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1. 发明申请

WO02084249A2 THERAPEUTIC AND DIAGNOSTIC USES OF ANTIBODY SPECIFICITY PROFILES 审中-公开
标题翻译：抗生素特异性分析的治疗和诊断用途
公开(公告)号：WO02084249A2
公开(公告)日：2002-10-24
申请号：PCT/US0211356
申请日：2002-04-10
申请人： UNIV LELAND STANFORD JUNIOR , ROBINSON WILLIAM H , HIRSCHBERG DAVID L , STEINMAN LAWRENCE , RUIZ PEDRO JOSE , UTZ PAUL J , GARREN HIDEKI
发明人： ROBINSON WILLIAM H , HIRSCHBERG DAVID L , STEINMAN LAWRENCE , RUIZ PEDRO JOSE , UTZ PAUL J , GARREN HIDEKI
IPC分类号： G01N33/53 , A61K39/00 , A61K39/35 , A61P1/18 , A61P3/10 , A61P11/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C12N15/09 , G01N33/564 , G01N33/68 , G01N37/00 , G01N
CPC分类号： A61K39/0008 , G01N33/564 , G01N33/6854 , G01N2800/102 , G01N2800/24 , G01N2800/52
摘要： This invention provides a method for determining the antibody specificity profile in an individual. This specificity profile reveals the individual's immune response to multiple antigens and/or epitopes of autoantigens, allergens, graft antigens, etc. The antibody specificity profile is determined through the binding of patient samples comprising antibodies to the arrays. The array can comprises antigens and epitopes. The invention also provides the means and methods for determining antigen or epitope specificity profiles that can be used in the development of either generic and individualized diagnosis and treatment for immune related diseases, including autoimmune disease, allergy and graft rejection.
摘要翻译：本发明提供了确定个体中抗体特异性谱的方法。该特异性特征揭示了个体对多种抗原和/或自身抗原，变应原，移植抗原等表位的免疫应答。通过将包含抗体的患者样品与阵列的结合来确定抗体特异性谱。阵列可以包括抗原和表位。本发明还提供了用于确定抗原或表位特异性谱的方法和方法，所述抗原或表位特异性特征可用于开发针对免疫相关疾病的通用和个体化诊断和治疗，包括自身免疫疾病，变态反应和移植排斥反应。

2. 发明申请

WO03045316A9 POLYNUCLEOTIDE THERAPY 审中-公开
标题翻译：多核苷酸治疗
公开(公告)号：WO03045316A9
公开(公告)日：2004-05-06
申请号：PCT/US0237686
申请日：2002-11-21
申请人： UNIV LELAND STANFORD JUNIOR , FONTOURA PAULO , GARREN HIDEKI , ROBINSON WILLIAM H , STEINMAN LAWRENCE , RUIZ PEDRO JOSE , UTZ PAUL J
发明人： FONTOURA PAULO , GARREN HIDEKI , ROBINSON WILLIAM H , STEINMAN LAWRENCE , RUIZ PEDRO JOSE , UTZ PAUL J
IPC分类号： C12N15/09 , A61K38/20 , A61K39/00 , A61K48/00 , A61P1/16 , A61P3/04 , A61P3/10 , A61P19/00 , A61P19/02 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P37/00 , A61K31/70
CPC分类号： A61K39/001 , A61K38/2026 , A61K39/0007 , A61K39/0008 , A61K48/00 , A61K2039/53 , A61K2039/55522 , A61K2039/55561 , C07K2319/30
摘要： This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), -polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal.
摘要翻译：本发明提供了一种治疗或预防动物中与一种或多种自身蛋白，多肽或肽存在或参与非生理过程相关的疾病的方法，所述动物包括向动物施用包含编码与疾病相关的自身蛋白质，多肽或肽的多核苷酸的自我载体。包含编码自身蛋白质，多肽或肽的多核苷酸的自身载体的施用调节对自身蛋白质，多肽或肽的免疫应答（s）表示从管理的自我载体。本发明还提供了包含编码一种或多种自身蛋白质，多肽或肽的多核苷酸的组合物，其在治疗的动物中非生理地存在，用于治疗或预防相关疾病与存在于动物中的非生理过程的目标和/或目标中的自身蛋白质，多肽或肽。

3. 发明申请

WO2003045316A3 POLYNUCLEOTIDE THERAPY 审中-公开
公开(公告)号：WO2003045316A3
公开(公告)日：2003-06-05
申请号：PCT/US2002/037686
申请日：2002-11-21
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , FONTOURA, Paulo , GARREN, Hideki , ROBINSON, William, H. , STEINMAN, Lawrence , RUIZ, Pedro, Jose , UTZ, Paul, J.
发明人： FONTOURA, Paulo , GARREN, Hideki , ROBINSON, William, H. , STEINMAN, Lawrence , RUIZ, Pedro, Jose , UTZ, Paul, J.
IPC分类号： A61K31/70
摘要： This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), -polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal.

4. 发明申请

WO03045316A2 POLYNUCLEOTIDE THERAPY 审中-公开
标题翻译：多核苷酸治疗
公开(公告)号：WO03045316A2
公开(公告)日：2003-06-05
申请号：PCT/US0237686
申请日：2002-11-21
申请人： UNIV LELAND STANFORD JUNIOR , FONTOURA PAULO , GARREN HIDEKI , ROBINSON WILLIAM H , STEINMAN LAWRENCE , RUIZ PEDRO JOSE , UTZ PAUL J
发明人： FONTOURA PAULO , GARREN HIDEKI , ROBINSON WILLIAM H , STEINMAN LAWRENCE , RUIZ PEDRO JOSE , UTZ PAUL J
IPC分类号： C12N15/09 , A61K38/20 , A61K39/00 , A61K48/00 , A61P1/16 , A61P3/04 , A61P3/10 , A61P19/00 , A61P19/02 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P37/00 , A61K
CPC分类号： A61K39/001 , A61K38/2026 , A61K39/0007 , A61K39/0008 , A61K48/00 , A61K2039/53 , A61K2039/55522 , A61K2039/55561 , C07K2319/30
摘要： This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), -polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal.
摘要翻译：本发明提供了一种治疗或预防与一种或多种自身蛋白，多肽或肽存在或参与非生理过程的一种或多种自身相关的动物疾病的方法，所述动物包括向所述动物施用包含编码与所述疾病相关的自身蛋白质多肽或多肽的多核苷酸的自身载体。施用包含编码自身蛋白，多肽或多肽的多核苷酸的自身载体调节对自身蛋白质的多肽或肽的免疫应答（s）表示自我向量的管理。本发明还提供了一种组合物，其包含编码一种或多种自身蛋白质，多肽或多肽或多肽的多核苷酸，所述多肽或多肽在治疗动物中非生理性地存在，可用于治疗或预防相关疾病其中存在于动物的非生理过程的和/或靶中的自身蛋白质，多肽或多肽。

5. 发明申请

WO2007123976A3 ANTIBODY PROFILING FOR DETERMINATION OF PATIENT RESPONSIVENESS 审中-公开
标题翻译：用于确定患者反应的抗体分型
公开(公告)号：WO2007123976A3
公开(公告)日：2008-12-11
申请号：PCT/US2007009537
申请日：2007-04-18
申请人： UNIV LELAND STANFORD JUNIOR , HUEBER WOLFGANG , ROBINSON WILLIAM H , STEINMAN LAWRENCE , UTZ PAUL J , GENOVESE MARK
发明人： HUEBER WOLFGANG , ROBINSON WILLIAM H , STEINMAN LAWRENCE , UTZ PAUL J , GENOVESE MARK
IPC分类号： G01N33/53
CPC分类号： G01N33/6869 , G01N33/564 , G01N33/6854 , G01N33/6863 , G01N2333/522 , G01N2333/523 , G01N2333/525 , G01N2333/5412 , G01N2333/5421 , G01N2333/545 , G01N2800/102 , G01N2800/52
摘要： Compositions and methods are provided for prognostic classification of autoimmune disease patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. The patterns of circulating blood levels of serum autoantibodies and/or cytokines provides for a signature pattern that can identify patients likely to benefit from therapeutic intervention as well as discriminate patients that have a high probability of responsiveness to a therapy from those that have a low probability of responsiveness. Additionally, serum autoantibody and/or cytokine signature patterns can be utilized to monitor responses to therapy. Assessment of this signature pattern of autoantibodies and/or cytokines in a patient thus allows improved methods of care. In one embodiment of the invention, the autoimmune disease is rheumatoid arthritis.
摘要翻译：提供组合物和方法用于将自身免疫性疾病患者预后分类为亚型，其中亚型对患者对治疗的需要和对感兴趣的治疗的反应性提供信息。血清自身抗体和/或细胞因子的循环血液水平的模式提供了可以识别可能受益于治疗性干预的患者的签名模式，以及将具有较低概率的患者对治疗的反应敏感性高的患者区分开来的反应。另外，可以利用血清自身抗体和/或细胞因子标记图来监测对治疗的反应。因此，患者自身抗体和/或细胞因子的这种特征图案的评估因此允许改进的护理方法。在本发明的一个实施方案中，自身免疫性疾病是类风湿性关节炎。

6. 发明申请

WO9937540A3 METHOD OF AND APPARATUS FOR PACKAGING INFUSION PACKAGES 审中-公开
标题翻译：用于包装输入包的方法和装置
公开(公告)号：WO9937540A3
公开(公告)日：2003-07-17
申请号：PCT/GB9900221
申请日：1999-01-22
申请人： TETLEY GB LTD , UTZ PAUL , WOLLMERSHAEUSER PAUL , SCHUBERT GERALD , WILKINSON DAVID JOHN , LOBLEY STEPHEN JOHN RICHARD
发明人： UTZ PAUL , WOLLMERSHAEUSER PAUL , SCHUBERT GERALD , WILKINSON DAVID JOHN , LOBLEY STEPHEN JOHN RICHARD
IPC分类号： B65B7/06 , B65B5/06
CPC分类号： B65B7/06
摘要： Infusion packages are produced in a machine (2) and stacked in carriers (6). The carriers (6) are conveyed to a vibration station (18) where the stacks of infusion packages are vibrated by displacing them reciprocally in a vertical direction so as to consolidate them. The carriers are then conveyed to a transfer means (10) where the stacks of packages are transferred into transfer chambers which move the stacks to overlie open-mouthed flat-bottomed, flexible bags (12), into which the packages are deposited. The stacks of packages are urged together so as to interleave or otherwise consolidate them as they are transferred into the transfer chambers.
摘要翻译：输液包装在机器（2）中生产并堆放在载体（6）中。载体（6）被输送到振动台（18），在该振动台（18）处，输送包装的堆叠通过沿垂直方向往复移动而振动，从而使它们固结。然后将载体输送到转移装置（10），其中将堆叠的包装转移到转移室中，该转移室将堆叠移动到覆盖开放的平底的柔性袋（12），包装被沉积到其中。一堆包装被推到一起，以便当它们被转移到传送室中时交织或以其它方式固结。

7. 发明申请

WO2002084249A3 THERAPEUTIC AND DIAGNOSTIC USES OF ANTIBODY SPECIFICITY PROFILES 审中-公开
公开(公告)号：WO2002084249A3
公开(公告)日：2002-10-24
申请号：PCT/US2002/011356
申请日：2002-04-10
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , ROBINSON, William, H. , HIRSCHBERG, David, L. , STEINMAN, Lawrence , RUIZ, Pedro, Jose , UTZ, Paul, J. , GARREN, Hideki
发明人： ROBINSON, William, H. , HIRSCHBERG, David, L. , STEINMAN, Lawrence , RUIZ, Pedro, Jose , UTZ, Paul, J. , GARREN, Hideki
IPC分类号： G01N33/53
摘要： This invention provides a method for determining the antibody specificity profile in an individual. This specificity profile reveals the individual's immune response to multiple antigens and/or epitopes of autoantigens, allergens, graft antigens, etc. The antibody specificity profile is determined through the binding of patient samples comprising antibodies to the arrays. The array can comprises antigens and epitopes. The invention also provides the means and methods for determining antigen or epitope specificity profiles that can be used in the development of either generic and individualized diagnosis and treatment for immune related diseases, including autoimmune disease, allergy and graft rejection.

8. 发明申请

WO2007123976A2 ANTIBODY PROFILING FOR DETERMINATION OF PATIENT RESPONSIVENESS 审中-公开
标题翻译：用于确定患者反应的抗体分型
公开(公告)号：WO2007123976A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/009537
申请日：2007-04-18
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , HUEBER, Wolfgang , ROBINSON, William, H. , STEINMAN, Lawrence , UTZ, Paul, J. , GENOVESE, Mark
发明人： HUEBER, Wolfgang , ROBINSON, William, H. , STEINMAN, Lawrence , UTZ, Paul, J. , GENOVESE, Mark
IPC分类号： G01N33/53
CPC分类号： G01N33/6869 , G01N33/564 , G01N33/6854 , G01N33/6863 , G01N2333/522 , G01N2333/523 , G01N2333/525 , G01N2333/5412 , G01N2333/5421 , G01N2333/545 , G01N2800/102 , G01N2800/52
摘要： Compositions and methods are provided for prognostic classification of autoimmune disease patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. The patterns of circulating blood levels of serum autoantibodies and/or cytokines provides for a signature pattern that can identify patients likely to benefit from therapeutic intervention as well as discriminate patients that have a high probability of responsiveness to a therapy from those that have a low probability of responsiveness. Additionally, serum autoantibody and/or cytokine signature patterns can be utilized to monitor responses to therapy. Assessment of this signature pattern of autoantibodies and/or cytokines in a patient thus allows improved methods of care. In one embodiment of the invention, the autoimmune disease is rheumatoid arthritis.
摘要翻译：提供组合物和方法用于将自身免疫性疾病患者预后分类为亚型，其中亚型对患者对治疗的需要和对感兴趣的治疗的反应性提供信息。血清自身抗体和/或细胞因子的循环血液水平的模式提供了可以识别可能受益于治疗性干预的患者的签名模式，以及将具有较低概率的患者对治疗的反应敏感性高的患者区分开来的反应。另外，可以利用血清自身抗体和/或细胞因子标记图来监测对治疗的反应。因此，患者自身抗体和/或细胞因子的这种特征图案的评估因此允许改进的护理方法。在本发明的一个实施方案中，自身免疫性疾病是类风湿性关节炎。

9. 发明申请

WO2005070021A3 MICROARRAY ANALYSIS OF POST-TRANSLATIONAL MODIFICATIONS 审中-公开
公开(公告)号：WO2005070021A3
公开(公告)日：2005-08-04
申请号：PCT/US2005/002384
申请日：2005-01-24
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , CHAN, Steven, M., C. , UTZ, Paul, J.
发明人： CHAN, Steven, M., C. , UTZ, Paul, J.
IPC分类号： G01N33/53
摘要： Methods and kits are provided for a multiplexed reverse phase protein (RPP) microarray platform, which is utilized for simultaneous monitoring of cellular components following exposure to an agent or agents of interest. The microarray comprises cell lysates or fractions thereof. The array is probed with a specific binding agent or agents. Binding agents of interest include agents specific for inducible proteins, constitutive proteins, apoptosis-specific modifications, etc., and particularly for post-translationally modified proteins, e.g. phosphoproteins, glycosylated proteins, and the like. The methods are of interest for determining patterns of modifications, and the like that define disease states or classify subsets of disease (including staging and subsets of cancers, autoimmune diseases, and the like); that follow response to therapy; that determine response patterns after exposure to a specific agent, and the like. This information is useful in the development of therapies, as a disease prognostic, determining patient specific therapies, and the like. Kits may comprise microarrays having a cell selection of interest, and may further comprise antibodies of desired specificity, and the like.

10. 发明申请

WO2005070021A2 MICROARRAY ANALYSIS OF POST-TRANSLATIONAL MODIFICATIONS 审中-公开
标题翻译：翻译后修饰的微阵列分析
公开(公告)号：WO2005070021A2
公开(公告)日：2005-08-04
申请号：PCT/US2005002384
申请日：2005-01-24
申请人： UNIV LELAND STANFORD JUNIOR , CHAN STEVEN M C , UTZ PAUL J
发明人： CHAN STEVEN M C , UTZ PAUL J
IPC分类号： G01N33/50 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/567 , G01N33/68
CPC分类号： G01N33/5023 , G01N33/6845 , G01N2800/52
摘要： Methods and kits are provided for a multiplexed reverse phase protein (RPP) microarray platform, which is utilized for simultaneous monitoring of cellular components following exposure to an agent or agents of interest. The microarray comprises cell lysates or fractions thereof. The array is probed with a specific binding agent or agents. Binding agents of interest include agents specific for inducible proteins, constitutive proteins, apoptosis-specific modifications, etc., and particularly for post-translationally modified proteins, e.g. phosphoproteins, glycosylated proteins, and the like. The methods are of interest for determining patterns of modifications, and the like that define disease states or classify subsets of disease (including staging and subsets of cancers, autoimmune diseases, and the like); that follow response to therapy; that determine response patterns after exposure to a specific agent, and the like. This information is useful in the development of therapies, as a disease prognostic, determining patient specific therapies, and the like. Kits may comprise microarrays having a cell selection of interest, and may further comprise antibodies of desired specificity, and the like.
摘要翻译：提供了用于多重反相蛋白（RPP）微阵列平台的方法和试剂盒，其用于在暴露于一种或多种感兴趣的试剂后同时监测细胞组分。微阵列包含细胞裂解物或其部分。该阵列用特定的结合剂或试剂进行探测。感兴趣的结合剂包括对可诱导蛋白质，组成型蛋白质，细胞凋亡特异性修饰等特异的试剂，特别是对于翻译后修饰的蛋白质，例如蛋白质。磷蛋白，糖基化蛋白等。这些方法对确定修饰模式以及定义疾病状态或分类疾病亚组（包括癌症的分期和亚组，自身免疫性疾病等）是有意义的; 遵循疗法的反应; 确定暴露于特定试剂后的响应模式，等等。这些信息在开发疗法，作为疾病预后，确定患者特异性疗法等方面是有用的。试剂盒可以包含具有感兴趣的细胞选择的微阵列，并且可以进一步包含具有期望特异性的抗体等。

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