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2. 发明专利

AP2011005941A0 Inhibitors of viral integrase and methods of use. 未知
公开(公告)号：AP2011005941A0
公开(公告)日：2011-10-31
申请号：AP2011005941
申请日：2010-03-18
申请人： INTEGRATECH PROTEOMICS LLC , US SEC DEP OF HEALTH AND HUMAN SERVICES
发明人： SANDROCK TANYA , CRAIGIE ROBERT
IPC分类号： C07K9/00 , C07H21/04

3. 发明专利

CA2318789C CELLULAR ARRAYS FOR RAPID MOLECULAR PROFILING 未知
公开(公告)号：CA2318789C
公开(公告)日：2011-05-10
申请号：CA2318789
申请日：1999-02-24
申请人： US SEC DEP OF HEALTH AND HUMAN SERVICES , KANTON BASEL STADT
发明人： KALLIONIEMI OLLI , KONONEN JUHA , SAUTER GUIDO
IPC分类号： C12Q1/68 , G01N33/48 , B01L3/00 , C12Q1/04 , C12Q1/24 , C12Q1/28 , G01N1/08 , G01N1/28 , G01N1/31 , G01N1/36 , G01N33/50 , G01N33/543 , G01N33/566 , G01N33/574 , G01N37/00 , G02B21/34
摘要： A method is disclosed for rapid molecular profiling of tissue or other cellular specimens by placing a donor specimen in an assigned location in a recipient array, providing copies of the array, and performing a different biological analysis of each copy. In one embodiment, the copies of the array are formed by placing elongated specimens in a three dimensional matrix, and cutting sections from the matrix to form multiple copies of a two dimensional array that can then be subjected to the different biological analyses. Alternatively, the array can be formed from cell suspensions such that identical multiple copies of an array are formed, in which corresponding positions in the copies of the array have samples from the same or similar specimen. The results of the different biological analyses are compared to determine if there are correlations between the results of the different biological analyses at each assigned location. In some embodiments, the specimens may be tissue specimens from different tumors, which are subjected to multiple parallel molecular (including genetic and immunological) analyses. The results of the parallel analyses are then used to detect common molecular characteristics of the tumor type, which can subsequently be used in the diagnosis or treatment of the disease. The biological characteristics of the tissue can be correlated with clinical or other information, to detect characteristics associated with the tissue, such as susceptibility or resistance to particular types of drug treatment. Other examples of suitable tissues which can be placed in the matrix include tissue from transgenic or model organisms, or cellular suspensions (such as cytological preparations or specimens of liquid malignancies or cell lines).

4. 发明专利

IN9618DEN2014A SALMONELLA TYPHI TY21A EXPRESSING YERSINIA PESTIS F1 V FUSION PROTEIN AND USES THEREOF 未知
公开(公告)号：IN9618DEN2014A
公开(公告)日：2015-07-31
申请号：IN9618DEN2014
申请日：2014-11-14
申请人： US SEC DEP OF HEALTH AND HUMAN SERVICES
发明人： KOPECKO DENNIS J , OSORIO MANUEL , FOOTE MONICA R
IPC分类号： A61K39/02 , C12N15/62
摘要： Described herein is the generation of a plasmid construct for expression of a Fl- V fusion protein. In the disclosed plasmid , the F1- V fusion protein coding sequence is operably linked to the htrA promoter , and is fused in frame to the HlyA secretion signal sequence. Also described is serovar Typhi strain Ty21a containing the F1- V fusion protein expression plasmid , such as for use as an oral vaccine against plague.

5. 发明专利

IN168DEN2014A CONJUGATING AMINES 未知
公开(公告)号：IN168DEN2014A
公开(公告)日：2015-05-22
申请号：IN168DEN2014
申请日：2014-01-08
申请人： GEN HOSPITAL CORP , INTERNAT CT FOR DIARRHOEAL DISEASE RES BANGLADESH , US SEC DEP OF HEALTH AND HUMAN SERVICES
发明人： RYAN EDWARD T , KOVAC PAVOL , QADRI FIRDAUSI , XU PENG , CALDERWOOD STEPHEN B , VANN WILLIE FRANK , PETERSON DWIGHT CHRISTOPHER
IPC分类号： A61K31/01 , A61K39/00 , A61K47/06
摘要： The disclosure provides directly conjugated polysaccharide vaccine molecules and methods related thereto.

6. 发明专利

IL237339D0 Multifunctional oral vaccine based on chromosome recombineering 未知
公开(公告)号：IL237339D0
公开(公告)日：2015-04-30
申请号：IL23733915
申请日：2015-02-22
申请人： US SEC DEP OF HEALTH AND HUMAN SERVICES , US GOVERNMENT
IPC分类号： C12N20060101 , A61K39/00
摘要： A recombineered Salmonella typhi Ty21a, compositions and vaccines comprising such a Ty21a, and a method for recombineering comprising inserting a large antigenic region into a bacterial chromosome for the purpose of making multivalent vaccines to protect against one or more disease agents are described herein.

7. 发明专利

AP201105941A0 Inhibitors of viral integrase and methods of use. 未知
公开(公告)号：AP201105941A0
公开(公告)日：2011-10-31
申请号：AP201105941
申请日：2010-03-18
申请人： INTEGRATECH PROTEOMICS LLC , US SEC DEP OF HEALTH AND HUMAN SERVICES
发明人： SANDROCK TANYA , CRAIGIE ROBERT
IPC分类号： C07K9/00 , C07H21/04
CPC分类号： C07K4/00 , A61K38/00 , A61K38/03 , A61K38/10 , A61K39/00 , C07K1/00 , C07K7/02 , C07K7/08 , C12Q1/68 , C12Q1/70 , C40B30/04 , G01N33/573 , G01N2333/15 , G01N2500/02

8. 发明专利

IL209107D0 LEISHMANIA VACCINE USING SAND FLY SALIVARY IMMUNOGEN 未知
公开(公告)号：IL209107D0
公开(公告)日：2011-01-31
申请号：IL20910710
申请日：2010-11-04
申请人： MERIAL LTD , GOVERNMENT OF THE US SEC DEP OF HEALTH AND HUMAN SERVICES
IPC分类号： C07K20060101
摘要： The present invention provides vectors that contain and express in vivo or in vitro sand fly Lu. longipalpis salivary antigens that elicit an immune response in animal or human against Leishmania, vaccine compositions comprising said vectors and/or Lu. longipalpis salivary polypeptides, methods of vaccination against Leishmania, and kits for use with such methods and compositions.

9. 发明专利

AP3500A INHIBITORS OF VIRAL INTEGRASE AND METHODS OF USE 未知
公开(公告)号：AP3500A
公开(公告)日：2015-12-31
申请号：AP2011005941
申请日：2010-03-18
申请人： INTEGRATED PROTEOMICS LLC , US SEC DEP OF HEALTH AND HUMAN SERVICES
发明人： CRAIGIE ROBERT , SANDROCK TANYA
IPC分类号： C07H21/04 , C07K9/00

10. 发明专利

NZ703668A Complexes of il-15 and il-15ralpha and uses thereof 未知
公开(公告)号：NZ703668A
公开(公告)日：2016-07-29
申请号：NZ70366808
申请日：2008-06-27
申请人： US SEC DEP OF HEALTH AND HUMAN SERVICES , ADMUNE THERAPEUTICS LLC
发明人： PAVLAKIS GEORGE N , VOURNAKIS JOHN N , FELBER BARBARA K , FINKIELSZTEIN SERGIO
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00
摘要： Disclosed is the use of an antibody in the preparation of a medicament for treating an autoimmune disorder or inflammatory disorder in a human subject, wherein the antibody binds specifically to IL-15/IL-15Ra complexes and reduces the binding of the IL-15/IL-15Ra complexes to the beta-gamma receptor complex as determined in cell culture or in vitro.

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