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1. 发明授权

US08460940B2 Method for analysing a complex sample by mass spectrometry 有权
标题翻译：通过质谱分析复杂样品的方法
公开(公告)号：US08460940B2
公开(公告)日：2013-06-11
申请号：US13058998
申请日：2009-08-14
申请人： Christoph Menzel , Christian Feckler , Udo Roth , Kerstin Steinert
发明人： Christoph Menzel , Christian Feckler , Udo Roth , Kerstin Steinert
IPC分类号： G01N33/68 , G01N33/48 , G01N24/00
CPC分类号： G01N33/6851 , Y10T436/10 , Y10T436/24 , Y10T436/25
摘要： A mass spectrometry method for analysing the presence or absence of at least one target analyte in a complex sample is provided. The method uses a sample carrier suitable for mass spectrometry with a pre-applied microcrystalline MALDI matrix spot which is at least partially encompassed by a hydrophobic region. A complex sample is applied such that it becomes located on the microcrystalline MALDI matrix spot. The sample is washed on the microcrystalline MALDI matrix spot and then analyzed for the presence or absence of at least one target analyte via mass spectrometry. The method is in particular suitable for quantitatively analysing target analytes such as hepcidin and other peptides, drug compounds and metabolites in body fluids.
摘要翻译：提供了用于分析复合物样品中至少一种目标分析物的存在或不存在的质谱法。该方法使用适合于质谱的样品载体，其具有至少部分被疏水区域包围的预先施加的微晶MALDI基质斑点。应用复杂样品使其位于微晶MALDI基质点上。将样品在微晶MALDI基质点上洗涤，然后通过质谱法分析至少一种目标分析物的存在或不存在。该方法特别适用于定量分析目标分析物，如铁调素和其他肽，药物化合物和体液中的代谢物。

2. 发明申请

US20110207227A1 METHOD FOR ANALYSING A COMPLEX SAMPLE BY MASS SPECTROMETRY 有权
标题翻译：通过质谱分析复合样品的方法
公开(公告)号：US20110207227A1
公开(公告)日：2011-08-25
申请号：US13058998
申请日：2009-08-14
申请人： Christoph Menzel , Christian Feckler , Udo Roth , Kerstin Steinert
发明人： Christoph Menzel , Christian Feckler , Udo Roth , Kerstin Steinert
IPC分类号： G01N31/00 , G01N33/00 , G01N24/00
CPC分类号： G01N33/6851 , Y10T436/10 , Y10T436/24 , Y10T436/25
摘要： The present invention pertains to a mass spectrometry method for analysing the presence or absence of at least one target analyte in a complex sample, comprising at least the following steps: a) Using a sample carrier suitable for mass spectrometry comprising a pre-applied microcrystalline MALDI matrix spot which is at least partially encompassed by a hydrophobic region; b) Applying a complex sample such that it becomes located on said microcrystalline MALDI matrix spot; c) washing said sample on said microcrystalline MALDI matrix spot; d) analysing said sample for the presence or absence of at least one target analyte via mass spectrometry. The method is in particular suitable for quantitatively analysing target analytes such as hepcidin and other peptides, drug compounds and metabolites in body fluids.
摘要翻译：本发明涉及用于分析复合物样品中至少一种目标分析物的存在或不存在的质谱法，其包括至少以下步骤：a）使用适合于质谱法的样品载体，其包含预先施加的微晶MALDI 至少部分被疏水区域包围的基质斑点; b）应用复杂样品，使其位于所述微晶MALDI基质点上; c）在所述微晶MALDI基质点上洗涤所述样品; d）通过质谱分析所述样品中是否存在至少一种目标分析物。该方法特别适用于定量分析目标分析物，如铁调素和其他肽，药物化合物和体液中的代谢物。

3. 发明申请

US20100273984A1 METHOD FOR ENRICHING PHOSPHOPEPTIDES 审中-公开
标题翻译：增强磷酸盐的方法
公开(公告)号：US20100273984A1
公开(公告)日：2010-10-28
申请号：US12747127
申请日：2008-12-29
申请人： Jan Petzel , Kerstin Steinert , Udo Roth
发明人： Jan Petzel , Kerstin Steinert , Udo Roth
IPC分类号： C07K1/04 , B32B9/04
CPC分类号： G01N33/6842 , C07K1/22
摘要： The invention relates to a method for enriching phosphopeptides. Said method is characterized in that a carrier is used which carries phosphate groups and/or phosphonate groups on the surface thereof. The phosphate groups and/or phosphonate groups are functionalized with zirconium ions and are bonded to the carrier by means of linker structures which have at least one alkyl chain containing at least 5 C atoms. Also disclosed are corresponding carriers and suitable kits for enriching phosphopeptides.
摘要翻译：本发明涉及一种富含磷酸肽的方法。所述方法的特征在于使用在其表面上携带磷酸基和/或膦酸酯基团的载体。磷酸基团和/或膦酸酯基团用锆离子官能化，并通过具有至少一个含有至少5个C原子的烷基链的连接体结构键合到载体上。还公开了相应的载体和用于富集磷酸肽的合适的试剂盒。

4. 发明授权

US4957176A Process and apparatus for determining the consumption of a raw material in a processing machine 失效
标题翻译：用于确定加工机器中原料消耗的方法和装置
公开(公告)号：US4957176A
公开(公告)日：1990-09-18
申请号：US377703
申请日：1989-07-10
申请人： Udo Roth
发明人： Udo Roth
IPC分类号： B29C31/02 , B29C31/06 , G01G13/16
CPC分类号： G01G13/16 , B29C31/02 , B29C31/06
摘要： A process for accurately determining the consumption of a raw material in a processing machine or machines, especially plastic processing machines, in which the raw material is stored in a central storage container, comprises weighing or gravimetrically determining only a portion of the raw material stored in the storage container and feeding it to an intermediate storage vessel, from which it is delivered to the processing machine. The apparatus for performing this process comprises a storage container, means for gravimetric determination of a portion of the raw material which comprise a weighing housing which is supported on weighing sensors and an intermediate storage vessel, and supply means for feeding the raw material from the intermediate storage vessel to the processing machine. The weight determination means and the intermediate storage vessel can be suitably disposed in the vicinity of the central raw material storage container. Means can be provided for detecting which of the processing machines is being fed with raw material from the intermediate storage vessel.
摘要翻译：一种用于准确地确定原料存储在中央存储容器中的加工机器或特别是塑料加工机械中的原材料消耗的方法包括称重或重量测定仅存储在原料中的原料的一部分储存容器并将其输送到中间储存容器中，从而将其输送到处理机器。用于执行该处理的装置包括存储容器，用于重量确定原料的一部分的装置，其包括称重传感器上的称重壳体和中间储存容器，以及用于从中间体供给原料的供给装置储存容器到加工机。重量确定装置和中间储存容器可以适当地设置在中央原料储存容器附近。可以提供用于检测哪个处理机器正在从中间储存容器供给原料的装置。

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