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1. 发明专利

CA2866185C PATHOGENIC PHLEBOVIRUS ISOLATES AND COMPOSITIONS AND METHODS OF USE 未知
公开(公告)号：CA2866185C
公开(公告)日：2021-04-06
申请号：CA2866185
申请日：2013-03-22
申请人： US GOV HEALTH & HUMAN SERVICES
发明人： MCMULLAN LAURA K , GOLDSMITH CYNTHIA , KELLY AUBREE , NICHOLSON WILLIAM L , NICHOL STUART T
IPC分类号： C12N7/00
摘要： Described herein are the clinical and laboratory characteristics of two patients bitten by ticks and infected with a unique member of the genus Phlebovirus (family Bunyaviridae) with a proposed name of Heartland virus (HRTLV). Provided herein are nucleotide and amino acid sequences of the Phlebovirus isolates, primers and probes that specifically hybridize with the Phlebovirus isolates, and antibodies specific for the Phlebovirus proteins. Also provided are detection assays using the Phlebovirus nucleic acid molecules, proteins, probes, primers and antibodies. Further provided are recombinant Phleboviruses and their use for eliciting an immune response in a subject.

2. 发明专利

NZ736967A Use of il-15 to increase thymic output and to treat lymphopenia 未知
公开(公告)号：NZ736967A
公开(公告)日：2020-11-27
申请号：NZ73696710
申请日：2010-08-13
申请人： US GOV HEALTH & HUMAN SERVICES
发明人： BERGAMASCHI CRISTINA , PAVLAKIS GEORGE N , VALENTIN ANTONIO , FELBER BARBARA K
IPC分类号： A61K38/20 , A61K48/00 , A61P37/04 , C07K19/00
摘要： Disclosed is the use of (a) an IL-15 and a soluble IL-15Rα (IL-15/IL-15sRα) complex and (b) an IL-15 and IL-15RαFc fusion protein (IL-15/IL-15RαFc) complex in the manufacture of a medicament for treating lymphopenia. IL-15RaFc fusion protein comprises a truncated IL-15Ra. The IL-15 may comprise a signal peptide from a heterologous protein. The patient may be receiving a chemotherapeutic agent.

3. 发明专利

CA3104142A1 MONOCLONAL ANTIBODY FOR THE DETECTION OF THE ANTIRETROVIRAL DRUG EMTRICITABINE (FTC, 2',3'-DIDEOXY-5-FLUORO-3'-THIACYTIDINE) 未知
公开(公告)号：CA3104142A1
公开(公告)日：2020-01-16
申请号：CA3104142
申请日：2019-07-10
申请人： US GOV HEALTH & HUMAN SERVICES
发明人： GRANADE TIMOTHY CLYDE , YOUNGPAIROJ AE SAEKHOU , SWITZER WILLIAM MARSHALL , HENEINE WALID M , PAU CHOU-PONG , ZHENG HAOQIANG , POHL JAN
IPC分类号： C07K16/44 , G01N33/577
摘要： Disclosed are monoclonal antibodies that specifically bind emtricitabine (FTC). Methods are also disclosed for using these antibodies to detect FTC in samples. In some embodiments, these methods are of use for determining if a subject is complying with a therapeutic or prophylactic protocol. In other embodiments, methods are disclosed for determining the dose of FTC to administer to a subject.

4. 发明专利

AU2019203525A1 METHODS AND COMPOSITIONS FOR DETECTION OF LEGIONELLA 未知
公开(公告)号：AU2019203525A1
公开(公告)日：2019-06-06
申请号：AU2019203525
申请日：2019-05-20
申请人： US GOV HEALTH & HUMAN SERVICES
发明人： WINCHELL JONAS M , BENITEZ ALVARO J
IPC分类号： C12Q1/68
摘要： Methods for detecting Legionella (such as Legionella spp., Legionella pneumophila, Legionellapneumophila serogroup 1, Legionella bozemanii, Legionella dumoffli, Legionellafeeleii, Legionella longbeachae, and/or Legionella micdadei) are disclosed. A sample suspected of containing one or more Legionella nucleic acids is screened for the presence or absence of that nucleic acid. Determining whether Legionella nucleic acid is present in the sample can be accomplished by detecting hybridization between a Legionella probe and a nucleic acid in a sample. Also disclosed are probes and primers for the detection of Legionella, and kits that contain the disclosed probes and/or primers.

5. 发明专利

ES2714999T3 Terapia de combinación que usa inmunoglobulina e inhibidor de C1 未知
公开(公告)号：ES2714999T3
公开(公告)日：2019-05-31
申请号：ES12761739
申请日：2012-09-21
申请人： CSL BEHRING GMBH , US GOV HEALTH & HUMAN SERVICES
发明人： BASTA MILAN , CHEN XINZHI , MATTSON MARK
IPC分类号： A61K39/395 , A61K38/55 , A61P9/10
摘要： Una composición para su uso en la prevención, el tratamiento o la reducción de los efectos de daño por inflamación o lesión por reperfusión tras isquemia cerebral, que comprende una combinación de inmunoglobulina G intravenosa (IVIG) derivada de plasma humano e inhibidor de C1 (C1-INH), en la que el C1-INH se administra a una concentración de 75 U/kg de peso corporal y en la que la IVIG se administra a una concentración de 0,5 g/kg de peso corporal.

6. 发明专利

CA2678404C BRACHYURY POLYPEPTIDES AND METHODS FOR USE 未知
公开(公告)号：CA2678404C
公开(公告)日：2019-03-19
申请号：CA2678404
申请日：2008-02-27
申请人： US GOV HEALTH & HUMAN SERVICES
发明人： SCHLOM JEFFREY , PALENA CLAUDIA M , KOZLOV ANDREI P , TSANG KWONG-YOK
IPC分类号： C07K4/12 , A61K39/00 , C07K14/47
摘要： It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immunogenic Brachyury polypeptides are disclosed herein. These polypeptides can be used in diagnostic assays for Brachyury expression, as well as for inducing an immune response to Brachyury. Polynucleotides encoding the immunogenic Brachyury polypeptides, vectors including these polypeptides, host cells transformed with these vectors, and methods of using these polypeptides, polynucleotides, vectors, and host cells are provided. Methods of diagnosing a Brachyury-expressing cancer are also provided. Exemplary cancers include small lung, colon, intestine, stomach, kidney, bladder, uterus, ovary, and testes and prostate cancers. Methods of treating cancer are also disclosed.

7. 发明专利

AU2013274879B2 Methods and compositions for detection of Legionella 未知
公开(公告)号：AU2013274879B2
公开(公告)日：2019-02-21
申请号：AU2013274879
申请日：2013-03-11
申请人： US GOV HEALTH & HUMAN SERVICES
发明人： WINCHELL JONAS M , BENITEZ ALVARO J
IPC分类号： C12Q1/68
摘要： Methods for detecting Legionella (such as

8. 发明专利

DK2655604T3 ADENOVIRUS SEROTYPE-26- OG SEROTYPE-35-FILOVIRUSVACCINER 未知
公开(公告)号：DK2655604T3
公开(公告)日：2018-08-06
申请号：DK11849865
申请日：2011-12-14
申请人： US GOV HEALTH & HUMAN SERVICES , JANSSEN VACCINES & PREVENTION BV
发明人： SULLIVAN NANCY J , NABEL GARY J , ASIEDU CLEMENT , CHENG CHENG , PAU MARIA GRAZIA , GOUDSMIT JAAP
IPC分类号： C12N7/01 , A61K39/00 , A61K39/12 , A61K39/235 , C07K14/005

9. 发明专利

ES2676196T3 Vacunas contra filovirus de adenovirus de serotipo 25 y serotipo 35 未知
公开(公告)号：ES2676196T3
公开(公告)日：2018-07-17
申请号：ES11849865
申请日：2011-12-14
申请人： US GOV HEALTH & HUMAN SERVICES , JANSSEN VACCINES & PREVENTION BV
发明人： SULLIVAN NANCY J , NABEL GARY J , ASIEDU CLEMENT , CHENG CHENG , PAU MARIA GRAZIA , GOUDSMIT JAAP
IPC分类号： C12N7/01 , A61K39/00 , A61K39/12 , A61K39/235 , C07K14/005
摘要： Un primer y segundo vector de adenovirus recombinante que comprende cada uno un ácido nucleico que codifica una proteína antigénica de filovirus, en el que el primer vector de adenovirus comprende una proteína de la cápside del adenovirus 26 y en el que el segundo vector de adenovirus comprende una proteína de la cápside del adenovirus 35, para su uso en la inducción de una respuesta inmunitaria en un sujeto contra dicho antígeno de filovirus, administrando al sujeto, como una vacunación de sensibilización, una cantidad inmunológicamente eficaz de dicho primer vector de adenovirus recombinante; seguido de la administración a dicho sujeto, como una vacuna de refuerzo, de una cantidad inmunológicamente eficaz de dicho segundo vector de adenovirus, en el que las proteínas antigénicas de filovirus codificadas por el primer y segundo vectores de adenovirus recombinantes comparten al menos un determinante antigénico.

10. 发明专利

AU2018200921A1 PREVENTION OF TISSUE ISCHEMIA, RELATED METHODS AND COMPOSITIONS 未知
公开(公告)号：AU2018200921A1
公开(公告)日：2018-03-01
申请号：AU2018200921
申请日：2018-02-08
申请人： US GOV HEALTH & HUMAN SERVICES , UNIV WASHINGTON
发明人： ISENBERG JEFFREY S , ROBERTS DAVID D , FRAZIER WILLIAM A
IPC分类号： C07K14/43 , C07K14/78 , G01N33/68
摘要： Provided herein are compositions and methods for preventing, ameliorating, and/or reducing tissue ischemia and/or tissue damage due to ischemia, increasing blood vessel diameter, blood flow and tissue perfusion in the presence of vascular disease including peripheral vascular disease, atherosclerotic vascular disease, coronary artery disease, stroke and influencing other conditions, by suppressing CD47 and/or blocking TSP1 and/or CD47 activity or interaction. Influencing the interaction of CD47-TSP1 in blood vessels allows for control of blood vessel diameter and blood flow, and permits modification of blood pressure and cardiac function. Under conditions of decreased blood flow, for instance through injury or atherosclerosis, blocking TSP1-CD47 interaction allows blood vessels to dilate and increases blood flow, tissue perfusion and tissue survival. This in turn reduces or prevents tissue necrosis and death. The therapeutics identified herein allow for precise regulation of blood flow to tissues and organs which need it, while substantially avoiding systemic complications. Methods and compositions described herein can be used to increase tissue survival under conditions of trauma and surgery, as well as conditions of chronic vascular disease. Also disclosed are methods for the treatment of elderly subjects using agents that affect TSP1 and CD47 and thereby affect tissue perfusion. Additionally, provided herein are compositions and methods for influencing blood coagulation, allowing for controlled increased or decreased blood clotting. Additionally, provided herein are compositions and methods for decreasing blood flow, as in the case of cancer through mimicking the effects of TSP1 and CD47 on blood vessel diameter and blood flow.

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