置并布置在杆上，其横向地限制中心纵向孔，使得滑块能够在板的纵向轴线的方向上移动。当滑块安装时，滑块设置有横向延伸到板的纵向轴线的纵向孔，从而允许装置的三维适应性。

3. 发明申请

US20050269956A1 Circuit arrangement for operating at least one light-emitting diode 失效
标题翻译：用于操作至少一个发光二极管的电路布置
公开(公告)号：US20050269956A1
公开(公告)日：2005-12-08
申请号：US10532544
申请日：2003-10-08
申请人： Ulrich Joos
发明人： Ulrich Joos
IPC分类号： H05B33/08 , H05B37/00
CPC分类号： H05B33/0815 , Y02B20/341 , Y02B20/346 , Y10S362/80
摘要： The invention relates to a circuit arrangement for operating at least one light-emitting diode LED in an electrical circuit at a service voltage, which is greater than the forward voltage of the at least one light-emitting diode which is to be operated. In this connection, the light-emitting diode is PWM-controlled. The circuit comprises reactances that are connected in series at both connections of the light-emitting diode, an additional switching means between the terminals, and a full-wave rectifier circuit, such that the circuit is protected against short-circuits on the service voltage and on ground while the LED can continue to be triggered.
摘要翻译：本发明涉及一种用于在服务电压下操作电路中的至少一个发光二极管LED的电路装置，其工作电压大于要被操作的至少一个发光二极管的正向电压。在这方面，发光二极管是PWM控制的。电路包括在发光二极管的两个连接处串联连接的电抗器，端子之间的附加开关装置和全波整流器电路，使得该电路被保护以防止服务电压上的短路， LED可以继续触发。

4. 发明授权

US06960211B1 Osteosynthetic bone plate 失效
标题翻译：骨质疏松骨板
公开(公告)号：US06960211B1
公开(公告)日：2005-11-01
申请号：US09979252
申请日：2000-05-25
申请人： Joachim Pfefferle , Ulrich Joos
发明人： Joachim Pfefferle , Ulrich Joos
IPC分类号： A61B17/58 , A61B17/80 , A61B17/56 , A61F2/30
CPC分类号： A61B17/8085 , A61B17/8004 , A61B17/8071
摘要： An osteosynthetic bone plate has elongated compression cavities containing eccentric countersinks. The plate includes a longitudinal axis, a transverse axis, a plate upper side, and a plate lower side for facing bone fragments. The bone plate also includes a compression element with two plate braces which run substantially parallel to the longitudinal axis. Both plate braces are linked together by bridging struts which intersect the longitudinal axis. A plate brace has an eyelet on at least one of the outer sides of the compression element. Additional eyelets can be positioned in front of this eyelet. A compression cavity is situated in each of said eyelets and a connecting strut, which intersects the transverse axis, extends between the eyelets which are located on each plate brace.
摘要翻译：骨接骨板具有包含偏心埋头孔的细长压缩腔。板包括纵向轴线，横向轴线，板上侧和用于面对骨碎片的板下侧。骨板还包括具有基本上平行于纵向轴线延伸的两个板支架的压缩元件。两个板支架通过与纵向轴线相交的桥接支柱连接在一起。板支架在压缩元件的至少一个外侧上具有孔眼。额外的孔眼可以放在这个孔眼的前面。压缩空腔位于每个所述孔眼中，并且与横向轴线相交的连接支柱在位于每个板支架上的孔眼之间延伸。

5. 发明授权

US5668451A Method for monitoring the opening and closing process in a system having at least one component moved by electric motor 失效
标题翻译：用于监测具有由电动机移动的至少一个部件的系统中的打开和关闭过程的方法
公开(公告)号：US5668451A
公开(公告)日：1997-09-16
申请号：US561199
申请日：1995-11-22
申请人： Dieter Driendl , Wolfgang Schulter , Ulrich Joos , Manfred Fischer
发明人： Dieter Driendl , Wolfgang Schulter , Ulrich Joos , Manfred Fischer
IPC分类号： G05B19/4062 , H02H7/085 , H02P3/00
CPC分类号： G05B19/4062 , G05B2219/37625 , G05B2219/45015 , H02H7/0851
摘要： A method for monitoring the opening and closing process in a system having at least one component moved by electric motor is described. During this process, the following process steps are provided:during the movement of the components, all operating parameters of the motor are captured continuously at time-equidistant measuring moments,the energy balance developing during the movement is formed with the aid of the captured operating parameters of the motor,the total force resulting from the movement is determined from the energy balance and the design parameters of motor and gear,the trapping force is determined from the total force at each measuring moment with the aid of a time window whose window width is selected as time difference between the respective measuring moment and a respective reference moment such that, at least at one reference moment, a trapping force does not yet occur,the course of the trapping force as a function of time is evaluated and a trapping situation is detected when predetermined limit values or threshold values are exceeded,specific reactions are initiated when a trapping situation is recognized.
摘要翻译：描述了一种用于监测具有由电动机移动的至少一个部件的系统中的打开和关闭过程的方法。在此过程中，提供以下工艺步骤：在部件移动过程中，马达的所有运行参数都以等距离的测量时刻连续捕获，运动过程中产生的能量平衡借助于捕获的操作电动机的参数，由运动产生的总力由能量平衡和电动机和齿轮的设计参数确定，所述牵引力是通过窗口宽度的时间窗从每个测量时刻的总力确定的被选择为相应测量力矩和相应的参考力矩之间的时间差，使得至少在一个参考时刻还没有产生捕获力，评估作为时间的函数的捕获力的过程和捕获情况当超过预定的极限值或阈值时被检测到，当捕获情况发生特定反应时被认可。

6. 发明授权

US07280375B2 Circuit arrangement for operating at least one light-emitting diode 失效
标题翻译：用于操作至少一个发光二极管的电路布置
公开(公告)号：US07280375B2
公开(公告)日：2007-10-09
申请号：US10532544
申请日：2003-10-08
申请人： Ulrich Joos
发明人： Ulrich Joos
IPC分类号： H02M3/335
CPC分类号： H05B33/0815 , Y02B20/341 , Y02B20/346 , Y10S362/80
摘要： A circuit arrangement is for operating at least one light-emitting diode LED in an electrical circuit at a service voltage greater than the forward voltage of the at least one light-emitting diode. The light-emitting diode is PWM-controlled. The circuit includes reactances that are connected in series at both connections of the light-emitting diode, an additional switching arrangement between the terminals, and a full-wave rectifier circuit, such that the circuit is protected against short-circuits on the service voltage and on ground while the LED can continue to be triggered.
摘要翻译：电路装置用于以大于至少一个发光二极管的正向电压的工作电压来操作电路中的至少一个发光二极管LED。发光二极管是PWM控制的。电路包括在发光二极管的两个连接处串联连接的电抗器，端子之间的附加开关装置和全波整流器电路，使得该电路被保护以防止服务电压上的短路， LED可以继续触发。

7. 发明授权

US06846180B1 Threaded intraosseous dental implant 有权
标题翻译：螺纹骨内牙种植体
公开(公告)号：US06846180B1
公开(公告)日：2005-01-25
申请号：US10088001
申请日：1999-09-22
申请人： Ulrich Joos
发明人： Ulrich Joos
IPC分类号： A61B17/58 , A61C8/00
CPC分类号： A61C8/0022 , A61C8/0018
摘要： The screw-type intraossal dental implant has a bottommost implant tip that is located in the apical area and comprises a root part which extends up to said implant tip and which is intended for insertion into a jaw bone. The implant neck extending up to the coronal area is placed on the root part and is intended for being placed inside the gingivae. The outer thread on the root part is preferably self-cutting. The invention is characterized in that the root part comprises an essentially parabolic outer contour with the implant tip serving as the vertex. The inventive outer contour makes it possible to obtain an improved primary stability and guarantees, to a great extent, the long-term success of the implant.
摘要翻译：螺旋型牙槽植入物具有位于顶端区域中的最底部植入物尖端，并且包括延伸到所述植入物尖端并且用于插入颚骨中的根部。延伸到冠状面的植入物颈部放置在根部上，并且用于放置在牙龈内。根部上的外螺纹优选是自切割的。本发明的特征在于，根部包括基本上抛物面的外轮廓，其中植入物尖端用作顶点。本发明的外轮廓使得可以获得改进的初级稳定性并且在很大程度上保证了植入物的长期成功。

8. 发明授权

US06554867B1 Surface structure for intraosseous implant 有权
标题翻译：骨内植入物的表面结构
公开(公告)号：US06554867B1
公开(公告)日：2003-04-29
申请号：US09869781
申请日：2001-07-05
申请人： Ulrich Joos
发明人： Ulrich Joos
IPC分类号： A61F228
CPC分类号： A61F2/30771 , A61F2/30767 , A61F2/3094 , A61F2002/30107 , A61F2002/30158 , A61F2002/30828 , A61F2002/30838 , A61F2002/3085 , A61F2002/30879 , A61F2002/30892 , A61F2002/3093 , A61F2002/3625 , A61F2210/0009 , A61F2230/0026 , A61F2310/00023 , A61F2310/0094
摘要： The intraosseous implant intended to be fitted in a bone is provided on the surface with a specific roughness, the implant surface having depressions (1) with a depth (c) of about 20 &mgr;m to about 60 &mgr;m. At the bottom of the depressions (1) there are base faces (2), and between the depressions (1) there are plateau faces (3). Base faces (2) and plateau faces (3) have a horizontal extent (a, b) of about 10 &mgr;m to about 20 &mgr;m. These depressions (1) are ideally as smooth as possible, i.e. they have no surface roughness below the cellular dimension. Obliquely ascending side faces (4) extend from the base faces (2) to the plateau faces (3), and the angle of inclination (&agr;) between the horizontal and the side faces (4) is about 30° maximum. Below the upper neck portion, the implant has a self-tapping thread, and the neck portion of the implant is provided with a porcelain-like coating. The surface energy and surface tension of the implant are kept as low as possible. Materials which can preferably be used for the implants are titanium, titanium-based alloys or porcelain-like substances. The surface structure results in an implant which, while providing sound immediate postoperative primary stability, is also distinguished by an accelerated and increased load-bearing capacity on account of more intensive osseointegration.
摘要翻译：旨在装配在骨中的骨内植入物在表面上具有特定的粗糙度，植入物表面具有深度（c）约20μm至约60μm的凹陷（1）。在凹部（1）的底部有基面（2），凹陷（1）之间有平台面（3）。基面（2）和平台面（3）具有约10μm至约20μm的水平范围（a，b）。这些凹陷（1）理想地尽可能平滑，即它们在细胞尺寸以下没有表面粗糙度。倾斜上升的侧面（4）从底面（2）延伸到平台面（3），并且水平面和侧面（4）之间的倾斜角（α）最大为30°。在上颈部下方，植入物具有自攻螺纹，并且植入物的颈部设置有瓷质涂层。植入物的表面能和表面张力保持尽可能低。可优选用于植入物的材料是钛，钛基合金或瓷器物质。表面结构导致植入物，其在提供立即术后主要稳定性的同时，还由于更密集的骨整合而被加速和增加的承载能力所区分。

9. 发明申请

US20050182408A1 Osteosynthetic bone plate 审中-公开
标题翻译：骨质疏松骨板
公开(公告)号：US20050182408A1
公开(公告)日：2005-08-18
申请号：US11094344
申请日：2005-03-31
申请人： Joachim Pfefferle , Ulrich Joos
发明人： Joachim Pfefferle , Ulrich Joos
IPC分类号： A61B17/58 , A61B17/80 , A61B17/56
CPC分类号： A61B17/8085 , A61B17/8004 , A61B17/8071
摘要： The invention relates to an osteosynthetic bone plate which has elongated compression cavities containing eccentric countersinkings. The plate comprises a longitudinal axis (X), a transverse axis (Y), a plate upper side and a plate lower side, whereby the latter is placed facing the bone fragments. The bone plate also comprises a compression element consisting of two plate braces which run substantially parallel to the longitudinal axis. Both plate braces are linked together by bridging struts which intersect the longitudinal axis. A plate brace has an eyelet on at least one of the outer sides of the compression element. Additional eyelets can be positioned in front of this eyelet. A compression cavity is situated in each of said eyelets and a connecting strut which intersects the transverse axis, extends between the eyelets which are located on each plate brace.
摘要翻译：本发明涉及一种具有细长的压缩腔的骨接骨板，其包含偏心的锪孔。板包括纵轴（X），横轴（Y），板上侧和板下侧，由此将其放置成面向骨碎片。骨板还包括由基本上平行于纵向轴线延伸的两个板支架组成的压缩元件。两个板支架通过与纵向轴线相交的桥接支柱连接在一起。板支架在压缩元件的至少一个外侧上具有孔眼。额外的孔眼可以放在这个孔眼的前面。压缩空腔位于每个所述孔眼中，并且与横向轴线相交的连接支柱在位于每个板支架上的孔眼之间延伸。

10. 发明授权

US06506191B1 Osteosynthetic fastening device 失效
标题翻译：骨质合成固定装置
公开(公告)号：US06506191B1
公开(公告)日：2003-01-14
申请号：US09763558
申请日：2001-02-22
申请人： Ulrich Joos
发明人： Ulrich Joos
IPC分类号： A61B1780
CPC分类号： A61B17/8033 , A61B17/8071 , A61B17/8695 , Y10S606/904
摘要： The device with a bone plate (1) and with a temporarily attachable retainer (100) is used for fixation of, in particular, fragments of a jaw bone. The bone plate (1) has a longitudinal guide slot (40) which is open at one end or closed at both ends. The retainer (100) comprises a disk (110) which engages partially over the bone plate (1) and in which a locking screw (120) sits preferably in a rotatable manner and secure against loss, said locking screw (120) being intended to be screwed into a bone fragment via the guide slot (40). At one end, the bone plate (1) advantageously has areas of members (30) comprising individual members which can be divided off to obtain the desired length, The device extends the possibilities of screwing the bone plate (1), so that better adaptability to the particular task is achieved, and also improved rigidity across the edge of the bone plate (1), while the elasticity of the latter across the surface can be increased by means of less material thickness. The as it were one-piece retainer simplifies handling. A fixing plate is provided for additionally stiffening the screwed-on bone plate (1) and/or for screwing it at one end. In a second embodiment, the retainer can be, screwed to the underlying bone fragment laterally outside the bone plate (1).
摘要翻译：具有骨板（1）和临时固定保持器（100）的装置用于特别是颚骨碎片的固定。骨板（1）具有在一端开口或在两端封闭的纵向引导槽（40）。所述保持器（100）包括盘（110），所述盘部分地部分地接合在所述骨板（1）上，并且锁定螺钉（120）优选地以可旋转的方式放置在所述盘中，并且防止损失，所述锁定螺钉（120）旨在通过引导槽（40）拧入骨碎片中。在一端，骨板（1）有利地具有包括单独构件的构件（30）的区域，该区域可被分开以获得期望的长度。该装置延伸了旋转骨板（1）的可能性，使得更好的适应性实现了特定的任务，并且还提高了骨板（1）的边缘的刚性，同时通过较小的材料厚度可以增加后者横过表面的弹性。因为它是一体式保持架简化了处理。提供固定板，用于附加地加固螺旋的骨板（1）和/或用于在一端拧紧它。在第二实施例中，保持器可以在骨板（1）的横向外侧螺纹连接到下面的骨碎片。

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